CaMKK

By Targets:	AAK1 (1) AMPK (5) Autophagy (3) Bacterial (1) CaMK (3) HDAC (1) IRAK (1) Isotope-Labeled Compounds (1) LRRK2 (3) Small Interfering RNA (siRNA) (2) STAT (1) TNF Receptor (1) Tyrosinase (1)
By Research Areas:	Cancer (2) Cardiovascular Disease (1) Infection (1) Inflammation/Immunology (4) Metabolic Disease (7) Neurological Disease (5)
Oligonucleotides:	Pre-designed siRNA Sets (2) siRNAs (2)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-162009

CaMKK2-IN-1	Others	Cancer
CaMKK2-IN-1 is a selective, ligand-efficient inhibitor of CaMKK2, with IC₅₀ of 7 nM .

HY-148757

TIM-063	CaMK	Metabolic Disease
TIM-063 is a selective and cell-permeable *CaMKK* inhibitor, ATP competitive inhibitor, can directly target the catalytic domain of CaMKK, with the K_i values of 0.35 μM and 0.2 μM for CaMKKα and CaMKKβ, respectively, the IC₅₀ values are 0.63 μM and 0.96 μM, respectively .

HY-N7676

Marein 1 Publications Verification	AMPK HDAC	Cardiovascular Disease Neurological Disease Metabolic Disease
Marein has the neuroprotective effect due to a reduction of damage to mitochondria function and activation of the AMPK signal pathway. Marein improves insulin resistance induced by high glucose in HepG2 cells through CaMKK/AMPK/GLUT1 to promote glucose uptake, through IRS/Akt/GSK-3β to increase glycogen synthesis, and through Akt/FoxO1 to decrease gluconeogenesis. Marein is a HDAC inhibitor with an IC₅₀ of 100 µM. Marein has beneficial antioxidative, antihypertensive, antihyperlipidemic and antidiabetic effects .

HY-19805

STO-609 Maximum Cited Publications 17 Publications Verification	CaMK AMPK Autophagy	Metabolic Disease
STO-609 is a selective and cell-permeable inhibitor of the Ca ²⁺/calmodulin-dependent protein kinase kinase (CaM-KK), with K_i values of 80 and 15 ng/mL for recombinant CaM-KKα and CaM-KKβ, respectively. STO-609 inhibits AMP-activated protein kinase kinase (AMPKK) activity in HeLa cell lysates with an IC₅₀ ~0.02 g/ml.

HY-163064

CC-3240	LRRK2	Cancer
CC-3240 (compound 13) is a molecular glue degrader of *CaMKK2* based on CC-8977, with the IC₅₀ of 9 nM .

HY-W017212

Methyl cinnamate 1 Publications Verification Methyl 3-phenylpropenoate	Tyrosinase Bacterial AMPK	Infection Metabolic Disease
Methyl cinnamate (Methyl 3-phenylpropenoate), an active component of Zanthoxylum armatum, is a widely used natural flavor compound. Methyl cinnamate (Methyl 3-phenylpropenoate) possesses antimicrobial activity and is a tyrosinase inhibitor that can prevent food browning. Methyl cinnamate (Methyl 3-phenylpropenoate) has antiadipogenic activity through mechanisms mediated, in part, by the *CaMKK2-AMPK* signaling pathway .

HY-RS01865

CAMKK1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
CAMKK1 Human Pre-designed siRNA Set A contains three designed siRNAs for CAMKK1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

CAMKK1 Human Pre-designed siRNA Set A CAMKK1 Human Pre-designed siRNA Set A

HY-RS01866

CAMKK2 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
CAMKK2 Human Pre-designed siRNA Set A contains three designed siRNAs for CAMKK2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

CAMKK2 Human Pre-designed siRNA Set A CAMKK2 Human Pre-designed siRNA Set A

HY-162388

TIM-098a	AAK1	Neurological Disease
TIM-098a is a selective AAK1 inhibitor with an IC₅₀ of 0.24 µM. TIM-098a has no inhibitory activity against CaMKK isoforms. TIM-098a inhibits AAK1-regulated endocytosis by suppressing AAK1 kinase activity .

HY-19805A

STO-609 acetate	CaMK AMPK Autophagy	Metabolic Disease
STO-609 acetate is a selective and cell-permeable inhibitor of the Ca ²⁺/calmodulin-dependent protein kinase kinase (CaM-KK), with K_i values of 80 and 15 ng/mL for recombinant CaM-KKα and CaM-KKβ, respectively. STO-609 acetate inhibits AMP-activated protein kinase kinase (AMPKK) activity in HeLa cell lysates with an IC₅₀ ~0.02 g/ml.

HY-N8016S2

Nonanal-d2	Isotope-Labeled Compounds	Metabolic Disease
Nonanal-d₂ is deuterated labeled Methyl cinnamate (HY-W017212). Methyl cinnamate (Methyl 3-phenylpropenoate), an active component of Zanthoxylum armatum, is a widely used natural flavor compound. Methyl cinnamate (Methyl 3-phenylpropenoate) possesses antimicrobial activity and is a tyrosinase inhibitor that can prevent food browning. Methyl cinnamate (Methyl 3-phenylpropenoate) has antiadipogenic activity through mechanisms mediated, in part, by the *CaMKK2-AMPK* signaling pathway .

HY-103238

RSVA405	AMPK STAT Autophagy	Neurological Disease Metabolic Disease Inflammation/Immunology
RSVA405 is a potent, orally active activator of AMPK, with an EC₅₀ of 1 μM. RSVA405 facilitates CaMKKβ-dependent activation of AMPK, inhibits mTOR, and promotes autophagy to increase Aβ degradation. RSVA405 has anti-inflammatory effects through the inhibition of STAT3 function. RSVA405 can also be used for the research of obesity .

HY-147141

HS-276	IRAK TNF Receptor	Inflammation/Immunology
HS-276 is an orally active, potent and highly selective TAK1 inhibitor, with a K_i of 2.5 nM. HS-276 shows significant inhibition of TAK1, CLK2, GCK, ULK2, MAP4K5, IRAK1, NUAK, CSNK1G2, CAMKKβ-1, and MLK1, with IC₅₀ values of 8.25, 29, 33, 63, 125, 264, 270, 810, 1280, and 5585 nM, respectively. HS-276 can be used for rheumatoid arthritis (RA) research .

HY-15800A

CZC-25146	LRRK2	Neurological Disease Inflammation/Immunology
CZC-25146 is a potent and orally active LRRK2 inhibitor with IC₅₀ values of 4.76 nM and 6.87 nM for wild-type LRRK2 and G2019S LRRK2, respectively. CZC-25146 inhibits PLK4, GAK, TNK1, CAMKK2 and PIP4K2C as well. CZC-25146 prevents mutant LRRK2-induced injury of neurons in vitro. CZC-25146 exhibits relatively favorable pharmacokinetic properties in mice. CZC-25146 can increase normal α-1-antitrypsin (AAT) secretion and reduce inflammatory cytokines. CZC-25146 can be used to research Parkinson's disease and liver diseases .

HY-15800

CZC-25146 hydrochloride	LRRK2	Neurological Disease Inflammation/Immunology
CZC-25146 hydrochloride is a potent LRRK2 inhibitor with IC₅₀ values of 4.76 nM and 6.87 nM for wild-type LRRK2 and G2019S LRRK2, respectively. CZC-25146 hydrochloride inhibits PLK4, GAK, TNK1, CAMKK2 and PIP4K2C as well. CZC-25146 hydrochloride prevents mutant LRRK2-induced injury of neurons in vitro. CZC-25146 hydrochloride exhibits relatively favorable pharmacokinetic properties in mice. CZC-25146 hydrochloride can increase normal α-1-antitrypsin (AAT) secretion and reduce inflammatory cytokines. CZC-25146 hydrochloride can be used to research Parkinson's disease and liver diseases .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N7676

Marein 1 Publications Verification	Cardiovascular Disease Flavonoids Chalcones other families Classification of Application Fields Neurological Disease Source classification Phenols Polyphenols Plants Disease Research Fields	AMPK HDAC
Marein has the neuroprotective effect due to a reduction of damage to mitochondria function and activation of the AMPK signal pathway. Marein improves insulin resistance induced by high glucose in HepG2 cells through CaMKK/AMPK/GLUT1 to promote glucose uptake, through IRS/Akt/GSK-3β to increase glycogen synthesis, and through Akt/FoxO1 to decrease gluconeogenesis. Marein is a HDAC inhibitor with an IC₅₀ of 100 µM. Marein has beneficial antioxidative, antihypertensive, antihyperlipidemic and antidiabetic effects .

HY-W017212

Methyl cinnamate 1 Publications Verification Methyl 3-phenylpropenoate	Structural Classification Microorganisms Classification of Application Fields Simple Phenylpropanols Source classification Rutaceae Metabolic Disease Phenylpropanoids Plants Disease Research Fields Zanthoxylum armatum DC.	Tyrosinase Bacterial AMPK
Methyl cinnamate (Methyl 3-phenylpropenoate), an active component of Zanthoxylum armatum, is a widely used natural flavor compound. Methyl cinnamate (Methyl 3-phenylpropenoate) possesses antimicrobial activity and is a tyrosinase inhibitor that can prevent food browning. Methyl cinnamate (Methyl 3-phenylpropenoate) has antiadipogenic activity through mechanisms mediated, in part, by the *CaMKK2-AMPK* signaling pathway .

Species:	Human (2) Rat (1)
Tag:	His (1) Tag Free (1) GST (1)
Source:	Sf9 insect cells (3)

Cat. No.	Compare	Product Name	Species	Source

HY-P701722

	CAMKK1 Protein, Human (Sf9) CaMKK1; Calcium/calmodulin-dependent protein kinase kinase 1; CaM-KK 1; CaM-kinase kinase 1; CaMKK 1; CaM-kinase IV kinase; Calcium/calmodulin-dependent protein kinase kinase alpha; CaM-KK alpha; CaM-kinase kinase alpha; CaMKK alpha	Human	Sf9 insect cells
	The CAMKK1 protein is a calcium/calmodulin-dependent kinase and a key player in calcium-triggered signaling cascades involved in various cellular processes. It phosphorylates multiple members of the CAMK1 family, including CAMK1, CAMK1D, CAMK1G, and CAMK4. CAMKK1 Protein, Human (Sf9) is the recombinant human-derived CAMKK1 protein, expressed by Sf9 insect cells , with tag free. The total length of CAMKK1 Protein, Human (Sf9) is 505 a.a., .

HY-P701723

	CAMKK1 Protein, Human (Sf9, His) CaMKK1; Calcium/calmodulin-dependent protein kinase kinase 1; CaM-KK 1; CaM-kinase kinase 1; CaMKK 1; CaM-kinase IV kinase; Calcium/calmodulin-dependent protein kinase kinase alpha; CaM-KK alpha; CaM-kinase kinase alpha; CaMKK alpha	Human	Sf9 insect cells
	The CAMKK1 protein is a calcium/calmodulin-dependent kinase and a key player in calcium-triggered signaling cascades involved in various cellular processes. It phosphorylates multiple members of the CAMK1 family, including CAMK1, CAMK1D, CAMK1G, and CAMK4. CAMKK1 Protein, Human (Sf9, His) is the recombinant human-derived CAMKK1 protein, expressed by Sf9 insect cells , with N-6*His labeled tag. The total length of CAMKK1 Protein, Human (Sf9, His) is 505 a.a., .

HY-P703030

	CAMKK1 Protein, Rat (F230G, sf9, GST) Calcium/calmodulin-dependent protein kinase kinase 1; CaM-KK 1; CaM-kinase kinase 1; CaMKK 1; CaM-kinase IV kinase; Calcium/calmodulin-dependent protein kinase kinase alpha (CaM-KK alpha; CaM-kinase kinase alpha; CaMKK alpha)	Rat	Sf9 insect cells
	CAMKK1 Protein, Rat (F230G, sf9, GST) is the recombinant rat-derived CAMKK1, expressed by Sf9 insect cells , with GST labeled tag. The total length of CAMKK1 Protein, Rat (F230G, sf9, GST) is 505 a.a.,

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Cat. No.	Product Name	Chemical Structure

HY-N8016S2

Nonanal-d2
Nonanal-d₂ is deuterated labeled Methyl cinnamate (HY-W017212). Methyl cinnamate (Methyl 3-phenylpropenoate), an active component of Zanthoxylum armatum, is a widely used natural flavor compound. Methyl cinnamate (Methyl 3-phenylpropenoate) possesses antimicrobial activity and is a tyrosinase inhibitor that can prevent food browning. Methyl cinnamate (Methyl 3-phenylpropenoate) has antiadipogenic activity through mechanisms mediated, in part, by the *CaMKK2-AMPK* signaling pathway .

Nonanal-d2

Nonanal-d₂ is deuterated labeled Methyl cinnamate (HY-W017212). Methyl cinnamate (Methyl 3-phenylpropenoate), an active component of Zanthoxylum armatum, is a widely used natural flavor compound. Methyl cinnamate (Methyl 3-phenylpropenoate) possesses antimicrobial activity and is a tyrosinase inhibitor that can prevent food browning. Methyl cinnamate (Methyl 3-phenylpropenoate) has antiadipogenic activity through mechanisms mediated, in part, by the CaMKK2-AMPK signaling pathway .

Cat. No.	Compare	Product Name	Application	Reactivity

HY-P81205

	CAMKK2 Antibody Calcium/calmodulin dependent protein kinase beta; Calcium/calmodulin dependent protein kinase kinase 2; Calcium/calmodulin dependent protein kinase kinase beta; CaM kinase kinase beta; CaM KK beta; CaMKK 2; CaMKK; CaMKK beta; CaMKK beta protein; CaMKKB.	WB, IHC-P, IHC-F, FC,	Human, Mouse, Rat, Sheep
	CAMKK2 Antibody is an unconjugated, approximately 55 kDa, rabbit-derived, anti-CAMKK2 polyclonal antibody. CAMKK2 Antibody can be used for: WB, IHC-P, IHC-F, Flow-Cyt, expriments in human, mouse, rat, sheep, and predicted: pig, cow, horse background without labeling.

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Size	* This product has been "discontinued". Optimized version of product available: / In-stock - + Add to Cart Get quote

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HY-RS01865

CAMKK1 Human Pre-designed siRNA Set A		siRNAs Pre-designed siRNA Sets
CAMKK1 Human Pre-designed siRNA Set A contains three designed siRNAs for CAMKK1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS01866

CAMKK2 Human Pre-designed siRNA Set A		siRNAs Pre-designed siRNA Sets
CAMKK2 Human Pre-designed siRNA Set A contains three designed siRNAs for CAMKK2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

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