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Results for "

Co-repressor

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Bcl-2 Family (2) BCL6 (2) Biochemical Assay Reagents (1) Caspase (2) Constitutive Androstane Receptor (1) Estrogen Receptor/ERR (2) LXR (1) PPAR (2) RAR/RXR (1) Small Interfering RNA (siRNA) (2)
By Research Areas:	Cancer (7) Cardiovascular Disease (2) Endocrinology (1) Inflammation/Immunology (3) Metabolic Disease (6)
Oligonucleotides:	siRNAs (2)

Inhibitors & Agonists

Peptides

Recombinant Proteins

Antibodies

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-115532

BCL6-IN-7	Bcl-2 Family	Inflammation/Immunology Cancer
BCL6-IN-7 is a potent BCL6−corepressor interaction inhibitor .

HY-119402

TP-021 BCL6-IN-8c	Bcl-2 Family	Cancer
TP-021 (BCL6-IN-8c) is a potent and orally active *B-cell lymphoma 6 (BCL6)-corepressor* interaction inhibitor with an IC₅₀** of 0.10 µM in cell-free enzyme-linked immunosorbent assay .

HY-16972

SR9243 5 Publications Verification	LXR	Cancer
SR9243 is a liver-X-receptor (LXR) inverse agonist that induces LXR-corepressor interaction.

HY-116247

ST247	PPAR	Metabolic Disease Inflammation/Immunology
ST247 a potent PPARβ/δ inverse agonist. ST247 has a higher affinity to PPARβ/δ. ST247 modulates expression of the activation marker CCL2 in the opposite direction. ST247 efficiently induces the interaction with corepressors. ST247 inhibits the agonist-induced transcriptional activity of PPARβ/δ .

HY-108529

BMS493 4 Publications Verification	RAR/RXR	Metabolic Disease
BMS493 is an inverse pan-retinoic acid receptor (RAR) agonist. BMS493 increases nuclear corepressor interaction with RARs. BMS493 also could prevent retinoic acid-induced differentiation . BMS493 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-143653

BCL6-IN-6	BCL6	Cancer
BCL6-IN-6 is a potent inhibitor of transcriptional repressor B-cell lymphoma 6 (BCL6). BCL6-IN-6 significantly blocks the interaction of BCL6 with its corepressors and reactivates BCL6 target genes in a dose-dependent manner. BCL6-IN-6 has the potential for the research of diffuse large B-cell lymphoma (DLBCL) .

HY-132205

DS45500853	Estrogen Receptor/ERR	Metabolic Disease
DS45500853 is an estrogen-related receptor α (ERRα) agonist. DS45500853 inhibits the binding between receptor-interacting protein 140 (RIP140) corepressor peptide (10 nM) and GST-ERRα ligand-binding domain (LBD; 1.2 μM) with an IC₅₀ value of 0.80 μM. DS45500853 can be used for the research of metabolic disorders, including type 2 diabetes mellitus (T2DM) .

HY-P10543

SMRT peptide	BCL6	Cancer
SMRT peptide is one of the co-repressors of BCL6 BTB domain interaction. SMRT peptide binds to the BTB domain of BCL6 and enhances the transcriptional repression function of BCL6. SMRT peptide can be used to study protein-protein interactions .

HY-161394

SPRT	Others	Cancer
SPRT is a short peptide of RB transcriptional corepressor 1 (RB), serving as a fragment of RB-CO-PEG5-C2-CO-VH032 (HY-161393) for the synthesis of PROTAC .

HY-110134

S07662	Constitutive Androstane Receptor	Metabolic Disease
S07662 is a human constitutive androstane receptor (hCAR) inhibitor with an IC₅₀ of 0.7 μM. S07662 recruits the corepressor NCoR in cell-based assays and attenuate the expression of CYP2B6 mRNA in human primary hepatocytes induced by phenytoin (HY-B0448) and CITCO (HY-103244) .

HY-143201

DS20362725	Estrogen Receptor/ERR	Metabolic Disease
DS20362725 is an estrogen-related receptor α (ERRα) agonist. DS20362725 inhibits the binding between receptor-interacting protein 140 (RIP140) corepressor peptide (10 nM) and GST-ERRα ligand-binding domain (LBD; 1.2 μM) with an IC₅₀ value of 0.6 μM. DS20362725 can be used for the research of metabolic disorders, including type 2 diabetes mellitus (T2DM) .

HY-158820

Cosdosiran QPI-1007	Small Interfering RNA (siRNA) Caspase	Cardiovascular Disease
Cosdosiran is a chemically modified siRNA designed to temporarily inhibit expression of the caspase 2 protein and can be used for the study of nonarteritic anterior ischemic optic neuropathy and other optic neuropathies such as glaucoma that result in the death of retinal ganglion cells.?

HY-158820A

Cosdosiran sodium QPI-1007 sodium	Small Interfering RNA (siRNA) Caspase	Cardiovascular Disease
Cosdosiran sodium is a chemically modified siRNA designed to temporarily inhibit expression of the caspase 2 protein and can be used for the study of nonarteritic anterior ischemic optic neuropathy and other optic neuropathies such as glaucoma that result in the death of retinal ganglion cells.?

HY-E70364

IgdE protease	Biochemical Assay Reagents	Inflammation/Immunology
IgdE protease is a cysteine protease, which is initially isolated from Streptococcus agalactiae. IgdE protease digests monoclonal antibodies (mAbs) of the IgG1 type specifically at their upper hinge region, produces Fc/2, hinge peptide dimers, and Fab fragment. IgdE protease can be used in disulfide bonds and free thiol analysis, as it requires no reducing agents for cleavage .

HY-121900

LT175	PPAR	Metabolic Disease Endocrinology
LT175, a dual PPARα/γ ligand, is an orally active partial agonist against PPARγ(hPPARα:EC₅₀=0.22 μm; mPPARα:EC₅₀=0.26 μm; hPPARγ:EC₅₀=0.48 μm). LT175 interacts with PPARγ and affects the recruitment of the coregulators cyclic-AMP response element-binding protein-binding protein and nuclear corepressor 1 (NCoR1). LT175 interacts with PPARγ in a hydrophobic region called “diphenyl pocket”. LT175 has potent insulin-sensitizing effects and reduced adipogenic properties .

Cat. No.	Product Name	Target	Research Area

HY-P10543

SMRT peptide	BCL6	Cancer
SMRT peptide is one of the co-repressors of BCL6 BTB domain interaction. SMRT peptide binds to the BTB domain of BCL6 and enhances the transcriptional repression function of BCL6. SMRT peptide can be used to study protein-protein interactions .

HY-P10488

cycFWRPW	Peptides	Cancer
cycFWRPW is a peptide inhibitor of TLE1. TLE1 is an oncogenic transcriptional co‐repressor that exerts its repressive effects through binding of transcription factors .

Cat. No.	Compare	Product Name	Species	Source

HY-P71146

	PRDX5/Peroxiredoxin-5 Protein, Human (HEK293, His) Peroxiredoxin-5; PRDX5; Alu Corepressor 1; Antioxidant enzyme B166; AOEB166; Liver tissue 2D-page spot 71B; PLP; Peroxiredoxin V; Prx-V; Peroxisomal antioxidant enzyme; TPx type VI; Thioredoxin peroxidase PMP20; Thioredoxin reductase	Human	HEK293
	The PRDX5 protein (or Peroxiredoxin-5) plays a critical role as a thiol-specific peroxidase that reduces hydrogen peroxide and organic hydroperoxides. This enzyme activity is essential for cells to defend against oxidative stress and detoxify peroxides. PRDX5/Peroxiredoxin-5 Protein, Human (HEK293, His) is the recombinant human-derived PRDX5/Peroxiredoxin-5 protein, expressed by HEK293 , with N-6*His labeled tag. The total length of PRDX5/Peroxiredoxin-5 Protein, Human (HEK293, His) is 162 a.a., with molecular weight of ~17.0 kDa.

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Cat. No.	Compare	Product Name	Application	Reactivity

HY-P80730

	KAP1 Antibody TRIM28; KAP1; RNF96; TIF1B; Transcription intermediary factor 1-beta; TIF1-beta; E3 SUMO-protein ligase TRIM28; KRAB-associated protein 1; KAP-1; KRAB-interacting protein 1; KRIP-1; Nuclear Corepressor KAP-1; RING finger protein 96; Tripart	WB, IHC-F, IHC-P, ICC/IF	Human
	KAP1 Antibody (YA719) is a non-conjugated and Mouse origined monoclonal antibody about 89 kDa, targeting to KAP1 (4E1). It can be used for WB,IHC-F,IHC-P,ICC/IF,IP assays with tag free, in the background of Human.

HY-P81311

	TBL1XR1 Antibody (YA1052) C21; DC42; F box like/WD repeat Containing protein TBL1XR1; F-box-like/WD repeat-Containing protein TBL1XR1; FLJ12894; IRA1; Nuclear receptor Corepressor/HDAC3 Complex subunit; Nuclear receptor Corepressor/HDAC3 Complex subunit TBLR1; TBL1 related protein 1; TBL1-related protein 1; TBL1R_HUMAN; TBL1XR1; Transducin (beta) like 1 X linked receptor 1; Transducin beta like 1X related protein 1; Transducin beta-like 1X-related protein 1.	WB, IHC-F, IHC-P, ICC/IF	Human, Mouse
	TBL1XR1 Antibody (YA1052) is a mouse-derived non-conjugated IgG1 antibody (Clone NO.: YA1052), targeting TBL1XR1, with a predicted molecular weight of 56 kDa (observed band size: 60 kDa). TBL1XR1 Antibody (YA1052) can be used for WB, IHC-F, IHC-P, ICC/IF experiment in human, mouse background.

HY-P81311A

	TBL1XR1 Antibody (YA1053) C21; DC42; F box like/WD repeat Containing protein TBL1XR1; F-box-like/WD repeat-Containing protein TBL1XR1; FLJ12894; IRA1; Nuclear receptor Corepressor/HDAC3 Complex subunit; Nuclear receptor Corepressor/HDAC3 Complex subunit TBLR1; TBL1 related protein 1; TBL1-related protein 1; TBL1R_HUMAN; TBL1XR1; Transducin (beta) like 1 X linked receptor 1; Transducin beta like 1X related protein 1; Transducin beta-like 1X-related protein 1.	WB, IHC-P, ICC/IF	Human, Mouse, Rat
	TBL1XR1 Antibody (YA1053) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA1053), targeting TBL1XR1, with a predicted molecular weight of 56 kDa (observed band size: 56 kDa). TBL1XR1 Antibody (YA1053) can be used for WB, IHC-P, ICC/IF experiment in human, mouse, rat background.

HY-P81339

	TBLR1 Antibody (YA1084) C21; DC42; F box like/WD repeat Containing protein TBL1XR1; F-box-like/WD repeat-Containing protein TBL1XR1; FLJ12894; IRA1; Nuclear receptor Corepressor/HDAC3 Complex subunit; Nuclear receptor Corepressor/HDAC3 Complex subunit TBLR1; TBL1 related protein 1; TBL1-related protein 1; TBL1R_HUMAN; TBL1XR1; Transducin (beta) like 1 X linked receptor 1; Transducin beta like 1X related protein 1; Transducin beta-like 1X-related protein 1.	WB, IHC-P, ICC/IF	Human, Monkey
	TBLR1 Antibody (YA1084) is a mouse-derived non-conjugated IgG1 antibody (Clone NO.: YA1084), targeting TBLR1, with a predicted molecular weight of 56 kDa (observed band size: 60 kDa). TBLR1 Antibody (YA1084) can be used for WB, IHC-P, ICC/IF experiment in human, monkey background.

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HY-158820

Cosdosiran QPI-1007		siRNAs
Cosdosiran is a chemically modified siRNA designed to temporarily inhibit expression of the caspase 2 protein and can be used for the study of nonarteritic anterior ischemic optic neuropathy and other optic neuropathies such as glaucoma that result in the death of retinal ganglion cells.?

HY-158820A

Cosdosiran sodium QPI-1007 sodium		siRNAs
Cosdosiran sodium is a chemically modified siRNA designed to temporarily inhibit expression of the caspase 2 protein and can be used for the study of nonarteritic anterior ischemic optic neuropathy and other optic neuropathies such as glaucoma that result in the death of retinal ganglion cells.?

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