Coelenterazine

By Targets:	Biochemical Assay Reagents (2) Calcium Channel (2) Fluorescent Dye (7) Reactive Oxygen Species (1)
By Research Areas:	Cancer (1) Neurological Disease (2)
Oligonucleotides:	mRNA (2)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-18743

*Coelenterazine* 3 Publications Verification	Reactive Oxygen Species	Cancer
Coelenterazine is a luminescent enzyme substrate for apoaequorin and Renilla luciferase. Renilla luciferase and substrate coelenterazine has been used as the bioluminescence donor in bioluminescence resonance energy transfer (BRET) to detect protein-protein interactions. Coelenterazine is a superoxide anion-sensitive chemiluminescent probe and it can also be used in chemiluminescent detection of peroxynitrite .

HY-D1024

Coelenterazine h 2 Publications Verification 2-DeoxyCoelenterazine; CLZN-h	Calcium Channel Biochemical Assay Reagents	Neurological Disease
Coelenterazine h (2-Deoxycoelenterazine), a coelenterazine derivative, is a luminescent substrate for RLuc8. Coelenterazine h is more sensitive to Ca ²⁺, thus providing a valuable tool for measuring small changes in Ca ²⁺ concentrations .

HY-D1024A

Coelenterazine h hydrochloride 2 Publications Verification 2-DeoxyCoelenterazine hydrochloride; CLZN-h hydrochloride	Biochemical Assay Reagents Calcium Channel	Neurological Disease
Coelenterazine h (2-Deoxycoelenterazine) hydrochloride, a coelenterazine derivative, is a luminescent substrate for RLuc8. Coelenterazine h hydrochloride is more sensitive to Ca ²⁺, thus providing a valuable tool for measuring small changes in Ca ²⁺ concentrations .

HY-118462

Coelenteramine 400a Coelenterazine 400a; BisdeoxyCoelenterazine	Fluorescent Dye	Others
Coelenteramine 400a (Coelenterazine 400a), a derivative of Coelenterazine, is a Renilla luciferase (RLuc) substrate. In the presence of Coelenteramine 400a, RLuc can emit blue light at 395 nm . Coelenterazine 400a will causes color change in the bioluminescence reaction of Rluc by replacing the sulfur and oxygen heteroatoms of the methylene bridge. Coelenterazine 400a provides higher signal resolution and can be used in the research of bioluminescence resonance energy transfer (BRET) .

HY-47176

QTZ	Fluorescent Dye	Others
QTZ is a bioluminescence agent for in vivo imaging. QTZ has red-shifted emission and yields very little background. QTZ is a coelenterazine analog with the 4-quinolinyl substitution at the C8 position of the imidazopyrazinone core .

HY-D1424

Coelenterazine hcp	Fluorescent Dye	Others
Coelenterazine hcp is a Coelenterazine analogue. Coelenterazine hcp shows high sensitivity to Ca ²⁺. Coelenterazine hcp is suited for monitoring intracellular Ca ²⁺ .

HY-118462A

Coelenteramine 400a hydrochloride Coelenterazine 400a hydrochloride; BisdeoxyCoelenterazine hydrochloride	Others	Others
Coelenteramine (Coelenterazine) 400a hydrochloride, a derivative of Coelenterazine, is a Renilla luciferase (RLuc) substrate. In the presence of Coelenteramine 400a hydrochloride, RLuc can emit blue light at 395 nm . Coelenteramine 400a hydrochloride will causes color change in the bioluminescence reaction of Rluc by replacing the sulfur and oxygen heteroatoms of the methylene bridge. Coelenteramine 400a hydrochloride provides higher signal resolution and can be used in the research of bioluminescence resonance energy transfer (BRET) .

HY-145385

Coelenteramide	Fluorescent Dye	Others
Coelenteramide is a oxidative product of Coelenterazine (HY-18743). Coelenteramide can form a complex with apoAequorin/Ca ²⁺, which is known as blue fluorescent protein (BFP) and shows continuous weak luminescence with Coelenterazine like a luciferase. Coelenteramide can be used as an imaging agent .

HY-135367B

pyCTZ hydrochloride Pyridyl CTZ hydrochloride	Fluorescent Dye	Others
pyCTZ (Pyridyl CTZ) hydrochloride, a pyridyl Coelenterazine (CTZ) analog, and is an ATP-independent pyridyl substrate of LumiLuc luciferase. pyCTZ hydrochloride generates strong blue bioluminescence in the presence of luciferases. pyCTZ hydrochloride can be used for aequorin-based calcium sensing .

HY-135367A

pyCTZ TFA Pyridyl CTZ TFA	Fluorescent Dye	Others
pyCTZ (Pyridyl CTZ) TFA, a pyridyl Coelenterazine (CTZ) analog, and is an ATP-independent pyridyl substrate of LumiLuc luciferase. pyCTZ TFA generates strong blue bioluminescence in the presence of luciferases. pyCTZ TFA can be used for aequorin-based calcium sensing .

HY-135367

pyCTZ Pyridyl CTZ	Fluorescent Dye	Others
pyCTZ (Pyridyl CTZ), a pyridyl Coelenterazine (CTZ) analog, and is an ATP-independent pyridyl substrate of LumiLuc luciferase. pyCTZ generates strong blue bioluminescence in the presence of luciferases. pyCTZ can be used for aequorin-based calcium sensing .

Cat. No.	Product Name	Type

HY-18743

*Coelenterazine* 3 Publications Verification	Fluorescent Dyes/Probes
Coelenterazine is a luminescent enzyme substrate for apoaequorin and Renilla luciferase. Renilla luciferase and substrate coelenterazine has been used as the bioluminescence donor in bioluminescence resonance energy transfer (BRET) to detect protein-protein interactions. Coelenterazine is a superoxide anion-sensitive chemiluminescent probe and it can also be used in chemiluminescent detection of peroxynitrite .

Coelenterazine

3 Publications Verification

Fluorescent Dyes/Probes

Coelenterazine is a luminescent enzyme substrate for apoaequorin and Renilla luciferase. Renilla luciferase and substrate coelenterazine has been used as the bioluminescence donor in bioluminescence resonance energy transfer (BRET) to detect protein-protein interactions. Coelenterazine is a superoxide anion-sensitive chemiluminescent probe and it can also be used in chemiluminescent detection of peroxynitrite .

HY-118462

Coelenteramine 400a Coelenterazine 400a; BisdeoxyCoelenterazine	Dyes
Coelenteramine 400a (Coelenterazine 400a), a derivative of Coelenterazine, is a Renilla luciferase (RLuc) substrate. In the presence of Coelenteramine 400a, RLuc can emit blue light at 395 nm . Coelenterazine 400a will causes color change in the bioluminescence reaction of Rluc by replacing the sulfur and oxygen heteroatoms of the methylene bridge. Coelenterazine 400a provides higher signal resolution and can be used in the research of bioluminescence resonance energy transfer (BRET) .

Coelenteramine 400a

Coelenterazine 400a; BisdeoxyCoelenterazine

Dyes

Coelenteramine 400a (Coelenterazine 400a), a derivative of Coelenterazine, is a Renilla luciferase (RLuc) substrate. In the presence of Coelenteramine 400a, RLuc can emit blue light at 395 nm . Coelenterazine 400a will causes color change in the bioluminescence reaction of Rluc by replacing the sulfur and oxygen heteroatoms of the methylene bridge. Coelenterazine 400a provides higher signal resolution and can be used in the research of bioluminescence resonance energy transfer (BRET) .

HY-135367

pyCTZ Pyridyl CTZ	Fluorescent Dyes/Probes
pyCTZ (Pyridyl CTZ), a pyridyl Coelenterazine (CTZ) analog, and is an ATP-independent pyridyl substrate of LumiLuc luciferase. pyCTZ generates strong blue bioluminescence in the presence of luciferases. pyCTZ can be used for aequorin-based calcium sensing .

HY-D1424

Coelenterazine hcp	Fluorescent Dyes/Probes
Coelenterazine hcp is a Coelenterazine analogue. Coelenterazine hcp shows high sensitivity to Ca ²⁺. Coelenterazine hcp is suited for monitoring intracellular Ca ²⁺ .

HY-145385

Coelenteramide	Fluorescent Dyes/Probes
Coelenteramide is a oxidative product of Coelenterazine (HY-18743). Coelenteramide can form a complex with apoAequorin/Ca ²⁺, which is known as blue fluorescent protein (BFP) and shows continuous weak luminescence with Coelenterazine like a luciferase. Coelenteramide can be used as an imaging agent .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-18743

*Coelenterazine* 3 Publications Verification	Alkaloids Structural Classification Monophenols Animals Classification of Application Fields Other Alkaloids Source classification Phenols Polyphenols Disease Research Fields Cancer	Reactive Oxygen Species
Coelenterazine is a luminescent enzyme substrate for apoaequorin and Renilla luciferase. Renilla luciferase and substrate coelenterazine has been used as the bioluminescence donor in bioluminescence resonance energy transfer (BRET) to detect protein-protein interactions. Coelenterazine is a superoxide anion-sensitive chemiluminescent probe and it can also be used in chemiluminescent detection of peroxynitrite .

Cat. No.	Compare	Product Name	Species	Source

HY-P703482

	rLuc Protein, Human (His, Strep) Coelenterazine h 2-monooxygenase; Renilla-luciferin 2-monooxygenase; Renilla-type luciferase; Renilla reniformis; Sea pansy; Decarboxylase; Lyase; Monooxygenase; Oxidoreductase; Photoprotein; 1.13.12.5	Human	E. coli
	rLuc Protein, Human (His, Strep) is the recombinant human-derived rLuc, expressed by E. coli , with Strep, His labeled tag. ,

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Cat. No.	Product Name		Classification

HY-164060

LZCap AG(3'Acm) RLuc mRNA		mRNA
Renilla luciferase (RLuc) is a novel luciferase enzyme with a size of 36 kD. RLuc catalyzes the oxidation reaction of coelenterazine under oxygen to emit fluorescence (maximum wavelength 480 nm). LZCap AG(3'Acm) RLuc mRNA is synthesized and purified in a one-step transcription process using T7 RNA polymerase and LZCap AG(3'Acm) cap analog from a linear template. This mRNA is suitable for experiments related to mRNA delivery, translation efficiency, transfection efficiency, and in vivo imaging.

HY-164061

LZCap AG(3'Acm) GLuc mRNA		mRNA
Gaussia luciferase (GLuc) is the smallest known naturally secreted luciferase enzyme (20 kD) in vivo. When conducting fluorescence reporter experiments with Gaussia luciferase, detection can be directly performed using cell culture supernatant. This luciferase enzyme catalyzes the oxidation of coelenterazine to emit light (480 nm) without requiring ATP. LZCap AG(3'Acm) GLuc mRNA is synthesized and purified in a one-step transcription process using T7 RNA polymerase and LZCap AG(3'Acm) cap analog from a linear template. This mRNA is suitable for experiments related to mRNA delivery, translation efficiency, and transfection efficiency.

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Coelenterazine

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Fluorescent Dye

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Recombinant Proteins

Oligonucleotides

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