Crown ether

By Targets:	Biochemical Assay Reagents (6)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-W103245

Benzo-18-crown-6-ether B18C6	Biochemical Assay Reagents	Others
Benzo-18-crown-6-ether (B18C6) is an organic compound that can be used to prepare stable microcapsule responsive layers for further assembly into bilayer microcapsules. For example, 18-Crown-6-ether is used to prepare the response layer and is coated with a G-quadruplex cross-linked hydrogel layer stabilized by K ⁺; when Mg ²⁺ ions are present, 18-Crown-6-ether and K ⁺ ions can respectively Dissociates and locks with the G-quadruplex cross-linked layer, thereby achieving switchable controlled release of the load .

HY-D0180

18-Crown-6-ether 18C6; 1,4,7,10,13,16-Hexaoxacyclooctadecane	Biochemical Assay Reagents	Others
18-Crown-6-ether (18C6; 1,4,7,10,13,16-Hexaoxacyclooctadecane) is an organic compound that can be used to prepare stable microcapsule responsive layers for further assembly into bilayer microcapsules. For example, 18-Crown-6-ether is used to prepare the response layer and is coated with a G-quadruplex cross-linked hydrogel layer stabilized by K ⁺; when Mg ²⁺ ions are present, 18-Crown-6-ether and K ⁺ ions can respectively Dissociates and locks with the G-quadruplex cross-linked layer, thereby achieving switchable controlled release of the load .

HY-W007656

Cyclen	Others	Others
Cyclen is the aza analogue of crown ether, used as a precursor for MRI contrast agents, and is an intermediate for the preparation of effective macrocyclic chelates .

HY-W008585

Benzo-15-crown-5-ether B15C5	Biochemical Assay Reagents	Others
Benzo-15-crown-5-ether can be used as a chelating agent for sodium and potassium .

HY-W073183

Dibenzo-24-crown-8-ether	Biochemical Assay Reagents	Others
Dibenzo-24-crown-8-ether is a phase transfer catalyst that can reduce H ²PtCl ⁶·6H ²O and FeCl ²·4H ²O in a thermal system to synthesize 17 nm monodispersed iron-platinum (FePt) alloy nanoparticles .

HY-W009048

Dicyclohexano-18-crown-6-ether DCH18C6; Perhydrodibenzo-18-Crown-6	Biochemical Assay Reagents	Others
Dicyclohexano-18-crown-6-ether selectively extracts lysine-rich cytochrome c proteins from other cationic proteins under weakly acidic and neutral conditions, demonstrating specificity in ligand-protein interactions .

HY-W102545

Diaza-15-crown-5	Biochemical Assay Reagents	Others
Diaza-15-crown-5 extends the lifetime of M intermediates in BR membranes. Diaza-15-crown-5 is a crown ether compound that alters the surface charge of BR membranes. Diaza-15-crown-5 changes the surface charge of the BR film. and overall membrane stability. Diaza-15-crown-5 allows the M state to be maintained for a longer period of time .

Cat. No.	Product Name

HY-L041

Macrocyclic Compound Library	385 compounds
Macrocycles, molecules containing 12-membered or larger rings, are receiving increased attention in small-molecule drug discovery. The reasons are several, including providing access to novel chemical space, challenging new protein targets, showing favorable ADME- and PK-properties. Macrocycles have demonstrated repeated success when addressing targets that have proved to be highly challenging for standard small-molecule drug discovery, especially in modulating macromolecular processes such as protein–protein interactions (PPI). Otherwise, the size and complexity of macrocyclic compounds make possible to ensure numerous and spatially distributed binding interactions, thereby increasing both binding affinity and selectivity. MCE offers a unique collection of 385 macrocyclic compounds which can be used for drug discovery for high throughput screening (HTS) and high content screening (HCS). MCE Macrocyclic Compound Library is a useful tool for discovering new drugs, especially for “undruggable” targets and protein–protein interactions.

Macrocyclic Compound Library

385 compounds

Macrocycles, molecules containing 12-membered or larger rings, are receiving increased attention in small-molecule drug discovery. The reasons are several, including providing access to novel chemical space, challenging new protein targets, showing favorable ADME- and PK-properties. Macrocycles have demonstrated repeated success when addressing targets that have proved to be highly challenging for standard small-molecule drug discovery, especially in modulating macromolecular processes such as protein–protein interactions (PPI). Otherwise, the size and complexity of macrocyclic compounds make possible to ensure numerous and spatially distributed binding interactions, thereby increasing both binding affinity and selectivity.

MCE offers a unique collection of 385 macrocyclic compounds which can be used for drug discovery for high throughput screening (HTS) and high content screening (HCS). MCE Macrocyclic Compound Library is a useful tool for discovering new drugs, especially for “undruggable” targets and protein–protein interactions.

Cat. No.	Product Name	Type

HY-W103245

Benzo-18-crown-6-ether B18C6	Chelators
Benzo-18-crown-6-ether (B18C6) is an organic compound that can be used to prepare stable microcapsule responsive layers for further assembly into bilayer microcapsules. For example, 18-Crown-6-ether is used to prepare the response layer and is coated with a G-quadruplex cross-linked hydrogel layer stabilized by K ⁺; when Mg ²⁺ ions are present, 18-Crown-6-ether and K ⁺ ions can respectively Dissociates and locks with the G-quadruplex cross-linked layer, thereby achieving switchable controlled release of the load .

Benzo-18-crown-6-ether

B18C6

Chelators

Benzo-18-crown-6-ether (B18C6) is an organic compound that can be used to prepare stable microcapsule responsive layers for further assembly into bilayer microcapsules. For example, 18-Crown-6-ether is used to prepare the response layer and is coated with a G-quadruplex cross-linked hydrogel layer stabilized by K ⁺; when Mg ²⁺ ions are present, 18-Crown-6-ether and K ⁺ ions can respectively Dissociates and locks with the G-quadruplex cross-linked layer, thereby achieving switchable controlled release of the load .

HY-D0180

18-Crown-6-ether 18C6; 1,4,7,10,13,16-Hexaoxacyclooctadecane	Chelators
18-Crown-6-ether (18C6; 1,4,7,10,13,16-Hexaoxacyclooctadecane) is an organic compound that can be used to prepare stable microcapsule responsive layers for further assembly into bilayer microcapsules. For example, 18-Crown-6-ether is used to prepare the response layer and is coated with a G-quadruplex cross-linked hydrogel layer stabilized by K ⁺; when Mg ²⁺ ions are present, 18-Crown-6-ether and K ⁺ ions can respectively Dissociates and locks with the G-quadruplex cross-linked layer, thereby achieving switchable controlled release of the load .

18-Crown-6-ether

18C6; 1,4,7,10,13,16-Hexaoxacyclooctadecane

Chelators

18-Crown-6-ether (18C6; 1,4,7,10,13,16-Hexaoxacyclooctadecane) is an organic compound that can be used to prepare stable microcapsule responsive layers for further assembly into bilayer microcapsules. For example, 18-Crown-6-ether is used to prepare the response layer and is coated with a G-quadruplex cross-linked hydrogel layer stabilized by K ⁺; when Mg ²⁺ ions are present, 18-Crown-6-ether and K ⁺ ions can respectively Dissociates and locks with the G-quadruplex cross-linked layer, thereby achieving switchable controlled release of the load .

HY-W008585

Benzo-15-crown-5-ether B15C5	Chelators
Benzo-15-crown-5-ether can be used as a chelating agent for sodium and potassium .

HY-W073183

Dibenzo-24-crown-8-ether	Chelators
Dibenzo-24-crown-8-ether is a phase transfer catalyst that can reduce H ²PtCl ⁶·6H ²O and FeCl ²·4H ²O in a thermal system to synthesize 17 nm monodispersed iron-platinum (FePt) alloy nanoparticles .

HY-W009048

Dicyclohexano-18-crown-6-ether DCH18C6; Perhydrodibenzo-18-Crown-6	Chelators
Dicyclohexano-18-crown-6-ether selectively extracts lysine-rich cytochrome c proteins from other cationic proteins under weakly acidic and neutral conditions, demonstrating specificity in ligand-protein interactions .

HY-W102545

Diaza-15-crown-5	Chelators
Diaza-15-crown-5 extends the lifetime of M intermediates in BR membranes. Diaza-15-crown-5 is a crown ether compound that alters the surface charge of BR membranes. Diaza-15-crown-5 changes the surface charge of the BR film. and overall membrane stability. Diaza-15-crown-5 allows the M state to be maintained for a longer period of time .

HY-157914

Dibenzyl-14-crown-4 6,6-Dibenzyl-1,4,8,11-tetraoxacyclotetradecane	Chelators
Dibenzyl-14-crown-4 (6,6-Dibenzyl-1,4,8,11-tetraoxacyclotetradecane) is a crown ether derivate, which serves as neutral carrier in PVC ion-selective electrode, improves the Li ⁺ selectivity against Na ⁺ and K ⁺ .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-W007656

Cyclen	Structural Classification Natural Products Classification of Application Fields Source classification Other Diseases Plants Menispermaceae Disease Research Fields Stephania japonica (Thunb.) Miers	Others
Cyclen is the aza analogue of crown ether, used as a precursor for MRI contrast agents, and is an intermediate for the preparation of effective macrocyclic chelates .

MCE Japan Authorized Agent ナミキ商事株式会社コスモ・バイオ株式会社
Salutation			Country or Region *
Applicant Name *			Organization Name *
Department *
Email Address *			Product Name *
Cat. No.			Requested quantity *
Phone Number *
Remarks

Inhibitors & Agonists

Screening Libraries

Biochemical Assay Reagents

Natural
Products