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Cyclen is the aza analogue of crown ether, used as a precursor for MRI contrast agents, and is an intermediate for the preparation of effective macrocyclic chelates.

For research use only. We do not sell to patients.

Cyclen Chemical Structure

Cyclen Chemical Structure

CAS No. : 294-90-6

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Based on 1 publication(s) in Google Scholar

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Description

Cyclen is the aza analogue of crown ether, used as a precursor for MRI contrast agents, and is an intermediate for the preparation of effective macrocyclic chelates[1].

Clinical Trial
Molecular Weight

172.27

Formula

C8H20N4
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

C1CNCCNCCNCCN1
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

Solvent & Solubility
In Vitro: 

H2O : 50 mg/mL (290.24 mM; Need ultrasonic)

DMSO : 1.85 mg/mL (10.74 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 5.8048 mL 29.0242 mL 58.0484 mL
5 mM 1.1610 mL 5.8048 mL 11.6097 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: 99.94%

SDS (786 KB)

COA (249 KB) HNMR (191 KB) GC (178 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO / H2O 1 mM 5.8048 mL 29.0242 mL 58.0484 mL 145.1210 mL
5 mM 1.1610 mL 5.8048 mL 11.6097 mL 29.0242 mL
10 mM 0.5805 mL 2.9024 mL 5.8048 mL 14.5121 mL
H2O 15 mM 0.3870 mL 1.9349 mL 3.8699 mL 9.6747 mL
20 mM 0.2902 mL 1.4512 mL 2.9024 mL 7.2561 mL
25 mM 0.2322 mL 1.1610 mL 2.3219 mL 5.8048 mL
30 mM 0.1935 mL 0.9675 mL 1.9349 mL 4.8374 mL
40 mM 0.1451 mL 0.7256 mL 1.4512 mL 3.6280 mL
50 mM 0.1161 mL 0.5805 mL 1.1610 mL 2.9024 mL
60 mM 0.0967 mL 0.4837 mL 0.9675 mL 2.4187 mL
80 mM 0.0726 mL 0.3628 mL 0.7256 mL 1.8140 mL
100 mM 0.0580 mL 0.2902 mL 0.5805 mL 1.4512 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Cyclen Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Cyclen294-90-6OthersInhibitorinhibitorinhibit

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