DLL4

By Targets:	HIF/HIF Prolyl-Hydroxylase (1) Notch (3) Small Interfering RNA (siRNA) (1) VEGFR (2)
By Research Areas:	Cancer (5) Cardiovascular Disease (1) Inflammation/Immunology (2) Metabolic Disease (1)
Oligonucleotides:	Human Pre-designed siRNA Sets (1) siRNAs (1)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-122094

Steppogenin	HIF/HIF Prolyl-Hydroxylase	Cardiovascular Disease Cancer
Steppogenin is a potent inhibitor of HIF-1α and *DLL4, with IC₅₀* values of 0.56 and 8.46 μM, respectively. Steppogenin can be sued for the research of angiogenic diseases, such as those involving solid tumors .

HY-P99852

Dilpacimab ABT165; PR1283233	VEGFR	Cancer
Dilpacimab (ABT165) is a potent dual-variable domain immunoglobulin, targets both delta-like ligand 4 (DLL4) and VEGF pathways.. Dilpacimab can be used in research of cancer .

HY-P99261

Demcizumab OMP 21M18	Notch	Cancer
Demcizumab (OMP 21M18) is an anti-DLL4 monoclonal antibody. Demcizumab is a potent inhibitor of the Notch pathway. Demcizumab alone or in combination with chemotherapy is effective in various cancer models .

HY-P99925

Enoticumab REGN421	Notch	Metabolic Disease Cancer
Enoticumab (REGN421, SAR153192) is an IgG1κ antibody targeting human *Dll4. DLL4* is a ligand of the Notch signaling pathway and regulates fatty acid uptake through non-transcriptional regulation of macropinocytosis-dependent long-chain fatty acid uptake. Specific in vivo activity of Enoticumab in an ovarian xenograft model. EGN421 (2.5 mg/kg once weekly) resulted in 86% and 83% tumor growth inhibition in mouse subcutaneous TOV-112D or intraperitoneal A2780 human tumor xenograft models, respectively .

HY-RS03810

DLL4 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
DLL4 Human Pre-designed siRNA Set A contains three designed siRNAs for DLL4 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

DLL4 Human Pre-designed siRNA Set A DLL4 Human Pre-designed siRNA Set A

HY-P99377

Navicixizumab OMP-305B83; Anti-DLL4 Reference Antibody (navicixizumab)	Notch	Cancer
Navicixizumab (OMP-305B83) is a bispecific anti-VEGF and anti-DLL4 inhibitory antibody. Navicixizumab can combine with Paclitaxel (HY-B0015) for cancer research. Navicixizumab can be used in the research of ovarian, primary peritoneal, or fallopian tube cancer .

HY-P991033

Tovecimig	VEGFR	Inflammation/Immunology
HY-P991033 is an *VEGFA/DLL4*-targeting G1-scFvlh_L-κ type bispecific antibody .

Cat. No.	Product Name	Target	Research Area

HY-P99852

Dilpacimab ABT165; PR1283233	VEGFR	Cancer
Dilpacimab (ABT165) is a potent dual-variable domain immunoglobulin, targets both delta-like ligand 4 (DLL4) and VEGF pathways.. Dilpacimab can be used in research of cancer .

HY-P99261

Demcizumab OMP 21M18	Notch	Cancer
Demcizumab (OMP 21M18) is an anti-DLL4 monoclonal antibody. Demcizumab is a potent inhibitor of the Notch pathway. Demcizumab alone or in combination with chemotherapy is effective in various cancer models .

HY-P99925

Enoticumab REGN421	Notch	Metabolic Disease Cancer
Enoticumab (REGN421, SAR153192) is an IgG1κ antibody targeting human *Dll4. DLL4* is a ligand of the Notch signaling pathway and regulates fatty acid uptake through non-transcriptional regulation of macropinocytosis-dependent long-chain fatty acid uptake. Specific in vivo activity of Enoticumab in an ovarian xenograft model. EGN421 (2.5 mg/kg once weekly) resulted in 86% and 83% tumor growth inhibition in mouse subcutaneous TOV-112D or intraperitoneal A2780 human tumor xenograft models, respectively .

HY-P990402

*Anti-DLL4* Antibody**	Inhibitory Antibodies	Inflammation/Immunology

HY-P990252

*Anti-Mouse Delta-like protein 4/DLL4* Antibody (HMD4-2)**	Inhibitory Antibodies	Others
Anti-Mouse Delta-like protein 4/DLL4 Antibody (HMD4-2) is a Armenian hamster-derived IgG, κ type antibody inhibitor, targeting to mouse Delta-like protein 4/DLL4.

HY-P99377

Navicixizumab OMP-305B83; Anti-DLL4 Reference Antibody (navicixizumab)	Notch	Cancer
Navicixizumab (OMP-305B83) is a bispecific anti-VEGF and anti-DLL4 inhibitory antibody. Navicixizumab can combine with Paclitaxel (HY-B0015) for cancer research. Navicixizumab can be used in the research of ovarian, primary peritoneal, or fallopian tube cancer .

HY-P991033

Tovecimig	VEGFR	Inflammation/Immunology
HY-P991033 is an *VEGFA/DLL4*-targeting G1-scFvlh_L-κ type bispecific antibody .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-122094

Steppogenin	Structural Classification Flavonoids Flavones Source classification Maclura tricuspidata Carriere Plants Moraceae	HIF/HIF Prolyl-Hydroxylase
Steppogenin is a potent inhibitor of HIF-1α and *DLL4, with IC₅₀* values of 0.56 and 8.46 μM, respectively. Steppogenin can be sued for the research of angiogenic diseases, such as those involving solid tumors .

Recombinant Proteins Recommended:

Delta-like 4 (DLL4)

Species:	Human (5) Rhesus Macaque (1) Mouse (2)
Tag:	His (5) Tag Free (1) Fc (2)
Source:	HEK293 (8)

Cat. No.	Compare	Product Name	Species	Source

HY-P78116

	*Delta-like protein 4/DLL4* Protein, Human (Biotinylated, HEK293, His)** DLL4; MGC126344; notch ligand DLL4; Delta4; Delta-like 4	Human	HEK293
	Delta-like protein 4 (DLL4) functions as a Notch ligand and activates NOTCH1 and NOTCH4 in the Notch signaling pathway. It regulates angiogenesis by inhibiting endothelial cell proliferation, migration, and angiogenesis. Delta-like protein 4/DLL4 Protein, Human (Biotinylated, HEK293, His) is the recombinant human-derived Delta-like protein 4/DLL4 protein, expressed by HEK293 , with C-His labeled tag. The total length of Delta-like protein 4/DLL4 Protein, Human (Biotinylated, HEK293, His) is 498 a.a., with molecular weight of 60-70 kDa.

HY-P72972

	*Delta-like protein 4/DLL4* Protein, Human (HEK293)** Delta-like protein 4; Delta4; DLL4	Human	HEK293
	Delta-like protein 4 (DLL4) functions as a Notch ligand and activates NOTCH1 and NOTCH4 in the Notch signaling pathway. It regulates angiogenesis by inhibiting endothelial cell proliferation, migration, and angiogenesis. Delta-like protein 4/DLL4 Protein, Human (HEK293) is the recombinant human-derived Delta-like protein 4/DLL4 protein, expressed by HEK293 , with tag free. The total length of Delta-like protein 4/DLL4 Protein, Human (HEK293) is 498 a.a., with molecular weight of 55-70 kDa.

HY-P75292

	*Delta-like protein 4/DLL4* Protein, Mouse (HEK293, His)** Delta-like protein 4; Delta4; DLL4	Mouse	HEK293
	Delta-like 4/DLL4 protein is a key player in the Notch signaling pathway, acting as a ligand to activate NOTCH1 and NOTCH4. In angiogenesis, DLL4 regulates endothelial cell proliferation, migration, and angiogenic sprouting. Delta-like protein 4/DLL4 Protein, Mouse (HEK293, His) is the recombinant mouse-derived Delta-like protein 4/DLL4 protein, expressed by HEK293 , with C-His labeled tag. The total length of Delta-like protein 4/DLL4 Protein, Mouse (HEK293, His) is 525 a.a., with molecular weight of ~68 kDa.

HY-P75294

	*Delta-like protein 4/DLL4* Protein, Human (HEK293, Fc)** Delta-like protein 4; Delta4; DLL4	Human	HEK293
	The DLL4 protein, a homolog of the Drosophila delta gene family, encodes Notch ligands with a DSL domain, EGF repeats, and a transmembrane domain. DLL4 is widely expressed in tissues, including placenta (RPKM 11.5), fat (RPKM 11.2), and 22 others. Delta-like protein 4/DLL4 Protein, Human (HEK293, Fc) is the recombinant human-derived Delta-like protein 4/DLL4 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of Delta-like protein 4/DLL4 Protein, Human (HEK293, Fc) is 498 a.a., with molecular weight of 100-110 kDa.

HY-P70111

	*Delta-like protein 4/DLL4* Protein, Human (HEK293, His)** rHuDelta-like protein 4/DLL4, His; Delta-like protein 4; Drosophila Delta homolog 4; Delta4; DLL4	Human	HEK293
	Delta-like protein 4 (DLL4) functions as a Notch ligand and activates NOTCH1 and NOTCH4 in the Notch signaling pathway. It regulates angiogenesis by inhibiting endothelial cell proliferation, migration, and angiogenesis. Delta-like protein 4/DLL4 Protein, Human (HEK293, His) is the recombinant human-derived Delta-like protein 4/DLL4 protein, expressed by HEK293 , with C-His labeled tag.

HY-P76872

	*Delta-like protein 4/DLL4* Protein, Rhesus Macaque (HEK293, His)** Delta-like protein 4; Delta4; DLL4	Rhesus Macaque	HEK293
	delta-like protein 4 involves in the Notch signaling pathway as Notch ligand, and activates NOTCH1 and NOTCH4. delta-like protein 4 involves in angiogenesis. Delta-like protein 4/DLL4 Protein, Rhesus Macaque (HEK293, His) is the recombinant Rhesus Macaque-derived Delta-like protein 4/DLL4 protein, expressed by HEK293 , with C-His labeled tag. The total length of Delta-like protein 4/DLL4 Protein, Rhesus Macaque (HEK293, His) is 502 a.a., with molecular weight of ~56.1 KDa.

HY-P75293

	*Delta-like protein 4/DLL4* Protein, Mouse (HEK293, Fc)** Delta-like protein 4; Delta4; DLL4	Mouse	HEK293
	Delta-like 4/DLL4 protein is a key player in the Notch signaling pathway, acting as a ligand to activate NOTCH1 and NOTCH4. In angiogenesis, DLL4 regulates endothelial cell proliferation, migration, and angiogenic sprouting. Delta-like protein 4/DLL4 Protein, Mouse (HEK293, Fc) is the recombinant mouse-derived Delta-like protein 4/DLL4 protein, expressed by HEK293 , with C-mFc labeled tag. The total length of Delta-like protein 4/DLL4 Protein, Mouse (HEK293, Fc) is 525 a.a., with molecular weight of ~80.61 kDa.

HY-P701309

	*Delta-like protein 4/DLL4* Protein, Human (HEK293, His-Avi)** Delta-like protein 4; Delta4; DLL4	Human	HEK293
	Delta-like protein 4 (DLL4) functions as a Notch ligand and activates NOTCH1 and NOTCH4 in the Notch signaling pathway. It regulates angiogenesis by inhibiting endothelial cell proliferation, migration, and angiogenesis. Delta-like protein 4/DLL4 Protein, Human (HEK293, His-Avi) is the recombinant human-derived Delta-like protein 4/DLL4 protein, expressed by HEK293 , with labeled tag. The total length of Delta-like protein 4/DLL4 Protein, Human (HEK293, His-Avi) is 498 a.a., with molecular weight of 62-68 kDa.

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Cat. No.	Product Name		Classification

HY-RS03810

DLL4 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
DLL4 Human Pre-designed siRNA Set A contains three designed siRNAs for DLL4 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

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