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Pathways Recommended: Cell Cycle/DNA Damage
Results for "

DNA polymerization

" in MedChemExpress (MCE) Product Catalog:

30

Inhibitors & Agonists

1

Fluorescent Dye

17

Biochemical Assay Reagents

1

Peptides

1

MCE Kits

2

Natural
Products

1

Isotope-Labeled Compounds

1

Click Chemistry

4

Oligonucleotides

Targets Recommended:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-W024881
    2,3,3-trimethyl-3H-Indole-5-sulfonic acid potassium salt (1:1)

    		Fluorescent Dye Others
    2,3,3-Trimethylindolenine-5-sulfonic acid potassium is a water-soluble fluorescent near-infrared dye that can be coupled to peptides, proteins, nucleic acids, RNA, DNA, carbohydrates, polymers, and small molecules via sulfonyl substituents .
    2,3,3-trimethyl-3H-Indole-5-sulfonic acid potassium salt (1:1)
  • HY-110139
    Procaspase-IN-5

    		DNA/RNA Synthesis Cancer
    Procaspase-IN-5 is a human DNA polymerase λ inhibitor. Procaspase-IN-5 has DNA polymerization function and TdT function with an IC50 value of 5.9 μM and 4.5 μM, respectively. Procaspase-IN-5 can be used for the research of cancer .
    Procaspase-IN-5
  • HY-147904
    HIV-IN-5

    		HIV Infection
    HIV-IN-5 (compound 5r) is a potent HIV-1 inhibitor, with an IC50 of 0.16 μM. HIV-IN-5 shows inhibition of HIV DNA-dependent DNA polymerization activity, with an IC50 of 2.18 μM. HIV-IN-5 can bind to NNIBP (NNRTIs (non-nucleoside reverse transcriptase inhibitors) binding pocket) .
    HIV-IN-5
  • HY-W440910
    DSPE-PEG-Cy3, MW 5000

    		Liposome Others
    DSPE-PEG-Cy3, MW 5000 is a phospholipid PEG polymer with Cy3 dye used in labeling and fluorescence microscopy. The polymer can self-assemble in aqueous solution to form micelles/lipid bilayer and used to prepare liposomes or nanoparticles for nutrients delivery such as mRNA or DNA vaccine.
    DSPE-PEG-Cy3, MW 5000
  • HY-W440909
    DSPE-PEG-Cy3, MW 3400

    		Liposome Others
    DSPE-PEG-Cy3, MW 3400 is a phospholipid PEG polymer with Cy3 dye used in labeling and fluorescence microscopy. The polymer can self-assemble in aqueous solution to form micelles/lipid bilayer and used to prepare liposomes or nanoparticles for nutrients delivery such as mRNA or DNA vaccine.
    DSPE-PEG-Cy3, MW 3400
  • HY-N8745
    α-Peltatin

    		Fungal Others
    α-Peltatin is an aryl lignan. α-Peltatin has anticancer and antifungal activity. α-Peltatin inhibits DNA topoisomerase and tubulin polymerization .
    α-Peltatin
  • HY-W440893
    DSPE-PEG-OH (MW 5000)

    		Biochemical Assay Reagents Others
    DSPE-PEG-OH, MW 5000 is a linear phospholipid PEG polymer. The lipid tails allow encapsulation of hdyrophobic therapeutics while the PEG chain maintains its hydrophilicity. The polymer can be used for drug nanocarrier, such as liposomal anti cancer drug or mRNA/DNA vaccine. Reagent grade, for research use only.
    DSPE-PEG-OH (MW 5000)
  • HY-W552525
    Deoxyadenosine diphosphate sodium

    		Phosphorylase Infection
    Deoxyadenosine diphosphate sodium is a nucleoside diphosphate, in which the nucleoside is deoxyadenosine. Deoxyadenosine diphosphate sodium participates in DNA synthesis and repair. Deoxyadenosine diphosphate sodium acts as the inhibitor of polynucleotide phosphorylase, interfers with the polymerization of ADP and CDP .
    Deoxyadenosine diphosphate sodium
  • HY-W440897
    DSPE-PEG-SH (MW 3400)

    		Biochemical Assay Reagents Others
    DSPE-PEG-SH, MW 3400 is a maleimide reactive PEG lipid. The amphiphilic polymer forms lipid bilayer in water and can be used to prepare liposomes for drug nanocarriers to deliver mRNA, DNA or siRNA. Reagent grade, for research use only.
    DSPE-PEG-SH (MW 3400)
  • HY-W440885
    DSPE-PEG-Ald (MW 5000)

    		Biochemical Assay Reagents Others
    DSPE-PEG-Ald, MW 5000 is a phospholipid PEG polymer which can self-assemble spontaneously in water with their hydrophilic heads oriented toward the water (micelles). The polymer can be used to prepare liposome as a drug nanocarrier for administration of nutrients and therapeutic drugs, such as lipid nanoparticles in mRNA or DNA vaccines. The aldehyde is reactive with aminooxy to form a stable oxime linkage or with amine at pH < 7 to form a reversible imine bond. Reagent grade, for research use only.
    DSPE-PEG-Ald (MW 5000)
  • HY-W440928
    Stearic acid-PEG-NHS (MW 3400)

    		Biochemical Assay Reagents Liposome Others
    DSPE-PEG-DBCO, MW 5000 is a phospholipid polyPEG which can self-assemble in water to form lipid bilayer. The polymer can be used to prepare liposomes as drug carrier to deliver nutrients/therpeutic agents, such as mRNA or DNA. Reagent grade, for research use only.
    Stearic acid-PEG-NHS (MW 3400)
  • HY-P3894
    P34cdc2 Kinase Fragment

    		Microtubule/Tubulin Others
    P34cdc2 Kinase Fragment is associated with the completion of DNA replication in yeast mitosis. P34cdc2 Kinase can phosphorylate mitogen-activated protein 2 (MAP2) to regulate microtubules polymerization in Xenopus oocytes meiosis .
    P34cdc2 Kinase Fragment
  • HY-W440906
    DSPE-PEG-Vinylsulfone (MW 3400)

    		Biochemical Assay Reagents Others
    DSPE-PEG-Vinylsulfone, MW 3400 is a thiol reactive PEG lipid. The polymer can self-assemble spontaneously in aqueous solution to form lipid bilayer and be used to prepare nanoparticles/liposomes for drug delivery, for example mRNA vaccine or DNA vaccine. Reagent grade, for research use only.
    DSPE-PEG-Vinylsulfone (MW 3400)
  • HY-138646
    Poly(deoxyadenylic-thymidylic) acid sodium
    1 Publications Verification

    Poly(dA:dT) sodium

    		 Cyclic GMP-AMP Synthase AIM2 Infection Cancer
    Polydeoxyadenylic-thymidylic acid (Poly(dA:dT)) sodium is a synthetic DNA polymer. Poly(dA:dT) sodium can be used to determine the activity of bound and free ribonucleic acid polymerase. Poly(dA:dT) sodium is recognized by multiple PRRs (cytosolic DNA sensors (CDS), including cGAS, AIM2, DAI, DDX41, IFI16, and LRRFIP1), and triggers the production of type I interferons. Poly(dA:dT) sodium can be used for the research of cancer and virus infection .
    Poly(deoxyadenylic-thymidylic) acid sodium
  • HY-W440912
    DSPE-PEG-Cy5, MW 3400

    		Liposome Others
    DSPE-PEG-Cy5, MW 3400 is a PEG phospholipid with Cy5 dye used in protein/nucelic acid labeling and fluorescence microscopy. The polymer can self-assemble in aqueous solution to form micelles/lipid bilayer and used to prepare liposomes or nanoparticles for nutrients delivery such as mRNA or DNA vaccine.
    DSPE-PEG-Cy5, MW 3400
  • HY-W440834
    DSPE-PEG-azide (MW 5000)

    		Biochemical Assay Reagents Liposome Others
    DSPE-PEG-Azide, MW 5000 is a click chemistry reactive phospholipid polyPEG which forms lipid bilayer or micelles in an aqueous solution. The polymer can be used to prepare liposomes or nanoparticles used for delivering nutrients or therapeutic agents, for example mRNA or DNA vaccine. Reagent grade, for research use only.
    DSPE-PEG-azide (MW 5000)
  • HY-W440913
    DSPE-PEG-Cy5, MW 5000

    		Liposome Others
    DSPE-PEG-Cy5, MW 5000 is a PEG phospholipid with Cy5 dye used in protein/nucelic acid labeling and fluorescence microscopy. The polymer can self-assemble in aqueous solution to form micelles/lipid bilayer and used to prepare liposomes or nanoparticles for nutrients delivery such as mRNA or DNA vaccine.
    DSPE-PEG-Cy5, MW 5000
  • HY-W440899
    DSPE-PEG-SPDP (MW 1000)

    		Liposome Others
    DSPE-PEG-SPDP, MW 1000 is a thiol reactive PEG lipid. The polymer is amphiphilic and spontaneously forms lipid bilayer in water. It can be used to encapsulate nutrients or therapeutics for targeted drug delivery, for example mRNA or DNA vaccine, liposomal doxorubicin for anti tumor. Reagent grade, for research use only.
    DSPE-PEG-SPDP (MW 1000)
  • HY-P2962
    Transglutaminase, Streptoverticillium mobaraense

    TG

    		 Biochemical Assay Reagents Infection Inflammation/Immunology
    Transglutaminase, Streptoverticillium mobaraense (TG) is an enzyme that forms cross-links between protein molecules. Transglutaminase, Streptoverticillium mobaraense attaches proteins and peptides to small molecules, polymers, surfaces, DNA and other proteins. Transglutaminase, Streptoverticillium mobaraense is widely used in food applications in the meat, fish, dairy and baking industries .
    Transglutaminase, Streptoverticillium mobaraense
  • HY-W440905
    DSPE-PEG-Vinylsulfone (MW 2000)

    		Biochemical Assay Reagents Others
    DSPE-PEG-Vinylsulfone, MW 2000 is a phospholipid PEG which can self-assemble to form lipid bilayer in water. The polymer can be used to encapsulate therapeutics, such as nucleic acid (mRNA/DNA) or protein, in drug delivery system. The vinyl sulfone is reactive with thiol molecule via thiol-ene reaction for bioconjugation. Reagent grade, for research use only.
    DSPE-PEG-Vinylsulfone (MW 2000)
  • HY-W440904
    DSPE-PEG-Vinylsulfone (MW 1000)

    		Biochemical Assay Reagents Others
    DSPE-PEG-Vinylsulfone, MW 1000 is a self-assembling PEG reagent which forms lipid bilayer. The amphiphilic polymer can be used to prepare liposome for delivering therapeutics, such as nucleic acid (mRNA/DNA) or protein. The vinyl sulfone moiety is reactive with cysteine or other thiol molecule via thiol-ene chemistry. Reagent grade, for research use only.
    DSPE-PEG-Vinylsulfone (MW 1000)
  • HY-W440907
    DSPE-PEG-Vinylsulfone (MW 5000)

    		Biochemical Assay Reagents Others
    DSPE-PEG-Vinylsulfone, MW 5000 is a viniyl sulfone PEG lipid which can be used for bioconjugation with cysteine or other thiol molecule through thiol-ene reaction. The polymer is a self-assembling reagetn which forms lipid bilayer in water and can be used as drug carrier to delivery therapeutic agents, such as mRNA or DNA vaccine. Reagent grade, for research use only.
    DSPE-PEG-Vinylsulfone (MW 5000)
  • HY-W440902
    DSPE-PEG-IA (MW 3400)

    		Biochemical Assay Reagents Others
    DSPE-PEG-IA, MW 3400 is an iodoacetyll PEG lipid. The polymer can form lipid bilayer or micelles spontaneoulsy in water. The lipophilic tails can be used to encapsulate hydrophobic therapeutic agents while the hydrophilic head can be used to encapuslate hydrophilic drugs/nutrient, such as antibody, mRNA/DNA. The iodoacetyl group is reactive with thiol to produce a thioether linkage. Reagent grade, for research use only.
    DSPE-PEG-IA (MW 3400)
  • HY-137658A
    Purine riboside-5'-O-triphosphate sodium

    PTP tetrasodium

    		 Nucleoside Antimetabolite/Analog DNA/RNA Synthesis CaMK Metabolic Disease
    Purine riboside-5'-O-triphosphate sodium, an active metabolite of Nebularine (HY-103694), acts as an inhibitor of DNA primase ATP and GTP polymerization activities, with IC50 values of 35 µM and 28 µM for the human enzyme, respectively. Purine riboside-5'-O-triphosphate sodium inhibits calmodulin-dependent protein kinase II (CaMKII) with a Ki value of 590 µM .
    Purine riboside-5'-O-triphosphate sodium
  • HY-137658
    Purine riboside triphosphate

    PTP

    		 Nucleoside Antimetabolite/Analog DNA/RNA Synthesis CaMK Metabolic Disease
    Purine riboside-5'-O-triphosphate, an active metabolite of Nebularine (HY-103694), acts as an inhibitor of DNA primase ATP and GTP polymerization activities, with IC50 values of 35 µM and 28 µM for the human enzyme, respectively. Purine riboside-5'-O-triphosphate also inhibits calmodulin-dependent protein kinase II (CaMKII) with a Ki value of 590 µM .
    Purine riboside triphosphate
  • HY-W250110B
    Polyethylenimine (linear, average Mn 2100, PDI<1.3)

    PEI (linear, average Mn 2100, PDI<1.3)

    		 Biochemical Assay Reagents Cancer
    Polyethylenimine (linear, average Mn 2100, PDI<1.3), a linear cationic polymer, is a versatile non-viral gene delivery vector, especially for oligonucleotide delivery. Polyethylenimine (linear, average Mn 2100, PDI<1.3) condenses DNA into positively charged particles that bind to anionic cell surfaces. Polyethylenimine (PEI) can be used in detergents, adhesives, water treatment agents and cosmetics .
    Polyethylenimine (linear, average Mn 2100, PDI<1.3)
  • HY-W749442
    7a-Hydroxyfrullanolide

    		Microtubule/Tubulin Cancer
    7a-Hydroxyfrullanolide has anticancer properties. 7a-Hydroxyfrullanolide reduces polymerization of α-, β-tubulin. 7a-Hydroxyfrullanolide preferrs to bind to β-tubulin over α-tubulin. 7a-Hydroxyfrullanolide also triggers DNA damage response arrests cells in the G2/M-phase. 7a-Hydroxyfrullanolide is an eudesmanolide sesquiterpene lactone (SL) and can be isolated from the flowering plants of the Asteraceae family .
    7a-Hydroxyfrullanolide
  • HY-147903
    HIV-1 inhibitor-42

    		HIV Infection
    HIV-1 inhibitor-42 (compound 5b) is a potent HIV-1 inhibitor, with an IC50 of 0.06 μM. HIV-1 inhibitor-42 inhibits HIV-1 RT RNA-dependent DNA polymerase and DNA-dependent DNA polymerase, with IC50 values of 0.518 and 0.072 μM .
    HIV-1 inhibitor-42
  • HY-17422S1
    Acyclovir-d4

    Aciclovir-d4; Acycloguanosine-d4

    		 Isotope-Labeled Compounds HSV Bacterial Apoptosis Antibiotic Infection Cancer
    Acyclovir-d4 is the deuterium labeled Acyclovir. Acyclovir (Aciclovir) is a guanosine analogue and an orally active antiviral agent. Acyclovir inhibits HSV-1 (IC50 of 0.85 μM), HSV-2 (IC50 of 0.86 μM) and varicella-zoster virus. Acyclovir can be phosphorylated by viral thymidine kinase (TK), and Acyclovir triphosphate interferes with viral DNA polymerization through competitive inhibition with guanosine triphosphate and obligatory chain termination[1][2][3]. Acyclovir prevents bacterial infections during induction therapy for acute leukaemia[4].
    Acyclovir-d4
  • HY-159067
    DEAE-dextran, MW 500000 hydrochloride

    DEAE-dextran, MW 500000 (hydrochloride), from bacterial (Leuconostoc mesenteroides); Diethylaminoethyl-dextran, MW 500000 hydrochloride

    		 Biochemical Assay Reagents Cancer
    DEAE-dextran, MW 500000 hydrochloride (DEAE-dextran, MW 500000 hydrochloride, from bacterial (Leuconostoc mesenteroides)) is a high-molecular-weight positively charged polymer that significantly enhances the uptake of viral RNA by tissue culture cells. When employed in the delivery system for "tumor immunity" RNA-splenocyte transfer, DEAE-dextran can markedly extend the lifespan of tumor-bearing animals, comparable to that of actively immunized animals. Furthermore, DEAE-dextran serves as a complexing agent for nucleic acids, forming composite particles with DNA/RNA for extensive applications in gene delivery. Additionally, DEAE-dextran can be utilized as a coating for liposomes .
    DEAE-dextran, MW 500000 hydrochloride

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