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Results for "

DUB

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Apoptosis (5) Autophagy (2) Bacterial (1) Bcr-Abl (1) Deubiquitinase (18) Fluorescent Dye (1) Proteasome (1)
By Research Areas:	Cancer (18) Cardiovascular Disease (1) Infection (2) Inflammation/Immunology (1) Neurological Disease (1)
Click Chemistry:	Azide (1)

Inhibitors & Agonists

Fluorescent Dye

Peptides

Recombinant Proteins

Antibodies

Click Chemistry

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-50737

DUB-IN-3 5 Publications Verification	Deubiquitinase	Infection Cardiovascular Disease Neurological Disease Inflammation/Immunology Cancer
DUB-IN-3 (compound 22c) is a potent and selective inhibitor of the deubiquitinating enzyme USP8 with an IC₅₀ value of 0.56 μM. DUB-IN-3 is promising for research of cancer, neurodegenerative diseases, inflammation, viral infection and cardiovascular disease .

HY-50737A

DUB-IN-2 10+ Cited Publications	Deubiquitinase	Cancer
DUB-IN-2 is a potent deubiquitinase inhibitor with an IC₅₀ of 0.28 μM for USP8 .

HY-50736

DUB-IN-1 5 Publications Verification	Deubiquitinase	Cancer
DUB-IN-1 is an active inhibitor of ubiquitin-specific proteases (USPs), with an IC₅₀ of 0.85 μM for USP8 .

HY-153045

BAY-805	Deubiquitinase	Cancer
BAY-805 is a selective inhibitor of ubiquitin-specific protease USP21. BAY-805 has high selectivity for deubiquitinating enzyme (DUB) targets, kinases, proteases and other common target enzymes .

HY-158774

TG2-179-1	Apoptosis	Cancer
TG2-179-1 is a potent BAP1 inhibitor. TG2-179-1 inhibits the domain-containing deubiquitinase (DUB) activity of BAP1 by covalently binding to its active site. TG2-179-1 exerts cytotoxic activity, leading to defective replication and increased apoptosis. TG2-179-1 has the potential for colon cancer research .

HY-13264

Degrasyn 10+ Cited Publications WP1130	Deubiquitinase Bcr-Abl Autophagy Apoptosis	Cancer
Degrasyn (WP1130) is a cell-permeable deubiquitinase (DUB) inhibitor, directly inhibiting DUB activity of USP9x, USP5, USP14, and UCH37. Degrasyn has been shown to downregulate the antiapoptotic proteins Bcr-Abl and JAK2.

HY-156001

DUB-IN-7	Deubiquitinase	Cancer
DUB-IN-7 (compound 43) is a Deubiquitinating enzymes (DUBs) inhibitor. DUB-IN-7 can be used in the study of diseases mediated by dysregulated JAK2 activity, such as leukemia .

HY-163769

DUB-IN-8	Deubiquitinase Bacterial	Infection
DUB-IN-8 (Compound 8q) is an inhibitor for Chlamydia deubiquitinase 1 (DUB1), with IC₅₀ of 7.7 μM. DUB-IN-8 exhibits antimicrobial activity, inhibits the chlamydial inclusions with an IIC₅₀ (the concentration to induce 50% inclusion inhibition) of 8.5 μg/mL .

HY-D2188

IMP-2373	Fluorescent Dye Deubiquitinase	Cancer
IMP-2373 is the activity-based probe (ABP). IMP-2373 is a covalent pan- deubiquitinase(DUB) ABP to monitor *DUB* activity in physiologically relevant live cells .

HY-P10714

Ub4ix	Proteasome Apoptosis Deubiquitinase	Cancer
Ub4ix is a DUB/26S proteasome inhibitor. Ub4ix can protect K48-linked Ub chains from being chopped up by deubiquitinating enzymes (DUBs) and prevent the proteasomal degradation of Ub-tagged proteins. Ub4ix can reduce the viability of Hela cells and induce apoptosis, with an IC₅₀ value of 1.6 μM .

HY-12471

VLX1570 2 Publications Verification	Deubiquitinase	Cancer
VLX1570 is a competitive inhibitor of proteasome deubiquitinases (DUBs) with an IC₅₀ of approximate 10 μM.

HY-148254

8RK64	Deubiquitinase	Cancer
8RK64 is a covalent UCHL1 inhibitor (IC₅₀: 0.32 μM) . 8RK64 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-111408

EOAI3402143 5+ Cited Publications	Deubiquitinase	Cancer
EOAI3402143 is a deubiquitinase (DUB) inhibitor, which inhibits dose-dependently inhibits Usp9x/Usp24 and Usp5.

HY-12988

C527 1 Publications Verification	Deubiquitinase	Cancer
C527 is a is a pan DUB enzyme inhibitor, with a high potency for the USP1/UAF1 complex (IC₅₀=0.88 μM).

HY-168220

FX-171-C	Deubiquitinase	Cancer
FX-171-C is a noncompetitive Deubiquitinase inhibitor with an IC₅₀ of 1.4 µM .

HY-111458

GSK2643943A 5 Publications Verification	Deubiquitinase	Cancer
GSK2643943A is a deubiquitinating enzyme *(DUB)* inhibitor targeting USP20. GSK2643943A has affinity with an IC₅₀ of 160 nM for USP20/Ub-Rho. GSK2643943A has anti-tumor efficacy and can be used for the research of oral squamous cell carcinoma (OSCC) .

HY-13814

PR-619 Maximum Cited Publications 17 Publications Verification	Deubiquitinase Autophagy Apoptosis	Cancer
PR-619 is a broad-range and reversible *DUB* inhibitor with EC₅₀s of 3.93, 4.9, 6.86, 7.2, and 8.61 μM for USP4, USP8, USP7, USP2, and USP5, respectively. PR-619 induces ER Stress and ER-Stress related apoptosis .

HY-111623

USP30 inhibitor 11	Deubiquitinase	Cancer
USP30 inhibitor 11 is a selective and potent ubiquitin specific peptidase 30 (USP30) inhibitor with an IC₅₀ of 0.01 µΜ, the example 83 extracted from patent WO2017009650A1. USP30 inhibitor 11 is used for the study of cancer and conditions involving mitochondrial dysfunction .

HY-136528

RA-9	Deubiquitinase Apoptosis	Cancer
RA-9 is a potent and selective proteasome-associated deubiquitinating enzymes (DUBs) inhibitor with favorable toxicity profile and anticancer activity. RA-9 blocks ubiquitin-dependent protein degradation without impacting 20S proteasome proteolytic activity. RA-9 selectively induces onset of apoptosis in ovarian cancer cell lines and primary cultures derived from donors. RA-9 induces endoplasmic reticulum (ER)-stress responses in ovarian cancer cells .

Cat. No.	Product Name	Type

HY-D2188

IMP-2373	Fluorescent Dyes/Probes
IMP-2373 is the activity-based probe (ABP). IMP-2373 is a covalent pan- deubiquitinase(DUB) ABP to monitor *DUB* activity in physiologically relevant live cells .

Cat. No.	Product Name	Target	Research Area

HY-P10714

Ub4ix	Proteasome Apoptosis Deubiquitinase	Cancer
Ub4ix is a DUB/26S proteasome inhibitor. Ub4ix can protect K48-linked Ub chains from being chopped up by deubiquitinating enzymes (DUBs) and prevent the proteasomal degradation of Ub-tagged proteins. Ub4ix can reduce the viability of Hela cells and induce apoptosis, with an IC₅₀ value of 1.6 μM .

Cat. No.	Compare	Product Name	Species	Source

HY-P702884

	OTUD6B Protein, Human (His, FLAG) DUB; OTUD6B; ovarian tumor domain	Human	E. coli
	OTUD6B Protein, Human (His, FLAG) is the recombinant human-derived OTUD6B, expressed by E. coli , with N-His, Flag labeled tag. ,

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HY-P80939

	MYSM1 Antibody Myb-like; SWIRM and MPN domains 1; 2ADUB; 2A-DUB; RP4-592A1.1	WB, IHC-P	Human, Mouse
	MYSM1 Antibody is a non-conjugated and Rabbit origined polyclonal antibody about 95 kDa, targeting to MYSM1. It can be used for WB,IHC-P assays in the background of Human, Mouse.

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Cat. No.	Product Name		Classification

HY-148254

8RK64		Azide
8RK64 is a covalent UCHL1 inhibitor (IC₅₀: 0.32 μM) . 8RK64 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

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