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Results for "

Deubiquitinase inhibitor

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Deubiquitinase (18) Apoptosis (2) Autophagy (2) Bacterial (3) Bcr-Abl (1) Cyclic GMP-AMP Synthase (1) Mitophagy (1) Proteasome (1)
By Research Areas:	Cancer (15) Infection (3) Inflammation/Immunology (2) Neurological Disease (2)
Click Chemistry:	Alkynes (1)

Inhibitors & Agonists

Screening Libraries

Click Chemistry

Targets Recommended: Deubiquitinase

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-138978

MF-095	Mitophagy Deubiquitinase	Neurological Disease
MF-095 is a USP30 inhibitor. MF-095 promotes mitochondrial autophagy. MF-095 can be used in neurological disease-related research .

HY-12471

VLX1570 2 Publications Verification	Deubiquitinase	Cancer
VLX1570 is a competitive inhibitor of proteasome deubiquitinases (DUBs) with an IC₅₀ of approximate 10 μM.

HY-50737A

DUB-IN-2 Maximum Cited Publications 17 Publications Verification	Deubiquitinase	Cancer
DUB-IN-2 is a potent *deubiquitinase* inhibitor with an IC₅₀ of 0.28 μM for USP8 .

HY-120458

LCAHA 1 Publications Verification LCA hydroxyamide	Deubiquitinase	Cancer
LCAHA (LCA hydroxyamide) is a deubiquitinase USP2a inhibitor with IC₅₀s of 9.7 μM and 3.7μM in Ub-AMC Assay and Di-Ub Assay, respectively. LCAHA destabilizes Cyclin D1 and induces G0/G1 arrest by inhibiting deubiquitinase USP2a .

HY-124855

STD1T 1 Publications Verification	Deubiquitinase	Cancer
STD1T is a deubiquitinase USP2a inhibitor with an IC₅₀ of 3.3 μM in Ub-AMC Assay .

HY-111408

EOAI3402143 5+ Cited Publications	Deubiquitinase	Cancer
EOAI3402143 is a *deubiquitinase* (DUB) inhibitor, which inhibits dose-dependently inhibits Usp9x/Usp24 and Usp5.

HY-122883

BC-1471	Deubiquitinase	Inflammation/Immunology
BC-1471 is a STAM-binding protein (STAMBP) deubiquitinase inhibitor. BC-1471 inhibits NALP7 (NACHT, LRR and PYD domains-containing protein 7) inflammasome activity .

HY-168220

FX-171-C	Deubiquitinase	Cancer
FX-171-C is a noncompetitive *Deubiquitinase* inhibitor with an IC₅₀ of 1.4 µM .

HY-162966

MS7829	Cyclic GMP-AMP Synthase	Cancer
MS7829 is a cGAS inhibitor-based deubiquitinase-targeted chimera (DUBTAC), a targeted protein stabilization (TPS) technology. cGAS is a key component in the cGAS-STING pathway. .

HY-169154

ChlaDUB1-IN-1	Bacterial	Infection
ChlaDUB1-IN-1 (Compound 8) is an inhibitor for Chlamydia deubiquitinase 1 (ChlaDUB1). ChlaDUB1-IN-1 can be used in antimicrobial research .

HY-164689

Cadmium pyrithione	Proteasome	Cancer
Cadmium pyrithione is a metal compound that inhibits protein deubiquitinase activity. Cadmium pyrithione treatment results in significant accumulation of ubiquitinated proteins in cancer cells and primary leukemia cells. Cadmium pyrithione strongly inhibits the activity of proteasome deubiquitinase (such as USP14 and UCHL5), but has a smaller inhibitory effect on 20S proteasome activity. The anticancer activity of Cadmium pyrithione is associated with the induction of apoptosis through caspase activation. Furthermore, Cadmium pyrithione inhibition inhibited proteasome function and suppressed tumor growth in animal xenograft models .

HY-13264

Degrasyn 10+ Cited Publications WP1130	Deubiquitinase Bcr-Abl Autophagy Apoptosis	Cancer
Degrasyn (WP1130) is a cell-permeable deubiquitinase (DUB) inhibitor, directly inhibiting DUB activity of USP9x, USP5, USP14, and UCH37. Degrasyn has been shown to downregulate the antiapoptotic proteins Bcr-Abl and JAK2.

HY-172220

ChlaDUB1-IN-2	Deubiquitinase Bacterial	Infection
ChlaDUB1-IN-2 (Compound 27a) is the inhibitor for Chlamydia trachomatis deubiquitinase ChlaDUB1 with an IC₅₀ of 0.97 μM. ChlaDUB1-IN-2 inhibits the inclusion body formation of C. trachomatis with an IIC₅₀ of 25.6 μg/mL .

HY-148482

USP7-IN-11	Deubiquitinase	Cancer
USP7-IN-11 is a potent ubiquitin-specific protease 7 (USP7) (Deubiquitinase) inhibitor with an IC₅₀ of 0.37 nM. USP7-IN-11 has anticancer effects (WO2022048498A1; Example 187) .

HY-149901

USP8-IN-2	Deubiquitinase	Cancer
USP8-IN-2 (Compd U52) is a *deubiquitinase* USP8 inhibitor with an IC₅₀ value of 6.0 μM. USP8-IN-2 also inhibits the proliferation of H1957 cells with an GI₅₀ value of 24.93 μM, respectively .

HY-163769

DUB-IN-8	Deubiquitinase Bacterial	Infection
DUB-IN-8 (Compound 8q) is an inhibitor for *Chlamydia deubiquitinase* 1 (DUB1), with IC₅₀** of 7.7 μM. DUB-IN-8 exhibits antimicrobial activity, inhibits the chlamydial inclusions with an IIC₅₀ (the concentration to induce 50% inclusion inhibition) of 8.5 μg/mL .

HY-114383

ST-539	Deubiquitinase Autophagy	Neurological Disease
ST-539 is the inhibitor for deubiquitinase USP30 with IC₅₀ of 0.37 μM. ST-539 promotes the ubiquitination of mitochondrial proteins, and induces mitochondrial autophagy, thereby regulating mitochondrial homeostasis. ST-539 can be used in research of neurodegenerative diseases .

HY-149902

USP8-IN-3	Deubiquitinase	Cancer
USP8-IN-3 (Compd U51) is a *deubiquitinase* USP8 inhibitor with an IC₅₀ value of 4.0 μM. USP8-IN-3 also inhibits the proliferation of GH3 and H1957 cells with GI₅₀s of 37.03 μM and 6.01 μM, respectively .

HY-153627

GK13S	Deubiquitinase	Cancer
G13KS is a deubiquitinase UCHL1 ligand and inhibitor. G13KS inhibits recombinant and cellular UCHL1. G13KS reduces levels of monoubiquitin in human glioblastoma cells . GK13S is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-139979

USP5-IN-1 1 Publications Verification	Deubiquitinase	Cancer
USP5-IN-1 (compound 64), a potent deubiquitinase USP5 inhibitor, binds to the USP5 ZnF-UBD with a K_D of 2.8 μM. USP5-IN-1 is selective over nine proteins containing structurally similar ZnF-UBD domains. USP5-IN-1 inhibits the USP5 catalytic cleavage of a di-ubiquitin substrate .

HY-158774

TG2-179-1	Apoptosis	Cancer
TG2-179-1 is a potent BAP1 inhibitor. TG2-179-1 inhibits the domain-containing deubiquitinase (DUB) activity of BAP1 by covalently binding to its active site. TG2-179-1 exerts cytotoxic activity, leading to defective replication and increased apoptosis. TG2-179-1 has the potential for colon cancer research .

HY-141852

STAMBP-IN-1	Deubiquitinase	Inflammation/Immunology
STAMBP-IN-1 is a small-molecule inhibitor of STAMBP deubiquitinase, and interrupts STAMBP-Ub-NALP7 interaction. STAMBP-IN-1 decreases protein level of its inflammasome substrate NALP7 and suppresses IL-1b release after Toll-like receptor (TLR) agonism. STAMBP-IN-1 inhibits the activity of STAMBP to cleave recombinant di-Ub with an IC₅₀ value of 0.33 mM .

Cat. No.	Product Name

HY-L050

Ubiquitination Compound Library	319 compounds
Protein ubiquitination is an enzymatic post-translational modification in which an ubiquitin protein is attached to a substrate protein. Ubiquitination involves three main steps: activation, conjugation, and ligation, performed by ubiquitin-activating enzymes (E1s), ubiquitin-conjugating enzymes (E2s), and ubiquitin ligases (E3s), respectively. Ubiquitination affects cellular processes such as apoptosis, cell cycle, DNA damage repair, and membrane transportation, etc. by regulating the degradation of proteins (via the proteasome and lysosome), altering the cellular localization of proteins, affecting proteins activity, and promoting or preventing protein-protein interactions. Deregulation of ubiquitin pathway leads to many diseases such as neurodegeneration, cancer, infection and immunity, etc. MCE offers a unique collection of 319 small molecule modulators with biological activity used for ubiquitination research. Compounds in this library target the key enzymes in ubiquitin pathway. MCE Ubiquitination Compound Library is a useful tool for the research of ubiquitination regulation and the corresponding diseases.

Ubiquitination Compound Library

319 compounds

Protein ubiquitination is an enzymatic post-translational modification in which an ubiquitin protein is attached to a substrate protein. Ubiquitination involves three main steps: activation, conjugation, and ligation, performed by ubiquitin-activating enzymes (E1s), ubiquitin-conjugating enzymes (E2s), and ubiquitin ligases (E3s), respectively. Ubiquitination affects cellular processes such as apoptosis, cell cycle, DNA damage repair, and membrane transportation, etc. by regulating the degradation of proteins (via the proteasome and lysosome), altering the cellular localization of proteins, affecting proteins activity, and promoting or preventing protein-protein interactions. Deregulation of ubiquitin pathway leads to many diseases such as neurodegeneration, cancer, infection and immunity, etc.

MCE offers a unique collection of 319 small molecule modulators with biological activity used for ubiquitination research. Compounds in this library target the key enzymes in ubiquitin pathway. MCE Ubiquitination Compound Library is a useful tool for the research of ubiquitination regulation and the corresponding diseases.

Cat. No.	Product Name		Classification

HY-153627

GK13S		Alkynes
G13KS is a deubiquitinase UCHL1 ligand and inhibitor. G13KS inhibits recombinant and cellular UCHL1. G13KS reduces levels of monoubiquitin in human glioblastoma cells . GK13S is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

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