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Results for "

Diuresis

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Adenosine Receptor (1) Bacterial (1) Carbonic Anhydrase (1) Chloride Channel (1) CRFR (2) HIF/HIF Prolyl-Hydroxylase (1) Neprilysin (2) NF-κB (2) Potassium Channel (3) VEGFR (1)
By Research Areas:	Cancer (1) Cardiovascular Disease (11) Endocrinology (3) Infection (3) Inflammation/Immunology (3) Metabolic Disease (6) Neurological Disease (3)

Inhibitors & Agonists

Peptides

Natural
Products

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-106616

Muzolimine BAY-g 2821; Edrul	Others	Cardiovascular Disease
Muzolimine (BAY-g 282) is a slow and long lasting diuresis agent. Muzolimine produces a diuresis in the loop of Henle and also shows anti-hypertensive effects. Muzolimine can be used for the research of cardiovascular disease .

HY-108868

Mersalyl Salirgan; Salurin; Salyrgan	HIF/HIF Prolyl-Hydroxylase VEGFR	Metabolic Disease
Mersalyl (Salirgan) is a potent vascular endothelial growth factor (VEGF) and hypoxia-inducible factor 1 (HIF-1) inducer. Mersalyl induces VEGF and ENO1 mRNA expression. Mersalyl shows diuresis effects .

HY-N0436

Engeletin 3 Publications Verification	NF-κB	Infection Inflammation/Immunology
Engeletin is a flavanonol glycoside isolated from Smilax glabra Roxb. , inhibits NF-κB signaling-pathway activation, and possesses anti-inflammatory, analgesic, diuresis, detumescence, and antibiosis effects.

HY-111961

Epitizide	Others	Metabolic Disease
Epitizide, a benzothiadiazine, commonly found in combination Triamterene (HY-B0575), is used to produce diuresis .

HY-106616R

Muzolimine (Standard)	Others	Cardiovascular Disease
Muzolimine (Standard) is the analytical standard of Muzolimine. This product is intended for research and analytical applications. Muzolimine (BAY-g 282) is a slow and long lasting diuresis agent. Muzolimine produces a diuresis in the loop of Henle and also shows anti-hypertensive effects. Muzolimine can be used for the research of cardiovascular disease .

HY-N9113

1,3,5,6-Tetrahydroxyxanthone	Others	Cardiovascular Disease
1,3,5,6-Tetrahydroxyxanthone is a natural xanthone that can be isolated from Garcinia achachairu Rusby (Clusiaceae) branches. 1,3,5,6-Tetrahydroxyxanthone induces diuresis and saluresis in normotensive and hypertensive rats .

HY-137364

Disulfamide	Carbonic Anhydrase	Cardiovascular Disease Metabolic Disease
Disulfamide, an orally active diuretic, is a carbonic anhydrase inhibitor with the IC₅₀ value of 0.07 μM. Disulfamide leads to diuresis by inhibiting carbonic anhydrase and preventing the reabsorption of sodium and bicarbonate in the proximal tubule .

HY-P1298

Sauvagine	CRFR	Cardiovascular Disease Neurological Disease Endocrinology
Sauvagine, a 40-amino-acid neuropeptide from the skin of the frog, is a mammalian CRF agonist. Sauvagine is effective at releasing ACTH from rat pituitary cells. Sauvagine possesses a number of pharmacological actions on diuresis, the cardiovascular system and endocrine glands .

HY-N0436R

Engeletin (Standard)	NF-κB	Infection Inflammation/Immunology
Engeletin (Standard) is the analytical standard of Engeletin. This product is intended for research and analytical applications. Engeletin is a flavanonol glycoside isolated from Smilax glabra Roxb. , inhibits NF-κB signaling-pathway activation, and possesses anti-inflammatory, analgesic, diuresis, detumescence, and antibiosis effects.

HY-N8228

17-Hydroxyneomatrine	Bacterial	Infection Inflammation/Immunology Cancer
17-Hydroxyneomatrine, extracted from Sophora flavescens, can well inhibit the growth of human cervical carcinoma Hela cells, has the wide-range antibacterial, anti-allergy, anti-tumor, anti-arrhythmia, swelling-subsiding diuresis, immunizing, and biological regulation functions .

HY-P1298A

Sauvagine TFA	CRFR	Cardiovascular Disease Neurological Disease Endocrinology
Sauvagine TFA, a 40-amino-acid neuropeptide from the skin of the frog, is a mammalian CRF agonist. Sauvagine TFA is effective at releasing ACTH from rat pituitary cells. Sauvagine TFA possesses a number of pharmacological actions on diuresis, the cardiovascular system and endocrine glands .

HY-19063

SCH-34826	Neprilysin	Cardiovascular Disease Others
SCH-34826 is an orally active neutral metalloendopeptidase (NEP) inhibitor that inhibits NEP and reduces the degradation of ANF, thereby enhancing its antihypertensive and diuretic effects. SCH-34826 can be used in the research of cardiovascular and renal diseases .

HY-N2499

Dehydrotumulosic acid	Others	Metabolic Disease
Dehydrotumulosic acid is one of the effective constituents of Poria cocos. Poria cocos, a popular Chinese medicinal herb of fungal origin, has been included in many combinations with other CM herbs for its traditionally claimed activities of inducing diuresis, excreting dampness, invigorating the spleen and tranquilizing the mind and its modern pharmacological use of modulating the immune system of the body .

HY-118233

Alilusem potassium M 17055	Chloride Channel	Neurological Disease
Alilusem potassium is a diuretic. In anesthetized dogs undergoing water diuresis, Alilusem potassium effectively decreased free water clearance and increased Na+ and Cl- levels in excreted urine. When combined with Furosemide (HY-B0135) or Hydrochlorothiazid, Alilusem potassium further inhibited free water clearance. Alilusem potassium inhibited the lumen-positive transepithelial voltage and lumen-to-cistern Cl- flux in isolated rabbit cortical thick ascending limbs of Henle .

HY-N2499R

Dehydrotumulosic acid (Standard)	Others	Metabolic Disease
Dehydrotumulosic acid (Standard) is the analytical standard of Dehydrotumulosic acid. This product is intended for research and analytical applications. Dehydrotumulosic acid is one of the effective constituents of Poria cocos. Poria cocos, a popular Chinese medicinal herb of fungal origin, has been included in many combinations with other CM herbs for its traditionally claimed activities of inducing diuresis, excreting dampness, invigorating the spleen and tranquilizing the mind and its modern pharmacological use of modulating the immune system of the body .

HY-124687

ROMK-IN-32	Potassium Channel	Cardiovascular Disease
ROMK-IN-32 is a renal outer medullary potassium channel (ROMK) inhibitor with an IC₅₀ of 35 nM. ROMK-IN-32 also inhibits hERG with an IC₅₀ of 22 μM .

HY-117961

Candoxatrilat UK 73967	Neprilysin	Cardiovascular Disease Endocrinology
Candoxatrilat (UK 73967) is an orally active inhibitor of neutral endopeptidase. By elevating the levels of atrial natriuretic peptides, Candoxatrilat exerts its diuretic and natriuretic effects. Candoxatrilat is utilized in the research of heart failure .

HY-122560A

VU0134992 hydrochloride 3 Publications Verification	Potassium Channel	Cardiovascular Disease
VU0134992 hydrochloride is the first subtype-preferring, orally active and selective Kir4.1 potassium channel pore blocker, with an IC₅₀ of 0.97 μM. VU0134992 hydrochloride is 9-fold selective for homomeric Kir4.1 over Kir4.1/5.1 concatemeric channels (IC₅₀=9 μM) at -120 mV .

HY-122560

VU0134992	Potassium Channel	Cardiovascular Disease
VU0134992 is the first subtype-preferring, orally active and selective Kir4.1 potassium channel pore blocker, with an IC₅₀ of 0.97 µM. VU0134992 is 9-fold selective for homomeric Kir4.1 over Kir4.1/5.1 concatemeric channels (IC₅₀=9 µM) at -120 mV .

HY-110186

PQ-69	Adenosine Receptor	Metabolic Disease
PQ-69 is a potent and selective adenosine A1 receptor antagonist with inverse agonist activity. PQ-69 binds to hA1 receptor with a K_i value of 0.96 nM, is 217-fold more selective compared with hA2A receptors (K_i=208 nM) and >1,000-fold selectivity over hA3 receptor (K_i >100 μM). PQ-69 can be used for the research of renal dysfunction .

Cat. No.	Product Name	Target	Research Area

HY-P1298A

Sauvagine TFA	CRFR	Cardiovascular Disease Neurological Disease Endocrinology
Sauvagine TFA, a 40-amino-acid neuropeptide from the skin of the frog, is a mammalian CRF agonist. Sauvagine TFA is effective at releasing ACTH from rat pituitary cells. Sauvagine TFA possesses a number of pharmacological actions on diuresis, the cardiovascular system and endocrine glands .

HY-P1298

Sauvagine	CRFR	Cardiovascular Disease Neurological Disease Endocrinology
Sauvagine, a 40-amino-acid neuropeptide from the skin of the frog, is a mammalian CRF agonist. Sauvagine is effective at releasing ACTH from rat pituitary cells. Sauvagine possesses a number of pharmacological actions on diuresis, the cardiovascular system and endocrine glands .

Engeletin 3 Publications Verification	Structural Classification Classification of Application Fields Source classification Plants Flavanonols Flavonoids Microorganisms Liliaceae Phenols Polyphenols Smilacis Glabrae Rhizoma Inflammation/Immunology Disease Research Fields	NF-κB
Engeletin is a flavanonol glycoside isolated from Smilax glabra Roxb. , inhibits NF-κB signaling-pathway activation, and possesses anti-inflammatory, analgesic, diuresis, detumescence, and antibiosis effects.

Dehydrotumulosic acid	Triterpenes Structural Classification Classification of Application Fields Terpenoids Polyporaceae Source classification Metabolic Disease Poria cocos Plants Disease Research Fields	Others
Dehydrotumulosic acid is one of the effective constituents of Poria cocos. Poria cocos, a popular Chinese medicinal herb of fungal origin, has been included in many combinations with other CM herbs for its traditionally claimed activities of inducing diuresis, excreting dampness, invigorating the spleen and tranquilizing the mind and its modern pharmacological use of modulating the immune system of the body .

1,3,5,6-Tetrahydroxyxanthone	Flavonoids Source classification Guttiferae Hyperlcurn perforatum L. Plants Other Flavonoids	Others
1,3,5,6-Tetrahydroxyxanthone is a natural xanthone that can be isolated from Garcinia achachairu Rusby (Clusiaceae) branches. 1,3,5,6-Tetrahydroxyxanthone induces diuresis and saluresis in normotensive and hypertensive rats .

Engeletin (Standard)	Flavanonols Structural Classification Flavonoids Microorganisms Liliaceae Source classification Phenols Polyphenols Smilacis Glabrae Rhizoma Plants	NF-κB
Engeletin (Standard) is the analytical standard of Engeletin. This product is intended for research and analytical applications. Engeletin is a flavanonol glycoside isolated from Smilax glabra Roxb. , inhibits NF-κB signaling-pathway activation, and possesses anti-inflammatory, analgesic, diuresis, detumescence, and antibiosis effects.

17-Hydroxyneomatrine	Structural Classification Alkaloids Leguminosae Other Alkaloids Source classification Plants Sophora flavescens Aiton	Bacterial
17-Hydroxyneomatrine, extracted from Sophora flavescens, can well inhibit the growth of human cervical carcinoma Hela cells, has the wide-range antibacterial, anti-allergy, anti-tumor, anti-arrhythmia, swelling-subsiding diuresis, immunizing, and biological regulation functions .

Dehydrotumulosic acid (Standard)	Triterpenes Structural Classification Terpenoids Polyporaceae Source classification Poria cocos Plants	Others
Dehydrotumulosic acid (Standard) is the analytical standard of Dehydrotumulosic acid. This product is intended for research and analytical applications. Dehydrotumulosic acid is one of the effective constituents of Poria cocos. Poria cocos, a popular Chinese medicinal herb of fungal origin, has been included in many combinations with other CM herbs for its traditionally claimed activities of inducing diuresis, excreting dampness, invigorating the spleen and tranquilizing the mind and its modern pharmacological use of modulating the immune system of the body .

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Diuresis

Inhibitors & Agonists

Peptides

NaturalProducts

Natural
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