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EC 3.4.2.2 (MS grade)

" in MedChemExpress (MCE) Product Catalog:

By Targets:	ADC Linker (2) Apoptosis (4) Autophagy (3) Bacterial (1) Bcr-Abl (1) Biochemical Assay Reagents (49) Caspase (1) COX (1) Drug-Linker Conjugates for ADC (1) E1/E2/E3 Enzyme (1) Endogenous Metabolite (5) Fluorescent Dye (2) Fungal (1) HDAC (2) Histone Acetyltransferase (1) HIV (1) Interleukin Related (1) Isotope-Labeled Compounds (3) MMP (22) NF-κB (2) NO Synthase (2) Protease Activated Receptor (PAR) (1) Ser/Thr Protease (3) Smo (1) Src (2) STAT (1) TAM Receptor (1) TGF-β Receptor (1) TNF Receptor (1) γ-secretase (1)
By Research Areas:	Cancer (16) Cardiovascular Disease (2) Infection (4) Inflammation/Immunology (31) Metabolic Disease (4) Neurological Disease (2)

By Targets:

ADC Linker (2)

Apoptosis (4)

Autophagy (3)

Bacterial (1)

Bcr-Abl (1)

Biochemical Assay Reagents (49)

Caspase (1)

COX (1)

Drug-Linker Conjugates for ADC (1)

E1/E2/E3 Enzyme (1)

Endogenous Metabolite (5)

Fluorescent Dye (2)

Fungal (1)

HDAC (2)

Histone Acetyltransferase (1)

HIV (1)

Interleukin Related (1)

Isotope-Labeled Compounds (3)

MMP (22)

NF-κB (2)

NO Synthase (2)

Protease Activated Receptor (PAR) (1)

Ser/Thr Protease (3)

Smo (1)

Src (2)

STAT (1)

TAM Receptor (1)

TGF-β Receptor (1)

TNF Receptor (1)

γ-secretase (1)

By Research Areas:

Cancer (16)

Cardiovascular Disease (2)

Infection (4)

Inflammation/Immunology (31)

Metabolic Disease (4)

Neurological Disease (2)

100

Inhibitors & Agonists

Fluorescent Dye

Biochemical Assay Reagents

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-NP102

Highly purified Type II collagen, from bovine articular cartilage Bovine Type II collagen, immunization grade	Biochemical Assay Reagents	Inflammation/Immunology
Highly purified Type II collagen, from bovine articular cartilage (Bovine Type II collagen, immunization grade), an immunization grade, is the major matrix protein in cartilage that can be used for the study of arthritis .

HY-129047A

*Trypsin (MS grade)*	Ser/Thr Protease Protease Activated Receptor (PAR)	Infection Inflammation/Immunology
Trypsin MS grade is a serine protease enzyme, and hydrolyzes proteins at the carboxyl side of the Lysine or Arginine. Trypsin MS grade activates PAR2 and PAR4. Trypsin MS grade induces cell-to-cell membrane fusion in PDCoV infection by the interaction of S glycoprotein of PDCoV and pAPN. Trypsin MS grade also promotes cell proliferation and differentiation. Trypsin MS grade can be used in the research of wound healing and neurogenic inflammation .

HY-108910A

*Chymotrypsin (MS grade)* 2 Publications Verification EC 3.4.21.1 (MS grade); Chymotrypsin A (MS grade)	Ser/Thr Protease	Others
Chymotrypsin (Chymotrypsin A) (MS grade) is a serine protease produced by the pancreas. Chymotrypsin (MS grade) cleaves protein chains at the carboxyl side of aromatic amino acids .

HY-E70198

*Pepsin (MS Grade)* EC 3.4.23.1 (MS grade)	Endogenous Metabolite	Others
Pepsin (MS Grade) is the major pig and human gastric proteases, it is a pepsin-like minor gastric proteolytic enzymes. Pepsin (MS Grade) contributes to proteolysis of food proteins in the vertebrate stomach .

HY-E70201

*Carboxypeptidase B (MS grade)* EC 3.4.2.2 (MS grade)	Endogenous Metabolite	Others
Carboxypeptidase B (MS grade) is a peptide exonuclease that can specifically degrade peptide chains. Carboxypeptidase B (MS grade) is progressively degraded from the C-terminal to release free amino acids. Carboxypeptidase B (MS grade) hydrolyzes only peptide bonds with basic amino acids (such as arginine and lysine) as C-terminal residues .

HY-22009A

*Strontium chloride,anhydrous grade,99.99% metals basis*	Biochemical Assay Reagents	Others
Strontium chloride,anhydrous grade,99.99% metals basis is a biochemical reagent.

HY-Y1422B

*Lipase (MS grade)*	Endogenous Metabolite	Metabolic Disease
Lipase (MS grade) catalyzes the hydrolysis of triacylglycerols to release long-chain fatty acids in a site-specific manner. Lipase (MS grade) is involved in a variety of biological processes, from fat metabolism to cell signaling and inflammation, and can be used to treat diseases such as pancreatic insufficiency, celiac disease and cystic fibrosis .

HY-113225H

Guanosine triphosphate, 100mM Solution, PCR Grade GTP, 100mM Solution, PCR grade	Biochemical Assay Reagents	Cancer
Guanosine triphosphate, 100 mM Solution, PCR Grade (GTP, 100 mM Solution, PCR Grade) is a 100 mM solution prepared with GTP. Guanosine triphosphate, 100 mM Solution, PCR Grade is free of DNase, RNase and phosphatase contamination and is suitable for molecular biology research .

HY-22009C

*Strontium chloride,monohydrate grade,99.99% metals basis*	Biochemical Assay Reagents	Others
Strontium chloride,monohydrate grade,99.99% metals basis is a biochemical reagent.

HY-W008661A

Deoxyguanosine triphosphate trisodium,100 mM Solution,PCR Grade dGTP trisodium,100 mM Solution,PCR grade; 2'-Deoxyguanosine-5'-triphosphate trisodium,100 mM Solution,PCR grade	Biochemical Assay Reagents	Others
Deoxyguanosine triphosphate trisodium,100 mM Solution,PCR Grade (dGTP trisodium,100 mM Solution,PCR Grade) is one of the raw materials used by DNA polymerase to synthesize long DNA chains during DNA replication. Deoxyguanosine triphosphate trisodium,100 mM Solution,PCR Grade (dGTP trisodium,100 mM Solution,PCR Grade) is used in reverse transcription polymerase chain reaction (RT-PCR) for DNA amplification. This product is provided in the form of aqueous solution .

HY-108717B

*Proteinase K (NGS grade)* Protease K (NGS grade)	Ser/Thr Protease	Others
Proteinase K (Protease K) (NGS grade) (EC 3.4.21.64) is a serine protease with high enzyme activity and broad substrate specificity. Proteinase K can preferentially decompose ester bonds and peptide bonds adjacent to the C-terminus of hydrophobic amino acids, sulfur-containing amino acids, and aromatic amino acids, and is often used to degrade proteins to produce short peptides. This product is NGS grade, no Nickase residue, and nucleic acid residue ≤5pg/mg .

HY-168804

*SOTS-1 (technical grade)*	Biochemical Assay Reagents	Metabolic Disease
SOTS-1 (technical grade) is an azo-compound that can generate superoxide radical anion.

HY-W743522

*Bilirubin-d4 (Technical Grade)*	Isotope-Labeled Compounds	Others
Bilirubin-d₄ (Technical Grade) is the deuterium labeled Bilirubin.

HY-136648B

2'-Deoxyadenosine-5'-triphosphate trisodium,100 mM Solution,PCR Grade dATP trisodium,100 mM Solution,PCR grade	Biochemical Assay Reagents	Others
2'-Deoxyadenosine-5'-triphosphate trisodium,100 mM Solution,PCR Grade (dATP trisodium,100 mM Solution,PCR Grade) 是 DNA 聚合酶在 DNA 复制过程中用来合成 DNA 长链的原料之一。2'-Deoxyadenosine-5'-triphosphate trisodium,100 mM Solution,PCR Grade 用于逆转录聚合酶链反应 (RT-PCR) 中以进行 DNA 扩增。本品以水溶液的形式提供。

HY-W010771A

Deoxycytidine triphosphate trisodium,100 mM Solution,PCR Grade dCTP trisodium,100 mM Solution,PCR grade; 2′-Deoxycytidine-5′-triphosphate trisodium,100 mM Solution,PCR grade	Biochemical Assay Reagents	Others
Deoxycytidine triphosphate trisodium,100 mM Solution,PCR Grade (dCTP trisodium,100 mM Solution,PCR Grade) is one of the raw materials used by DNA polymerase to synthesize long DNA chains during DNA replication. This product is provided in the form of aqueous solution .

HY-107372H

Uridine triphosphate, 100mM Solution, PCR Grade UTP, 100mM Solution, PCR grade; Uridine 5'-triphosphate, 100mM Solution, PCR grade	Biochemical Assay Reagents	Inflammation/Immunology
Uridine triphosphate, 100 mM Solution, PCR Grade (UTP, 100 mM Solution, PCR Grade) A solution prepared from uridine triphosphate at a concentration of 100 mM, free of DNase, RNase and phosphatase contamination, suitable for molecular biology research. Uridine triphosphate (HY-107372) is a pyrimidine nucleoside triphosphate used as a substrate for RNA synthesis or as an energy source in metabolic reactions .

HY-E70563

*Endoproteinase Lys-N (MS grade)*	Biochemical Assay Reagents	Others
Endoproteinase Lys-N (MS grade) is a protease that specifically hydrolyzes the N-terminal peptide bond of lysine fragments .

HY-W013715B

Deoxythymidine-5'-triphosphate trisodium,100 mM Solution,PCR Grade dTTP trisodium,100 mM Solution,PCR grade	Biochemical Assay Reagents	Others
Deoxythymidine-5'-triphosphate trisodium,100 mM Solution,PCR Grade (dTTP trisodium,100 mM Solution,PCR Grade) is one of the raw materials used by DNA polymerase to synthesize long DNA chains during DNA replication and can be used for PCR analysis. This product is provided in the form of aqueous solution .

HY-W017068B

dUTP trisodium,100 mM Solution,PCR Grade 2'-Deoxyuridine-5'-triphosphate trisodium,100 mM Solution,PCR grade	Biochemical Assay Reagents	Others
dUTP trisodium,100 mM Solution,PCR Grade (2'-Deoxyuridine-5'-triphosphate trisodium,100 mM Solution,PCR Grade) is a highly stable nucleotide that can participate in the biosynthesis of DNA and is suitable for various conventional molecular biology experiments. This product is provided in the form of aqueous solution .

HY-P3208B

*Endoproteinase Lys-C (MS grade)*	Biochemical Assay Reagents	Others
Endoproteinase Lys-C (MS grade) is a protease that cleaves proteins on the C-terminal side of lysine residues and is commonly used for protein sequencing .

HY-B2176I

ATP, 100mM Solution, PCR Grade Adenosine 5'-triphosphate, 100mM Solution, PCR grade	Biochemical Assay Reagents	Metabolic Disease
ATP, 100 mM Solution, PCR Grade (Adenosine 5'-triphosphate, 100 mM Solution, PCR Grade) A solution prepared from ATP with a concentration of 100 mM and free of DNase, RNase and phosphatase contamination, suitable for molecular biology research. ATP (HY-B2176) is an important substance for energy storage and metabolism in the body, providing energy for metabolism and acting as a coenzyme in cells. ATP is an important endogenous signaling molecule in immunity and inflammation .

HY-NP158E

*Type II Collagen, T Cell Grade, from Porcine*	Biochemical Assay Reagents	Others
Type II Collagen, T Cell Grade, from Porcine is a T-cell dependent antigen with unique immunological features. Type II Collagen, T Cell Grade, from Porcine can be used as a stimulating antigen for T-cells in in vitro culture systems .

HY-NP158

*Type II Collagen, T Cell Grade, from Bovine*	Biochemical Assay Reagents	Others
Type II Collagen, T Cell Grade, from Bovine is a T-cell dependent antigen with unique immunological features. Type II Collagen, T Cell Grade, from Bovine can be used as a stimulating antigen for T-cells in in vitro culture systems .

HY-NP158D

*Type II Collagen, T Cell Grade, from Mouse*	Biochemical Assay Reagents	Others
Type II Collagen, T Cell Grade, from Mouse is a T-cell dependent antigen with unique immunological features. Type II Collagen, T Cell Grade, from Mouse can be used as a stimulating antigen for T-cells in in vitro culture systems .

HY-D0227F

*THAM hydrochloride (≥99%, reagent grade)* 1 Publications Verification Tris HCl (≥99%, reagent grade); Tris hydrochloride (≥99%, reagent grade)	Biochemical Assay Reagents	Others
THAM hydrochloride (≥99%, reagent grade), also known as Tris-HCl, is a buffer commonly used in various biochemical and molecular biology applications to maintain a stable pH environment. Tris-HCl has unique chemical properties that allow it to resist changes in pH when acidic or basic substances are added, which makes it useful for stabilizing biological samples or reagents. It is commonly used in electrophoresis and protein purification procedures.

HY-W011425B

NTPO, 25mM Solution, PCR Grade Nitrilotris(methylenephosphonic acid), 25mM Solution, PCR grade	Biochemical Assay Reagents	Cancer
NTPO, 25 mM Solution, PCR Grade (Nitrilotris(methylenephosphonic acid), 25 mM Solution, PCR Grade) A 25 mM solution prepared from NTPO (HY-W011425) free of DNase, RNase and phosphatase contamination, suitable for molecular biology research. NTPO is a DNA damage inducer that causes genomic DNA damage and breaks, activating ATR-mediated cell cycle checkpoints. The DNA damage effect of NTPO can be eliminated by base excision repair (BER) but not nucleotide excision repair (NER) .

HY-125818I

Cytidine-5'-triphosphate, 100mM Solution, PCR Grade Cytidine triphosphate, 100mM Solution, PCR grade; 5'-CTP, 100mM Solution, PCR grade	Biochemical Assay Reagents	Metabolic Disease
Cytidine-5'-triphosphate, 100 mM Solution, PCR Grade (Cytidine triphosphate, 100mM Solution, PCR Grade) Cytidine-5'-triphosphate solution is 100 mM and free of DNase, RNase and phosphatase contamination, suitable for molecular biology research. Cytidine-5'-triphosphate (HY-125818) is a nucleoside triphosphate that serves as a building block for the biosynthesis of nucleotides and nucleic acids and lipids. Cytidine triphosphate synthase can catalyze the conversion of UTP to 5'-CTP .

HY-109521A

*Manganese chloride (tetrahydrate), molecular biology grade,≥99.0% (KT)* Manganese(Ⅱ) chloride (tetrahydrate), molecular biology grade,≥99.0% (KT)	Biochemical Assay Reagents Histone Acetyltransferase HDAC	Neurological Disease
Manganese chloride (tetrahydrate), molecular biology grade,≥99.0% (KT) is an orally active and a blood-brain barrier penetrant compound. It affects the activities of multiple enzymes in cells, such as regulating the activities of histone acetyltransferase (HAT) and histone deacetylase (HDAC), thereby affecting gene expression. It has multiple activities such as neurotoxicity, embryotoxicity, and reproductive toxicity. It is currently mainly used in neurodegenerative diseases and toxicology research.

HY-W110789

Ethyl Orange (sodium), indicator grade	Biochemical Assay Reagents	Others
Ethyl Orange (sodium), indicator grade is an organic azo compound that can be used as a pH indicator from pH 3.0 to pH 4.8, changing color from red to orange.

HY-NP157C

*Type I Collagen, T Cell Grade, from Mouse*	Biochemical Assay Reagents	Others
Type I Collagen, T Cell Grade, from Mouse has unique immunological features and plays an important role in the structure and function of skin, bones, tendons, etc. Type I Collagen, T Cell Grade, from Mouse can be used as a stimulating antigen for T-cells in in vitro culture systems .

HY-NP157D

*Type I Collagen, T Cell Grade, from Porcine*	Biochemical Assay Reagents	Others
Type I Collagen, T Cell Grade, from Porcine has unique immunological features and plays an important role in the structure and function of skin, bones, tendons, etc. Type I Collagen, T Cell Grade, from Porcine can be used as a stimulating antigen for T-cells in in vitro culture systems .

HY-NP157

*Type I Collagen, T Cell Grade, from Bovine*	Biochemical Assay Reagents	Others
Type I Collagen, T Cell Grade, from Bovine has unique immunological features and plays an important role in the structure and function of skin, bones, tendons, etc. Type I Collagen, T Cell Grade, from Bovine can be used as a stimulating antigen for T-cells in in vitro culture systems .

HY-P1956A

*Human serum albumin (Cell culture grade, Endotoxin<0.125 EU/mg)* HSA (Cell culture grade, Endotoxin<0.125 EU/mg)	NF-κB NO Synthase	Cardiovascular Disease Inflammation/Immunology
Human serum albumin (Cell culture grade, Endotoxin<0.125 EU/mg) (HSA) is the most abundant protein in plasma and is a major determinant of plasma oncotic pressure. Human serum albumin (Cell culture grade, Endotoxin<0.125 EU/mg) exhibits antioxidant, anticoagulant, anti-inflammatory, anti-platelet aggregation activities as well as colloid osmotic action. Human serum albumin (Cell culture grade, Endotoxin<0.125 EU/mg) can block the inhibitory effect of GML on human T cells, providing protective function for T cells. Human serum albumin (Cell culture grade, Endotoxin<0.125 EU/mg) is also associated with cardiovascular diseases and can partially prevent the LPS (HY-D1056) induced oxidative stress, as well as the upregulation of NF-κB, iNOS, and peroxynitrite (ONOO ⁻) in the vascular wall, contributing to the reduction of blood pressure .

HY-170224

dNTP Mixture,10 mM Solution,PCR Grade	Biochemical Assay Reagents	Others
dNTP Mixture, 10 mM Solution, PCR Grade is an equimolar mixture of dATP, dGTP, dCTP, and dTTP, suitable for amplification reactions of biology applications including PCR .

HY-134181A

Tremella polysaccharide, MW<1000000, cosmetic grade	Biochemical Assay Reagents	Inflammation/Immunology
Tremella polysaccharide, MW<1000000, cosmetic grade, one of the fungus polysaccharides, possesses immunity enhancing capabilities. Polysaccharidase has the potential for leukopenia induced by chemotherapy and radiotherapy research .

HY-134181

Tremella polysaccharide, MW>1000000, cosmetic grade	Biochemical Assay Reagents	Inflammation/Immunology
Tremella polysaccharide, MW>1000000, cosmetic grade, one of the fungus polysaccharides, possesses immunity enhancing capabilities. Polysaccharidase has the potential for leukopenia induced by chemotherapy and radiotherapy research .

HY-170238

dNTP Mixture,25 mM Solution,PCR Grade	Biochemical Assay Reagents	Others
dNTP Mixture,25 mM Solution,PCR Grade is an equimolar mixture of dATP, dGTP, dCTP, and dTTP, suitable for amplification reactions of biology applications including PCR .

HY-Y0649

Lithium chloride, 99.3%-T LiCl, Premium grade	Biochemical Assay Reagents	Others
Lithium chloride, 99% (LiCl, Premium grade) is a biochemical reagent that can be used as a biological material or organic compound for life science related research .

HY-W769743

*Propineb-d3 (Technical grade)*	Isotope-Labeled Compounds Bacterial	Infection
Propineb-d₃ (Technical grade) is the deuterium labeled Propineb (HY-119630). Propineb (Zinc propylenebis) is a compound widely used in fruit and vegetables cultures, due to its large spectrum of activity against fungal plant diseases .

HY-Y1219C

*Silica gel, high-purity grade, 220-440 mesh*	Biochemical Assay Reagents	Others
Silica gel, high-purity grade, 220-440 mesh is a rigid 3D network of colloidal silica that can be used for drug delivery .

HY-Y1219H

*Silica gel, high-purity grade, 200-400 mesh*	Biochemical Assay Reagents	Others
Silica gel, high-purity grade, 200-400 mesh is a rigid 3D network of colloidal silica that can be used for drug delivery .

HY-Y1219I

*Silica gel, high-purity grade, 70-230 mesh*	Biochemical Assay Reagents	Others
Silica gel, high-purity grade, 70-230 mesh is a rigid 3D network of colloidal silica that can be used for drug delivery .

HY-Y1219D

*Silica gel, high-purity grade, 35-70 mesh*	Biochemical Assay Reagents	Others
Silica gel, high-purity grade, 35-70 mesh is a rigid 3D network of colloidal silica that can be used for drug delivery .

HY-Y1219E

*Silica gel, high-purity grade, 130-270 mesh*	Biochemical Assay Reagents	Others
Silica gel, high-purity grade, 130-270 mesh is a rigid 3D network of colloidal silica that can be used for drug delivery .

HY-NP111

Highly purified Type V collagen, from mouse intestine Mouse Type V collagen, immunization grade	MMP	Inflammation/Immunology
Highly purified Type V collagen, from mouse intestine (Mouse Type II collagen, immunization grade) is an immune grade collagen derived from mouse intestine, which can stimulate the animal's immune system to produce specific antibodies against this collagen. Collagen is also a substrate for hydrolysis by MMPs .

HY-NP103

Highly purified Type III collagen, from bovine skin Bovine Type III collagen, immunization grade	MMP	Inflammation/Immunology
Highly purified Type III collagen, from bovine skin (Bovine Type III collagen, immunization grade) is an immune grade collagen derived from bovine skin, which can stimulate the animal's immune system to produce specific antibodies against this collagen. Collagen is also a substrate for hydrolysis by MMPs .

HY-NP127

Highly purified Type I collagen, from canine skin Canine Type I collagen, immunization grade	MMP	Inflammation/Immunology
Highly purified Type I collagen, from canine skin (Canine Type I collagen, immunization grade) is an immune grade collagen derived from canine skin, which can stimulate the animal's immune system to produce specific antibodies against this collagen. Collagen is also a substrate for hydrolysis by MMPs .

HY-NP122

Highly purified Type I collagen, from porcine skin Porcine Type I collagen, immunization grade	MMP	Inflammation/Immunology
Highly purified Type I collagen, from porcine skin (Porcine Type I collagen, immunization grade) is an immune grade collagen derived from porcine skin, which can stimulate the animal's immune system to produce specific antibodies against this collagen. Collagen is also a substrate for hydrolysis by MMPs .

HY-NP124

Highly purified Type III collagen, from porcine skin Porcine Type III collagen, immunization grade	MMP	Inflammation/Immunology
Highly purified Type III collagen, from porcine skin (Porcine Type III collagen, immunization grade) is an immune grade collagen derived from porcine skin, which can stimulate the animal's immune system to produce specific antibodies against this collagen. Collagen is also a substrate for hydrolysis by MMPs .

HY-NP128

Highly purified Type I collagen, from rabbit skin Rabbit Type I collagen, immunization grade	MMP	Inflammation/Immunology
Highly purified Type I collagen, from rabbit skin (Canine Type I collagen, immunization grade) is an immune grade collagen derived from rabbit skin, which can stimulate the animal's immune system to produce specific antibodies against this collagen. Collagen is also a substrate for hydrolysis by MMPs .

Cat. No.	Product Name	Type

HY-15764G

A 419259 (GMP) RK-20449 (GMP)	Fluorescent Dye
A 419259 GMP is the GMP grade A 419259 (HY-15764), inducing cell apoptosis. GMP-grade small molecules can be used as auxiliary reagents in cell therapy. A 419259 (RK-20449) is a broad-spectrum pyrrole-pyrimidine inhibitor targeting Src, Lck, and Lyn with IC₅₀s of 9 nM, <3 nM, and <3 nM, respectively .

HY-Y1311G

Malic acid (GMP) Hydroxybutanedioic acid (GMP); E 296 (GMP)	Fluorescent Dye
Malic acid (GMP) is Malic acid (HY-Y1311) in GMP grade. GMP-grade small molecules can be used as auxiliary reagents in cell therapy. Malic acid (Hydroxybutanedioic acid) is a dicarboxylic acid that occurs naturally in fruits like apples and pears with oral activities. Malic acid plays a role in many sour or tangy foods. Malic acid is an intermediate in the citric acid cycle .

HY-10221G

Vorinostat (GMP) SAHA (GMP); Suberoylanilide hydroxamic acid (GMP)	Fluorescent Dye
Vorinostat (GMP) is a GMP grade Vorinosta (HY-10221). GMP-grade small molecules can be used as auxiliary agents in cell therapy. Vorinostat is a potent, orally available HDAC1, HDAC2, HDAC3 (Class I), HDAC6 and Inhibitors of HDAC7 (Class II) and Class IV (HDAC11) .

HY-12848G

SAG (GMP)	Fluorescent Dye
SAG (GMP) is SAG (HY-12848) in GMP grade. GMP-grade small molecules can be used as auxiliary reagents in cell therapy. SAG is a potent Smoothened (Smo) receptor agonist (EC₅₀=3 nM; K_d=59 nM). SAG activates the Hedgehog signaling pathway and counteracts Cyclopamine (HY-17024) inhibition of Smo .

HY-12273G

DMH-1 (GMP)	Fluorescent Dye
DMH-1 (GMP) is a GMP-grade version of DMH-1 (HY-12273). Small molecules of GMP grade can be used as adjuvant reagents in cell therapy. DMH-1 (GMP) promotes cardiac differentiation in mouse embryonic stem cells. DMH-1 (GMP) promotes neurogenesis of hiPSCs. DMH-1 is a potent and selective BMP inhibitor .

HY-141432G

NX-1607 (GMP) Cbl-b-IN-3 (GMP)	Fluorescent Dye
NX-1607 (Cbl-b-IN-3) (GMP) is a GMP-grade NX-1607 (HY-141432). GMP-grade small molecules can be used as adjuvant agents in cell therapy. NX-1607 (GMP) enhances antigen recall, reduces T cell exhaustion and increases cytokine production. NX-1607 is an inhibitor of Cbl-b (an E3 enzyme) .

HY-16658BG

Z-VAD-FMK (GMP)	Fluorescent Dye
Z-VAD-FMK (GMP) is Z-VAD-FMK (HY-16658B) in GMP grade. GMP-grade small molecules can be used as auxiliary reagents in cell therapy. Z-VAD-FMK (Z-VAD(OH)-FMK) is a well-know pan caspase inhibitor, which does not inhibit ubiquitin carboxy-terminal hydrolase L1 (UCHL1) activity even at concentrations as high as 440 μM .

HY-13631EG

Deruxtecan (GMP) MC-GGFG-DXD (GMP)	Fluorescent Dye
Deruxtecan (GMP) (MC-GGFG-DXD (GMP)) is Deruxtecan (HY-13631E) in GMP grade. GMP-grade small molecules can be used as auxiliary reagents in cell therapy. Deruxtecan is an ADC drug-linker conjugate composed of an DX-8951 derivative (DXd) and a maleimide-GGFG peptide linker, used for synthesizing Trastuzumab deruxtecan (HY-138298A) and Patritumab deruxtecan (HY-P99813) .

HY-14176G

Compound E (GMP) γ-Secretase-IN-1 (GMP)	Fluorescent Dye
Compound E (GMP) is a GMP-grade Compound E (HY-14176). GMP-grade small molecules can be used as adjuvant reagents in cell therapy. Compound E is a γ-secretase inhibitor. Compound E inhibits β-amyloid(40), β-amyloid(42), and Notch γ-secretase cleavage with IC₅₀ values of 0.24, 0.37, and 0.32 nM, respectively .

HY-12362G

Val-cit-PAB-OH (GMP)	Fluorescent Dye
Val-cit-PAB-OH GMP is a GMP grade Val-cit-PAB-OH (HY-12362). Val-cit-PAB-OH is a degradable ADC linker.

HY-19318G

Fmoc-Val-Cit-PAB (GMP)	Fluorescent Dye
Fmoc-Val-Cit-PAB GMP is a GMP grade Fmoc-Val-Cit-PAB (HY-19318). Fmoc-Val-Cit-PAB is a cleavable antibody-conjugated active molecule (ADC) commonly used linker.

HY-15150G

Bemcentinib (GMP)

R428 (GMP); BGB324 (GMP)

Fluorescent Dye

Bemcentinib (R428) GMP is Bemcentinib (HY-15150) in GMP grade. GMP-grade small molecules can be used as auxiliary reagents in cell therapy.Bemcentinib (R428) is a selective and orally active Axl inhibitor with an IC₅₀ of 14 nM. Bemcentinib retards cancer cell migration and invasion. Bemcentinib exhibits >100-fold selectivity for Axl versus Abl and 50- and >100-fold selectivity over TAM family kinases Mer and Tyro3, respectively, in cells. Bemcentinib blocks tumor spread and prolongs survival in models of metastatic breast cancer .

Cat. No.	Product Name	Chemical Structure

HY-W743522

*Bilirubin-d4 (Technical Grade)*
Bilirubin-d₄ (Technical Grade) is the deuterium labeled Bilirubin.

HY-W769743

*Propineb-d3 (Technical grade)*
Propineb-d₃ (Technical grade) is the deuterium labeled Propineb (HY-119630). Propineb (Zinc propylenebis) is a compound widely used in fruit and vegetables cultures, due to its large spectrum of activity against fungal plant diseases .

HY-W738554

Cuprolinic Blue-d12
Cuprolinic Blue-d₁₂ is the deuterium labeled Cuprolinic Blue (Technical Grade) (HY-W738479).

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