EPHA4

Isoforms Recommended:	EphA4

By Targets:	Cyclin G-associated Kinase (GAK) (1) Dengue virus (1) Ephrin Receptor (5) NF-κB (2) Small Interfering RNA (siRNA) (1)
By Research Areas:	Cancer (2) Infection (1) Inflammation/Immunology (1) Metabolic Disease (1) Neurological Disease (2)
Click Chemistry:	Azide (1)
Oligonucleotides:	Pre-designed siRNA Sets (1) siRNAs (1)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-P2264

KYL peptide	Ephrin Receptor	Inflammation/Immunology
KYL peptide, an antagonistic peptide, selectively targets EphA4 receptor (IC₅₀:4.22 μM, Kd:1.3 μM). KYL peptide binds to the ligand-binding domain of EphA4, effectively alleviates Aβ-induced synaptic dysfunction and synaptic plasticity defects in AD mice. KYL peptide can promote nerve regeneration after injury and modulating immune responses .

HY-P0177

123C4	Ephrin Receptor	Metabolic Disease
123C4 is a potent, selective and competitive agonist of the receptor tyrosine kinase *EPHA4, with a K_i* value of 0.65 μM .

HY-N0387

Rhynchophylline 1 Publications Verification	NF-κB	Neurological Disease
Rhyncholphylline is an alkaloid compound isolated from Uncaria rhynchophyllum. Rhyncholphylline is an EphA4 inhibitor. It has high biological activity and is widely used in anti-inflammatory, neuroprotective and other research. .

HY-RS04428

EPHA4 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
EPHA4 Human Pre-designed siRNA Set A contains three designed siRNAs for EPHA4 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

EPHA4 Human Pre-designed siRNA Set A EPHA4 Human Pre-designed siRNA Set A

HY-N0387R

Rhynchophylline (Standard)	NF-κB	Neurological Disease
Rhynchophylline (Standard) is the analytical standard of Rhynchophylline. This product is intended for research and analytical applications. Rhyncholphylline is an alkaloid compound isolated from Uncaria rhynchophyllum. Rhyncholphylline is an EphA4 inhibitor. It has high biological activity and is widely used in anti-inflammatory, neuroprotective and other research. .

HY-P10579

123B9	Ephrin Receptor	Cancer
123B9, a tumor-homing agent, is a potent and selective *EphA2* agonist with a K_d value of 4.0 μM. 123B9 selectively targets the EphA2 tyrosine kinase receptor ligand-binding domain. 123B9 does not appreciably inhibit the ligand binding domains of the most closely related EphA3 and EphA4 receptors .

HY-159174

EPHA2/A4/GAK-IN-1	Ephrin Receptor Cyclin G-associated Kinase (GAK) Dengue virus	Infection
EPHA2/A4/GAK-IN-1 (compound 55) is a potent inhibitor of *EPHA2/EPHA4* and GAK with K_D values of 180.5 nM for EPHA2 and 19.2 nM for GAK, respectively. EPHA2/GAK-IN-1 shows an extrapolated half-life time of 4.6 h in a microsomal stability assay. EPHA2/GAK-IN-1 shows antiviral activity and prevents dengue virus infection of Huh7 liver cells .

HY-146375

UniPR505	Ephrin Receptor	Cancer
UniPR505 (Compound 14) is an *EphA2* antagonist with an IC₅₀ of 0.95 µM. UniPR505 displays anti-angiogenic properties .

Cat. No.	Product Name	Target	Research Area

HY-P2264

KYL peptide	Ephrin Receptor	Inflammation/Immunology
KYL peptide, an antagonistic peptide, selectively targets EphA4 receptor (IC₅₀:4.22 μM, Kd:1.3 μM). KYL peptide binds to the ligand-binding domain of EphA4, effectively alleviates Aβ-induced synaptic dysfunction and synaptic plasticity defects in AD mice. KYL peptide can promote nerve regeneration after injury and modulating immune responses .

HY-P0177

123C4	Ephrin Receptor	Metabolic Disease
123C4 is a potent, selective and competitive agonist of the receptor tyrosine kinase *EPHA4, with a K_i* value of 0.65 μM .

HY-P10579

123B9	Ephrin Receptor	Cancer
123B9, a tumor-homing agent, is a potent and selective *EphA2* agonist with a K_d value of 4.0 μM. 123B9 selectively targets the EphA2 tyrosine kinase receptor ligand-binding domain. 123B9 does not appreciably inhibit the ligand binding domains of the most closely related EphA3 and EphA4 receptors .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N0387

Rhynchophylline 1 Publications Verification	Uncaria rhynchophylla (Miq.) Miq. ex Havil. Alkaloids Structural Classification Classification of Application Fields Source classification Rubiaceae Other Diseases Plants Disease Research Fields Indole Alkaloids	NF-κB
Rhyncholphylline is an alkaloid compound isolated from Uncaria rhynchophyllum. Rhyncholphylline is an EphA4 inhibitor. It has high biological activity and is widely used in anti-inflammatory, neuroprotective and other research. .

HY-N0387R

Rhynchophylline (Standard)	Uncaria rhynchophylla (Miq.) Miq. ex Havil. Alkaloids Structural Classification Source classification Rubiaceae Plants Indole Alkaloids	NF-κB
Rhynchophylline (Standard) is the analytical standard of Rhynchophylline. This product is intended for research and analytical applications. Rhyncholphylline is an alkaloid compound isolated from Uncaria rhynchophyllum. Rhyncholphylline is an EphA4 inhibitor. It has high biological activity and is widely used in anti-inflammatory, neuroprotective and other research. .

Recombinant Proteins Recommended:

EphA4

Species:	Human (3) Rhesus Macaque (2) Mouse (2) Rat (2)
Tag:	His (5) Tag Free (1) GST (1) Fc (4)
Source:	HEK293 (8) Sf9 insect cells (1)

Cat. No.	Compare	Product Name	Species	Source

HY-P72995

	EphA4 Protein, Mouse (HEK293, Fc) Ephrin type-A receptor 4; EPH-like kinase 8; EK8; EPHA4; HEK8; SEK; TYRO1	Mouse	HEK293
	The EphA4 protein is a receptor tyrosine kinase that participates in contact-dependent bidirectional signaling with ephrin A and ephrin B ligands. EphA4 is activated by GPI-anchored EFNA and transmembrane EFNB and regulates cell morphology, integrin-dependent adhesion, and GTPase activity. EphA4 Protein, Mouse (HEK293, Fc) is the recombinant mouse-derived EphA4 protein, expressed by HEK293 , with C-hFc labeled tag.

HY-P75238

	EphA4 Protein, Rat (HEK293, His) Ephrin type-A receptor 4; EPH-like kinase 8; EK8; EPHA4; HEK8; SEK; TYRO1	Rat	HEK293
	EphA4 Protein, a receptor tyrosine kinase, engages in contact-dependent bidirectional signaling with ephrin-A and ephrin-B ligands. Activated by GPI-anchored EFNA and transmembrane EFNB, EphA4 regulates cell morphology, integrin-dependent adhesion, and GTPase activity. Crucial in nervous system development, it guides axonal projections, segregates motor and sensory axons, and influences synaptic plasticity. In injury repair and angiogenesis, EphA4 inhibits axonal regeneration and contributes to vascular formation. Its promiscuity extends to thymic epithelium development, cochlear organ of Corti formation, and phosphorylation of CAPRIN1 for membraneless compartment formation. EphA4 Protein, Rat (HEK293, His) is the recombinant rat-derived EphA4 protein, expressed by HEK293 , with C-His labeled tag. The total length of EphA4 Protein, Rat (HEK293, His) is 528 a.a., with molecular weight of ~70-80 kDa.

HY-P76909

	EphA4 Protein, Rhesus Macaque (HEK293, His) Ephrin type-A receptor 4; EPH-like kinase 8; EK8; EPHA4; HEK8; SEK; TYRO1	Rhesus Macaque	HEK293
	The EphA4 protein is a receptor tyrosine kinase that participates in contact-dependent bidirectional signaling with ephrin A and ephrin B ligands. EphA4 is activated by GPI-anchored EFNA and transmembrane EFNB and regulates cell morphology, integrin-dependent adhesion, and GTPase activity. EphA4 Protein, Rhesus Macaque (HEK293, His) is the recombinant Rhesus Macaque-derived EphA4 protein, expressed by HEK293 , with C-His labeled tag. The total length of EphA4 Protein, Rhesus Macaque (HEK293, His) is 528 a.a., with molecular weight of ~59.8-80 KDa.

HY-P70382

	EphA4 Protein, Human (HEK293) rHuEphrin type-A receptor 4/EPHA4; Ephrin type-A receptor 4; HEK8; SEK; TYRO1; EPHA4; Tyrosine-protein kinase receptor SEK; Tyrosine-protein kinase TYRO1; EK8; hEK8; EPH-like kinase 8	Human	HEK293
	The EphA4 protein is a receptor tyrosine kinase that participates in bidirectional signaling with membrane-bound ephrin ligands including EFNA1 and EFNB3. EphA4 is activated by GPI-anchored ephrin A and transmembrane ephrin B and regulates cell morphology and integrin-dependent adhesion through regulation of Rac, Rap, and Rho GTPases. EphA4 Protein, Human (HEK293) is the recombinant human-derived EphA4 protein, expressed by HEK293 , with tag free.

HY-P78293

	EphA4 Protein, Mouse (HEK293, His) Sek; Sek1; EPHA4; HEK8; SEK; TYRO1; EK8	Mouse	HEK293
	The EphA4 protein is a receptor tyrosine kinase that participates in contact-dependent bidirectional signaling with ephrin A and ephrin B ligands. EphA4 is activated by GPI-anchored EFNA and transmembrane EFNB and regulates cell morphology, integrin-dependent adhesion, and GTPase activity. EphA4 Protein, Mouse (HEK293, His) is the recombinant mouse-derived EphA4 protein, expressed by HEK293 , with C-His labeled tag.

HY-P75239

	EphA4 Protein, Rat (HEK293, Fc) Ephrin type-A receptor 4; EPH-like kinase 8; EK8; EPHA4; HEK8; SEK; TYRO1	Rat	HEK293
	EphA4 Protein, a receptor tyrosine kinase, engages in contact-dependent bidirectional signaling with ephrin-A and ephrin-B ligands. Activated by GPI-anchored EFNA and transmembrane EFNB, EphA4 regulates cell morphology, integrin-dependent adhesion, and GTPase activity. Crucial in nervous system development, it guides axonal projections, segregates motor and sensory axons, and influences synaptic plasticity. In injury repair and angiogenesis, EphA4 inhibits axonal regeneration and contributes to vascular formation. Its promiscuity extends to thymic epithelium development, cochlear organ of Corti formation, and phosphorylation of CAPRIN1 for membraneless compartment formation. EphA4 Protein, Rat (HEK293, Fc) is the recombinant rat-derived EphA4 protein, expressed by HEK293 , with C-hFc labeled tag.

HY-P72993

	EphA4 Protein, Human (sf9, His-GST) Ephrin type-A receptor 4; EPH-like kinase 8; EK8; EPHA4; HEK8; SEK; TYRO1	Human	Sf9 insect cells
	The EphA4 protein is a receptor tyrosine kinase that participates in bidirectional signaling with membrane-bound ephrin ligands including EFNA1 and EFNB3. EphA4 is activated by GPI-anchored ephrin A and transmembrane ephrin B and regulates cell morphology and integrin-dependent adhesion through regulation of Rac, Rap, and Rho GTPases. EphA4 Protein, Human (sf9, His-GST) is the recombinant human-derived EphA4 protein, expressed by Sf9 insect cells , with N-His, N-GST labeled tag.

HY-P72994

	EphA4 Protein, Human (HEK293, His-Fc) Ephrin type-A receptor 4; EPH-like kinase 8; EK8; EPHA4; HEK8; SEK; TYRO1	Human	HEK293
	The EphA4 protein is a receptor tyrosine kinase that participates in bidirectional signaling with membrane-bound ephrin ligands including EFNA1 and EFNB3. EphA4 is activated by GPI-anchored ephrin A and transmembrane ephrin B and regulates cell morphology and integrin-dependent adhesion through regulation of Rac, Rap, and Rho GTPases. EphA4 Protein, Human (HEK293, His-Fc) is the recombinant human-derived EphA4 protein, expressed by HEK293 , with C-hFc, C-His labeled tag.

HY-P76908

	EphA4 Protein, Rhesus Macaque (HEK293, Fc) Ephrin type-A receptor 4; EPH-like kinase 8; EK8; EPHA4; HEK8; SEK; TYRO1	Rhesus Macaque	HEK293
	The EphA4 protein is a receptor tyrosine kinase that participates in contact-dependent bidirectional signaling with ephrin A and ephrin B ligands. EphA4 is activated by GPI-anchored EFNA and transmembrane EFNB and regulates cell morphology, integrin-dependent adhesion, and GTPase activity. EphA4 Protein, Rhesus Macaque (HEK293, Fc) is the recombinant Rhesus Macaque-derived EphA4 protein, expressed by HEK293 , with C-hFc labeled tag.

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Cat. No.	Product Name		Classification

HY-159174

EPHA2/A4/GAK-IN-1		Azide
EPHA2/A4/GAK-IN-1 (compound 55) is a potent inhibitor of *EPHA2/EPHA4* and GAK with K_D values of 180.5 nM for EPHA2 and 19.2 nM for GAK, respectively. EPHA2/GAK-IN-1 shows an extrapolated half-life time of 4.6 h in a microsomal stability assay. EPHA2/GAK-IN-1 shows antiviral activity and prevents dengue virus infection of Huh7 liver cells .

Cat. No.	Product Name		Classification

HY-RS04428

EPHA4 Human Pre-designed siRNA Set A		siRNAs Pre-designed siRNA Sets
EPHA4 Human Pre-designed siRNA Set A contains three designed siRNAs for EPHA4 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

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EPHA4

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