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Results for "

FXI

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Factor Xa (4)
By Research Areas:	Cardiovascular Disease (6) Inflammation/Immunology (1)
Oligonucleotides:	Antisense Oligonucleotides (2)

5

Inhibitors & Agonists

3

Inhibitory Antibodies

3

Recombinant Proteins

2

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

Abelacimab MAA868	Factor Xa	Cardiovascular Disease
Abelacimab (MAA868) is a fully human IgG1 monoclonal antibody that binds with high affinity to the catalytic structural domain of *FXI* and locks it in the zymogen conformation, thereby preventing its activation by FXIIa or thrombin. Abelacimab can be used in thromboembolic disease studies .

Osocimab BAY 1213790	Factor Xa	Cardiovascular Disease
Osocimab (BAY 1213790), an anti-FXIa antibody (K_i=2.4 nM; EC₅₀=0.2 nM). FXI inhibition may reduce the risk of thrombosis. Osocimab inhibits thrombin generation, and prolongs activated partial thromboplastin time. Osocimab exhibits anticoagulant effects .

BMS-962212	Factor Xa	Cardiovascular Disease
BMS-962212 is a direct, reversible, selective factor XIa (FXIa) inhibitor . BMS-962212 is well tolerated, with fast onset of pharmacodynamic (PD) responses and rapid elimination. BMS-962212 increases exposure dependently in activated partial thromboplastin time, and decreases exposure dependently in FXI clotting activity .

ISIS 416858	Others	Cardiovascular Disease
ISIS 416858, a single-stranded antisense oligodeoxynucleotide, is a potent and selective inhibitor of FXI mRNA expression.

Lofacimig	Factor Xa	Inflammation/Immunology
HY-P991006 is an *FXI/PTA*-targeting VH-VH-G1(h-CH2-CH3) dimer type bispecific antibody .

Cat. No.	Product Name	Target	Research Area

Abelacimab MAA868	Factor Xa	Cardiovascular Disease
Abelacimab (MAA868) is a fully human IgG1 monoclonal antibody that binds with high affinity to the catalytic structural domain of *FXI* and locks it in the zymogen conformation, thereby preventing its activation by FXIIa or thrombin. Abelacimab can be used in thromboembolic disease studies .

Osocimab BAY 1213790	Factor Xa	Cardiovascular Disease
Osocimab (BAY 1213790), an anti-FXIa antibody (K_i=2.4 nM; EC₅₀=0.2 nM). FXI inhibition may reduce the risk of thrombosis. Osocimab inhibits thrombin generation, and prolongs activated partial thromboplastin time. Osocimab exhibits anticoagulant effects .

Lofacimig	Factor Xa	Inflammation/Immunology
HY-P991006 is an *FXI/PTA*-targeting VH-VH-G1(h-CH2-CH3) dimer type bispecific antibody .

Species:	Human (2) Cynomolgus (1)
Tag:	His (3)
Source:	HEK293 (2) E. coli (1)

Cat. No.	Compare	Product Name	Species	Source

	Coagulation Factor XI/F11 Protein, Human (His) coagulation factor XI; Coagulation factor XIa light chain; F11; FA11_HUMAN; FXI; MGC141891; Plasma thromboplastin antecedent; Platelet coagulation factor XI ; PTA	Human	E. coli
	Coagulation factor XI (F11) occupies a central position in the middle phase of the intrinsic pathway of blood coagulation, where it assumes the key role of activating factor IX. This complex process plays a key role in the chain of events that lead to the formation of a blood clot. Coagulation Factor XI/F11 Protein, Human (His) is the recombinant human-derived Coagulation Factor XI/F11 protein, expressed by E. coli , with N-6*His labeled tag.

	Coagulation Factor XI/F11 Protein, Human (HEK293, His) Coagulation factor XI; Coagulation factor XIa light chain; PTA; FXI; F11	Human	HEK293
	Coagulation factor XI (F11) occupies a central position in the middle phase of the intrinsic pathway of blood coagulation, where it assumes the key role of activating factor IX. This complex process plays a key role in the chain of events that lead to the formation of a blood clot. Coagulation Factor XI/F11 Protein, Human (HEK293, His) is the recombinant human-derived Coagulation Factor XI/F11 protein, expressed by HEK293 , with C-His labeled tag.

	Coagulation Factor XI/F11 Protein, Cynomolgus (HEK293, His) FXI; PTA; F11; Coagulation factor XI	Cynomolgus	HEK293
	Coagulation factor XI (F11) occupies a central position in the middle phase of the intrinsic pathway of blood coagulation, where it assumes the key role of activating factor IX. This complex process plays a key role in the chain of events that lead to the formation of a blood clot. Coagulation Factor XI/F11 Protein, Cynomolgus (HEK293, His) is the recombinant cynomolgus-derived Coagulation Factor XI/F11 protein, expressed by HEK293 , with C-His labeled tag. The total length of Coagulation Factor XI/F11 Protein, Cynomolgus (HEK293, His) is 607 a.a., with molecular weight of 70-85 kDa.

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Cat. No.	Product Name		Classification

Fesomersen sodium ION-957943; BAY-2976217; IONIS-FXI-LRx sodium		Antisense Oligonucleotides
Fesomersen (sodium) is an antisense oligonucleotide designed to inhibit the production of Factor XI.

Fesomersen ION-957943 free acid; BAY-3563450; IONIS-FXI-LRx		Antisense Oligonucleotides
Fesomersen is an antisense oligonucleotide designed to inhibit the production of Factor XI.

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