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Results for "

GHSR

" in MedChemExpress (MCE) Product Catalog:

By Targets:	GHSR (26) Small Interfering RNA (siRNA) (3)
By Research Areas:	Cancer (2) Endocrinology (8) Metabolic Disease (15) Neurological Disease (5)
Oligonucleotides:	Pre-designed siRNA Sets (3) siRNAs (3)

Inhibitors & Agonists

Peptides

Natural
Products

Oligonucleotides

Targets Recommended: GHSR

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-19884B

Relamorelin TFA RM-131 TFA; BIM-28131 TFA	GHSR	Metabolic Disease
Relamorelin (RM-131) TFA, a pentapeptide ghrelin analog, is a selective ghrelin/growth hormone secretagogue receptor (GHSR) agonist with a K_i of 0.42 nM for GHS-1a receptor. Relamorelin TFA is centrally penetrant. Relamorelin TFA increases growth hormone levels and accelerates gastric emptying. Relamorelin TFA has the potential for cachexia, gastroparesis, and gastric/intestinal dysmobility disorders research .

HY-RS05416

GHSR Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
GHSR Human Pre-designed siRNA Set A contains three designed siRNAs for GHSR gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

GHSR Human Pre-designed siRNA Set A GHSR Human Pre-designed siRNA Set A

HY-RS05417

Ghsr Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Ghsr Mouse Pre-designed siRNA Set A contains three designed siRNAs for Ghsr gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Ghsr Mouse Pre-designed siRNA Set A Ghsr Mouse Pre-designed siRNA Set A

HY-RS05418

Ghsr Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Ghsr Rat Pre-designed siRNA Set A contains three designed siRNAs for Ghsr gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Ghsr Rat Pre-designed siRNA Set A Ghsr Rat Pre-designed siRNA Set A

HY-10199A

Ibutamoren MK-677 free base; MK-0677 free base	GHSR	Metabolic Disease
Ibutamoren (MK-677) is an orally active growth hormone secretagogue receptor (GHSR) agonist and a nonpeptide growth hormone secretagogue. Ibutamoren can be used for metabolic research .

HY-153095

PF-6870961	GHSR	Metabolic Disease
PF-6870961 is an inverse agonist of *GHSR1a* with K_i values of 73.6 nM (human GHSR), 239 nM (rat GHSR), and 217 nM (dog GHSR), respectively. PF-6870961 inhibits the constitutive GHSR1a-induced IP accumulation with an IC₅₀ value of 300 nM. PF-6870961 also inhibits constitutive GHSR1a β-arrestin mobilization with an IC₅₀ value of 1.10 nM .

HY-153095A

PF-6870961 hydrochloride	GHSR	Metabolic Disease
PF-6870961 hydrochloride is an inverse agonist of *GHSR1a* with K_i values of 73.6 nM (human GHSR), 239 nM (rat GHSR), and 217 nM (dog GHSR), respectively. PF-6870961 hydrochloride inhibits the constitutive GHSR1a-induced IP accumulation with an IC₅₀ value of 300 nM. PF-6870961 hydrochloride also inhibits constitutive GHSR1a β-arrestin mobilization with an IC₅₀ value of 1.10 nM .

HY-19884

Relamorelin RM-131; BIM-28131	GHSR	Metabolic Disease
Relamorelin (RM-131), a pentapeptide ghrelin analog, is a selective ghrelin/growth hormone secretagogue receptor (GHSR) agonist with a K_i of 0.42 nM for GHS-1a receptor. Relamorelin is centrally penetrant. Relamorelin increases growth hormone levels and accelerates gastric emptying. Relamorelin has the potential for cachexia, gastroparesis, and gastric/intestinal dysmobility disorders research .

HY-19884A

Relamorelin acetate RM-131 acetate; BIM-28131 acetate	GHSR	Metabolic Disease
Relamorelin (RM-131) acetate, a pentapeptide ghrelin analog, is a selective ghrelin/growth hormone secretagogue receptor (GHSR) agonist with a K_i of 0.42 nM for GHS-1a receptor. Relamorelin acetate is centrally penetrant. Relamorelin acetate increases growth hormone levels and accelerates gastric emptying. Relamorelin acetate has the potential for cachexia, gastroparesis, and gastric/intestinal dysmobility disorders research .

HY-157556

BPP-2	GHSR	Others
BPP-2 is a *GHSR* ligand with an F element. Using ¹⁸F isotope labeling BPP-2, a PET probe targeting GHSR can be obtained. The binding affinity K_i of ¹⁸F-BPP-2 for GHSR is 274 nM .

HY-115272

GSK894490A	GHSR	Neurological Disease
GSK894490A is a non-peptide ghrelin receptor agonist .

HY-U00433

JMV 2959 2 Publications Verification	GHSR	Neurological Disease Endocrinology
JMV 2959 is a growth hormone secretagogue receptor type 1a (GHS-R_1a) antagonist with an IC₅₀ of 32 nM.

HY-15243

Capromorelin Tartrate CP 424391-18	GHSR	Neurological Disease Endocrinology
Capromorelin Tartrate is an orally active, potent growth hormone secretagogue receptor (GHSR) agonist, with K_i of 7 nM for hGHS-R1a.

HY-P3595

GHRF, porcine	GHSR	Endocrinology
GHRF, porcine is a growth hormone releasing factor (GHRF) peptide (porcine). GHRF binds to GHSR and induces the release of growth hormone .

HY-50844

Ibutamoren Mesylate 5 Publications Verification MK-677; MK-0677	GHSR	Endocrinology
Ibutamoren Mesylate (MK-677) is a potent, non-peptide Growth hormone secretagogue receptor (GHSR) agonist. Ibutamoren Mesylate is an orally active growth hormone (GH) secretagogue.

HY-137061

AZ-GHS-22	GHSR	Metabolic Disease
AZ-GHS-22 is a potent, non-CNS penetrant *GHS-R1a* inverse agonist (IC₅₀=0.77 nM) .

HY-N12348

Emoghrelin	GHSR	Others
Emoghrelin, isolated from? Heshouwu Polygonum multiflorum, stimulates growth hormone secretion via activation of the ghrelin receptor .

HY-U00433A

JMV 2959 hydrochloride 2 Publications Verification	GHSR	Neurological Disease Endocrinology
JMV 2959 hydrochloride is a growth hormone secretagogue receptor type 1a (GHS-R_1a) antagonist with an IC₅₀ of 32±3 nM in LLC-PK₁ cells.

HY-P1139

Cortistatin-8 PCFWKTCK	GHSR	Metabolic Disease
Cortistatin-8 (CST-8; PCFWKTCK), a neuropeptide, is a *GHS-R1a* antagonist by counteracting the response of ghrelin on gastric acid secretion. Cortistatin-8 can modulate GH release from somatotroph cells. Cortistatin-8 is a synthetic CST-analogue devoid of any binding affinity to SST-R but capable to bind the GHS-R1a. Cortistatin-8 can exert antagonistic effects on ghrelin actions either in vitro or in vivo in animals .

HY-50760

L-692585	GHSR	Endocrinology
L-692585 is a potent and nonpeptidyl growth hormone secretagogue receptor (GHS-R1a) agonist, with a K_i of 0.8 nM. L-692585 acts directly on somatotropes causing GH release .

HY-14820

Macimorelin EP-1572; AEZS-130	GHSR	Endocrinology Cancer
Macimorelin (EP-1572), a GH secretagogue, is an orally active *GHSR* agonist. Macimorelin stimulates GH release. Macimorelin can be used in the research of adult growth hormone deficiency (AGHD), and Cancer anorexia-cachexia syndrome (CACS) .

HY-14820A

Macimorelin acetate EP-1572 acetate; AEZS-130 acetate	GHSR	Neurological Disease Endocrinology Cancer
Macimorelin (EP-1572) acetate, a GH secretagogue, is an orally active *GHSR* agonist. Macimorelin acetate stimulates GH release. Macimorelin acetate can be used in the research of adult growth hormone deficiency (AGHD), and Cancer anorexia-cachexia syndrome (CACS) .

HY-P1366

des-Gln14-Ghrelin	GHSR	Metabolic Disease
des-Gln14-Ghrelin is a second endogenous ligand for the growth hormone secretagogue receptor. a). des-Gln14-ghrelin potently induces increases in [Ca ²⁺]i in CHO-GHSR62 cells, with an EC₅₀ of 2.4 nM .

HY-P1366A

des-Gln14-Ghrelin TFA	GHSR	Metabolic Disease
des-Gln14-Ghrelin TFA is a second endogenous ligand for the growth hormone secretagogue receptor. a). des-Gln14-ghrelin potently induces increases in [Ca ²⁺]i in CHO-GHSR62 cells, with an EC₅₀ of 2.4 nM .

HY-13964A

YIL781 hydrochloride	GHSR	Metabolic Disease
YIL781 hydrochloride is a potent and orally active ghrelin receptor (GHSR) antagonist. YIL781 hydrochloride produces a greater improvement in glucose homeostasis in rats. YIL781 hydrochloride inhibits the calcium response induced by ghrelin with pIC₅₀ values of 7.90 and 8.27, respectively .

HY-13964

YIL781	GHSR	Metabolic Disease
YIL781 is a potent and orally active ghrelin receptor (GHSR) antagonist. YIL781 produces a greater improvement in glucose homeostasis in rats. YIL781 inhibits the calcium response induced by ghrelin with pIC₅₀ values of 7.90 and 8.27, respectively .

HY-14495

BMS-604992 EX-1314	GHSR	Metabolic Disease
BMS-604992 (EX-1314) is a selective, orally active small-molecule growth hormone secretagogue receptor (GHSR) agonist. BMS-604992 demonstrates high-affinity binding (K_i=2.3 nM) and potent functional activity (EC₅₀=0.4 nM). BMS-604992 can stimulate food intake in rodents .

HY-14495B

BMS-604992 dihydrochloride EX-1314 dihydrochloride	GHSR	Metabolic Disease
BMS-604992 (EX-1314) dihydrochloride is a selective, orally active small-molecule growth hormone secretagogue receptor (GHSR) agonist. BMS-604992 dihydrochloride demonstrates high-affinity binding (k_i=2.3 nM) and potent functional activity (EC₅₀=0.4 nM). BMS-604992 dihydrochloride can stimulate food intake in rodents .

HY-14495A

BMS-604992 free base EX-1314 free base	GHSR	Metabolic Disease
BMS-604992 (EX-1314) free base is a selective, orally active small-molecule growth hormone secretagogue receptor (GHSR) agonist. BMS-604992 free base demonstrates high-affinity binding (k_i=2.3 nM) and potent functional activity (EC₅₀=0.4 nM). BMS-604992 free base can stimulate food intake in rodents .

Cat. No.	Product Name	Target	Research Area