2. GPCR/G Protein
  3. GHSR
  4. Macimorelin acetate

Macimorelin acetate  (Synonyms: EP-1572 acetate; AEZS-130 acetate)

Cat. No.: HY-14820A Purity: 98.96%
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Macimorelin (EP-1572) acetate, a GH secretagogue, is an orally active GHSR agonist. Macimorelin acetate stimulates GH release. Macimorelin acetate can be used in the research of adult growth hormone deficiency (AGHD), and Cancer anorexia-cachexia syndrome (CACS).

For research use only. We do not sell to patients.

Macimorelin acetate Chemical Structure

Macimorelin acetate Chemical Structure

CAS No. : 945212-59-9

Size Price Stock Quantity
5 mg USD 175 In-stock
10 mg USD 280 In-stock
25 mg USD 540 In-stock
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100 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

Other Forms of Macimorelin acetate:

Macimorelin acetate Related Antibodies

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GHSR1a

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Macimorelin (EP-1572) acetate, a GH secretagogue, is an orally active GHSR agonist. Macimorelin acetate stimulates GH release. Macimorelin acetate can be used in the research of adult growth hormone deficiency (AGHD), and Cancer anorexia-cachexia syndrome (CACS)[1][2][3].

IC50 & Target

GHSR[1]
In Vivo

Macimorelin (5 mg/kg, i.p. twice daily for 2 weeks) acetate decreased the number and duration of seizures in IHKA mouse model[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Intrahippocampal kainic acid (IHKA) mouse model[2]
Dosage: 5 mg/kg
Administration: Intraperitoneal injection (i.p.), twice daily for 2 weeks.
Result: Significantly decreased the number and duration of seizures during the treatment period, but had no antiepileptogenic or disease-modifying effect.
Clinical Trial
Molecular Weight

534.61

Formula

C28H34N6O5
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=CN[C@@H](CC1=CNC2=CC=CC=C12)NC([C@H](NC(C(C)(N)C)=O)CC3=CNC4=CC=CC=C34)=O.CC(O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (187.05 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.8705 mL 9.3526 mL 18.7052 mL
5 mM 0.3741 mL 1.8705 mL 3.7410 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 2.5 mg/mL (4.68 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

    Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
  • Protocol 2

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

    Solubility: ≥ 2.5 mg/mL (4.68 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

    Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
%
DMSO +
% 
+
%
Tween-80 +
%
Saline
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Calculation results:
Working solution concentration: mg/mL
Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
 If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.8705 mL 9.3526 mL 18.7052 mL 46.7631 mL
5 mM 0.3741 mL 1.8705 mL 3.7410 mL 9.3526 mL
10 mM 0.1871 mL 0.9353 mL 1.8705 mL 4.6763 mL
15 mM 0.1247 mL 0.6235 mL 1.2470 mL 3.1175 mL
20 mM 0.0935 mL 0.4676 mL 0.9353 mL 2.3382 mL
25 mM 0.0748 mL 0.3741 mL 0.7482 mL 1.8705 mL
30 mM 0.0624 mL 0.3118 mL 0.6235 mL 1.5588 mL
40 mM 0.0468 mL 0.2338 mL 0.4676 mL 1.1691 mL
50 mM 0.0374 mL 0.1871 mL 0.3741 mL 0.9353 mL
60 mM 0.0312 mL 0.1559 mL 0.3118 mL 0.7794 mL
80 mM 0.0234 mL 0.1169 mL 0.2338 mL 0.5845 mL
100 mM 0.0187 mL 0.0935 mL 0.1871 mL 0.4676 mL
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Macimorelin acetate Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Macimorelin945212-59-9EP-1572AEZS-130EP1572EP 1572AEZS130AEZS 130GHSRGrowth hormone secretagogue receptorGhrelin receptorIHKAGHgrowth hormoneAGHDCACSInhibitorinhibitorinhibit

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