Search Result

Isoforms Recommended:	HIV-1

Results for "

HIV-1IIIB

" in MedChemExpress (MCE) Product Catalog:

By Targets:	HIV (23) HIV Integrase (5) Akt (2) Amino Acid Derivatives (1) Dengue Virus (1) DNA/RNA Synthesis (2) Flavivirus (1) Isotope-Labeled Compounds (2) PROTACs (1) Reverse Transcriptase (2) STAT (2)
By Research Areas:	Cancer (2) Infection (23) Inflammation/Immunology (1)

Inhibitors & Agonists

Peptides

Natural
Products

Isotope-Labeled Compounds

Targets Recommended: HIV HIV Integrase HIV Protease

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-14740

Elvitegravir Maximum Cited Publications 11 Publications Verification GS-9137; JTK-303; D06677	HIV Integrase HIV	Infection
Elvitegravir (GS-9137; JTK-303; D06677) is an HIV integrase inhibitor for HIV-1_IIIB, HIV-2_EHO and HIV-2_ROD with IC₅₀ of 0.7 nM, 2.8 nM and 1.4 nM, respectively.

HY-N0751

Scutellarin Maximum Cited Publications 11 Publications Verification	STAT Akt HIV	Infection Cancer
Scutellarin, an active flavone isolated from Scutellaria baicalensis, can down-regulates the STAT3/Girdin/Akt signaling in HCC cells, and inhibits RANKL-mediated MAPK and NF-κB signaling pathway in osteoclasts. Scutellarin is active against *HIV-1IIIB, HIV-1(74V)* and *HIV-1KM018* with EC₅₀s of 26 μM, 253 μM and 136 μM, respectively.

HY-134851

HIV-1 inhibitor-6 1 Publications Verification	HIV	Infection
HIV-1 inhibitor-6 (compound 9), a diheteroarylamide-based compound, is a potent HIV-1 pre-mRNA alternative splicing inhibitor. HIV-1 inhibitor-6 blocks HIV replication. HIV-1 inhibitor-6 is active against wild-type HIV-1IIIB (subtype B, X4-tropic) and HIV-1 97USSN54 (subtype A, R5-tropic) with EC₅₀s of 0.6 μM and 0.9 μM, respectively. HIV-1 inhibitor-6 inhibits HIV strains resistant to agents targeting HIV reverse transcriptase, protease, integrase, and coreceptor CCR5 with EC₅₀s ranging from 0.9 to 1.5 μM ^[1].

HY-143274

DENV-IN-5	Flavivirus Dengue Virus HIV DNA/RNA Synthesis	Infection
DENV-IN-5 (Compound 4b) is a dengue virus (DENV) inhibitor with EC₅₀s of 1.47, 9.23, 7.08 and 8.91 μM against DENV-I ∼ IV replication, respectively. DENV-IN-5 also inhibits *HIV-1_IIIB* strain with an EC₅₀ of 0.1512 μM ^[1].

HY-14740R

Elvitegravir (Standard)	HIV Integrase HIV	Infection
Elvitegravir (Standard) is the analytical standard of Elvitegravir. This product is intended for research and analytical applications. Elvitegravir (GS-9137; JTK-303; D06677) is an HIV integrase inhibitor for HIV-1_IIIB, HIV-2_EHO and HIV-2_ROD with IC₅₀ of 0.7 nM, 2.8 nM and 1.4 nM, respectively.

HY-18666

D77	HIV	Infection
D77 is anti-HIV-1 inhibitor targeting the interaction between integrase and cellular LEDGF/p75. D77 inhibits HIV-1(IIIB) replication by EC50 value of 23.8 μg/ml in MT-4 cell (5.03 μg/ml for C8166 cells).

HY-14740S

Elvitegravir-d8 GS-9137-d₈; JTK-303-d₈; D06677-d₈	Isotope-Labeled Compounds HIV Integrase HIV	Infection
Elvitegravir-d₈ is deuterium labeled Elvitegravir. Elvitegravir (GS-9137; JTK-303; D06677) is an HIV integrase inhibitor for HIV-1IIIB, HIV-2EHO and HIV-2ROD with IC50 of 0.7 nM, 2.8 nM and 1.4 nM, respectively.

HY-163851

PROTAC Vif degrader-1	PROTACs HIV	Infection
PROTAC Vif degrader-1 (Compound L15) is a Vif PROTAC degrader. PROTAC Vif degrader-1 has antiviral activity against HIV-1 (EC₅₀: 33.35 μM against HIV-1_IIIB). Blue: CRBN ligand (HY-10984); Black: linker; Pink: HIV-1 inhibitor(HY-163852) ^[1].

HY-14740S1

Elvitegravir-d6 GS-9137-d₆; JTK-303-d₆; D06677-d₆	Isotope-Labeled Compounds HIV Integrase HIV	Infection
Elvitegravir-d₆ (GS-9137-d₆) is deuterium labeled Elvitegravir. Elvitegravir (GS-9137; JTK-303; D06677) is an HIV integrase inhibitor for HIV-1_IIIB, HIV-2_EHO and HIV-2_ROD with IC₅₀ of 0.7 nM, 2.8 nM and 1.4 nM, respectively ^[1].

HY-N0751R

Scutellarin (Standard)	STAT Akt HIV	Infection Cancer
Scutellarin (Standard) is the analytical standard of Scutellarin. This product is intended for research and analytical applications. Scutellarin, an active flavone isolated from Scutellaria baicalensis, can down-regulates the STAT3/Girdin/Akt signaling in HCC cells, and inhibits RANKL-mediated MAPK and NF-κB signaling pathway in osteoclasts. Scutellarin is active against HIV-1IIIB, HIV-1(74V) and HIV-1KM018 with EC₅₀s of 26 μM, 253 μM and 136 μM, respectively.

HY-P10834

NYAD-13	HIV	Infection
NYAD-13 exhibits antiviral activity against **HIV-1 IIIB**, but it also possesses significant cytotoxicity. ^[1]

HY-146031

A3N19	HIV	Infection
A3N19 is a potent HIV-1 non-nucleoside reverse transcriptase inhibitor, with an EC₅₀ of 3.28 nM against HIV-1 IIIB ^[1].

HY-168525

IC-1k	HIV	Infection
IC-1k is a potent *HIV-1* inhibitor with EC₅₀ values of 2.69, 97.97 nM for HIV-1 IIIB, HIV-2 ROD, respectively. IC-1k shows cytotoxicity. IC-1k shows antiviral activity ^[1].

HY-162526

HIV capsid modulator 2	HIV	Infection
HIV capsid modulator 2 (Compound 7t) is a modulator for the HIV capsid (CA) protein. HIV capsid modulator 2 exhibits antiviral activity, which inhibits HIV-1 IIIB strain and HIV-2 ROD strain with EC₅₀ of 0.04 and 0.13 μM. HIV capsid modulator 2 is metabolically stable in human liver microsomes ^[1].

HY-143273

DENV-IN-6	HIV DNA/RNA Synthesis	Infection
DENV-IN-6 is a potent DENV (I-IV) inhibitor with EC₅₀s of 17.5, 13.20, 6.8 and 11.41 μM for the inhibition of DENV (I-IV) replication, respectively. DENV-IN-6 also exhibits activity of anti-HIV-1_IIIB (EC₅₀=0.0181 µM; CC₅₀=64.92 µM) ^[1].

HY-152160

HIV-1 inhibitor-50	HIV Reverse Transcriptase	Infection
HIV-1 invistor-50 is a non-nucleoside reverse transcriptase inhibitor (NNRTI) that targets HIV-1 reverse transcriptase (RT) (IC₅₀=50 nM). HIV-1 inhibitor-50 shows significant antiviral activity, with EC₅₀s of 2.22-53.3nM against **HIV-1 IIIB** and its mutant strains ^[1].

HY-12108

S 1360	HIV Integrase HIV	Infection
S 1360 is a potent and selective inhibitor of HIV-1 integrase. S 1360 inhibits the catalytic activity of purified integrase ( IC₅₀: 20 nM). The EC₅₀, and CC₅₀ of S 1360 in MTT assay (MT-4 cells infected with HIV-1 IIIB) are 200 nM and 12 μM, respectively. S 1360 has antiviral activity against both X4 tropic and R5 tropic strains, as well as NRTI, NNRTI and PI drug-resistant variants ^[1].

HY-130241

Reverse transcriptase-IN-1	HIV	Infection
Reverse transcriptase-IN-1 (Compound 12z), a diarylbenzopyrimidine (DABP) analogue, is a potent, orally active HIV-1 nonnucleoside reverse transcriptase inhibitor. Reverse transcriptase-IN-1 has antiviral activity with EC₅₀ values of 3.4 nM, 4.3 nM and 3.6 nM for **HIV-1 III_B, E138K and K103N** mutants, respectively. Reverse transcriptase-IN-1 also has an IC₅₀of 13.7 nM against HIV-1 reverse transcriptase enzyme ^[1].

HY-161986

HIV-1 inhibitor-74	HIV	Infection
HIV-1 inhibitor-74 (compound 10c) is a potent *HIV-1* inhibitor with an EC₅₀ value of 0.0047 µM for HIV-1 IIIB. HIV-1 inhibitor-74 shows cytotoxicity. HIV-1 inhibitor-74 inhibits WT HIV-1 RT activity with an IC₅₀ value of 0.134 µM. HIV-1 inhibitor-74 shows broad-spectrum anti HIV-1 activity ^[1].

HY-P4292

H-Gly-Pro-Gly-NH2	HIV Amino Acid Derivatives	Infection
H-Gly-Pro-Gly-NH2 is a tripeptide that inhibits *HIV-1* replication. H-Gly-Pro-Gly-NH2 inhibits the activity of **HIV-1 III_B and HIV-2 ROD with EC₅₀** values of 35 µM and 30 µM, respectively. H-Gly Pro Gly NH2 inhibits HIV-1 replication in vitro by interfering with capsid formation. H-Gly Pro Gly NH2 has antiviral activity and can be used for virus research ^[1] .

HY-146353

HIV-1 inhibitor-29	HIV	Infection Inflammation/Immunology
HIV-1 inhibitor-29 (compound 14d2) is a potent *HIV-1* inhibitor with an EC₅₀ of 2.18 μM for HIV-1 IIIB. HIV-1 inhibitor-29 has high anti-resistance profile toward F227L/V106A strain (EC₅₀ = 0.974 μM), and exhibits low cytotoxicity in MT-4 cells (CC₅₀ = 211 μM). HIV-1 inhibitor-29 can be used for researching AIDS ^[1].

HY-102077

SAMT-247	HIV	Infection
SAMT-247 is a microbicide that selectively inactivate the viral nucleocapsid protein NCp7, causing zinc ejection and preventing RNA encapsidation. SAMT-247 shows good antiviral activity ^[1] .

HY-152161

HIV-1 inhibitor-51	HIV Reverse Transcriptase	Infection
HIV-1 inhibitor-51, a non-nucleoside reverse transcriptase inhibitor (NNRTI), exhibits outstanding antiviral activity against WT HIV-1 (IIIB) and a panel of mutant strains. HIV-1 inhibitor-51 has high binding affinity (K_D=2.50 μM) and inhibitory activity (IC₅₀=0.03 μM) to WT HIV-1 RT. HIV-1 inhibitor-51 has EC₅₀s of 2.22-53.3 nM for mutant strains (L100I, K103N, Y181C, Y188L, E138K, F227L + V106A, RES056) ^[1].

Cat. No.	Product Name	Target	Research Area

HY-P10834

NYAD-13	HIV	Infection
NYAD-13 exhibits antiviral activity against **HIV-1 IIIB**, but it also possesses significant cytotoxicity. ^[1]

HY-P4292

H-Gly-Pro-Gly-NH2	HIV Amino Acid Derivatives	Infection
H-Gly-Pro-Gly-NH2 is a tripeptide that inhibits *HIV-1* replication. H-Gly-Pro-Gly-NH2 inhibits the activity of **HIV-1 III_B and HIV-2 ROD with EC₅₀** values of 35 µM and 30 µM, respectively. H-Gly Pro Gly NH2 inhibits HIV-1 replication in vitro by interfering with capsid formation. H-Gly Pro Gly NH2 has antiviral activity and can be used for virus research ^[1] .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N0751

Scutellarin 10+ Cited Publications	Infection Structural Classification Flavonoids Classification of Application Fields Flavones Labiatae Source classification Phenols Polyphenols Plants Medicago truncatula Gaertn. Disease Research Fields	STAT Akt HIV
Scutellarin, an active flavone isolated from Scutellaria baicalensis, can down-regulates the STAT3/Girdin/Akt signaling in HCC cells, and inhibits RANKL-mediated MAPK and NF-κB signaling pathway in osteoclasts. Scutellarin is active against *HIV-1IIIB, HIV-1(74V)* and *HIV-1KM018* with EC₅₀s of 26 μM, 253 μM and 136 μM, respectively.

HY-N0751R

Scutellarin (Standard)	Structural Classification Flavonoids Flavones Labiatae Source classification Phenols Polyphenols Plants Medicago truncatula Gaertn.	STAT Akt HIV
Scutellarin (Standard) is the analytical standard of Scutellarin. This product is intended for research and analytical applications. Scutellarin, an active flavone isolated from Scutellaria baicalensis, can down-regulates the STAT3/Girdin/Akt signaling in HCC cells, and inhibits RANKL-mediated MAPK and NF-κB signaling pathway in osteoclasts. Scutellarin is active against HIV-1IIIB, HIV-1(74V) and HIV-1KM018 with EC₅₀s of 26 μM, 253 μM and 136 μM, respectively.

Cat. No.	Product Name	Chemical Structure

HY-14740S

Elvitegravir-d8
Elvitegravir-d₈ is deuterium labeled Elvitegravir. Elvitegravir (GS-9137; JTK-303; D06677) is an HIV integrase inhibitor for HIV-1IIIB, HIV-2EHO and HIV-2ROD with IC50 of 0.7 nM, 2.8 nM and 1.4 nM, respectively.

HY-14740S1

Elvitegravir-d6
Elvitegravir-d₆ (GS-9137-d₆) is deuterium labeled Elvitegravir. Elvitegravir (GS-9137; JTK-303; D06677) is an HIV integrase inhibitor for HIV-1_IIIB, HIV-2_EHO and HIV-2_ROD with IC₅₀ of 0.7 nM, 2.8 nM and 1.4 nM, respectively ^[1].

Inquiry Online

Your information is safe with us. * Required Fields.

MCE Japan Authorized Agent ナミキ商事株式会社コスモ・バイオ株式会社
Salutation			Country or Region *
Applicant Name *			Organization Name *
Department *
Email Address *			Product Name *
Cat. No.			Requested quantity *
Phone Number *
Remarks

Inquiry Online

Inquiry Information

Product Name:
Cat. No.:
Quantity:
MCE Japan Authorized Agent:

Name
Email *

	Sorry, but the email address you supplied was invalid.

HIV-1IIIB

Inhibitors & Agonists

Peptides

NaturalProducts

Isotope-Labeled Compounds

Natural
Products