Search Result
Results for "
Hamsters
" in MedChemExpress (MCE) Product Catalog:
3
Isotope-Labeled Compounds
| Cat. No. |
Product Name |
Target |
Research Areas |
Chemical Structure |
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- HY-N9453
-
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Others
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Others
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5α-Cholesta-7,24-dien-3β-ol, a sterol, can be found in hamster cauda epididymal mature spermatozoa .
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- HY-A0032A
-
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CMV
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Infection
Inflammation/Immunology
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Valganciclovir hydrochloride is an orally active antiviral agent. Valganciclovir hydrochloride can inhibit the growth of adenoviruses and have a protective effect on immunosuppressed hamsters. Valganciclovir hydrochloride can be used for the research of Cytomegalovirus .
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- HY-P99865
-
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AK-119
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CD73
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Others
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Dresbuxelimab (AK-119) is an IgG-κ monoclonal antibody targeting CD73. The expression system is usually CHO (Chinese Hamster Ovary) cells .
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- HY-160659
-
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Androgen Receptor
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Endocrinology
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Androgen receptor antagonist 10 (compound 6h) is a androgen receptor antagonist. Androgen receptor antagonist 10 reduces the wax esters in the golden syrian hamster model .
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-
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- HY-P99871
-
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AK102
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PCSK9
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Others
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Ebronucimab (AK102) is an IgG1-λ2 antibody targeting PCSK9 and is primarily expressed by CHO DG44 (Chinese Hamster Ovary) cells .
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- HY-122259
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Others
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Cancer
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AMPte-Glu-γ-Glu is a substrate for folylpoly-γ-glutamate synthetase (FPGS). AMPte-Glu-γ-Glu exhibits cytotoxicity against chinese hamster ovaries cells, with IC50s of 20, 350 and 3 nM, for Pro3, R2, and 43-10, respectively .
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-
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- HY-P99844
-
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ALPN-202; CD80 vIgD-Fc
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CTLA-4
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Others
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Davoceticept (ALPN-202; CD80 vIgD-Fc) is a monoclonal antibody targeting CTLA-4. Davoceticept consists of the (1-107) fragment of CD80 linked to IGHG1 Fc via a peptidyl linker. The expression system of Davoceticept is usually CHO (Chinese Hamster Ovary) cells .
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- HY-109059
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BAY1142524
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Others
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Cardiovascular Disease
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Fulacimstat is an orally available chymase inhibitor, with IC50s of 4, 3 nM for human and hamster chymase enzyme, respectively.
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-
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- HY-P99133
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-
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- HY-P99136
-
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IFNAR
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Inflammation/Immunology
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Anti-Mouse IFN gamma Antibody is an anti-mouse IFN gamma IgG antibody inhibitor derived from host Armenian Hamster.
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- HY-P99149
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-
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- HY-P99123
-
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CD28
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Inflammation/Immunology
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Anti-Mouse CD28 Antibody is an anti-mouse CD28 IgG antibody inhibitor derived from the host Syrian Hamster.
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- HY-17372
-
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MK 966
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COX
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Inflammation/Immunology
Cancer
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Rofecoxib is a potent, specific and orally active COX-2 inhibitor, with IC50s of 26 and 18 nM for human COX-2 in human osteosarcoma cells and Chinese hamster ovary cells, with a 1000-fold selectivity for COX-2 over human COX-1 (IC50 > 50 μM in U937 cells and > 15 μM in Chinese hamster ovary cells).
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- HY-P1037
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Motilin Receptor
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Others
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Motilin (26-47), human, porcine is an endogenous motilin receptor ligand with Ki and EC50 of 2.3 nM and 0.3 nM in a Chinese hamster ovary cell line.
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- HY-P99892
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PR-1594407; DC-1630423
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EGFR
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Others
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Serclutamab is a humanized chimeric antibody targeting EGFR IgG1-κ. Mainly expressed by CHO (Chinese Hamster Ovary) cells .
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- HY-114128
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Factor VIII
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Others
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Turoctocog alfa is a recombinant coagulation factor VIII (FVIII) from chinese hamster ovary (CHO) cells. Turoctocog alfa can be used for researching haemophilia A .
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- HY-114841
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13,14-Dihydrodinoprost; 13,14-dihydro PGF2α
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Prostaglandin Receptor
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Endocrinology
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13,14-dihydro Prostaglandin F2α (13,14-dihydro PGF2α) is the analog of PGF2α which has no unsaturation in the lower side chain. It causes luteolysis in hamsters with a potency five times higher than PGF2α. The ED50 value for 13,14-dihydro PGF2α as a luteolytic agent in hamsters is 1.5 μg/100 g.
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- HY-17372S
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Isotope-Labeled Compounds
COX
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Inflammation/Immunology
Cancer
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Rofecoxib-d5 is the deuterium labeled Rofecoxib. Rofecoxib is a potent, specific and orally active COX-2 inhibitor, with IC50s of 26 and 18 nM for human COX-2 in human osteosarcoma cells and Chinese hamster ovary cells, with a 1000-fold selectivity for COX-2 over human COX-1 (IC50 > 50 μM in U937 cells and > 15 μM in Chinese hamster ovary cells)[1][2].
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- HY-17372R
-
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COX
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Inflammation/Immunology
Cancer
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Rofecoxib (Standard) is the analytical standard of Rofecoxib. This product is intended for research and analytical applications. Rofecoxib is a potent, specific and orally active COX-2 inhibitor, with IC50s of 26 and 18 nM for human COX-2 in human osteosarcoma cells and Chinese hamster ovary cells, with a 1000-fold selectivity for COX-2 over human COX-1 (IC50 > 50 μM in U937 cells and > 15 μM in Chinese hamster ovary cells).
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- HY-P99138
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-
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- HY-P99864
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ZTS-00521505
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Interleukin Related
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Others
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Dovanvetmab (ZTS-00521505) is an IgG1-κ antibody targeting Felcat IL31. Mainly expressed by CHO (Chinese Hamster Ovary) cells .
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- HY-P99139
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- HY-P99884
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PF-06801591
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PD-1/PD-L1
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Others
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Sasanlimab (PF-06801591) is a humanized IgG4-κ antibody targeting PD-1. Mainly expressed by CHO (Chinese Hamster Ovary) cells .
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- HY-P99727
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SYN023
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RABV
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Infection
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Mazorelvimab (SYN023) is a combination of CTB011 and CTB012 humanized monoclonal antibodies cocktail against rabies virus (RABV). Mezagitamab binds to non-overlapping epitopes on RABV glycoprotein (G). Mezagitamab has potential application in the prevention of rabies .
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- HY-163452
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Others
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Metabolic Disease
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Squalene synthase-IN-2 (comppund isomer A-(1S, 3R)-14i) is an orally active squalene synthase inhibitor with IC50 values of 3.4, 99 nM for squalene synthase and cholesterol synthesis, respectively. Squalene synthase-IN-2 reduces plasma cholesterol and triglyceride .
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- HY-P99831
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GB-221
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EGFR
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Others
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Coprelotamab (GB-221) is an IgG-κ monoclonal antibody targeting EGFR2. The commonly used expression system for Coprelotamab is CHO DG44 (Chinese Hamster Ovary) cells .
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- HY-P99140
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-
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- HY-116822
-
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Neurokinin Receptor
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Neurological Disease
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SSR 146977 is a potent and selective antagonist of the tachykinin NK3 receptor. SSR 146977 inhibits the binding of radioactive neurokinin B to NK3 receptors in Chinese hamster ovary cells, with a Ki of 0.26 nM .
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- HY-N8933
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Others
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Others
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Glucolimnanthin is a plant glucoside that can be isolated from Limnanthes douglasii. Glucolimnanthin can increase metabolic activation of benzo[a]pyrene (B[a]P) in cultured mammalian cells
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- HY-N10229
-
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Fungal
Antibiotic
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Infection
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Harzianum A is a trichothecene that isolated from the soil-borne fungus Trichoderma harzianum. Harzianum A shows no cytotoxicity against baby hamster kidney cells, no activity against Gram-negative and Gram-positive bacteria, but modest antifungal activity at 100 μg/mL .
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- HY-160680
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Androgen Receptor
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Endocrinology
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AR antagonist 6 (compound 6i) is a diphenyl ether androgen receptor (AR) antagonist that binds AR at a concentration of 120 nM. AR antagonist 6 exhibits low toxicity and in vitro activity against the golden Syrian hamster ear model .
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- HY-14569
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CDPPB
1 Publications Verification
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mGluR
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Neurological Disease
|
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CDPPB is a potent, selective and brain penetrant positive allosteric modulator of the metabotropic glutamate receptor subtype 5 (mGluR5), with an EC50 of 27 nM in Chinese hamster ovary cells expressing human mGluR5. CDPPB may provide an approach for development of antipsychotic agents .
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- HY-A0032AR
-
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CMV
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Infection
Inflammation/Immunology
|
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Valganciclovir (hydrochloride) (Standard) is the analytical standard of Valganciclovir (hydrochloride). This product is intended for research and analytical applications. Valganciclovir hydrochloride is an orally active antiviral agent. Valganciclovir hydrochloride can inhibit the growth of adenoviruses and have a protective effect on immunosuppressed hamsters. Valganciclovir hydrochloride can be used for the research of Cytomegalovirus .
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- HY-15996
-
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VT-464
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Cytochrome P450
Androgen Receptor
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Cancer
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Seviteronel (VT-464) is a potent CYP17 lyase inhibitor(h-Lyase IC50=69 nM) and an AR antagonist. Seviteronel demonstrates both exceptional in vitro lyase/hydroxylase selectivity (~10-fold) and oral activity in a hamster model of androgen biosynthesis inhibition.
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- HY-P5872
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JZTX-XI
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Sodium Channel
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Neurological Disease
|
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Jingzhaotoxin XI (JZTX-XI) is a sodium conductance inhibitor with an IC50 of 124 nM. Jingzhaotoxin XI slows the fast inactivation (EC50=1.18±0.2 μM) of Nav1.5 expressed in Chinese hamster ovary (CHO-K1) cells .
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- HY-122331
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Calcium Channel
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Cardiovascular Disease
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Norbormide shows vasoconstrictor activity by blocking calcium channel. The activity of Norbormide is species- and tissue-specific, endothelium independent, and is restricted to the peripheral arteries of rat. Norbormide is also a toxicant, and the oral LD50s in mouse, hamster, guinea pig and rabbit are 2250, 140, 620, and 1000 mg/kg .
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- HY-N0018
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-
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- HY-P2974
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EC 3.4.21.36; Pancreatopeptidase E
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Elastase
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Metabolic Disease
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Elastase, Porcine pancreas (EC 3.4.21.36) is a single polypeptide chain of 240 amino acid residues, derived from pig pancreas. Elastase, Porcine pancreas is a serine protease that can hydrolyze proteins and polypeptide. Elastase from porcine pancreas can induce emphysema in hamsters .
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- HY-107013
-
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MMP
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Inflammation/Immunology
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CP-544439 is a potent and orally active matrix metalloproteinase-13 (MMP-13) inhibitor with an IC50 of 0.75 nM .
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- HY-151265
-
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SARS-CoV
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Infection
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MMT5-14 is a remdesivir analogue with a higher antiviral activity in four variants of SARS-CoV-2 than Remdesivir (HY-104077). MMT5-14 inhibits SARS-CoV-2, α, β, γ and δ variants with EC50s of 0.4, 2.5, 15.9, 1.7 and 5.6 μM, respectively. MMT5-14 can be used for the research of COVID-19 .
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- HY-19436
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GW 427353
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Adrenergic Receptor
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Metabolic Disease
Endocrinology
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Solabegron (GW 427353) is a selective β3-adrenergic receptor agonist, stimulating cAMP accumulation in Chinese hamster ovary cells expressing the human β3-AR, with an EC50 value of 22 nM . Solabegron (GW 427353) is being developed for the treatment of overactive bladder and irritable bowel syndrome .
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- HY-117507
-
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5-HT Receptor
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Neurological Disease
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U92016A hydrochloride is a potent, metabolically stable, orally acitive 5-HT1A receptor agonist with an exceptionally high degree of intrinsic activity . U92016A hydrochloride binds with high affinity to human 5-HT1A receptors expressed in Chinese hamster ovary cells (Ki=0.2 nM) .
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- HY-135957
-
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N3dUrd
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DNA/RNA Synthesis
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Cancer
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2'-Azido-2'-deoxyuridine (N3dUrd) is a ribonucleotide reductase inhibitor. 2'-Azido-2'-deoxyuridine has anti-cancer activity . 2'-Azido-2'-deoxyuridine is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.
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- HY-19906
-
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Bacterial
Antibiotic
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Infection
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LFF-571 is an orally active semisynthetic thiopeptide antibiotic. LFF-571 shows potent activity against a Clostridium difficile and Staphylococcus aureus with MIC values of 0.03 and 0.125 μg/mL, respectively. LFF-571 can be used for the research of infection .
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- HY-B0528A
-
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(±)-p-Octopamine hydrochloride
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Adrenergic Receptor
Endogenous Metabolite
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Neurological Disease
Endocrinology
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Octopamine ((±)-p-Octopamine) hydrochloride, a biogenic monoamine structurally related to noradrenaline, acts as a neurohormone, a neuromodulator and a neurotransmitter in invertebrates. Octopamine hydrochloride can stimulate alpha2-adrenoceptors (ARs) in Chinese hamster ovary cells transfected with human alpha2-ARs. Octopamine hydrochloride increased glycogenolysis, glycolysis, oxygen uptake, gluconeogenesis and the portal perfusion pressure .
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- HY-N0594
-
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Interleukin Related
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Inflammation/Immunology
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Deacetylasperulosidic acid (DAA) is a major phytochemical constituent of Morinda citrifolia fruit. Deacetylasperulosidic acidhas antioxidant activity by increasing superoxide dismutase activity. Deacetylasperulosidic acid has anticlastogenic activity, suppressing the induction of chromosome aberrations in hamster ovary cells and mice . Deacetylasperulosidic acid prevents 4-nitroquinoline 1-oxide (4NQO) induced DNA damage in vitro, suppresses IL-2 production along with the activation of natural killer cells .
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- HY-117213
-
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S1P1-IN-Ex26
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LPL Receptor
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Neurological Disease
Metabolic Disease
Inflammation/Immunology
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Ex26 (S1P1-IN-Ex26) is a potent and selective sphingosine 1-phosphate receptor 1 (S1P1) antagonist (IC50=0.93 nM). Ex26 shows >3,000-fold selectivity for S1P1 over other Sphingosine 1-phosphate receptors. Ex26 can be used in experimental autoimmune encephalomyelitis reseach .
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- HY-B0528AS
-
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(±)-p-Octopamine-d4 hydrochloride
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Adrenergic Receptor
Endogenous Metabolite
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Neurological Disease
Endocrinology
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Octopamine-d4 (hydrochloride) is the deuterium labeled Octopamine hydrochloride. Octopamine ((±)-p-Octopamine) hydrochloride, a biogenic monoamine structurally related to noradrenaline, acts as a neurohormone, a neuromodulator and a neurotransmitter in invertebrates. Octopamine hydrochloride can stimulate alpha2-adrenoceptors (ARs) in Chinese hamster ovary cells transfected with human alpha2-ARs. Octopamine hydrochloride increased glycogenolysis, glycolysis, oxygen uptake, gluconeogenesis and the portal perfusion pressure[1][2][3].
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- HY-N9453S
-
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Isotope-Labeled Compounds
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Others
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5α-Cholesta-7,24-dien-3β-ol-d6 is deuterium labeled 5α-Cholesta-7,24-dien-3β-ol. 5α-Cholesta-7,24-dien-3β-ol, a sterol, can be found in hamster cauda epididymal mature spermatozoa[1].
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- HY-137355
-
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15(S)-15-Methyl PGD2
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Prostaglandin Receptor
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Metabolic Disease
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15(S)-15-methyl Prostaglandin D2 (15(S)-15-methyl PGD2) is a metabolically stable synthetic analog of PGD2. In contrast to PGD2, 15(S)-15-methyl PGD2 induces vasoconstriction and increases systemic blood pressure with much reduced inhibitory activity on ADP-induced platelet aggregation. It also exhibits strong antifertility activity in hamsters (200-fold more potent than PGD2).
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- HY-147704
-
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Bacterial
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Infection
|
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Antimycobacterial agent-2 (compound 58) is a potent antimycobacterial agent. Antimycobacterial agent-2 shows anti-mycobacterial activities with an MIC99 of 0.8 µM for Mycobacterium tuberculosis (M.tb) H37Rv. Antimycobacterial agent-2 shows cytotoxic activities with an IC50 of48.1 µM for CHO cells .
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- HY-117239
-
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Adrenergic Receptor
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Cardiovascular Disease
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SB-206606, a stereoisomer of BRL 37344, is a potentially specific, beta 3-adrenergic receptor (β3-AR) ligand. The affinity of [3H]SB 206606 is 76 times higher for the β3-AR than for the beta 1/beta 2-adrenergic receptors .
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- HY-A0148
-
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SKF-102886 free base; WR-171669
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Parasite
Potassium Channel
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Infection
|
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Halofantrine (SKF-102886 free base) is a highly lipophilic antimalarial active against Chloroquine-resistant strains of Plasmodium falciparum . Halofantrine blocks HERG potassium channels .
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- HY-101317
-
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SB-205607 dihydrobromide
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Opioid Receptor
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Neurological Disease
|
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TAN-67 (SB-205607) dihydrobromide is a potent and selective nonpeptidic δ-opioid receptor agonist with a Ki value of 0.647 nM. TAN-67 dihydrobromide has neuroprotective effect. TAN-67 dihydrobromide can be used in research of ischemic stroke .
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- HY-100554
-
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Adrenergic Receptor
5-HT Receptor
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Cardiovascular Disease
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BMY 7378 is a selective antagonist of α1D-adrenoceptor (α1D-AR). BMY 7378 binds to membranes expressing the cloned rat α1D-AR with a >100-fold higher affinity (Ki=2 nM) than binding to either the cloned rat α1A-AR (Ki=800 nM) or the hamster α1B-AR (Ki=600 nM). BMY 7378 is a 5-HT1A receptor partial agonist .
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- HY-141645
-
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WS070117
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AMPK
TGF-β Receptor
NF-κB
JNK
AP-1
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Cardiovascular Disease
Metabolic Disease
Inflammation/Immunology
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IMM-H007 (WS070117) is an orally active and potent AMPK (AMP-activated protein kinase) activator and TGFβ1 (transforming growth factor β1) antagonist. IMM-H007 has protective effects in cardiovascular diseases via activation of AMPK. IMM-H007 negatively regulates endothelium inflammation through inactivating NF-κB and JNK/AP1 signaling. IMM-H007 inhibits ABCA1 degradation. IMM-H007 resolves hepatic steatosis in HFD-fed hamsters by the regulation of lipid metabolism. IMM-H007 can be used for the research of nonalcoholic fatty liver disease (NAFLD) and inflammatory atherosclerosis .
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- HY-10898
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-
| Cat. No. |
Product Name |
Target |
Research Area |
-
- HY-P1037
-
|
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Motilin Receptor
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Others
|
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Motilin (26-47), human, porcine is an endogenous motilin receptor ligand with Ki and EC50 of 2.3 nM and 0.3 nM in a Chinese hamster ovary cell line.
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- HY-123492
-
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Peptides
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Neurological Disease
Endocrinology
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Kentsin, a contraceptive tetrapeptide, is originally extracted from hamster embryos. Kentsin prevents the maturation of Graafian follicles and consequently inhibits ovulation. Kentsin has opiate properties on gastrointestinal motility .
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- HY-P5872
-
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JZTX-XI
|
Sodium Channel
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Neurological Disease
|
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Jingzhaotoxin XI (JZTX-XI) is a sodium conductance inhibitor with an IC50 of 124 nM. Jingzhaotoxin XI slows the fast inactivation (EC50=1.18±0.2 μM) of Nav1.5 expressed in Chinese hamster ovary (CHO-K1) cells .
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- HY-P3050
-
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Peptides
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Cardiovascular Disease
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Helospectin II is a neuropeptide of the vasoactive intestinal peptide (VIP) family. Helospectin II has vasodilatory and antihypertensive activities, and decreases blood pressure. Helospectin II is originally isolated from the salivary gland venom of the lizard Heloderma suspectum .
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- HY-P3053
-
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Peptides
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Cardiovascular Disease
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Helospectin I is a neuropeptide of the vasoactive intestinal peptide (VIP) family. Helospectin I has vasodilatory and antihypertensive activities, and decreases blood pressure. Helospectin I is originally isolated from the salivary gland venom of the lizard Heloderma suspectum .
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| Cat. No. |
Product Name |
Target |
Research Area |
-
- HY-P99865
-
|
AK-119
|
CD73
|
Others
|
|
Dresbuxelimab (AK-119) is an IgG-κ monoclonal antibody targeting CD73. The expression system is usually CHO (Chinese Hamster Ovary) cells .
|
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- HY-P99871
-
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AK102
|
PCSK9
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Others
|
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Ebronucimab (AK102) is an IgG1-λ2 antibody targeting PCSK9 and is primarily expressed by CHO DG44 (Chinese Hamster Ovary) cells .
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- HY-P99844
-
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ALPN-202; CD80 vIgD-Fc
|
CTLA-4
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Others
|
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Davoceticept (ALPN-202; CD80 vIgD-Fc) is a monoclonal antibody targeting CTLA-4. Davoceticept consists of the (1-107) fragment of CD80 linked to IGHG1 Fc via a peptidyl linker. The expression system of Davoceticept is usually CHO (Chinese Hamster Ovary) cells .
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- HY-P990107
-
-
- HY-P99133
-
-
- HY-P99136
-
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IFNAR
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Inflammation/Immunology
|
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Anti-Mouse IFN gamma Antibody is an anti-mouse IFN gamma IgG antibody inhibitor derived from host Armenian Hamster.
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- HY-P99149
-
-
- HY-P99123
-
|
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CD28
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Inflammation/Immunology
|
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Anti-Mouse CD28 Antibody is an anti-mouse CD28 IgG antibody inhibitor derived from the host Syrian Hamster.
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- HY-P990145
-
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Inhibitory Antibodies
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Others
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Anti-Mouse VISTA Antibody (13F3) is a Armenian hamster-derived IgG type antibody inhibitor, targeting to mouse VISTA.
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- HY-P99869
-
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Inhibitory Antibodies
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Others
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Ebdarokimab (AK101) is a humanized IgG1-κ antibody, usually expressed in CHO (Chinese Hamster Ovary) cells .
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- HY-P990159
-
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Inhibitory Antibodies
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Others
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Anti-Mouse TCRβ Antibody (HB218) is a Armenian hamster-derived IgG type antibody inhibitor, targeting to mouse TCRβ.
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- HY-P99892
-
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PR-1594407; DC-1630423
|
EGFR
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Others
|
|
Serclutamab is a humanized chimeric antibody targeting EGFR IgG1-κ. Mainly expressed by CHO (Chinese Hamster Ovary) cells .
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- HY-P99122
-
-
- HY-P990266
-
|
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Inhibitory Antibodies
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Others
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Anti-Mouse CD48 Antibody (HM48-1) is a Armenian hamster-derived IgG type antibody inhibitor, targeting to mouse CD48.
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- HY-P990206
-
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Inhibitory Antibodies
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Others
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Anti-Mouse Jagged 2 Antibody (HMJ2-1) is a Armenian hamster-derived IgG type antibody inhibitor, targeting to mouse Jagged 2.
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- HY-P99146
-
-
- HY-P99147
-
-
- HY-P990168
-
|
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Inhibitory Antibodies
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Others
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Anti-Mouse Podoplanin/glycoprotein 38 Antibody (8.1.1) is a Syrian hamster-derived IgG type antibody inhibitor, targeting to mouse Podoplanin/glycoprotein 38.
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- HY-P990177
-
|
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Inhibitory Antibodies
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Others
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Anti-Mouse Notch4 Antibody (HMN4-14) is a Armenian hamster-derived IgG, κ type antibody inhibitor, targeting to mouse Notch4.
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-
- HY-P990184
-
|
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Inhibitory Antibodies
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Others
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Anti-Mouse MHC Class II (βchain) Antibody (KL277) is a hamster/mouse-derived IgG type antibody inhibitor, targeting to mouse MHC Class II.
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-
- HY-P99138
-
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- HY-P99864
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ZTS-00521505
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Interleukin Related
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Others
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Dovanvetmab (ZTS-00521505) is an IgG1-κ antibody targeting Felcat IL31. Mainly expressed by CHO (Chinese Hamster Ovary) cells .
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- HY-P99139
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- HY-P99884
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PF-06801591
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PD-1/PD-L1
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Others
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Sasanlimab (PF-06801591) is a humanized IgG4-κ antibody targeting PD-1. Mainly expressed by CHO (Chinese Hamster Ovary) cells .
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- HY-P990298
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Inhibitory Antibodies
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Others
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Anti-Mouse BTLA/CD272 Antibody (6A6) is a Armenian hamster-derived IgG, κ type antibody inhibitor, targeting to mouse BTLA/CD272.
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- HY-P990205
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Inhibitory Antibodies
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Others
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Anti-Mouse/Human KLRG-1 Antibody (2F1) is a Syrian hamster-derived IgG type antibody inhibitor, targeting to mouse/human KLRG-1.
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- HY-P990291
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Inhibitory Antibodies
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Others
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Anti-Mouse CD16.2 Antibody (9E9) is a Armenian hamster-derived IgG type antibody inhibitor, targeting to mouse CD16.2.
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- HY-P99727
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SYN023
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RABV
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Infection
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Mazorelvimab (SYN023) is a combination of CTB011 and CTB012 humanized monoclonal antibodies cocktail against rabies virus (RABV). Mezagitamab binds to non-overlapping epitopes on RABV glycoprotein (G). Mezagitamab has potential application in the prevention of rabies .
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- HY-P99831
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GB-221
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EGFR
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Others
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Coprelotamab (GB-221) is an IgG-κ monoclonal antibody targeting EGFR2. The commonly used expression system for Coprelotamab is CHO DG44 (Chinese Hamster Ovary) cells .
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- HY-P99140
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- HY-P99828
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PF-06523435; hu24
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Inhibitory Antibodies
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Others
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Cofetuzumab (PF-06523435) is a humanized IgG1-κ monoclonal antibody targeting PTK7. The expression system of Cofetuzumab is usually CHO (Chinese Hamster Ovary) cells .
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- HY-P99877
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AMG592
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Inhibitory Antibodies
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Others
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Efavaleukin alfa (AMG592) is a human monoclonal antibody. Efavaleukin alfa is composed of the IGHG1 Fc fragment fused to IL-2. The expression system of Efavaleukin alfa is usually CHO (Chinese Hamster Ovary) cells .
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- HY-P990134
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Inhibitory Antibodies
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Others
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Anti-Mouse CD40L/CD154 Antibody (MR-1) is a Armenian hamster-derived IgG type antibody inhibitor, targeting to mouse CD40L/CD154.
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- HY-P990232
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Inhibitory Antibodies
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Others
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Anti-Mouse IFNγRα/CD119 Antibody (2E2) is a Armenian hamster-derived IgG type antibody inhibitor, targeting to mouse IFNγRα/CD119.
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- HY-P990254
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Inhibitory Antibodies
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Others
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Anti-Mouse CXCR3/CD183 Antibody (CXCR3-173) is a Armenian hamster-derived IgG type antibody inhibitor, targeting to mouse CXCR3/CD183.
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- HY-P990249
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Inhibitory Antibodies
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Others
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Anti-Mouse DR5/CD262 Antibody (MD5-1) is a Armenian hamster-derived IgG, κ type antibody inhibitor, targeting to mouse DR5/CD262.
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- HY-P990236
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Inhibitory Antibodies
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Others
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Anti-Mouse/Rat/Monkey/Human ICOS/CD278 Antibody (C398.4A) is a Armenian hamster-derived IgG type antibody inhibitor, targeting to mouse/rat/monkey/human ICOS/CD278.
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- HY-P990255
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Inhibitory Antibodies
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Others
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Anti-Mouse CXCL9/MIG Antibody (MIG-2F5.5) is a Armenian hamster-derived IgG, κ type antibody inhibitor, targeting to mouse CXCL9/MIG.
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- HY-P990151
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Inhibitory Antibodies
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Others
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Anti-Mouse TL1A/TNFSF15 Antibody (5G4.6) is a Armenian hamster-derived IgG type antibody inhibitor, targeting to mouse TL1A/TNFSF15.
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- HY-P99872
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CSJ-117; NVP-CSJ117
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Inhibitory Antibodies
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Others
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Ecleralimab (CSJ-117; NVP-CSJ117) is a Fab-IgG1-λ2 antibody targeting the thymic stromal lymphopoietin TSLP. The expression system of Ecleralimab is usually CHO (Chinese Hamster Ovary) cells .
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- HY-P990297
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Inhibitory Antibodies
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Others
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Anti-Mouse/Rat/Human CCL2/MCP-1 Antibody (2H5) is a Armenian hamster-derived IgG, κ type antibody inhibitor, targeting to mouse/rat/human CCL2/MCP-1.
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- HY-P990253
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Inhibitory Antibodies
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Others
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Anti-Mouse Delta-like protein 1/DLL1 Antibody (HMD1-5) is a Armenian hamster-derived IgG, κ type antibody inhibitor, targeting to mouse Delta-like protein 1/DLL1.
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- HY-P990252
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Inhibitory Antibodies
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Others
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Anti-Mouse Delta-like protein 4/DLL4 Antibody (HMD4-2) is a Armenian hamster-derived IgG, κ type antibody inhibitor, targeting to mouse Delta-like protein 4/DLL4.
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- HY-P990161
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Inhibitory Antibodies
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Others
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Anti-Mouse TCR Vγ1.1/Cr4 Antibody (2.11) is a Armenian hamster-derived IgG type antibody inhibitor, targeting to mouse TCR Vγ1.1/Cr4.
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| Cat. No. |
Product Name |
Category |
Target |
Chemical Structure |
| Cat. No. |
Product Name |
Chemical Structure |
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- HY-17372S
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Rofecoxib-d5 is the deuterium labeled Rofecoxib. Rofecoxib is a potent, specific and orally active COX-2 inhibitor, with IC50s of 26 and 18 nM for human COX-2 in human osteosarcoma cells and Chinese hamster ovary cells, with a 1000-fold selectivity for COX-2 over human COX-1 (IC50 > 50 μM in U937 cells and > 15 μM in Chinese hamster ovary cells)[1][2].
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- HY-B0528AS
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Octopamine-d4 (hydrochloride) is the deuterium labeled Octopamine hydrochloride. Octopamine ((±)-p-Octopamine) hydrochloride, a biogenic monoamine structurally related to noradrenaline, acts as a neurohormone, a neuromodulator and a neurotransmitter in invertebrates. Octopamine hydrochloride can stimulate alpha2-adrenoceptors (ARs) in Chinese hamster ovary cells transfected with human alpha2-ARs. Octopamine hydrochloride increased glycogenolysis, glycolysis, oxygen uptake, gluconeogenesis and the portal perfusion pressure[1][2][3].
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- HY-N9453S
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5α-Cholesta-7,24-dien-3β-ol-d6 is deuterium labeled 5α-Cholesta-7,24-dien-3β-ol. 5α-Cholesta-7,24-dien-3β-ol, a sterol, can be found in hamster cauda epididymal mature spermatozoa[1].
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| Cat. No. |
Product Name |
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Classification |
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- HY-135957
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N3dUrd
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Azide
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2'-Azido-2'-deoxyuridine (N3dUrd) is a ribonucleotide reductase inhibitor. 2'-Azido-2'-deoxyuridine has anti-cancer activity . 2'-Azido-2'-deoxyuridine is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.
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