Valganciclovir hydrochloride

Name: Valganciclovir hydrochloride
Brand: MedChemExpress
SKU: HY-A0032A
Rating: 4.5 (1 reviews)

Cat. No.: HY-A0032A Purity: ≥98.0%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

Valganciclovir hydrochloride is an orally active antiviral agent. Valganciclovir hydrochloride can inhibit the growth of adenoviruses and have a protective effect on immunosuppressed hamsters. Valganciclovir hydrochloride can be used for the research of Cytomegalovirus.

For research use only. We do not sell to patients.

Valganciclovir hydrochloride Chemical Structure

CAS No. : 175865-59-5

Size	Price	Stock	Quantity

Free Sample (0.1 - 0.5 mg)		Apply Now
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	USD 41	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	USD 41	In-stock	Estimated Time of Arrival: December 31
Solid
10 mg	USD 37	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 68	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 110	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 170	In-stock	Estimated Time of Arrival: December 31
200 mg		Get quote
500 mg		Get quote

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This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of Valganciclovir hydrochloride:

Valganciclovir-d₈ hydrochloride Get quote
Valganciclovir Get quote
Valganciclovir hydrochloride (Standard) Get quote

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Biological Activity
Purity & Documentation
References
Customer Review

Description

In Vitro

Valganciclovir (500 μM, 5-7 days) inhibits the growth of human adenoviruses (Ads) in A549 cells^[1]. Valganciclovir (0.003-10 mM, 10 min) with ganciclovir (HY-13637) inhibits the uptake of glycylsarcosine in Caco-2 cells^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:	A549 cells
Concentration:	500 μM
Incubation Time:	5 days, 7days
Result:	Showed EC₅₀ values ranged from 120.5 μM (Ad4) to 244.4 μM (Ad6). Showed IC₅₀ values was calculated to be 11.74 mM at 7 days post-infection.

In Vivo

Valganciclovir (200 mg/kg, Oral gavage, twice daily for16 days) protects immunosuppressed hamsters challenged intravenously with adenovirus type 5 (Ad5)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Immunosuppressed hamsters^[1]
Dosage:	200 mg/kg
Administration:	Oral gavage (p.o.)
Result:	Resulted in significantly smaller magnitude of weight loss for all groups. Reduced the liver pathology.

Clinical Trial

Molecular Weight

390.82

Formula

C₁₄H₂₃ClN₆O₅

CAS No.

175865-59-5

Appearance

Solid

Color

White to off-white

SMILES

N[C@@H](C(C)C)C(OCC(OCN1C=NC2=C1N=C(N)NC2=O)CO)=O.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

DMSO : 50 mg/mL (127.94 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H₂O : ≥ 50 mg/mL (127.94 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.5587 mL	12.7936 mL	25.5872 mL
5 mM	0.5117 mL	2.5587 mL	5.1174 mL
10 mM	0.2559 mL	1.2794 mL	2.5587 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (6.40 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (6.40 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 2.5 mg/mL (6.40 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: PBS
Solubility: 100 mg/mL (255.87 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: ≥98.0%

Select Batch:

Data Sheet (275 KB) SDS (393 KB)

COA (251 KB) HNMR (266 KB)

Handling Instructions (2659 KB)

References

[1]. Toth K, et al. Valganciclovir inhibits human adenovirus replication and pathology in permissive immunosuppressed female and male Syrian hamsters [J]. Viruses, 2015, 7(3): 1409-1428. [Content Brief]

[2]. Sugawara M, et al. Transport of valganciclovir, a ganciclovir prodrug, via peptide transporters PEPT1 and PEPT2 [J]. Journal of pharmaceutical sciences, 2000, 89(6): 781-789. [Content Brief]

[3]. Cvetkovic R S, et al. Valganciclovir: a review of its use in the management of CMV infection and disease in immunocompromised patients [J]. Drugs, 2005, 65: 859-878. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO / H₂O	1 mM	2.5587 mL	12.7936 mL	25.5872 mL	63.9681 mL
	5 mM	0.5117 mL	2.5587 mL	5.1174 mL	12.7936 mL
	10 mM	0.2559 mL	1.2794 mL	2.5587 mL	6.3968 mL
	15 mM	0.1706 mL	0.8529 mL	1.7058 mL	4.2645 mL
	20 mM	0.1279 mL	0.6397 mL	1.2794 mL	3.1984 mL
	25 mM	0.1023 mL	0.5117 mL	1.0235 mL	2.5587 mL
	30 mM	0.0853 mL	0.4265 mL	0.8529 mL	2.1323 mL
	40 mM	0.0640 mL	0.3198 mL	0.6397 mL	1.5992 mL
	50 mM	0.0512 mL	0.2559 mL	0.5117 mL	1.2794 mL
	60 mM	0.0426 mL	0.2132 mL	0.4265 mL	1.0661 mL
	80 mM	0.0320 mL	0.1599 mL	0.3198 mL	0.7996 mL
	100 mM	0.0256 mL	0.1279 mL	0.2559 mL	0.6397 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.