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Results for "

Hh

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Antibiotic (4) Apoptosis (4) Autophagy (4) Bacterial (9) c-Fms (1) Calcium Channel (1) CDK (1) Cholinesterase (ChE) (1) Cytochrome P450 (4) Dopamine Receptor (5) DYRK (1) Endogenous Metabolite (5) FGFR (1) Fluorescent Dye (1) Fungal (4) Gli (3) HCV (1) HDAC (1) Hedgehog (30) Histamine Receptor (16) Histone Methyltransferase (3) HSP (1) Monoamine Oxidase (1) Phosphodiesterase (PDE) (1) RAR/RXR (1) Ras (1) Sigma Receptor (1) Smo (27) Toll-like Receptor (TLR) (2)
By Research Areas:	Cancer (56) Endocrinology (1) Infection (7) Inflammation/Immunology (8) Metabolic Disease (1) Neurological Disease (14)
Oligonucleotides:	CpG ODNs (2)

Inhibitors & Agonists

Biochemical Assay Reagents

Inhibitory Antibodies

Natural
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Isotope-Labeled Compounds

Antibodies

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-124899

Hh-Ag1.5 1 Publications Verification SAg1.5	Hedgehog	Metabolic Disease
Hh-Ag1.5 (SAg1.5) is a potent Hedgehog (Hh) agonist with an EC₅₀ of 1 nM . Hh-Ag1.5 mediated reprogramming breaks the quiescence of noninjured liver stem cells for rescuing liver failure .

HY-P99707

Lilotomab Hh1	Apoptosis	Cancer
Lilotomab (HH1) is a murine anti-CD37 monoclonal antibody. Lilotomab reduces clonogenic survival. Lilotomab shows anti-tumor activity .

HY-15412

HhAntag	Smo	Cancer
HhAntag is a specific, potent and orally active small molecule SMO antagonist of the Hh pathway .

HY-124639

CDK9 inhibitor HH1	CDK	Cancer
CDK9 inhibitor HH1 is a potent and selectively CDK9 inhibitor. CDK9 inhibitor HH1 inhibits the transcription of CDK. CDK9 inhibitor HH1 can be used in research of cancer .

HY-161714

HH0043	Ras	Cancer
HH0043 (Compound 10f) is an orally active and potent SOS1 inhibitor, with IC₅₀ value of 5.8 nM. HH0043 can be used for the research of cancer .

HY-159503A

Segigratinib hydrochloride 3D185; Hh185	FGFR c-Fms	Cancer
Segigratinib hydrochloride (3D185) is a potent inhibitor of FGFR1/2/3 and CSF-1R; The IC₅₀ values for FGFR1, FGFR2, FGFR3 and CSF-1R are 0.5, 1.3, 3.6 and 3.8 nM, respectively. Segigratinib hydrochloride has antitumor activity .

HY-159503

Segigratinib 3D185 free base; Hh185 free base	Others	Cancer
Segigratinib is a fibroblast growth factor receptor tyrosine kinase inhibitor, with antineoplastic effect .

HY-144882

(R)-HH2853	Histone Methyltransferase	Inflammation/Immunology Cancer
(R)-HH2853 is a mutant EZH2 inhibitor with an IC₅₀ of <100 nM for EZH2-Y641F. (R)-HH2853 can be used for cancer and autoimmune diseases (WO2018045971A1; compound 201) .

HY-144881

(S)-HH2853	Histone Methyltransferase	Inflammation/Immunology Cancer
(S)-HH2853 (compound 200), a PYRIDINO five membered aromatic ring compound, is a potent EZH1/2 dual inhibitor with an IC₅₀ of <100 nM for EZH2_Y641F. (S)-HH2853 has the potential to be used in the research of anti-tumor or autoimmune diseases .

HY-123781A

RUSKI-201 dihydrochloride	Hedgehog	Cancer
RUSKI-201 dihydrochloride is a potent and specific Hedgehog acyltransferase (Hhat) inhibitor with an IC₅₀ of 0.20 μM. RUSKI-201 dihydrochloride is able to block Hh signaling from Shh overexpressing cells and inhibits Hh palmitoylation. RUSKI-201 dihydrochloride is potential Hhat chemical probe in cells and can used in studies of Hhat catalytic function .

HY-123781

RUSKI-201	Hedgehog	Cancer
RUSKI-201 is a potent and specific Hedgehog acyltransferase (Hhat) inhibitor, with an IC₅₀ of 0.20 μM. RUSKI-201 is able to block Hh signaling from Shh overexpressing cells and inhibits Hh palmitoylation. RUSKI-201 is potential Hhat chemical probe in cells and can used in studies of Hhat catalytic function .

HY-147743

SMO-IN-1	Smo	Cancer
SMO-IN-1 (Compound 15) is an orally active Smoothened (SMO) inhibitor with an EC₅₀ of 89 nM against sonic Hh protein (shh) .

HY-121037

Eggmanone EGM1	Phosphodiesterase (PDE)	Cancer
Eggmanone (EGM1) is a potent and selective phosphodiesterase 4 (PDE4) antagonist with an IC₅₀ of 72 nM for PDE4D3. Eggmanone shows approximately 40- to 50-fold selective for PDE4D3 over other PDEs. Eggmanone exerts its Hh-inhibitory effects through selective antagonism of PDE4, leading to protein kinase A activation and subsequent Hh blockade .

HY-147744

AZD7254	Smo	Cancer
AZD7254 is an orally active Smoothened (SMO) inhibitor with an EC₅₀ of 1.0 nM against sonic Hh protein (shh) .

HY-13459

PF-5274857	Smo	Cancer
PF-5274857 is a potent, selective, orally active and brain-penetrant antagonist of Smo, with an IC₅₀ of 5.8 nM and K_i of 4.6 nM. PF-5274857 has potential for research of tumor types including brain tumors and brain metastasis driven by an activated Hh pathway .

HY-13459A

PF-5274857 hydrochloride	Smo	Cancer
PF-5274857 hydrochloride is a potent, selective, orally active and brain-penetrant antagonist of Smo, with an IC₅₀ of 5.8 nM and K_i of 4.6 nM. PF-5274857 hydrochloride has potential for research of tumor types including brain tumors and brain metastasis driven by an activated Hh pathway .

HY-N0836

Jervine 2 Publications Verification 11-Ketocyclopamine	Hedgehog Smo	Inflammation/Immunology Cancer
Jervine (11-Ketocyclopamine) is a potent Hedgehog (Hh) inhibitor with an IC₅₀ of 500-700 nM . Jervine is a natural teratogenic sterodial alkaloid from rhizomes of Veratrum nigrum. Jervine has anti-inflammatory and antioxidant properties .

HY-N0836R

Jervine (Standard)	Hedgehog Smo	Inflammation/Immunology Cancer
Jervine (Standard) is the analytical standard of Jervine. This product is intended for research and analytical applications. Jervine (11-Ketocyclopamine) is a potent Hedgehog (Hh) inhibitor with an IC₅₀ of 500-700 nM . Jervine is a natural teratogenic sterodial alkaloid from rhizomes of Veratrum nigrum. Jervine has anti-inflammatory and antioxidant properties .

HY-17514

Itraconazole 10+ Cited Publications R51211	Fungal Hedgehog Cytochrome P450 Autophagy Antibiotic Bacterial	Infection Cancer
Itraconazole (R51211) is a triazole antifungal agent and a potent and orally active Hedgehog (Hh) signaling pathway antagonist with an IC₅₀ of ~800 nM. Itraconazole potently inhibits lanosterol 14α-demethylase (cytochrome P450 enzyme), thereby inhibits the oxidative conversion of lanosterol to ergosterol. Itraconazole has anticancer and antiangiogenic effects. Itraconazole is a oxysterol-binding protein (OSBP) inhibitor .

HY-17514R

Itraconazole (Standard)	Fungal Hedgehog Cytochrome P450 Autophagy Antibiotic Bacterial	Infection Cancer
Itraconazole (Standard) is the analytical standard of Itraconazole. This product is intended for research and analytical applications. Itraconazole (R51211) is a triazole antifungal agent and a potent and orally active Hedgehog (Hh) signaling pathway antagonist with an IC50 of ~800 nM. Itraconazole potently inhibits lanosterol 14α-demethylase (cytochrome P450 enzyme), thereby inhibits the oxidative conversion of lanosterol to ergosterol. Itraconazole has anticancer and antiangiogenic effects. Itraconazole is a oxysterol-binding protein (OSBP) inhibitor .

HY-111040

Hedgehog agonist 1	Hedgehog	Neurological Disease
Hh agonist 1 (compound 21k) is a potent Hedgehog (Hh) agonist, with an EC₅₀ 0.3 nM. Hh agonist 1 can be used for the research of stroke and other neurological disorders .

HY-17024

Cyclopamine Maximum Cited Publications 40 Publications Verification 11-Deoxojervine	Hedgehog Smo Endogenous Metabolite	Cancer
Cyclopamine is a Hedgehog (Hh) pathway antagonist with an IC₅₀ of 46 nM in the Hh cell assay. Cyclopamine is also a selective Smo inhibitor.

HY-121364

Bodilisant	Histamine Receptor Fluorescent Dye	Others
Bodilisant is a fluorescent histamine H₃ receptor ligand. Bodilisant can be used at low concentrations (1-10 nM) to detect the performance of hH₃R in cells overexpressing hH₃R, and at about 1 μM concentration for tissues rich in hH₃R. Bodilisant is a useful pharmacological tool for receptor imaging .

HY-120531

UR-PI376	Histamine Receptor	Neurological Disease
UR-PI376 is a potent and selective histamine H4 receptor (H4R) agonist with a pEC₅₀ value of 7.47. UR-PI376 shows negligible hH1R and hH2R activities and moderate inverse agonistic activity at the hH3R .

HY-17024R

Cyclopamine (Standard)	Hedgehog Smo Endogenous Metabolite	Cancer
Cyclopamine (Standard) is the analytical standard of Cyclopamine. This product is intended for research and analytical applications. Cyclopamine is a Hedgehog (Hh) pathway antagonist with an IC50 of 46 nM in the Hh cell assay. Cyclopamine is also a selective Smo inhibitor.

HY-145918

MRT-14	Smo	Cancer
MRT-14 is a potent antagonist of Smo. Smo is the major component involved in signal transduction of the Hedgehog (Hh) morphogens. MRT-14 has the potential for the research of several types of cancers linked to abnormal Hh signaling .

HY-162372

Hedgehog IN-6	Hedgehog Smo	Cancer
Hedgehog IN-6 (Compound Q29) is a Hedgehog (Hh) inhibitor that can be used in cancer research. Hedgehog IN-6 inhibits the hedgehog (Hh) pathway by binding to the cysteine-rich domain (CRD) of Smoothened (Smo) and blocking its cholesterization .

HY-13307

JK184 2 Publications Verification	Hedgehog	Cancer
JK184 is a potent Hedgehog (Hh) pathway inhibitor with IC₅₀ of 30 nM in mammalian cells.

HY-12848C

SAG dihydrochloride 20+ Cited Publications	Smo	Cancer
SAG dihydrochloride is a potent Smoothened (Smo) receptor agonist (EC₅₀=3 nM; K_d=59 nM). SAG dihydrochloride activates the Hedgehog signaling pathway and counteracts Cyclopamine (HY-17024) inhibition of Smo .

HY-16587

Saridegib IPI-926; Patidegib	Smo	Cancer
Saridegib is a potent and specific inhibitor of Smoothened (Smo), a key signaling transmembrane protein in the Hedgehog (Hh) pathway.

HY-W111144

T-1330	Hedgehog	Cancer
T-1330 (Compound 45) is a Hh pathway inhibitor and reduces Gli1 expression .

HY-16587A

Saridegib hydrochloride IPI 926 hydrochloride; Patidegib hydrochloride	Smo	Cancer
Saridegib hydrochloride is a potent and specific inhibitor of Smoothened (Smo), a key signaling transmembrane protein in the Hedgehog (Hh) pathway.

HY-119607

DYRKi	DYRK	Cancer
DYRKi is an inhibitor of DYRK1 and DYRK1B with IC₅₀ values of 3.7 µM and 90 nM, respectively, which is used as a potent antagonist of Hh/Gli signaling. DYRKi impairs SMO-dependent and SMO-independent oncogenic GLI activity in human medulloblastoma cells. DYRKi is promising for research of HH/GLI-associated cancers .

HY-107408

SANT 2	Hedgehog	Cancer
SANT 2 is a potent antagonist of Hh-signaling pathway. Hedgehog (Hh) signaling plays an important role in cell signaling of embryonic development and adult tissue homeostasis. SANT 2 has the potential for the research of several malignancies including Gorlin syndrome (a disorder predisposing to basal cell carcinoma, medulloblastoma and rhabdomyosarcoma), prostate, pancreatic and breast cancers .

HY-167897

UR-AK49	Histamine Receptor	Neurological Disease
UR-AK49 (compound 11) is a human histamine H1 and H2 receptor agonist. UR-AK49 has an EC₅₀ of 23 nM in a GTPase assay with hH2R-Gsalpha fusion protein expressed in Sf9 insect cells. UR-AK49 can be used in neuro-related research .

HY-18287

MRT-83	Smo	Cancer
MRT-83 is a potent antagonist of Smo, with an IC₅₀ in the nanomolar range. MRT-83 also blocks Hedgehog (Hh) signaling.

HY-101188

INCB38579	Histamine Receptor	Infection
INCB38579 is an orally active, highly brain penetrable, and selective histamine H₄ receptor (HH₄R) antagonist (hH₄R IC₅₀=4.8 nM, mH₄R IC₅₀=42 nM, rH₄R IC₅₀=32 nM). INCB38579 shows anti-inflammatory pain and anti-pruritic activities .

HY-100790

Ciliobrevin A 3 Publications Verification HPI-4	Hedgehog	Cancer
Ciliobrevin A (HPI-4) is a hedgehog (Hh) signaling pathway inhibitor with median inhibitory concentration (IC₅₀) less than 10 μM .

HY-128656

LML134	Histamine Receptor	Neurological Disease Endocrinology
LML134 (compound 18b) is an orally active and high selective Histamine 3 receptor (H3R) inverse agonist with K_is of 0.3 nM and 12 nM for hH3R cAMP and hH3R bdg. LML134 penetrates the brain rapidly, leading to high H3R occupancy, and disengages its target with a fast kinetic profile. LML134 has the potential for excessive sleep disorders .

HY-120499

AZD8542	Hedgehog Smo	Cancer
AZD8542 is an antagonist of Smoothened (SMO), playing an important role in oncology. AZD8542 is a? Hedgehog (Hh) pathway antagonist on tumor progression with an emphasis on the role of the stroma compartment .

HY-150217

CpG ODN 10101 ODN 10101	Toll-like Receptor (TLR) HCV	Infection Inflammation/Immunology
CpG ODN 10101, a synthetic oligodeoxynucleotide (ODN), is a toll-like receptor 9 (TLR9) agonist. CpG ODN 10101 is a potent inducer of cytokine/chemokine expression ex vivo when used in combination with HH2(VQLRIRVAVIRA-NH2). CpG ODN 10101 induces IFN- secretion from dendritic cells (DCs) and stimulates B-cells.CpG ODN 10101 has antiviral and immunomodulatory properties that can influence chronic infection with HCV .

HY-150217A

CpG ODN 10101 sodium 1 Publications Verification ODN 10101 sodium	Toll-like Receptor (TLR)	Infection
CpG ODN 10101 sodium, a synthetic oligodeoxynucleotide (ODN), is a toll-like receptor 9 (TLR9) agonist. CpG ODN 10101 sodium is a potent inducer of cytokine/chemokine expression ex vivo when used in combination with HH2(VQLRIRVAVIRA-NH2). CpG ODN 10101 sodium induces IFN- secretion from dendritic cells (DCs) and stimulates B-cells.CpG ODN 10101 sodium has antiviral and immunomodulatory properties that can influence chronic infection with HCV .

HY-161333

ADS031	Histamine Receptor	Inflammation/Immunology
ADS031, a histamine H3R antagonist, displays 12.5 nM affinity at the *hH3R* and the highest inhibitory activity against AChE (IC₅₀ = 1.537 μM) .

HY-123752

MS-0022	Hedgehog Smo	Cancer
MS-0022 is a Smoothened (SMO) antagonist. MS-0022 can inhibit the Hedgehog (Hh) signaling pathway. MS-0022 can be used in anti-tumor research .

HY-129250

AZD5213	Histamine Receptor	Neurological Disease
AZD5213 is a selective and competitive human H3 receptor antagonist with a pK_i value of 9.3 for hH3R. AZD5213 can be used for the research of sleep and cognitive regulation .

HY-161364

Antibacterial agent 200	Bacterial	Inflammation/Immunology
Antibacterial agent 200 (pyridyl HH 7), a unique hydrazyl hydroxycoumarin (HH), has strong antibacterial efficacy and broad antibacterial spectrum with MIC values ranging from 0.5 to 32 μg/mL for Gram-positive and Gram-negative bacteria. Antibacterial agent 200 exhibits a good inhibition against Pseudomonas aeruginosa 27853 with a low MIC value of 0.5 μg/mL. Antibacterial agent 200 can eradicate the integrity of bacterial membrane, result in the leakage of intracellular proteins, and interact with bacterial DNA gyrase via non-covalent binding .

HY-16475

TAK-441	Hedgehog	Cancer
TAK-441 is a highly potent and orally active hedgehog (Hh) signaling inhibitor with an IC₅₀value of 4.4 nM. TAK-441 has strong antitumor activity in solid tumors .

HY-B0274

Chlorprothixene	Dopamine Receptor Histamine Receptor Bacterial	Neurological Disease
Chlorprothixene is a dopamine and histamine receptors antagonist with K_is of 18 nM, 2.96 nM, 4.56 nM, 9 nM and 3.75 nM for hD1, hD2, hD3, hD5 and hH1 receptors, respectively. Antipsychotic activity .

HY-B0274A

Chlorprothixene hydrochloride	Dopamine Receptor Histamine Receptor Bacterial	Neurological Disease
Chlorprothixene hydrochloride is a dopamine and histamine receptors antagonist with K_is of 18 nM, 2.96 nM, 4.56 nM, 9 nM and 3.75 nM for hD1, hD2, hD3, hD5 and hH1 receptors, respectively. Antipsychotic activity .

HY-149335

Sigma-1 receptor antagonist 5	Sigma Receptor Histamine Receptor	Neurological Disease
Sigma-1 receptor antagonist 5 (compound 12)，a 4-pyridylpiperidine derivative with analgesic activity，is an antagonist of sigma receptor (Ki=4.5 nM (σ1R)，10 nM (σ2R)) and histamine H3 (hH₃R，Ki=7.7 nM，IC₅₀=215 nM). Sigma-1 receptor antagonist 5 suppresses Capsaicin-induced nociception with antinociceptive activity and shows potent efficacy in nociceptive and neuropathic pain models .

Cat. No.	Product Name	Type

HY-W414581

7-Keto-27-hydroxycholesterol 3ß,27-Dihydroxy-5-cholesten-7-one	Cell Assay Reagents
7-Keto-27-hydroxycholesterol (3?,27-Dihydroxy-5-cholesten-7-one) is an important bioactive compound that agonizes the activity of smoothened (SMO) protein in the Hedgehog (Hh) signaling pathway, which is essential for proper cell differentiation in embryonic tissues.

Cat. No.	Product Name	Target	Research Area

HY-P99707

Lilotomab Hh1	Apoptosis	Cancer
Lilotomab (HH1) is a murine anti-CD37 monoclonal antibody. Lilotomab reduces clonogenic survival. Lilotomab shows anti-tumor activity .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N0836

Jervine 2 Publications Verification 11-Ketocyclopamine	Alkaloids Piperidine Alkaloids Structural Classification Veratrum nigrum Linn. Liliaceae Classification of Application Fields Source classification Plants Inflammation/Immunology Disease Research Fields	Hedgehog Smo
Jervine (11-Ketocyclopamine) is a potent Hedgehog (Hh) inhibitor with an IC₅₀ of 500-700 nM . Jervine is a natural teratogenic sterodial alkaloid from rhizomes of Veratrum nigrum. Jervine has anti-inflammatory and antioxidant properties .

HY-17514

Itraconazole 10+ Cited Publications R51211	Microorganisms Source classification	Fungal Hedgehog Cytochrome P450 Autophagy Antibiotic Bacterial
Itraconazole (R51211) is a triazole antifungal agent and a potent and orally active Hedgehog (Hh) signaling pathway antagonist with an IC₅₀ of ~800 nM. Itraconazole potently inhibits lanosterol 14α-demethylase (cytochrome P450 enzyme), thereby inhibits the oxidative conversion of lanosterol to ergosterol. Itraconazole has anticancer and antiangiogenic effects. Itraconazole is a oxysterol-binding protein (OSBP) inhibitor .

HY-17024

Cyclopamine Maximum Cited Publications 40 Publications Verification 11-Deoxojervine	Alkaloids Structural Classification Veratrum nigrum Linn. Liliaceae Classification of Application Fields Source classification Pyridine Alkaloids Plants Endogenous metabolite Disease Research Fields Steroids Cancer	Hedgehog Smo Endogenous Metabolite
Cyclopamine is a Hedgehog (Hh) pathway antagonist with an IC₅₀ of 46 nM in the Hh cell assay. Cyclopamine is also a selective Smo inhibitor.

HY-12316

20(S)-Hydroxycholesterol 2 Publications Verification 20α-Hydroxycholesterol	Structural Classification Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields Steroids Cancer	Smo Endogenous Metabolite
20(S)-hydroxyCholesterol (20α-Hydroxycholesterol) is an allosteric activator of the oncoprotein smoothened (Smo) that activates the hedgehog (Hh) signaling pathway with an EC₅₀ of 3 μM in a gene transcription reporter assay using NIH3T3 cells .

HY-N9093

(3R,5R)-3,5-Diacetoxy-1-(3,4-dihydroxyphenyl)-7-(4-hydroxyphenyl)heptane	Source classification Phenols Curcuma kwangsiensis S. K. Lee & C. F. Liang Plants Zingiberaceae	Others
(3R,5R)-3,5-Diacetoxy-1-(3,4-dihydroxyphenyl)-7-(4-hydroxyphenyl)heptane, a diarylheptanoid from the rhizomes of Curcuma kwangsiensis, possesses a variety of biological and pharmacological activities including antioxidant, antihepa totoxic, anti-inflammatory, antiproliferative, antiemetic, and antitumor activities .

HY-N0836R

Jervine (Standard)	Alkaloids Piperidine Alkaloids Structural Classification Veratrum nigrum Linn. Liliaceae Source classification Plants	Hedgehog Smo
Jervine (Standard) is the analytical standard of Jervine. This product is intended for research and analytical applications. Jervine (11-Ketocyclopamine) is a potent Hedgehog (Hh) inhibitor with an IC₅₀ of 500-700 nM . Jervine is a natural teratogenic sterodial alkaloid from rhizomes of Veratrum nigrum. Jervine has anti-inflammatory and antioxidant properties .

HY-17514R

Itraconazole (Standard)	Microorganisms Source classification	Fungal Hedgehog Cytochrome P450 Autophagy Antibiotic Bacterial
Itraconazole (Standard) is the analytical standard of Itraconazole. This product is intended for research and analytical applications. Itraconazole (R51211) is a triazole antifungal agent and a potent and orally active Hedgehog (Hh) signaling pathway antagonist with an IC50 of ~800 nM. Itraconazole potently inhibits lanosterol 14α-demethylase (cytochrome P450 enzyme), thereby inhibits the oxidative conversion of lanosterol to ergosterol. Itraconazole has anticancer and antiangiogenic effects. Itraconazole is a oxysterol-binding protein (OSBP) inhibitor .

HY-17024R

Cyclopamine (Standard)	Alkaloids Structural Classification Veratrum nigrum Linn. Liliaceae Source classification Pyridine Alkaloids Plants Endogenous metabolite Steroids	Hedgehog Smo Endogenous Metabolite
Cyclopamine (Standard) is the analytical standard of Cyclopamine. This product is intended for research and analytical applications. Cyclopamine is a Hedgehog (Hh) pathway antagonist with an IC50 of 46 nM in the Hh cell assay. Cyclopamine is also a selective Smo inhibitor.

HY-12316R

20(S)-Hydroxycholesterol (Standard) 20α-Hydroxycholesterol (Standard)	Structural Classification Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields Steroids Cancer	Smo Endogenous Metabolite
20(S)-Hydroxycholesterol (Standard) is the analytical standard of 20(S)-Hydroxycholesterol. This product is intended for research and analytical applications. 20(S)-hydroxyCholesterol (20α-Hydroxycholesterol) is an allosteric activator of the oncoprotein smoothened (Smo) that activates the hedgehog (Hh) signaling pathway with an EC₅₀ of 3 μM in a gene transcription reporter assay using NIH3T3 cells .

HY-N8270

Physalin H	Structural Classification Cardiacglycosides Source classification Solanum nigrum Linn. Plants Solanaceae Steroids	Hedgehog Endogenous Metabolite
Physalin H is a natural product that can be isolated from Solanum nigrum. Physalin H is an inhibitor of Hedgehog (Hh) signaling and it disrupts GLI1-DNA-complex formation. Physalin H inhibits GLI1 transcription with an IC₅₀ value of 0.7 μM. Physalin H shows cytotoxicity to PANC1 and DU145 cells with IC₅₀ values of 5.7 and 6.8 μM, respectively .

Species:	Human (3)
Tag:	His (2) Tag Free (1)
Source:	E. coli (3)

Cat. No.	Compare	Product Name	Species	Source

HY-P700287

	FGF-17 Protein, Human Fibroblast Growth Factor 17; FGF-17; FGF17; Hh20 Protein, Human; Fibroblast growth factor 17	Human	E. coli
	FGF-17 Protein plays a crucial role in embryonic development, serving as a signaling molecule for brain induction and patterning. Its presence is vital for normal brain development, emphasizing its significance in shaping embryogenesis intricacies. FGF-17 interacts with FGFR3 and FGFR4, underscoring its involvement in signaling cascades that precisely orchestrate developmental events in the embryonic brain. FGF-17 Protein, Human is the recombinant human-derived FGF-17 protein, expressed by E. coli , with tag free.

HY-P71905A

	FGF-17 Protein, Human (His) FGF 13; FGF 17; FGF-17; FGF13; Fgf17; FGF17_HUMAN; Fibroblast growth factor 17; Hh20	Human	E. coli
	FGF-17 Protein plays a crucial role in embryonic development, serving as a signaling molecule for brain induction and patterning. Its presence is vital for normal brain development, emphasizing its significance in shaping embryogenesis intricacies. FGF-17 interacts with FGFR3 and FGFR4, underscoring its involvement in signaling cascades that precisely orchestrate developmental events in the embryonic brain. FGF-17 Protein, Human (His) is the recombinant human-derived FGF-17 protein, expressed by E. coli , with N-6*His labeled tag. The total length of FGF-17 Protein, Human (His) is 194 a.a., with molecular weight of ~25 kDa.

HY-P702580

	HRH1 Protein, Human (His) Histamine H1 receptor; H1R; Hh1R	Human	E. coli
	HRH1 Protein, Human (His) is the recombinant human-derived HRH1, expressed by E. coli , with N-6*His labeled tag. The total length of HRH1 Protein, Human (His) is 206 a.a.,

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Cat. No.	Product Name	Chemical Structure

HY-17514S

Itraconazole-d5

Itraconazole-d₅ is the deuterium labeled Itraconazole. Itraconazole (R51211) is a triazole antifungal agent and a potent and orally active Hedgehog (Hh) signaling pathway antagonist with an IC50 of ~800 nM. Itraconazole potently inhibits lanosterol 14α-demethylase (cytochrome P450 enzyme), thereby inhibits the oxidative conversion of lanosterol to ergosterol. Itraconazole has anticancer and antiangiogenic effects[1][2][3].

HY-17514S2

Itraconazole-d9

Itraconazole-d₉ is the deuterium labeled Itraconazole[1]. Itraconazole (R51211) is a triazole antifungal agent and a potent and orally active Hedgehog (Hh) signaling pathway antagonist with an IC50 of ~800 nM. Itraconazole potently inhibits lanosterol 14α-demethylase (cytochrome P450 enzyme), thereby inhibits the oxidative conversion of lanosterol to ergosterol. Itraconazole has anticancer and antiangiogenic effects. Itraconazole is a oxysterol-binding protein (OSBP) inhibitor[2][3][4][5].

HY-B0274AS

Chlorprothixene-d6 hydrochloride
Chlorprothixene-d₆ (hydrochloride) is the deuterium labeled Chlorprothixene hydrochloride. Chlorprothixene hydrochloride is a dopamine and histamine receptors antagonist with Kis of 18 nM, 2.96 nM, 4.56 nM, 9 nM and 3.75 nM for hD1, hD2, hD3, hD5 and hH1 receptors, respectively. Antipsychotic activity[1].

Cat. No.	Compare	Product Name	Application	Reactivity

HY-P82535

	DUSP6 Antibody (YA2280) Hh19; MKP3; PYST1; DUSP6; DUSP6a; Dual specificity phosphatase 6	WB, IHC-P, ICC/IF, IP, FC	Human, Mouse, Rat
	DUSP6 Antibody (YA2280) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA2280), targeting DUSP6, with a predicted molecular weight of 42 kDa (observed band size: 42 kDa). DUSP6 Antibody (YA2280) can be used for WB, IHC-P, ICC/IF, IP, FC experiment in human, mouse, rat background.

HY-P83448

	PTP4A2 Antibody (YA3193) protein tyrosine phosphatase type IVA; member 2; Hh13; OV-1; PRL2; Hh7-2; PRL-2; PTP4A; HU-PP-1; PTPCAAX2; ptp-IV1a; ptp-IV1b	WB, IP	Human
	PTP4A2 Antibody (YA3193) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA3193), targeting PTP4A2, with a predicted molecular weight of 19 kDa (observed band size: 19 kDa). PTP4A2 Antibody (YA3193) can be used for WB, IP experiment in human background.

HY-P82956

	HRH3 Antibody (YA2701) HRH3; GPCR97; Histamine H3 receptor; H3R; Hh3R; G-protein coupled receptor 97	WB, ICC/IF, FC	Human, Mouse, Rat
	HRH3 Antibody (YA2701) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA2701), targeting HRH3, with a predicted molecular weight of 49 kDa (observed band size: 45 kDa). HRH3 Antibody (YA2701) can be used for WB, ICC/IF, FC experiment in human, mouse, rat background.