Chlorprothixene hydrochloride

Name: Chlorprothixene hydrochloride
Brand: MedChemExpress
SKU: HY-B0274A
Rating: 4.5 (1 reviews)

Cat. No.: HY-B0274A Purity: 99.91%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

Chlorprothixene hydrochloride is a dopamine and histamine receptors antagonist with K_is of 18 nM, 2.96 nM, 4.56 nM, 9 nM and 3.75 nM for hD1, hD2, hD3, hD5 and hH1 receptors, respectively. Antipsychotic activity.

For research use only. We do not sell to patients.

Chlorprothixene hydrochloride Chemical Structure

CAS No. : 6469-93-8

Size	Price	Stock	Quantity
50 mg	USD 25	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 40	In-stock	Estimated Time of Arrival: December 31
200 mg	USD 60	In-stock	Estimated Time of Arrival: December 31
500 mg	USD 120	In-stock	Estimated Time of Arrival: December 31
1 g		Get quote
5 g		Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of Chlorprothixene hydrochloride:

Chlorprothixene In-stock
Chlorprothixene-d₆ hydrochloride Get quote
Chlorprothixene hydrochloride (Standard) Get quote

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•Related Screening Libraries:

•Related Small Molecules:

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View All Dopamine Receptor Isoform Specific Products:

View All Isoforms

Dopamine Receptor D₁ Receptor D₂ Receptor D₃ Receptor D₄ Receptor D₅ Receptor

View All Histamine Receptor Isoform Specific Products:

View All Isoforms

H₁ Receptor H₂ Receptor H₃ Receptor H₄ Receptor Histamine Receptor

Biological Activity
Purity & Documentation
References
Customer Review

Description

IC₅₀ & Target^[1]

Human D₁ Receptor

18 nM (Ki)

Human D₂ Receptor

2.96 nM (Ki)

Human D₃ Receptor

4.56 nM (Ki)

Human D₅ Receptor

9 nM (Ki)

Human H₁ Receptor

3.75 nM (Ki)

In Vitro

Chlorprothixene binds to 5-HT receptors with pK_is of 8.3, 8.5, and 9.4 for 5-HT7, 5-HT6 and 5-HT2, respectively^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial

Molecular Weight

352.32

Formula

C₁₈H₁₉Cl₂NS

CAS No.

6469-93-8

Appearance

Solid

Color

White to off-white

SMILES

CN(C)CC/C=C1C2=C(SC3=C\1C=CC=C3)C=CC(Cl)=C2.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

H₂O : 25 mg/mL (70.96 mM; Need ultrasonic)

Ethanol : 25 mg/mL (70.96 mM; Need ultrasonic)

DMSO : 2.5 mg/mL (7.10 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.8383 mL	14.1916 mL	28.3833 mL
5 mM	0.5677 mL	2.8383 mL	5.6767 mL
10 mM	0.2838 mL	1.4192 mL	2.8383 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% EtOH 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (7.10 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL EtOH stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% EtOH 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (7.10 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL EtOH stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Protocol 3

Add each solvent one by one: 10% EtOH 90% Corn Oil
Solubility: ≥ 2.5 mg/mL (7.10 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL EtOH stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: 99.91%

Select Batch:

Data Sheet (274 KB) SDS (420 KB)

COA (250 KB) HNMR (254 KB) LCMS (93 KB)

Handling Instructions (2659 KB)

References

[1]. Y von Coburg, et al. Potential utility of histamine H3 receptor antagonist pharmacophore in antipsychotics. Bioorg Med Chem Lett. 2009 Jan 15;19(2):538-42. [Content Brief]

[2]. B L Roth, et al. Binding of typical and atypical antipsychotic agents to 5-hydroxytryptamine-6 and 5-hydroxytryptamine-7 receptors. J Pharmacol Exp Ther. 1994 Mar;268(3):1403-10. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO / H₂O / Ethanol	1 mM	2.8383 mL	14.1916 mL	28.3833 mL	70.9582 mL
DMSO / H₂O / Ethanol	5 mM	0.5677 mL	2.8383 mL	5.6767 mL	14.1916 mL
H₂O / Ethanol	10 mM	0.2838 mL	1.4192 mL	2.8383 mL	7.0958 mL
	15 mM	0.1892 mL	0.9461 mL	1.8922 mL	4.7305 mL
	20 mM	0.1419 mL	0.7096 mL	1.4192 mL	3.5479 mL
	25 mM	0.1135 mL	0.5677 mL	1.1353 mL	2.8383 mL
	30 mM	0.0946 mL	0.4731 mL	0.9461 mL	2.3653 mL
	40 mM	0.0710 mL	0.3548 mL	0.7096 mL	1.7740 mL
	50 mM	0.0568 mL	0.2838 mL	0.5677 mL	1.4192 mL
	60 mM	0.0473 mL	0.2365 mL	0.4731 mL	1.1826 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.