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Isoforms Recommended:	IRAK1

Results for "

IRAK1

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Apoptosis (2) Autophagy (5) c-Met/HGFR (3) Casein Kinase (1) CDK (1) FLT3 (1) HSV (2) IRAK (14) MAP3K (2) Mitophagy (2) MyD88 (1) Na+/K+ ATPase (2) NF-κB (3) p38 MAPK (1) PROTACs (1) Small Interfering RNA (siRNA) (3) TNF Receptor (2)
By Research Areas:	Cancer (12) Infection (3) Inflammation/Immunology (11)
Oligonucleotides:	Pre-designed siRNA Sets (3) siRNAs (3)

Inhibitors & Agonists

Peptides

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Products

Recombinant Proteins

Antibodies

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-13329

IRAK-1-4 Inhibitor I 5+ Cited Publications IRAK-1/4 Inhibitor I	IRAK	Inflammation/Immunology
IRAK-1-4 Inhibitor I is an inhibitor of interleukin-1 receptor-associated kinase 1/4 (IRAK 1/4) with IC₅₀s of 0.2 μM and 0.3 μM, respectively.

HY-160487

KME-2780	IRAK	Cancer
KME-2780 is a potent and selective dual *IRAK1* and *IRAK4* inhibitor and can be used for research of dysregulation of innate immune signaling and hematologic malignancies ^[1].

HY-103017A

JH-X-119-01 3 Publications Verification	IRAK	Infection Inflammation/Immunology Cancer
JH-X-119-01 is a potent and selective interleukin-1 receptor-associated kinases 1 (IRAK1) inhibitor. JH-X-119-01 ameliorates LPS-induced sepsis in mice ^[1]. JH-X-119-01 inhibits IRAK1 biochemically with an apparent IC₅₀ of 9 nM while exhibiting no inhibition of IRAK4 at concentrations up to 10 μM .

HY-103017

JH-X-119-01 hydrochloride 3 Publications Verification	IRAK	Infection
JH-X-119-01 hydrochloride is a potent and selective interleukin-1 receptor-associated kinases 1 (IRAK1) inhibitor. JH-X-119-01 hydrochloride ameliorates LPS-induced sepsis in mice ^[1].

HY-RS06893

IRAK1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
IRAK1 Human Pre-designed siRNA Set A contains three designed siRNAs for IRAK1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

IRAK1 Human Pre-designed siRNA Set A IRAK1 Human Pre-designed siRNA Set A

HY-RS06894

Irak1 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Irak1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Irak1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Irak1 Mouse Pre-designed siRNA Set A Irak1 Mouse Pre-designed siRNA Set A

HY-RS06895

Irak1 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Irak1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Irak1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Irak1 Rat Pre-designed siRNA Set A Irak1 Rat Pre-designed siRNA Set A

HY-P5432

IRAK-4 Peptide substrate IRAK-1 (360-380)	IRAK	Others
IRAK-4 Peptide substrate (IRAK-1 (360-380)) is a biological active peptide. (This is a substrate peptide for Interleukin-1 Receptor-Associated Kinase (IRAK) 4)

HY-158434

IRAK1-IN-1	IRAK	Inflammation/Immunology
IRAK1-IN-1 (compound B8) is an orally active *IRAK1* inhibitor. IRAK1-IN-1 inhibits the release of IL-6 with the IC₅₀ values of 4.57 μM and 6.51 μM on mouse cells J774A. 1 and human cells THP-1, respectively. IRAK1-IN-1 alleviats LPS (HY-D1056)-induced acute lung injury (ALI) and DSS(HY-116282C)-induced colitis in mice ^[1].

HY-159953

IRAK1/4/pan-FLT3 Kinase-IN-1	IRAK FLT3	Cancer
IRAK1/4/pan-FLT3 Kinase-IN-1 (Compound 31) is a potent inhibitor of *IRAK1, IRAK4, and FLT3* kinases, with an IC₅₀ of 5 nM for *IRAK1, 0.6 nM for IRAK4, and less than 0.5 nM for FLT3. IRAK1/4/pan-FLT3 Kinase*-IN-1 has good pharmacokinetic properties and shows promising potential for research in acute myeloid leukemia, with a survival prolongation effect comparable to that of Gilteritinib (HY-12432) ^[1].

HY-153188

JNJ-1013	PROTACs Apoptosis IRAK	Cancer
JNJ-1013 is a potent and selective IRAK1 PROTAC degrader with an IC₅₀s of 72, 443, 1071 nM for IRAK1, IRAK4, VHL FP respectively. JNJ-1013 induces apoptosis and increases the expression of cleavaged PARP. JNJ-1013 decreases the expression IRAK1, p-IKBα, pSTAT3(Tyr705) (Pink: ligand for target protein (HY-138834); black: linker (HY-Y1760); Blue: E3 ligase ligand (HY-112078)) ^[1].

HY-N0039

Ginsenoside Rb1 5+ Cited Publications Gypenoside III	Na+/K+ ATPase IRAK NF-κB Autophagy Mitophagy HSV	Inflammation/Immunology Cancer
Ginsenoside Rb1, a main constituent of the root of Panax ginseng, inhibits Na ⁺, K ⁺-ATPase activity with an IC₅₀ of 6.3±1.0 μM. Ginsenoside also inhibits *IRAK-1* activation and phosphorylation of NF-κB p65 .

HY-169949

TAK-756	MAP3K	Inflammation/Immunology
TAK-756 is a *TAK1* inhibitor with good selectivity for *IRAK1/4* and excellent intra-articular pharmacokinetic properties. TAK1 is a potential molecular target for osteoarthritis (OA) with complementary anti-catabolic and anti-inflammatory effects ^[1].

HY-50937

ST 2825 Maximum Cited Publications 67 Publications Verification	MyD88	Inflammation/Immunology
ST 2825 is a specific MyD88 dimerization inhibitor. ST2825 interferes with recruitment of IRAK1 and IRAK4 by MyD88, causing inhibition of IL-1β-mediated activation of NF-κB transcriptional activity ^[1] .

HY-N0039R

Ginsenoside Rb1 (Standard) Gypenoside III (Standard)	Na+/K+ ATPase IRAK NF-κB Autophagy Mitophagy HSV	Inflammation/Immunology Cancer
Ginsenoside Rb1 (Standard) is the analytical standard of Ginsenoside Rb1. This product is intended for research and analytical applications. Ginsenoside Rb1, a main constituent of the root of Panax ginseng, inhibits Na ⁺, K ⁺-ATPase activity with an IC₅₀ of 6.3±1.0 μM. Ginsenoside also inhibits *IRAK-1* activation and phosphorylation of NF-κB p65 .

HY-134911

HS-243	IRAK CDK	Inflammation/Immunology Cancer
HS-243 is a potent and selective *IRAK-4* and *IRAK-1* inhibitor, with IC₅₀ values of 20 and 24 nM. HS-243 shows minimal *TAK1* (transforming growth factor β-activated kinase 1) inhibition activity, with a IC₅₀ of 0.5 μM. HS-243 shows anti-inflammatory and anticancer activity ^[1].

HY-14721

Tepotinib 5 Publications Verification EMD-1214063	c-Met/HGFR Autophagy	Cancer
Tepotinib (EMD-1214063) is an orally active and highly selective, reversible, ATP-competitive c-Met inhibitor with an IC₅₀ of 3 nM, >200-fold selective for c-Met than IRAK4, TrkA, Axl, IRAK1, and Mer. Tepotinib inhibits c-Met phosphorylation and induces autophagy. Tepotinib has antitumor effects ^[1] .

HY-14721A

Tepotinib hydrochloride EMD-1214063 hydrochloride	c-Met/HGFR Autophagy	Cancer
Tepotinib (EMD-1214063) hydrochloride is an orally active and highly selective, reversible, ATP-competitive c-Met inhibitor with an IC₅₀ of 3 nM, >200-fold selective for c-Met than IRAK4, TrkA, Axl, IRAK1, and Mer. Tepotinib hydrochloride inhibits c-Met phosphorylation and induces autophagy. Tepotinib hydrochloride has antitumor effects ^[1] .

HY-14721R

Tepotinib (Standard)	c-Met/HGFR Autophagy	Cancer
Tepotinib (Standard) is the analytical standard of Tepotinib. This product is intended for research and analytical applications. Tepotinib (EMD-1214063) is an orally active and highly selective, reversible, ATP-competitive c-Met inhibitor with an IC₅₀ of 3 nM, >200-fold selective for c-Met than IRAK4, TrkA, Axl, IRAK1, and Mer. Tepotinib inhibits c-Met phosphorylation. Tepotinib has antitumor effects ^[1] .

HY-111101

AZ1495	IRAK	Cancer
AZ1495, a weak base, is a potent orally active interleukin-1 receptor associated kinase 4 *(IRAK4)* inhibitor. AZ1495 has a favorable physicochemical and kinase selectivity for IRAK4 and IRAK1 with IC₅₀ values of 0.005 μM and 0.023 μM, respectively. AZ1495 has IRAK4 inhibition with a K_d value of 0.0007 μM. AZ1495 can be used for the research of diffuse large B-cell lymphoma (DLBCL) ^[1].

HY-147141

HS-276	IRAK TNF Receptor Casein Kinase	Inflammation/Immunology
HS-276 is an orally active, potent and highly selective *TAK1* inhibitor, with a K_i of 2.5 nM. HS-276 shows significant inhibition of TAK1, CLK2, GCK, ULK2, MAP4K5, IRAK1, NUAK, CSNK1G2, CAMKKβ-1, and MLK1, with IC₅₀ values of 8.25, 29, 33, 63, 125, 264, 270, 810, 1280, and 5585 nM, respectively. HS-276 can be used for rheumatoid arthritis (RA) research ^[1].

HY-103490

Takinib 15+ Cited Publications EDHS-206	MAP3K Apoptosis	Infection Inflammation/Immunology Cancer
Takinib (EDHS-206) is an orally active and selective *TAK1* inhibitor (IC₅₀=9.5 nM), more than 1.5 log more potent than the second and third ranked targets, IRAK4 (120 nM) and IRAK1 (390 nM), respectively. Takinib is an inhibitor of autophosphorylated TAK1 that non-competitively binds within the ATP binding pocket. Takinib induces apoptosis following TNFα stimulation in cell models of rheumatoid arthritis and metastatic breast cancer. Takinib is also a P. falciparum protein kinase 9 (PfPK9) inhibitor (K_D(app) of 0.46 μM) ^[1] .

HY-162641

AF-45	IRAK NF-κB p38 MAPK TNF Receptor	Inflammation/Immunology
AF-45 inhibits *IRAK4* and *IRAK1, with IC₅₀s of 128 nM and 1765 nM. AF-45 inhibits the release of IL-6* and TNF-α in macrophages, with IC₅₀s of 0.53-1.54 μM and 0.6-2.75 μM. AF-45 is also an inhibitor for NF-κB/MAPK signaling pathway. AF-45 exhibits anti-inflammatory activities against DSS-induced ulcerative colitis and Lipopolysaccharide (HY-D1056)-induced acute lung injury in mouse model. AF-45 exhibits good pharmacokinetic characteristics in rat models ^[1].

Cat. No.	Product Name	Target	Research Area

HY-P5432

IRAK-4 Peptide substrate IRAK-1 (360-380)	IRAK	Others
IRAK-4 Peptide substrate (IRAK-1 (360-380)) is a biological active peptide. (This is a substrate peptide for Interleukin-1 Receptor-Associated Kinase (IRAK) 4)

Ginsenoside Rb1 5+ Cited Publications Gypenoside III	Panax ginseng C. A. Meyer Triterpenes Structural Classification Classification of Application Fields Terpenoids Source classification Plants Disease Research Fields Araliaceae Cancer	Na+/K+ ATPase IRAK NF-κB Autophagy Mitophagy HSV
Ginsenoside Rb1, a main constituent of the root of Panax ginseng, inhibits Na ⁺, K ⁺-ATPase activity with an IC₅₀ of 6.3±1.0 μM. Ginsenoside also inhibits *IRAK-1* activation and phosphorylation of NF-κB p65 .

Ginsenoside Rb1 (Standard) Gypenoside III (Standard)	Panax ginseng C. A. Meyer Structural Classification Classification of Application Fields Terpenoids Source classification Plants Disease Research Fields Araliaceae Cancer	Na+/K+ ATPase IRAK NF-κB Autophagy Mitophagy HSV
Ginsenoside Rb1 (Standard) is the analytical standard of Ginsenoside Rb1. This product is intended for research and analytical applications. Ginsenoside Rb1, a main constituent of the root of Panax ginseng, inhibits Na ⁺, K ⁺-ATPase activity with an IC₅₀ of 6.3±1.0 μM. Ginsenoside also inhibits *IRAK-1* activation and phosphorylation of NF-κB p65 .

Cat. No.	Compare	Product Name	Species	Source

HY-P701789

	IRAK1 Protein, Human (Sf9, GST) IRAK1; Interleukin-1 receptor-associated kinase 1; IRAK-1	Human	Sf9 insect cells
	IRAK1 is a serine/threonine protein kinase that initiates innate immune responses against pathogens through Toll-like receptor (TLR) and IL-1R signaling. After TLR activation, IRAK1 is recruited by MYD88 and undergoes IRAK4 phosphorylation, autophosphorylation, and kinase activation. IRAK1 Protein, Human (Sf9, GST) is the recombinant human-derived IRAK1 protein, expressed by Sf9 insect cells , with N-GST labeled tag. The total length of IRAK1 Protein, Human (Sf9, GST) is 519 a.a., .

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Cat. No.	Compare	Product Name	Application	Reactivity

HY-P80420

	IRAK-1 Antibody	WB, IHC-P	Human, Mouse
	IRAK-1 Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 77 kDa, targeting to IRAK-1. It can be used for WB,IHC-P assays with tag free, in the background of Human, Mouse.

HY-P82709

	IRAK1 Antibody (YA2454) Il1rak; IRAK; IRAK1; IRAK1-S; mPLK; Pelle; Pelle homolog; Pelle-like protein kinase; Plpk	WB, ICC/IF, IP	Human
	IRAK1 Antibody (YA2454) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA2454), targeting IRAK1, with a predicted molecular weight of 77 kDa (observed band size: 77 kDa). IRAK1 Antibody (YA2454) can be used for WB, ICC/IF, IP experiment in human background.