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Results for "

KLHDC2

" in MedChemExpress (MCE) Product Catalog:

10

Inhibitors & Agonists

2

Recombinant Proteins

1

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-RS07348
    KLHDC2 Human Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    KLHDC2 Human Pre-designed siRNA Set A contains three designed siRNAs for KLHDC2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    KLHDC2 Human Pre-designed siRNA Set A
    KLHDC2 Human Pre-designed siRNA Set A
  • HY-157559
    KDRLKZ-2

    		Others Others
    KDRLKZ-2 is a selective E3 ligase. KDRLKZ-2 is a ligand for KLHDC2, with an IC50 value of 0.068 μM in the alphaLISA experiment .
    KDRLKZ-2
  • HY-157560
    KDRLKZ-3

    1NEG

    		 Others Others
    KDRLKZ-3 is a selective E3 ligase. KDRLKZ-3 is a ligand for KLHDC2 with a IC50 value of 4.1 μM in the alphaLISA experiment .
    KDRLKZ-3
  • HY-168634
    SJ46421

    		PROTACs Epigenetic Reader Domain Cancer
    SJ46421 is a (+)-JQ-1 (HY-13030) based KLHDC2 PROTAC protein degrader. SJ46421 is able to promote a substantially tight ternary complex with KLHDC2 with an IC50 of 7.8 nM. SJ46421 promotes polyubiquitylation of the BD2 domain from BRD2, BRD3, or BRD4 (Pink: ligand for target protein (HY-168536); Black: linker (HY-20797); Blue: E3 ligase ligand (HY-13030)) .
    SJ46421
  • HY-157558
    KDRLKZ-1

    8SGE

    		 Others Others
    KDRLKZ-1 is a KLHDC2 ligand (Kd = 0.36 μM), with IC50s of 0.21 μM and 0.31 μM in alphaLISA and time-resolved fluorescence resonance energy transfer (TR-FRET) displacement assays .
    KDRLKZ-1
  • HY-168535
    SJ6145

    		Ligands for E3 Ligase Cancer
    SJ6145 is a potent ligand for KLHDC2 SBD, with the Kd of 16.9 μM in SPR test, IC50 value of 42 μM in inhibiting KLHDC2 SBD binding to a di-Gly degron peptide test .
    SJ6145
  • HY-157491
    K2-B4-5e

    		PROTACs Androgen Receptor Epigenetic Reader Domain Cancer
    K2-B4-5e is a E3 ligase KLHDC2-based BRD4 and androgen receptor (AR) degradation PROTAC. K2-B4-5e is capable of inducing rapid and robust degradation of BET-family and AR proteins in cells .
    K2-B4-5e
  • HY-168646
    SJ46411-Br

    		PROTACs
    SJ46411-Br is a JQ1 based KLHDC2 PROTAC protein degrader. SJ46411-Br promotes cooperative paralog selective ternary complex formation.
    SJ46411-Br
  • HY-168536
    SJ46411

    		Others Cancer
    SJ46411 is a potent ligand for KLHDC2, with a Kd of ~260 nM measured by isothermal titration calorimetry (SPR Kd = 0.5 μM, TR-FRET IC50 = 3.9 μM, ΔTm = 6.0 °C) .
    SJ46411
  • HY-168635
    SJ46420

    		PROTACs Epigenetic Reader Domain Cancer
    SJ46420, a SJ46421 (HY-168634) pro-drug variant, is a potent and selective BRD3 PROTAC degrader. SJ46420 degrads BRD3 in a KLHDC2-dependent manner, thereby partially reducing the levels of BRD2 or BRD4 (Pink: ligand for target protein (HY-159973); Black: linker (HY-20797); Blue: E3 ligase ligand (HY-13030)) .
    SJ46420

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