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Isoforms Recommended: KLHDC2
Results for "

KLHDC2

" in MedChemExpress (MCE) Product Catalog:

10

Inhibitors & Agonists

2

Recombinant Proteins

1

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-RS07348
    KLHDC2 Human Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    KLHDC2 Human Pre-designed siRNA Set A contains three designed siRNAs for KLHDC2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    KLHDC2 Human Pre-designed siRNA Set A
    KLHDC2 Human Pre-designed siRNA Set A
  • HY-168634
    SJ46421

    		PROTACs Epigenetic Reader Domain Cancer
    SJ46421 is a (+)-JQ-1 (HY-13030) based KLHDC2-BRD3 PROTAC protein degrader. SJ46421 induces cooperative ternary complexes with KLHDC2 and BRD3BD2, with an IC50 of 7.8 nM. SJ46421 selectively inhibits KLHDC2 substrate ubiquitylation. SJ46421 promotes polyubiquitylation of the BD2 domain from BRD2, BRD3, or BRD4. SJ46421 possesses poor cell permeability. (Pink: ligand for target protein (HY-13030); Black: linker (HY-20797); Blue: E3 ligase ligand (HY-168536)) .
    SJ46421
  • HY-157560
    KDRLKZ-3

    1NEG

    		 Ligands for E3 Ligase Others
    KDRLKZ-3 is a selective E3 ligase. KDRLKZ-3 is a ligand for KLHDC2 with a IC50 value of 4.1 μM in the alphaLISA experiment .
    KDRLKZ-3
  • HY-157559
    KDRLKZ-2

    		Ligands for E3 Ligase Others
    KDRLKZ-2 is a selective E3 ligase. KDRLKZ-2 is a ligand for KLHDC2, with an IC50 value of 0.068 μM in the alphaLISA experiment .
    KDRLKZ-2
  • HY-157558
    KDRLKZ-1

    8SGE

    		 Ligands for E3 Ligase Others
    KDRLKZ-1 is a KLHDC2 ligand (Kd = 0.36 μM), with IC50s of 0.21 μM and 0.31 μM in alphaLISA and time-resolved fluorescence resonance energy transfer (TR-FRET) displacement assays .
    KDRLKZ-1
  • HY-168535
    SJ6145

    		Ligands for E3 Ligase Cancer
    SJ6145 is a potent ligand for KLHDC2 SBD, with the Kd of 16.9 μM in SPR test, IC50 value of 42 μM in inhibiting KLHDC2 SBD binding to a di-Gly degron peptide test .
    SJ6145
  • HY-157491
    K2-B4-5e

    		PROTACs Androgen Receptor Epigenetic Reader Domain Cancer
    K2-B4-5e is a E3 ligase KLHDC2-based BRD4 and androgen receptor (AR) degradation PROTAC. K2-B4-5e is capable of inducing rapid and robust degradation of BET-family and AR proteins in cells .
    K2-B4-5e
  • HY-168646
    SJ46411-Br

    		Ligands for E3 Ligase Molecular Glues Cancer
    SJ46411-Br is one of CRL2 KLHDC2 targeting Ligands for E3 Ligase. SJ46411-Br can bind to KLHDC2 to form a complex to promote cooperative homologous selective ternary complex formation. SJ46411-Br can be coupled to BET ligand JQ1 (HY-13030) through PROTAC linker to synthesize corresponding PROTACs .
    SJ46411-Br
  • HY-168536
    SJ46411

    		Others Cancer
    SJ46411 is a potent ligand for KLHDC2, with a Kd of ~260 nM measured by isothermal titration calorimetry (SPR Kd = 0.5 μM, TR-FRET IC50 = 3.9 μM, ΔTm = 6.0 °C) .
    SJ46411
  • HY-168635
    SJ46420

    		PROTACs Epigenetic Reader Domain Cancer
    SJ46420, a SJ46421 (HY-168634) pro-drug variant, is a potent and selective BRD3 PROTAC degrader. SJ46420 degrads BRD3 in a KLHDC2-dependent manner, thereby partially reducing the levels of BRD2 or BRD4 (Pink: ligand for target protein (HY-13030); Black: linker (HY-20797); Blue: E3 ligase ligand (HY-159973)) .
    SJ46420

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