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L-Homoserine lactone

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37

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5

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1

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2

Isotope-Labeled Compounds

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-W015800
    L-Homoserine lactone hydrochloride

    		Biochemical Assay Reagents Others
    L-Homoserine lactone hydrochloride is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
    L-Homoserine lactone hydrochloride
  • HY-W243002
    Acetyl-L-homoserine lactone

    		Bacterial Infection
    Acetyl-L-homoserine lactone is a member of the family of N-acylated homoserine lactones (HSLs). Acetyl-L-homoserine lactone is a polar mediator of cell-cell interactions in bacterial biofilms .
    Acetyl-L-homoserine lactone
  • HY-114816
    N-Butanoyl-L-homoserine lactone
    1 Publications Verification

    C4-HSL; N-Butyryl-L-Homoserine lactone

    		 ADC Linker Bacterial Infection Inflammation/Immunology
    N-Butanoyl-L-homoserine lactone (C4-HSL) is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). N-Butanoyl-L-homoserine lactone has antibacterial activity and is used in antibacterial biofilm . N-Butanoyl-L-homoserine lactone aptamers blocks qurom sensing and inhibits biofilm formation in Pseudomonas aeruginosa .
    N-Butanoyl-L-homoserine lactone
  • HY-133685
    N-Hexanoyl-L-homoserine lactone

    		Bacterial Infection Metabolic Disease
    N-Hexanoyl-L-homoserine lactone is a short-chained N-acyl homoserine lactone (AHL). N-hexanoyl-L-homoserine lactone is also a mediator of bacterial quorum-sensing regulation. N-hexanoyl-L-homoserine lactone promotes lipid accumulation in algae. AHL is an intercellular communication signal molecule in the quorum sensing system of Gram-negative bacteria and a medium for mediating information exchange between eukaryotic plants and prokaryotic bacteria. AHL can affect bacteria activities, such as biofilm formation, pigment synthesis, and antibiotic synthesis .
    N-Hexanoyl-L-homoserine lactone
  • HY-137407
    N-Phenylacetyl-L-homoserine lactone

    		Bacterial Infection
    N-Phenylacetyl-L-homoserine lactone is a small diffusible signaling molecule that strongly antagonizes or super-activates the quorum sensing of Vibrio fischeri .
    N-Phenylacetyl-L-homoserine lactone
  • HY-124237A
    N-Octanoyl-L-homoserine lactone

    		Bacterial Infection
    N-octanoyl-L-Homoserine lactone is a small diffusible signaling molecule involved in quorum sensing, thereby controlling gene expression and affecting cellular metabolism. N-octanoyl-L-Homoserine lactone can be used for the infection prevention and regulation of virulence in cystic fibro.
    N-Octanoyl-L-homoserine lactone
  • HY-W337872
    N-(3-Hydroxyoctanoyl)-L-homoserine lactone

    		Bacterial Infection
    N-(3-Hydroxyoctanoyl)-L-homoserine lactone (compound 11), a hydroxyl-containing N-acyl l-homoserine lactone (AHL) ligand, is a competitive AbaR and LasR inhibitor .
    N-(3-Hydroxyoctanoyl)-L-homoserine lactone
  • HY-W408239
    N-Pentadecanoyl-L-homoserine lactone

    		Bacterial Others
    N-pentadecanoyl-L-Homoserine lactone is an N-acyl Homoserine lactone compound. N-pentadecanoyl-L-Homoserine lactone is a sensing molecule for bacterial populations .
    N-Pentadecanoyl-L-homoserine lactone
  • HY-W127487
    N-Octadecanoyl-L-homoserine lactone

    		Biochemical Assay Reagents Others
    Quorum sensing is a regulatory system used by bacteria to control gene expression in response to increased cell density. This regulatory process manifests itself in a variety of phenotypes, including biofilm formation and virulence factor production. Coordinated gene expression is achieved through the production, release and detection of small diffusible signaling molecules called autoinducers. N-acylated homoserine lactones (AHLs) comprise a class of such autoinducers, each of which generally consists of a fatty acid coupled to a homoserine lactone (HSL). Modulation of bacterial quorum-sensing signaling systems to suppress pathogenesis represents a new approach to antimicrobial research for infectious diseases. AHLs differ in acyl length (C4-C18), C3 substitution (hydrogen, hydroxyl, or oxo group), and the presence or absence of one or more carbon-carbon double bonds in the fatty acid chain. These differences confer signaling specificity through the affinity of the LuxR family of transcriptional regulators. C18-HSL, one of four lipophilic long acyl side chain AHLs produced by the LuxI AHL synthase homolog SinI, is involved in quorum-sensing signaling in strains of Rhizobium meliloti (a nitrogen-fixing bacterial symbiont of the legume M. sativa) . C18-HSL and other hydrophobic AHLs tend to localize in the relatively lipophilic environment of bacterial cells and cannot diffuse freely across the cell membrane. Long-chain N-acyl homoserine lactones can be exported from cells by efflux pumps, or can be transported between communicating cells by extracellular outer membrane vesicles.
    N-Octadecanoyl-L-homoserine lactone
  • HY-W127610
    N-hexadecanoyl-L-Homoserine lactone

    		Biochemical Assay Reagents Others
    N-hexadecanoyl-L-Homoserine lactone is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
    N-hexadecanoyl-L-Homoserine lactone
  • HY-115393A
    N-Heptanoyl-L-homoserine lactone

    		Bacterial Infection
    N-Heptanoyl-L-homoserine lactone is a member of N-acyl-homoserine lactone family. N-acyl-homoserine lactones (AHL) can regulate gene expression in gram-negative bacteria, such as Echerichia and Salmonella, and are involved in quorum sensing, cell to cell communication among bacteria.
    N-Heptanoyl-L-homoserine lactone
  • HY-133684
    N-Tetradecanoyl-L-homoserine lactone

    		Bacterial Infection
    N-Tetradecanoyl-L-homoserine lactone is a short-chained N-acyl homoserine lactone (AHL). Diatoms are frequently found in association with Proteobacteria, many members of which employ cell-to-cell communication via AHLs in aquatic habitats .
    N-Tetradecanoyl-L-homoserine lactone
  • HY-W127393
    N-Nonanoyl-L-homoserine lactone

    		Biochemical Assay Reagents Others
    Quorum sensing is a regulatory system used by bacteria to control gene expression in response to increased cell density. This regulatory process manifests itself in a variety of phenotypes, including biofilm formation and virulence factor production. Coordinated gene expression is achieved through the production, release and detection of small diffusible signaling molecules called autoinducers. N-acylated homoserine lactones (AHLs) comprise a class of such autoinducers, each of which generally consists of a fatty acid coupled to a homoserine lactone (HSL). Modulation of bacterial quorum-sensing signaling systems to suppress pathogenesis represents a new approach to antimicrobial research for infectious diseases. AHLs differ in acyl length (C4-C18), C3 substitution (hydrogen, hydroxyl, or oxo group), and the presence or absence of one or more carbon-carbon double bonds in the fatty acid chain. These differences confer signaling specificity through the affinity of the LuxR family of transcriptional regulators. C9-HSL is a rare odd-numbered acyl carbon chain produced by wild-type Erwinia carotovora strain SCC 3193 grown in nutrient-rich Luria-Bertani broth (LB) medium.
    N-Nonanoyl-L-homoserine lactone
  • HY-114773
    N-Undecanoyl-L-homoserine lactone

    		Biochemical Assay Reagents Others
    Quorum sensing is a regulatory system used by bacteria to control gene expression in response to increased cell density. This regulatory process manifests itself in a variety of phenotypes, including biofilm formation and virulence factor production. Coordinated gene expression is achieved through the production, release and detection of small diffusible signaling molecules called autoinducers. N-acylated homoserine lactones (AHLs) comprise a class of such autoinducers, each of which generally consists of a fatty acid coupled to a homoserine lactone (HSL). Modulation of bacterial quorum-sensing signaling systems to suppress pathogenesis represents a new approach to antimicrobial research for infectious diseases. AHLs differ in acyl length (C4-C18), C3 substitution (hydrogen, hydroxyl, or oxo group), and the presence or absence of one or more carbon-carbon double bonds in the fatty acid chain. These differences confer signaling specificity through the affinity of the LuxR family of transcriptional regulators. C11-HSL has a rare odd-numbered acyl carbon chain and may be a minor quorum-sensing signaling molecule in Pseudomonas aeruginosa strains.
    N-Undecanoyl-L-homoserine lactone
  • HY-W337680
    N-3-Hydroxydecanoyl-L-homoserine lactone

    		Bacterial Infection
    N-3-Hydroxydecanoyl-L-homoserine lactone is a type of N-acyl-L-homoserine lactone (AHL), which is a class of signaling molecules in bacterial quorum sensing systems, and it has a weak activating effect on AbaR .
    N-3-Hydroxydecanoyl-L-homoserine lactone
  • HY-120242
    N-(3-Oxobutanoyl)-L-homoserine lactone

    		Antibiotic Infection
    N-(3-Oxobutanoyl)-L-homoserine lactone (3-oxo-C4-HSL) is a carbapenem antibiotic biosynthesis autoregulator in Erwinia carotovora ATCC 39048. N-(3-Oxobutanoyl)-L-homoserine lactone induces expression of rhiI in R. leguminosarum .
    N-(3-Oxobutanoyl)-L-homoserine lactone
  • HY-136409R
    N-Decanoyl-L-homoserine lactone (Standard)

    		Bacterial Reactive Oxygen Species Infection
    Formoterol (hemifumarate hydrate) (Standard) is the analytical standard of Formoterol (hemifumarate hydrate). This product is intended for research and analytical applications. Formoterol hemifumarate hydrate is a selective, long-acting beta 2-adrenoceptor agonist. Formoterol is a bronchodilator used for the research of the asthma and chronic obstructive pulmonary disease (COPD). Formoterol hemifumarate hydrate induces mitochondrial biogenesis and promotes cognitive recovery after traumatic brain injury .
    N-Decanoyl-L-homoserine lactone (Standard)
  • HY-141641
    N-(3-Oxopentanoyl)-L-homoserine lactone

    HSL

    		 Bacterial Infection
    N-(3-Oxopentanoyl)-L-homoserine lactone is an autoinducer, a kind of chemical signal molecule which passively diffuses across the bacterial envelope and accumulates intracellularly at high bacterial densities. It may bind to a protein related to the LuxR protein of V. fischeri and causes cell density-dependent gene expression. N-(3-Oxopentanoyl)-L-homoserine can be used for research of quorum sensing .
    N-(3-Oxopentanoyl)-L-homoserine lactone
  • HY-108700
    N-3-Oxo-octanoyl-L-homoserine lactone

    		SOD Infection
    N-3-Oxo-octanoyl-L-homoserine lactone, a quorum-sensing signal, is an Agrobacterium autoinducer .
    N-3-Oxo-octanoyl-L-homoserine lactone
  • HY-114816S
    N-butyryl-L-Homoserine lactone-d5

    		Isotope-Labeled Compounds ADC Linker Bacterial Infection Inflammation/Immunology
    N-butyryl-L-Homoserine lactone-d5 is the deuterium labeled N-Butanoyl-L-homoserine lactone. N-Butanoyl-L-homoserine lactone (C4-HSL) is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). N-Butanoyl-L-homoserine lactone has antibacterial activity and is used in antibacterial biofilm[1]. N-Butanoyl-L-homoserine lactone aptamers blocks qurom sensing and inhibits biofilm formation in Pseudomonas aeruginosa[2][3].
    N-butyryl-L-Homoserine lactone-d5
  • HY-114544A
    N-3-oxo-dodecanoyl-L-homoserine lactone

    OdDHL

    		 Bacterial NF-κB ERK Caspase Reactive Oxygen Species Apoptosis Metabolic Disease Inflammation/Immunology Cancer
    N-3-oxo-dodecanoyl-L-Homoserine lactone (3-oxo-C12-HSL) is a bacterial quorum-sensing signaling molecule produced by P. aeruginosa and strains of the B. cepacia complex .Quorum sensing is a regulatory system used by bacteria for controlling gene expression in response to increasing cell density.N-3-oxo-dodecanoyl-L-Homoserine lactone induces the production of IL-8 in 16HBE human bronchial epithelial cells .
    N-3-oxo-dodecanoyl-L-homoserine lactone
  • HY-118697
    N-dodecanoyl-L-Homoserine lactone
    1 Publications Verification

    C12-HSL

    		 Bacterial Infection
    N-dodecanoyl-L-Homoserine lactone (C12-HSL) is a quorum sensing (QS) signaling molecule. N-dodecanoyl-L-Homoserine lactone (C12-HSL) aptamers blocks qurom sensing and inhibits biofilm formation in Pseudomonas aeruginosa .
    N-dodecanoyl-L-Homoserine lactone
  • HY-136409
    N-Decanoyl-L-homoserine lactone

    C10-HSL

    		 Bacterial Reactive Oxygen Species Infection
    N-decanoyl-L-homoserine lactone (C10-HSL) is a N-acyl-homoserine lactone (AHL) N-decanoyl-L-homoserine lactone can inhibit primary root growth in Arabidopsis. N-decanoyl-L-homoserine lactone triggers a transient and immediate increase in the concentrations of cytosolic free Ca 2+ and reactive oxygen species (ROS), increases the activity of mitogen-activated protein kinase 6 (MPK6), and induces nitric oxide (NO) production in Arabidopsis roots .
    N-Decanoyl-L-homoserine lactone
  • HY-W008806
    N-(3-Oxohexanoyl)-L-homoserine lactone

    OHHL; N-(3-Oxohexanoyl)Homoserine lactone

    		 Bacterial Infection Inflammation/Immunology
    N-(β-ketocaproyl)-L-Homoserine lactone is a component of quorum regulatory sensing .
    N-(3-Oxohexanoyl)-L-homoserine lactone
  • HY-145462
    N-cis-Octadec-9Z-enoyl-L-homoserine lactone

    		Bacterial Infection
    N-cis-octadec-9Z-enoyl-L-Homoserine lactone is a potent inhibitor of AhyI. AhyI (expressing acylhomoserine lactone) is responsible for the biosynthesis of autoinducer-1 (AI-1), commonly referred to as a quorum sensing (QS) signaling molecule, which plays an essential role in bacterial communication. N-cis-octadec-9Z-enoyl-L-Homoserine lactone is a competitive inhibitor of AI-1 biosynthesis .
    N-cis-Octadec-9Z-enoyl-L-homoserine lactone
  • HY-145509
    N-(3-Hydroxy-7-cis tetradecenoyl)-L-Homoserine lactone

    		Bacterial
    N-(3-Hydroxy-7-cis tetradecenoyl)-L-Homoserine lactone is an N-acyl-homoserine lactone (AHL) signaling molecule primarily secreted by Gram-negative bacteria for quorum sensing. It can be used to study bacterial quorum sensing mechanisms and their behavioral characteristics in the environment .
    N-(3-Hydroxy-7-cis tetradecenoyl)-L-Homoserine lactone
  • HY-158730
    N-3-Hydroxybutyryl-L-homoserine lactone

    3-OH-C4-HSL; N-3-Hydroxybutanoyl-L-Homoserine lactone; N-3-Hydroxybutyryl-L-HSL

    		 Bacterial Infection
    N-3-Hydroxybutyryl-L-homoserine lactone (3-OH-C4-HSL) is an acyl-homoserine lactone, that can be isolated from Vibrionaceae. N-3-Hydroxybutyryl-L-homoserine lactone is a signaling molecule that is involved in bacterial quorum sensing (QS). N-3-Hydroxybutyryl-L-homoserine lactone senses the density of bacterial population, regulates the cellular process, such as bioluminescence, biofilm formation, and exo-enzyme production .
    N-3-Hydroxybutyryl-L-homoserine lactone
  • HY-W554514
    D-Homoserine lactone

    		Bacterial Infection
    D-Homoserine lactone is a signaling molecule with the activity of regulating bacterial quorum sensing. The chemical structure of D-Homoserine lactone makes it a potential regulator of the AHL synthase RhlI. D-Homoserine lactone has been shown to inhibit the activity of RhlI, thereby affecting the bacterial quorum sensing signaling pathway. D-Homoserine lactone is also an enantiomer of L-homoserine lactone and is used as an inhibitor of serine hydroxymethyltransferase .
    D-Homoserine lactone
  • HY-W127486
    N-3-oxo-Hexadec-11Z-enoyl-L-homoserine lactone

    		Biochemical Assay Reagents Others
    N-3-oxo-hexadec-11Z-enoyl-L-Homoserine lactone is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
    N-3-oxo-Hexadec-11Z-enoyl-L-homoserine lactone
  • HY-164128
    AHL modulator-1

    		Others Others
    AHL modulator-1 (compound 12) is a modulator of N-acylated L-homoserine lactone (AHL), with the agonism and antagonism of 21% and 42% in cellulase activity and 5% and 32% in potato macerationa, respectively .
    AHL modulator-1
  • HY-134560
    N-(3-Oxodecanoyl)-L-homoserine lactone

    3-Oxo-C10-HSL

    		 Bacterial Inflammation/Immunology
    N-(3-Oxodecanoyl)-L-homoserine lactone (3-Oxo-C10-HSL) is a bacterial quorum sensing signal autoinducer molecule .
    N-(3-Oxodecanoyl)-L-homoserine lactone
  • HY-116536
    N-3-Oxo-tetradecanoyl-L-homoserine lactone

    oxo-C14-HSL

    		 Bacterial Infection
    N-3-Oxo-tetradecanoyl-L-homoserine lactone (oxo-C14-HSL) is a rhizobacterial inducer and can improve basic defense against nematodes .
    N-3-Oxo-tetradecanoyl-L-homoserine lactone
  • HY-W685561
    3-Oxo-C8-HSL

    N-(3-Oxooctanoyl)-l-Homoserine lactone

    		 Biochemical Assay Reagents Infection
    3-Oxo-C8-HSL (N-(3-Oxooctanoyl)-l-homoserine lactone) is an autoinducer pheromone. 3-Oxo-C8-HSL is a TraR-regulated promoter. 3-Oxo-C8-HSL significantly stimulates tra gene expression .
    3-Oxo-C8-HSL
  • HY-115399A
    N-3-Oxo-hexadecanoyl-L-Homoserine lactone

    3-Oxo-C16-AHL

    		 Bacterial Metabolic Disease
    N-3-Oxo-hexadecanoyl-L-Homoserine lactone is a signaling molecule to coordinate group behaviors at high densities in many bacteria. N-3-Oxo-hexadecanoyl-L-Homoserine lactone adsorbs to and promotes the remodeling of lipid membranes in ways that could underpin cell-cell or host-cell interactions .
    N-3-Oxo-hexadecanoyl-L-Homoserine lactone
  • HY-124286
    N-cis-Tetradec-9Z-enoyl-L-homoserine lactone

    C14-9Z-HSL

    		 Bacterial Inflammation/Immunology
    N-cis-Tetradec-9Z-enoyl-L-homoserine lactone (C14-9Z-HSL) is an autoinducer in C. rodentium, that serves as signal molecule, coordinates the gene expression and behaviors through diffusion into cells of different bacterial species .
    N-cis-Tetradec-9Z-enoyl-L-homoserine lactone
  • HY-133685S
    N-Hexanoyl-L-Homoserine lactone-d3

    C6-HSL-d3

    		 Isotope-Labeled Compounds Bacterial Infection
    N-Hexanoyl-L-Homoserine lactone-d3 (C6-HSL-d3) is deuterium labeled N-Hexanoyl-L-homoserine lactone. N-Hexanoyl-L-homoserine lactone is a short-chained N-acyl homoserine lactone (AHL). Diatoms are frequently found in association with Proteobacteria, many members of which employ cell-to-cell communication via AHLs in aquatic habitats .
    N-Hexanoyl-L-Homoserine lactone-d3
  • HY-145492
    Δ7(Z)-C14-HSL

    N-(3-Oxo-7Z-tetradecenoyl)-L-Homoserine lactone

    		 Others Inflammation/Immunology
    Δ7(Z)-C14-HSL (Compound 12) is an immunosuppressive agent that can inhibit the proliferation of mouse splenic cells with an IC50 of 17 μM. Δ7(Z)-C14-HSL can be used for further studying its potential as a molecular mechanism in TNF-R-driven immune diseases, especially autoimmune diseases such as psoriasis, rheumatoid arthritis, and type 1 diabetes .
    Δ7(Z)-C14-HSL

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