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Results for "

Metabotropic glutamate receptor 5

" in MedChemExpress (MCE) Product Catalog:

By Targets:	iGluR (1) mGluR (5)
By Research Areas:	Inflammation/Immunology (1) Neurological Disease (4)

6

Inhibitors & Agonists

1

Recombinant Proteins

2

Antibodies

Targets Recommended: mGluR Glutamate Dehydrogenase (GLDH) iGluR EAAT

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

VU-1545	mGluR	Neurological Disease
VU-1545 is a metabotropic glutamate receptor 5 positive allosteric modulator (mGluR5 PAM) with a K_i of 156 nM and an EC₅₀ of 9.6 nM .

PF-06422913	mGluR	Inflammation/Immunology
PF-06422913 is an orally active, potent and selective metabotropic glutamate receptor 5 (mGluR5) negative allosteric modulator .

NCFP	mGluR	Neurological Disease
NCFP is a metabotropic glutamate receptor 5 (mGlu5) positive allosteric modulator (PAM). NCFP can be used in the study of central nervous system diseases .

PF-06462894	iGluR	Neurological Disease
PF-06462894 is an alkyne-lacking metabotropic glutamate receptor 5 (mGluR5) negative allosteric modulator profiled in both rat and nonhuman primates .

PF470 PF-06297470	mGluR	Others
PF470 (PF-06297470) is a negative allosteric modulator of **metabotropic glutamate receptor 5** (mGluR5) with significant efficacy in Parkinson's disease models, but clinical development was halted due to potential issues found in toxicology studies.

BOMA	mGluR	Neurological Disease
BOMA (Compound 7) is a potent and selective metabotropic glutamate receptor 5 (mGluR 5) antagonist with an IC₅₀ value of 3 nM and an K_i value of 3 nM. BOMA is promising for research of various pain states, including acute, persistent and chronic pain, inflammatory pain and neuropathic pain .

Cat. No.	Compare	Product Name	Species	Source

	GRM5 Protein, Human (His) GRM5; Metabotropic glutamate receptor 5; mGluR5	Human	Sf9 insect cells
	The GRM5 protein is a G protein-coupled glutamate receptor that undergoes ligand-induced conformational changes and activates signaling cascades through G proteins, affecting downstream effectors. This cascade includes the phosphatidylinositol-calcium second messenger system and induces calcium-activated chloride currents. GRM5 Protein, Human (His) is the recombinant human-derived GRM5 protein, expressed by Sf9 insect cells , with C-10*His labeled tag. ,

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	Metabotropic glutamate receptor 5 Antibody	WB, ICC/IF, IHC-P, FC, IP	Human, Mouse, Rat
	Metabotropic glutamate receptor 5 Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 132 kDa, targeting to Metabotropic glutamate receptor 5. It can be used for WB,ICC/IF,IHC-P,FC,IP assays with tag free, in the background of Human, Mouse, Rat.

	GRM5 Antibody (YA1509) GPRC1E; GRM5; Metabotropic glutamate receptor 5 precursor; MGLUR5; MGR5	WB, IHC-P, ICC/IF, FC	Human, Mouse, Rat
	GRM5 Antibody (YA1509) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA1509), targeting GRM5, with a predicted molecular weight of 132 kDa. GRM5 Antibody (YA1509) can be used for WB, IHC-P, ICC/IF, FC experiment in human, mouse, rat background.

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