N-Myristoyltransferase

By Targets:	N-myristoyltransferase (1) ADC Cytotoxin (1) ADC Linker (1) Apoptosis (1) DNA/RNA Synthesis (2) Dynamin (2) Endogenous Metabolite (2) Fungal (1) Parasite (3) PKA (2) PPAR (1)
By Research Areas:	Cancer (6) Infection (7) Neurological Disease (2)
Click Chemistry:	Azide (1)

Targets Recommended: N-myristoyltransferase

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-103056

DDD85646 IMP-366	DNA/RNA Synthesis Parasite	Infection
DDD85646 (IMP-366) is an orally active of trypanosoma brucei *N-myristoyltransferase* (TbNMT IC₅₀=2 nM; hNMT IC₅₀=4 nM). The enzyme N-myristoyltransferase (NMT) is a potential agent target for human African trypanosomiasis .

HY-153021

NMT-IN-1	Parasite	Infection
NMT-IN-1 (compound 9) is a potent N-Myristoyltransferase (NMT) Inhibitor with IC₅₀ values of 31 and 66 μM for TbNMT and hNMT, respectively. NMT-IN-1 can be used in research of african trypanosomiasis .

HY-164285

MYX1715	ADC Cytotoxin N-myristoyltransferase	Cancer
MYX1715 is an inhibitor of N-Myristoyltransferase (NMT) with a K_D value of 0.09 nM. MYX1715 inhibits the proliferation of LU0884 and LU2511 with IC₅₀ values of 44 nM and 9 nM. MYX1715 exhibits antitumor efficacy against neuroblastoma and gastric cancer in mouse models. MYX1715 can be used as ADC toxin .

HY-147308

PCLX-001 2 Publications Verification	Apoptosis	Cancer
PCLX-001 is an orally acitve, small-molecule, dual *N-myristoyltransferase* (NMT) inhibitor, with IC₅₀s of 5 nM (NMT1) and 8 nM (NMT2), respectively. PCLX-001 can induce cell apoptosis, has anti-cancer activity, inhibits early B cell receptor (BCR) signaling, and can be used to study malignant lymphoma .

HY-126833A

Myristoyl coenzyme A lithium 1 Publications Verification	Endogenous Metabolite	Infection Cancer
Myristoyl coenzyme A lithium is lithium-labeled myristoylated coenzyme A (CoA). Myristoylation is an essential process in viruses and is generally controlled by N-myristoyltransferase (NMT). And NMT is more active in colon epithelial tumors than in normal cells. Reduced Ccoenzyme A (CoA) is known to be a key regulator of NMT activity, whereas oxidized CoA does not allow NMT to promote myristoylation. Myristoyl coenzyme A blocks the demyristoylation process and has potential anticancer and antiviral mechanisms.

HY-112258

IMP-1088 4 Publications Verification	DNA/RNA Synthesis	Infection
IMP-1088 is a potent *human N-myristoyltransferases* NMT1 and NMT2 dual inhibitor with IC₅₀s of <1 nM for HsNMT1 and HsNMT2. IMP-1088 has a K_d of <210 pM for HsNMT1. IMP-1088 efficiently blocks rhinovirus replication** by blocking rhinovirus virus-encoded protein (VP0) N-myristoylation. IMP-1088 protects host cells from the cytotoxic effects of viral infection .

HY-132211

3-Thiatetradecanoic acid	PPAR	Others
3-Thiatetradecanoic acid is a substrate of N-myristoyltransferase (NMT), which is involved in the metabolism of thiofatty acids .

HY-158364

NMT-IN-3	Parasite	Infection
NMT-IN-3 is an inhibitor of N-myristoyltransferase (NMT). The IC₅₀ of NMT-IN-3 for Plasmodium vivax NMT is 38 mM .

HY-122134

SC-58272	Fungal	Infection
SC-58272 is a potent and selective dipeptide N-myristoyltransferase (Nmt) inhibitor with an IC₅₀ of 56 nM for C. albicans (strain B311) Nmt. SC-58272 shows 250-fold selective for the fungal enzyme compared to human enzyme .

HY-126833

Myristoyl coenzyme A	Endogenous Metabolite	Infection Cancer
Myristoyl coenzyme A is a myristoylated coenzyme A (CoA). Myristoylation is an essential process in viruses and is generally controlled by N-myristoyltransferase (NMT). And NMT is more active in colon epithelial tumors than in normal cells. Reduced Ccoenzyme A (CoA) is known to be a key regulator of NMT activity, whereas oxidized CoA does not allow NMT to promote myristoylation. Myristoyl coenzyme A blocks the demyristoylation process and has potential anticancer and antiviral mechanisms.

HY-151692

18-Azido-stearic acid	ADC Linker	Others
18-Azido-stearic acid is a click chemistry reagent containing an azide group. 18-Azido-stearic acid can be used as a hydrophobic bioconjugation linker (using N-Myristoyltransferase) that can be further modified at the azido-position using Click-chemistry . It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. It can also undergo ring strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.

HY-P1291

PKI 14-22 amide,myristoylated 1 Publications Verification	PKA	Cancer
PKI 14-22 amide,myristoylated is a potent cAMP-dependent PKA inhibitor. PKI 14-22 amide,myristoylated reduces the IgG-mediated phagocytic response and also inhibits neutrophil adhesion .

HY-P1291A

PKI 14-22 amide,myristoylated TFA 1 Publications Verification	PKA	Cancer
PKI 14-22 amide,myristoylated TFA is a potent cAMP-dependent PKA inhibitor. PKI 14-22 amide,myristoylated TFA reduces the IgG-mediated phagocytic response and also inhibits neutrophil adhesion .

HY-P1369

DynaMin inhibitory peptide, myristoylated	Dynamin	Neurological Disease
DynaMin inhibitory peptide, myristoylated is a DynaMin inhibitor to interfere with the binding of amphiphysin with dynamin. DynaMin inhibitory peptide, myristoylated is a membrane-permeant form of the peptide that prevents endocytosis .

HY-P1369A

DynaMin inhibitory peptide, myristoylated TFA	Dynamin	Neurological Disease
DynaMin inhibitory peptide, myristoylated TFA is a DynaMin inhibitor to interfere with the binding of amphiphysin with dynamin. DynaMin inhibitory peptide, myristoylated TFA is a membrane-permeant form of the peptide that prevents endocytosis .

Cat. No.	Product Name	Type

HY-126833

Myristoyl coenzyme A	Enzyme Substrates
Myristoyl coenzyme A is a myristoylated coenzyme A (CoA). Myristoylation is an essential process in viruses and is generally controlled by N-myristoyltransferase (NMT). And NMT is more active in colon epithelial tumors than in normal cells. Reduced Ccoenzyme A (CoA) is known to be a key regulator of NMT activity, whereas oxidized CoA does not allow NMT to promote myristoylation. Myristoyl coenzyme A blocks the demyristoylation process and has potential anticancer and antiviral mechanisms.

Myristoyl coenzyme A

Enzyme Substrates

Myristoyl coenzyme A is a myristoylated coenzyme A (CoA). Myristoylation is an essential process in viruses and is generally controlled by N-myristoyltransferase (NMT). And NMT is more active in colon epithelial tumors than in normal cells. Reduced Ccoenzyme A (CoA) is known to be a key regulator of NMT activity, whereas oxidized CoA does not allow NMT to promote myristoylation. Myristoyl coenzyme A blocks the demyristoylation process and has potential anticancer and antiviral mechanisms.

Cat. No.	Product Name	Target	Research Area

HY-P1291

PKI 14-22 amide,myristoylated 1 Publications Verification	PKA	Cancer
PKI 14-22 amide,myristoylated is a potent cAMP-dependent PKA inhibitor. PKI 14-22 amide,myristoylated reduces the IgG-mediated phagocytic response and also inhibits neutrophil adhesion .

HY-P1291A

PKI 14-22 amide,myristoylated TFA 1 Publications Verification	PKA	Cancer
PKI 14-22 amide,myristoylated TFA is a potent cAMP-dependent PKA inhibitor. PKI 14-22 amide,myristoylated TFA reduces the IgG-mediated phagocytic response and also inhibits neutrophil adhesion .

HY-P1369

DynaMin inhibitory peptide, myristoylated	Dynamin	Neurological Disease
DynaMin inhibitory peptide, myristoylated is a DynaMin inhibitor to interfere with the binding of amphiphysin with dynamin. DynaMin inhibitory peptide, myristoylated is a membrane-permeant form of the peptide that prevents endocytosis .

HY-P10266

Myristoyl tripeptide-1	Peptides	Others
Myristoyl tripeptide-1 is the reaction product of Myristic acid (HY-N2041) and Tripeptide-1. Myristoyl tripeptide-1 is utilized in cosmetics as the conditioning agent of skin .

HY-P1391

ZIP(Scrambled)	Peptides	Others
ZIP(Scrambled) is a scrambled control peptide for zeta inhibitory peptide (ZIP) .

HY-P1391A

ZIP(Scrambled) TFA	Peptides	Others
ZIP(Scrambled) TFA is a scrambled control peptide for zeta inhibitory peptide (ZIP) .

HY-P1369A

DynaMin inhibitory peptide, myristoylated TFA	Dynamin	Neurological Disease
DynaMin inhibitory peptide, myristoylated TFA is a DynaMin inhibitor to interfere with the binding of amphiphysin with dynamin. DynaMin inhibitory peptide, myristoylated TFA is a membrane-permeant form of the peptide that prevents endocytosis .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-126833A

Myristoyl coenzyme A lithium 1 Publications Verification	Infection Structural Classification Natural Products Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields Cancer	Endogenous Metabolite
Myristoyl coenzyme A lithium is lithium-labeled myristoylated coenzyme A (CoA). Myristoylation is an essential process in viruses and is generally controlled by N-myristoyltransferase (NMT). And NMT is more active in colon epithelial tumors than in normal cells. Reduced Ccoenzyme A (CoA) is known to be a key regulator of NMT activity, whereas oxidized CoA does not allow NMT to promote myristoylation. Myristoyl coenzyme A blocks the demyristoylation process and has potential anticancer and antiviral mechanisms.

Cat. No.	Product Name		Classification

HY-151692

18-Azido-stearic acid		Azide
18-Azido-stearic acid is a click chemistry reagent containing an azide group. 18-Azido-stearic acid can be used as a hydrophobic bioconjugation linker (using N-Myristoyltransferase) that can be further modified at the azido-position using Click-chemistry . It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. It can also undergo ring strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.

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Click Chemistry