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NALP3

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By Targets:	Akt (1) Caspase (1) Endogenous Metabolite (1) HIF/HIF Prolyl-Hydroxylase (1) Interleukin Related (4) MicroRNA (1) PI3K (1) Reactive Oxygen Species (1) TGF-beta/Smad (2) TNF Receptor (3) Tyrosinase (3)
By Research Areas:	Cardiovascular Disease (1) Inflammation/Immunology (4) Neurological Disease (3)

6

Inhibitors & Agonists

4

Natural
Products

4

Recombinant Proteins

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

Mulberroside A 3 Publications Verification	TNF Receptor Interleukin Related Tyrosinase	Inflammation/Immunology
Mulberroside A is one of the main bioactive constituent in mulberry (Morus alba L.) . Mulberroside A decreases the expressions of TNF-α, IL-1β, and IL-6 and inhibits the activation of NALP3, caspase-1, and NF-κB and the phosphorylation of ERK, JNK, and p38, exhibiting anti-inflammatory antiapoptotic effects . Mulberroside A shows inhibitory activity against mushroom tyrosinase with an IC₅₀ of 53.6 μM ^[3].

Protectin D1 Neuroprotectin D1; NPD1	Endogenous Metabolite PI3K Akt HIF/HIF Prolyl-Hydroxylase Reactive Oxygen Species Caspase Interleukin Related MicroRNA	Cardiovascular Disease Neurological Disease Inflammation/Immunology
Protectin D1, a neuroprotectin D1 produced by neuronal cells, is a member of a newly discovered family of bioactive products derived from docosahexaenoic acid. Protectin D1 also serves as a specialized pro-resolving mediator, exhibiting effective in vivo pro-resolving activity in various human disease models. Additionally, Protectin D1 is an inhibitor of *NALP3* inflammasomes and regulates the *PI3K/AKT* and HIF-1α signaling pathways. Protectin D1 exerts anti-inflammatory effects by reducing ROS levels, inhibiting the expression of *NALP3, ASC, and Caspase-1, and consequently decreasing the release of pro-inflammatory cytokines IL-1β* and IL-18. Furthermore, Protectin D1 enhances miRNA-210 expression, activates the *PI3K/AKT* signaling pathway, and exerts cardioprotective effects. Protectin D1 holds promise for research in cardiovascular diseases and inflammatory disorders .

SRI-011381 Maximum Cited Publications 44 Publications Verification	TGF-beta/Smad	Neurological Disease
SRI-011381 is an orally active TGF-β signaling agonist, exhibits neuroprotective effects .

cis-Mulberroside A Mulberroside D	TNF Receptor Interleukin Related Tyrosinase	Inflammation/Immunology
cis-Mulberroside A (Mulberroside D) is the cis-isomer of Mulberroside A. Mulberroside A is one of the main bioactive constituent in mulberry (Morus alba L.) . Mulberroside A decreases the expressions of TNF-α, IL-1β, and IL-6 and inhibits the activation of NALP3, caspase-1, and NF-κB and the phosphorylation of ERK, JNK, and p38, exhibiting anti-inflammatory and anti-apoptotic effects . Mulberroside A shows inhibitory activity against mushroom tyrosinase with an IC₅₀ of 53.6 μM ^[3].

Mulberroside A (Standard)	TNF Receptor Interleukin Related Tyrosinase	Inflammation/Immunology
Mulberroside A (Standard) is the analytical standard of Mulberroside A. This product is intended for research and analytical applications. Mulberroside A is one of the main bioactive constituent in mulberry (Morus alba L.) . Mulberroside A decreases the expressions of TNF-α, IL-1β, and IL-6 and inhibits the activation of NALP3, caspase-1, and NF-κB and the phosphorylation of ERK, JNK, and p38, exhibiting anti-inflammatory antiapoptotic effects . Mulberroside A shows inhibitory activity against mushroom tyrosinase with an IC₅₀ of 53.6 μM ^[3].

SRI-011381 hydrochloride	TGF-beta/Smad	Neurological Disease
SRI-011381 hydrochloride is an orally active TGF-β signaling agonist, exhibits neuroprotective effects .

Species:	Human (3) Mouse (1)
Tag:	His (3) SUMO (1) GST (1)
Source:	E. coli (4)

Cat. No.	Compare	Product Name	Species	Source

	NLRP3 Protein, Human (GST) C1orf7; CIAS1; NALP3; PYPAF1; FCAS; FCU; MWS; NACHT; CLR1.1; Cryopyrin;	Human	E. coli
	The NLRP3 protein acts as a sensor in the NLRP3 inflammasome, which is activated in response to membrane defects. It forms a complex with CASP1 and PYCARD/ASC, promotes the release of IL1B, IL18 and GSDMD, and induces pyroptosis. NLRP3 Protein, Human (GST) is the recombinant human-derived NLRP3 protein, expressed by E. coli , with N-GST labeled tag. The total length of NLRP3 Protein, Human (GST) is 574 a.a., with molecular weight of 93.20 kDa.

	NLRP3 Protein, Human (1-536a.a, His) C1orf7; CIAS1; NALP3; PYPAF1; FCAS; FCU; MWS; NACHT; CLR1.1; Cryopyrin;	Human	E. coli
	The NLRP3 protein acts as a sensor in the NLRP3 inflammasome, which is activated in response to membrane defects. It forms a complex with CASP1 and PYCARD/ASC, promotes the release of IL1B, IL18 and GSDMD, and induces pyroptosis. NLRP3 Protein, Human (1-536a.a, His) is the recombinant human-derived NLRP3 protein, expressed by E. coli , with N-6*His labeled tag.

	NLRP3 Protein, Mouse (His-SUMO) 1 Publications Verification Nlrp3; Cias1; Mmig1; NALP3; Pypaf1; NACHT; LRR and PYD domains-containing protein 3; Cold autoinflammatory syndrome 1 protein homolog; Cryopyrin; Mast cell maturation-associated-inducible protein 1; PYRIN-containing APAF1-like protein 1	Mouse	E. coli
	The NLRP3 protein acts as a sensor in the NLRP3 inflammasome, which is activated in response to membrane defects caused by pathogens or damage signals. It assembles the inflammasome complex, including NLRP3, CASP1, and PYCARD/ASC. NLRP3 Protein, Mouse (His-SUMO) is the recombinant mouse-derived NLRP3 protein, expressed by E. coli , with N-SUMO, N-6*His labeled tag.

	NLRP3 Protein, Human (His) Angiotensin/vasopressin receptor AII/AVP-like; Caterpiller protein 1.1; Cold-induced autoinflammatory syndrome 1 protein; Cryopyrin; PYRIN-containing APAF1-like protein 1; NLRP3; NALP3; PYPAF1; CIAS1	Human	E. coli
	The NLRP3 protein acts as a sensor in the NLRP3 inflammasome, which is activated in response to membrane defects. It forms a complex with CASP1 and PYCARD/ASC, promotes the release of IL1B, IL18 and GSDMD, and induces pyroptosis. NLRP3 Protein, Human (His) is the recombinant human-derived NLRP3, expressed by E. coli , with C-6*His labeled tag. ,

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