SRI-011381 hydrochloride

Name: SRI-011381 hydrochloride
Brand: MedChemExpress
SKU: HY-100347A
Rating: 5.0 (36 reviews)

Cat. No.: HY-100347A Purity: 99.55%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

SRI-011381 hydrochloride is an orally active TGF-β signaling agonist, exhibits neuroprotective effects.

For research use only. We do not sell to patients.

SRI-011381 hydrochloride Chemical Structure

CAS No. : 2070014-88-7

Size	Price	Stock	Quantity

Free Sample (0.1 - 0.5 mg)		Apply Now
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	USD 88	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	USD 88	In-stock	Estimated Time of Arrival: December 31
Solid
5 mg	USD 80	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 140	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 290	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 480	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 790	In-stock	Estimated Time of Arrival: December 31
200 mg		Get quote
500 mg		Get quote

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Customer Review

Based on 36 publication(s) in Google Scholar

Other Forms of SRI-011381 hydrochloride:

SRI-011381 Get quote

34 Publications Citing Use of MCE SRI-011381 hydrochloride

: SRI-011381 hydrochloride purchased from MedChemExpress. Usage Cited in: Life Sci. 2021 Aug 15;279:119359. [Abstract]; The expression of pSmad2/3 in PBMCs treated with Curcumin or SRI-011381 (10 μM) detected by Western blot analysis normalized to GAPDH. SRI-011381 is found to up-regulate the phosphorylation of Smad2/3, while Curcumin reduces the activation of Smad2/3, whereas the inhibitory effect of curcumin in the activation of Smad2/3 is reversed by SRI-011381.

: SRI-011381 hydrochloride purchased from MedChemExpress. Usage Cited in: Mol Med Rep. 2021 Nov;24(5):758. [Abstract]; Mimics-exo significantly inhibits the expression levels of TGF-β2 and p-Smad3, as well as downregulated the expression levels of Col-I, Col-III and α-SMA, while SRI-011381 hydrochloride (10 µM) reverses the inhibition of miR-29a-overexpressing hADSCs-exo on the activation of TGF-β2/Smad3 signaling and the fibrosis of HSFBs.

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Biological Activity
Purity & Documentation
References
Customer Review

Description

SRI-011381 hydrochloride is an orally active TGF-β signaling agonist, exhibits neuroprotective effects^[1]^[2].

IC₅₀ & Target

TGF-beta^[1]

In Vitro

SRI-011381 (10 μM) hydrochloride promotes the proliferation of mouse lung fibroblasts, and significantly increases TGF-β1, NALP3, collagen-1, and α-SMA expression^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

SRI-011381 (30 mg/kg; i.p.; every 2 d; for 22 days) hydrochloride partially rescues the deficits in optic nerve and retina of YAPGFAP-CKO EAE mice^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	YAPGFAP-CKO mice bearing experimental autoimmune encephalomyelitis (EAE)^[2]
Dosage:	30 mg/kg
Administration:	Intraperitoneally injection; every 2 d; for 22 days
Result:	Significantly inhibited inflammatory infiltration and relieved the loss of neurons in YAPGFAP-CKO EAE mice.

Molecular Weight

365.94

Formula

C₂₀H₃₂ClN₃O

CAS No.

2070014-88-7

Appearance

Solid

Color

White to off-white

SMILES

O=C(NC1CCCCC1)N(CC2=CC=CC=C2)CC3CCNCC3.Cl[H]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

DMSO : 33.33 mg/mL (91.08 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H₂O : 25 mg/mL (68.32 mM; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.7327 mL	13.6634 mL	27.3269 mL
5 mM	0.5465 mL	2.7327 mL	5.4654 mL
10 mM	0.2733 mL	1.3663 mL	2.7327 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (6.83 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (6.83 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 2.5 mg/mL (6.83 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: PBS
Solubility: 50 mg/mL (136.63 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: 99.55%

Select Batch:

Data Sheet (276 KB) SDS (252 KB)

COA (249 KB) LCMS (88 KB)

Handling Instructions (2659 KB)

References

[1]. Jingyin Han, et al. The Improvement Effect of Sodium Ferulate on the Formation of Pulmonary Fibrosis in Silicosis Mice Through the Neutrophil Alkaline Phosphatase 3 (NALP3)/Transforming Growth Factor-β1 (TGF-β1)/α-Smooth Muscle Actin (α-SMA) Pathway. Med Sci Monit. 2021 Jun 15;27:e927978. [Content Brief]

[2]. Qian Wu, et al. Astrocytic YAP protects the optic nerve and retina in an experimental autoimmune encephalomyelitis model through TGF-β signaling. Theranostics. 2021 Jul 25;11(17):8480-8499. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O / DMSO	1 mM	2.7327 mL	13.6634 mL	27.3269 mL	68.3172 mL
	5 mM	0.5465 mL	2.7327 mL	5.4654 mL	13.6634 mL
	10 mM	0.2733 mL	1.3663 mL	2.7327 mL	6.8317 mL
	15 mM	0.1822 mL	0.9109 mL	1.8218 mL	4.5545 mL
	20 mM	0.1366 mL	0.6832 mL	1.3663 mL	3.4159 mL
	25 mM	0.1093 mL	0.5465 mL	1.0931 mL	2.7327 mL
	30 mM	0.0911 mL	0.4554 mL	0.9109 mL	2.2772 mL
	40 mM	0.0683 mL	0.3416 mL	0.6832 mL	1.7079 mL
	50 mM	0.0547 mL	0.2733 mL	0.5465 mL	1.3663 mL
	60 mM	0.0455 mL	0.2277 mL	0.4554 mL	1.1386 mL
DMSO	80 mM	0.0342 mL	0.1708 mL	0.3416 mL	0.8540 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.