2. Stem Cell/Wnt TGF-beta/Smad
  3. TGF-beta/Smad
  4. SRI-011381

SRI-011381 is an orally active TGF-β signaling agonist, exhibits neuroprotective effects.

For research use only. We do not sell to patients.

SRI-011381 Chemical Structure

SRI-011381 Chemical Structure

CAS No. : 1629138-41-5

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 58 In-stock
Solution
10 mM * 1 mL in DMSO USD 58 In-stock
Solid
1 mg USD 38 In-stock
5 mg USD 80 In-stock
10 mg USD 140 In-stock
25 mg USD 290 In-stock
50 mg USD 480 In-stock
100 mg USD 790 In-stock
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

Based on 36 publication(s) in Google Scholar

Other Forms of SRI-011381:

SRI-011381 Related Antibodies

Top Publications Citing Use of Products

34 Publications Citing Use of MCE SRI-011381

WB

    SRI-011381 purchased from MedChemExpress. Usage Cited in: Life Sci. 2021 Aug 15;279:119359.  [Abstract]

    The expression of pSmad2/3 in PBMCs treated with Curcumin or SRI-011381 (10 μM) detected by Western blot analysis normalized to GAPDH. SRI-011381 is found to up-regulate the phosphorylation of Smad2/3, while Curcumin reduces the activation of Smad2/3, whereas the inhibitory effect of curcumin in the activation of Smad2/3 is reversed by SRI-011381.

    SRI-011381 purchased from MedChemExpress. Usage Cited in: Mol Med Rep. 2021 Nov;24(5):758.  [Abstract]

    Mimics-exo significantly inhibits the expression levels of TGF-β2 and p-Smad3, as well as downregulated the expression levels of Col-I, Col-III and α-SMA, while SRI-011381 hydrochloride (10 µM) reverses the inhibition of miR-29a-overexpressing hADSCs-exo on the activation of TGF-β2/Smad3 signaling and the fibrosis of HSFBs.

    • Biological Activity

    • Purity & Documentation

    • References

    • Customer Review

    Description

    SRI-011381 is an orally active TGF-β signaling agonist, exhibits neuroprotective effects[1][2].

    In Vitro

    SRI-011381 (10 μM) promotes the proliferation of mouse lung fibroblasts, and significantly increases TGF-β1, NALP3, collagen-1, and α-SMA expression[1].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    SRI-011381 Related Antibodies
    In Vivo

    SRI-011381 (30 mg/kg; i.p.; every 2 d; for 22 days) partially rescues the deficits in optic nerve and retina of YAPGFAP-CKO EAE mice[2].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: YAPGFAP-CKO mice bearing experimental autoimmune encephalomyelitis (EAE)[2]
    Dosage: 30 mg/kg
    Administration: Intraperitoneally injection; every 2 d; for 22 days
    Result: Significantly inhibited inflammatory infiltration and relieved the loss of neurons in YAPGFAP-CKO EAE mice.
    Molecular Weight

    329.48

    Formula

    C20H31N3O
    CAS No.
    Appearance

    Solid

    Color

    White to off-white

    SMILES

    O=C(NC1CCCCC1)N(CC2=CC=CC=C2)CC3CCNCC3
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage

    4°C, protect from light

    *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

    Solvent & Solubility
    In Vitro: 

    DMSO : 50 mg/mL (151.75 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 3.0351 mL 15.1754 mL 30.3509 mL
    5 mM 0.6070 mL 3.0351 mL 6.0702 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    • Molarity Calculator

    • Dilution Calculator

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    Concentration (start)

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    In Vivo:

    Select the appropriate dissolution method based on your experimental animal and administration route.

    For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
    To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
    The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

    • Protocol 1

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

      Solubility: ≥ 2.5 mg/mL (7.59 mM); Clear solution

      This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

      Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

      Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
    • Protocol 2

      Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

      Solubility: ≥ 2.5 mg/mL (7.59 mM); Clear solution

      This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

      Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

      Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

    Dosage

    mg/kg

    Animal weight
    (per animal)

    g

    Dosing volume
    (per animal)

    μL

    Number of animals

    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
    Please enter your animal formula composition:
    %
    DMSO +
    % 
    +
    %
    Tween-80 +
    %
    Saline
    Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
    The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
    Calculation results:
    Working solution concentration: mg/mL
    Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).

    *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

    The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
    Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
     If the continuous dosing period exceeds half a month, please choose this protocol carefully.
    Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
    Purity & Documentation

    Purity: 99.58%

    COA (248 KB) HNMR (259 KB) LCMS (255 KB)

    Handling Instructions (2659 KB)
    References

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    DMSO 1 mM 3.0351 mL 15.1754 mL 30.3509 mL 75.8771 mL
    5 mM 0.6070 mL 3.0351 mL 6.0702 mL 15.1754 mL
    10 mM 0.3035 mL 1.5175 mL 3.0351 mL 7.5877 mL
    15 mM 0.2023 mL 1.0117 mL 2.0234 mL 5.0585 mL
    20 mM 0.1518 mL 0.7588 mL 1.5175 mL 3.7939 mL
    25 mM 0.1214 mL 0.6070 mL 1.2140 mL 3.0351 mL
    30 mM 0.1012 mL 0.5058 mL 1.0117 mL 2.5292 mL
    40 mM 0.0759 mL 0.3794 mL 0.7588 mL 1.8969 mL
    50 mM 0.0607 mL 0.3035 mL 0.6070 mL 1.5175 mL
    60 mM 0.0506 mL 0.2529 mL 0.5058 mL 1.2646 mL
    80 mM 0.0379 mL 0.1897 mL 0.3794 mL 0.9485 mL
    100 mM 0.0304 mL 0.1518 mL 0.3035 mL 0.7588 mL
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    SRI-011381 Related Classifications

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    SRI-0113811629138-41-5SRI011381SRI 011381TGF-beta/SmadTransforming growth factor betaTGF-βmultiplesclerosisNALP3collagen-1α-SMAneuroprotectiveInhibitorinhibitorinhibit

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