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Results for "

NPs

" in MedChemExpress (MCE) Product Catalog:

By Targets:	5-HT Receptor (3) Aminopeptidase (1) Apoptosis (1) Bacterial (1) Biochemical Assay Reagents (2) c-Met/HGFR (1) CaSR (5) Dopamine Receptor (1) Fluorescent Dye (2) iGluR (2) Liposome (2) mGluR (1) Mucin (1) Neuropeptide S Receptor (1) Neuropeptide Y Receptor (1) Opioid Receptor (1) PD-1/PD-L1 (1) Photosensitizer (1) PPAR (1) Reactive Oxygen Species (1) Serotonin Transporter (2) Small Interfering RNA (siRNA) (1) TAM Receptor (1)
By Research Areas:	Cancer (6) Cardiovascular Disease (2) Endocrinology (1) Infection (1) Metabolic Disease (3) Neurological Disease (13)
Oligonucleotides:	Cationic Lipids (1) Human Pre-designed siRNA Sets (1) siRNAs (1)

Inhibitors & Agonists

Screening Libraries

Fluorescent Dye

Biochemical Assay Reagents

Peptides

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-11095

NPS 2390	mGluR CaSR	Cardiovascular Disease Neurological Disease
NPS 2390 is a noncompetitive antagonist of mGluR1 and mGluR5 . NPS 2390 is also a potent CaSR (calcium-sensing receptor) inhibitor .

HY-100509

NPS-1034 1 Publications Verification	TAM Receptor c-Met/HGFR Apoptosis	Cancer
NPS-1034 is a dual inhibitor of AXL and MET with IC₅₀s of 10.3 and 48 nM, respectively.

HY-10171

NPS-2143 hydrochloride Maximum Cited Publications 19 Publications Verification SB-262470A hydrochloride	CaSR	Metabolic Disease
NPS-2143 hydrochloride (SB-262470A hydrochloride), an orally active calcilytic agent, is a selective and potent calcium ion-sensing receptor (CaSR) antagonist. NPS-2143 hydrochloride (SB-262470A hydrochloride) blocks increases in cytoplasmic Ca ²⁺ concentrations (IC₅₀=43 nM) elicited by activating the Ca ²⁺ receptor in HEK 293 cells expressing the human Ca ²⁺ receptor .

HY-10007

NPS-2143 Maximum Cited Publications 19 Publications Verification SB-262470A	CaSR	Metabolic Disease
NPS-2143 (SB-262470A), an orally active calcilytic agent, is a selective and potent calcium ion-sensing receptor (CaSR) antagonist. NPS-2143 (SB-262470A) blocks increases in cytoplasmic Ca ²⁺ concentrations (IC₅₀=43 nM) elicited by activating the Ca ²⁺ receptor in HEK 293 cells expressing the human Ca ²⁺ receptor .

HY-RS09502

NPS Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
NPS Human Pre-designed siRNA Set A contains three designed siRNAs for NPS gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

NPS Human Pre-designed siRNA Set A NPS Human Pre-designed siRNA Set A

HY-103090

NPS ALX Compound 4a	5-HT Receptor	Neurological Disease
NPS ALX Compound 4a is a potent and selective 5-hydroxytryptamine₆ (5-HT₆) receptor antagonist, with an IC₅₀ of 7.2 nM and a K_i of 0.2 nM .

HY-103090A

NPS ALX Compound 4a dihydrochloride	5-HT Receptor	Neurological Disease
NPS ALX Compound 4a dihydrochloride is a potent and selective 5-hydroxytryptamine₆ (5-HT₆) receptor antagonist, with an IC₅₀ of 7.2 nM and a K_i of 0.2 nM .

HY-106397

Delucemine NPs-1506	Serotonin Transporter iGluR	Neurological Disease
Delucemine is a selective serotonin reuptake inhibitor (SSRI) and NMDAR antagonist. Delucemine can be used as an antidepressant .

HY-106397A

Delucemine hydrochloride NPs-1506 hydrochloride	Serotonin Transporter iGluR	Neurological Disease
Delucemine hydrochloride is a selective serotonin reuptake inhibitor (SSRI) and NMDAR antagonist. Delucemine hydrochloride can be used as an antidepressant .

HY-17633

Fonadelpar NPs-005; SJP-0035	PPAR	Neurological Disease
Fonadelpar is a PPARδ agonist, used in the research of neuroparalytic keratopathy.

HY-10167A

Tecalcet Hydrochloride 5+ Cited Publications R-568 hydrochloride; NPs R-568	CaSR	Others
Tecalcet Hydrochloride (R 568 Hydrochloride), an orally active calcimimetic compound, allosterically and positively modulates the calcium-sensing receptor (CaSR). Tecalcet Hydrochloride (R 568 Hydrochloride) increases the sensitivity to activation by extracellular Ca ²⁺ .

HY-10167

Tecalcet R-568; NPs R-568 free base	CaSR	Others
Tecalcet (R 568), an orally active calcimimetic compound, allosterically and positively modulates the calcium-sensing receptor (CaSR). Tecalcet (R 568) increases the sensitivity to activation by extracellular Ca ²⁺ .

HY-138232

*Lys-psi(CH2NH)-Trp(Nps)-OMe* LTNAM	Aminopeptidase	Neurological Disease
Lys-psi(CH2NH)-Trp(Nps)-OMe is a lysine-tryptophan (Nps) pseudodipeptide analog. It is obtained by replacing the peptide bond in the Lys-Trp(Nps) molecule with an aminomethylene bond and has analgesic activity. Lys-psi(CH2NH)-Trp(Nps)-OMe induces a dose-dependent and naloxone-reversible analgesia after intracerebroventricular administration in mice, and its analgesic effect lasts longer than that of the original compound. It protects methionine enkephalin from degradation in rat striatal slices and binds to low-dose opioid peptides to produce analgesia. Lys-psi(CH2NH)-Trp(Nps)-OMe effectively inhibits brain aminopeptidase activity both in vitro and in vivo. The enhanced resistance of this pseudodipeptide to proteolysis may explain its prolonged analgesic activity.

HY-121870A

Dimethocaine hydrochloride Larocaine hydrochloride	Dopamine Receptor	Neurological Disease
Dimethocaine (Larocaine) hydrochloride is distributed and consumed as "new psychoactive substance" (NPS) without any safety testing

HY-159702

Eudragit RS 100	Mucin	Others
Eudragit RS 100 is a mucoadhesive, nonbiodegradable positively charged polymer,which can be used for research of developing nanoparticles (NPs) for the ophthalmic and oral administration of Ibuprofen (HY-78131) and Cyclosporins (HY-100731), as well as nano- and micro-fibres used as scaffolds. Eudragit RS 100 NPs interacts efficiently with mucin and promotes glutathione (GSH) transmucosal absorption .

HY-W075770

Nickel(II) oxide Nickel monoxide	Bacterial Reactive Oxygen Species	Infection Metabolic Disease Cancer
Nickel(II) oxide is a chemical compound which nanoparticle form (NiO NPs) exhibits antibacterial, antifungal, antileishmanial, anti-diabetic and anticancer activities. NiO NPs can be activated by ultraviolet and visible light to generate reactive oxygen species, which may be the main cause for the antimicrobial potential .

HY-152229

G0-C14	Liposome	Cancer
G0-C14 is a cationic lipid-like compound alkyl-modified polyamidoamine (PAMAM) dendrimer. G0-C14 involves in the preparation of a series of macrophage-targeted nanoparticles (NPs). NPs can be used for agent and vaccine delivery .

HY-W010713

Meso-tetraphenylchlorin Fimaporfin free base	Photosensitizer	Cancer
Meso-tetraphenylchlorin (TPCS2a) is a photosensitizer with poor water solubility, which limits its use in the blood circulation. However, TPCS2a@NPs nanoparticles can be prepared based on polylactic-co-polyethylene glycol acid (PLGA) polymer core loaded with TPCS2. Such nanoparticles can be coated with mesenchymal stem cell-derived plasma membranes (mMSCs) to form mMSC-TPCS2a@NPs, which prolongs blood circulation time and improves tumor targeting ability. Compared with uncoated TPCS2a@NPs, mMSC-TPCS2a@NPs can reduce macrophage uptake by 54% to 70% under different conditions. Both nanoparticle forms are effectively accumulated in MCF7 and MDA-MB-231 breast cancer cells, while uptake in normal breast epithelial cells MCF10A is significantly lower .

HY-P10646

Muscle homing peptide M12	Biochemical Assay Reagents	Neurological Disease
Muscle homing peptide M12 can preferentially bind to surface protein of muscle cells. Muscle homing peptide M12 mediates enhanced cellular uptake of nanoparticles (NPs) in myoblasts in vitro. Muscle homing peptide M12 is covalently conjugated to PLGA-PEG NPs via the N-terminal α-amino groups of peptides using the N-hydroxysuccinimide ester reaction .

HY-D2314

Cyanine 7-amine chloride hydrochloride	Liposome	Others
Cyanine 7-amine (chloride hydrochloride) can be used to label cationic nanoparticles (NPs) or to NP conjugates (NPCs). It can track the residence time and clearance of nanoparticles in the body .

HY-170310

AP-238	Opioid Receptor	Neurological Disease
AP-238 is a a new synthetic opioid (NSO), and acts as an agonist for μ-opioid receptor (MOR) with an EC₅₀ of 248 nM. AP-238 exhibits analgesic activity .

HY-P1438

Neuropeptide S(Rat)	Neuropeptide Y Receptor	Neurological Disease
Neuropeptide S (Rat) is an endogenous ligand of a previously orphan G-protein-coupled receptor now named NPS receptor. Neuropeptide S (Rat) can be used for the research of nervous system disease .

HY-D1724

IR-806	Fluorescent Dye	Cancer
IR-806 is a near-infrared cyanine liquid crystal dye. IR-806 can be used as a molecular antenna to synthesized nanoprobes (NPs). IR-806 can be used for in vivo imaging studies .

HY-118796

4-Hydroxy MET 4-HO-MET; 4-Hydroxy-N-methyl-N-ethyltryptamine	5-HT Receptor	Neurological Disease
4-Hydroxy MET (4-HO-MET) is a psychoactive tryptamine (NPS), a structural variant of the endogenous neurotransmitter serotonin. 4-Hydroxy MET has hallucinogenic effects, affecting mood, movement, and cognitive function .

HY-P2491

Atrial Natriuretic Peptide (1-28), human, porcine, Biotin-labeled	Fluorescent Dye	Cardiovascular Disease Endocrinology
Atrial Natriuretic Peptide (1-28), human, porcine, Biotin-labeled, one of three mammalian natriuretic peptides (NPs), has endocrine effects on fluid homeostasis and blood pressure. Atrial Natriuretic Peptide has the potential for cardiovascular diseases research .

HY-108626

ML154 NCGC84	Neuropeptide S Receptor	Neurological Disease
ML154 (NCGC84) is a selective, brain-penetrant and non-peptide neuropeptide S receptor (NPSR) antagonist with a pA₂ of 9.98. ML154 potently inhibits NPS-stimulated cellular calcium, cAMP, and ERK phosphorylation responses with IC₅₀ values of 36.5 nM, 22.1 nM, and 9.3 nM, respectively .

HY-169434

LTB Lon-TK-BMS-1	PD-1/PD-L1	Cancer
LTB is a prodrug formed by coupling glycolysis inhibitor (Lonidamine (HY-B0486)) with PD1/PDL1 blocker (BMS-1 (HY-19991)) by thioketal linkage. LTB can further encapsulate photosensitizer chlorine e6 (Ce6) (HY-13594) to construct a co-delivery photodynamic nanoplatform (LTB-6 NPs) by self-assembly .

HY-P10510

R5 peptide	Biochemical Assay Reagents	Others
R5 peptide is one of the repeating peptide sequences that form the protein diatom in Cylindrotheca fusiformis. R5 peptide can be used as a template for the synthesis of Pd (palladium) nanoparticles (NPs). R5 peptide forms complexes with metal ions through the amine groups in its sequence, and the self-assembled structure of the peptide provides a confined spatial environment for the reduction of metal ions and the nucleation of nanoparticles. R5 peptide can be used in the research of biomimetic nanomaterials .

Cat. No.	Product Name

HY-L107

Anti-Cancer Natural Product Library	1,750 compounds
With features of enormous scaffold diversity and structural complexity, natural products (NPs) are the main sources of lead compounds and new drugs and play a highly significant role in the drug discovery and development process, especially for cancer and infectious diseases. A large number of natural products have been proven to have potential anti-tumor effects, mainly from plants, animals, Marine organisms and microorganisms. At present, derived than 60% of anti-tumor drugs come from natural sources, and they are widely used in breast, prostate and colon cancers. MCE offers a unique collection of 1,750 natural products with validated anti-cancer activity. MCE anti-cancer natural product library is a useful tool for anti-tumor drugs screening and other related research.

Anti-Cancer Natural Product Library

1,750 compounds

With features of enormous scaffold diversity and structural complexity, natural products (NPs) are the main sources of lead compounds and new drugs and play a highly significant role in the drug discovery and development process, especially for cancer and infectious diseases. A large number of natural products have been proven to have potential anti-tumor effects, mainly from plants, animals, Marine organisms and microorganisms. At present, derived than 60% of anti-tumor drugs come from natural sources, and they are widely used in breast, prostate and colon cancers.

MCE offers a unique collection of 1,750 natural products with validated anti-cancer activity. MCE anti-cancer natural product library is a useful tool for anti-tumor drugs screening and other related research.

HY-L206

High-Throughput Natural Product Library	4,664 compounds
Natural products (NPs) are a class of widely bioactive compounds that have been shown to have a variety of uses, including pharmaceutical, agricultural, industrial and other fields. Historically, natural products have played a key role in drug discovery, particularly for cancer and infectious diseases, but also in other therapeutic areas, including cardiovascular disease (e.g., statins) and multiple sclerosis (e.g., Fingolimod). Compared to traditional synthetic molecules, natural products have special structure and function, which brings advantages and challenges to the drug discovery process. Compared to synthetic compounds, natural products have higher skeleton diversity, structural complexity, and generally have higher molecular mass, more sp3 carbon atoms and oxygen atoms, more hydrogen bond acceptors and donors, and so on. Overall, natural product libraries cover a broader chemical space than typical synthetic small molecules. MCE provides a unique collection of 4,664 natural compounds that contain Saccharides and Glycosides, Phenylpropanoids, Quinones, Flavonoids, Terpenoids and Glycosides, Steroids, Alkaloid, Phenols, Acids and Aldehydes. Natural Product Library is a useful tool for drug discovery that can be used for high-throughput screening (HTS) and high-content screening (HCS).

High-Throughput Natural Product Library

4,664 compounds

Natural products (NPs) are a class of widely bioactive compounds that have been shown to have a variety of uses, including pharmaceutical, agricultural, industrial and other fields. Historically, natural products have played a key role in drug discovery, particularly for cancer and infectious diseases, but also in other therapeutic areas, including cardiovascular disease (e.g., statins) and multiple sclerosis (e.g., Fingolimod). Compared to traditional synthetic molecules, natural products have special structure and function, which brings advantages and challenges to the drug discovery process. Compared to synthetic compounds, natural products have higher skeleton diversity, structural complexity, and generally have higher molecular mass, more sp3 carbon atoms and oxygen atoms, more hydrogen bond acceptors and donors, and so on. Overall, natural product libraries cover a broader chemical space than typical synthetic small molecules.

MCE provides a unique collection of 4,664 natural compounds that contain Saccharides and Glycosides, Phenylpropanoids, Quinones, Flavonoids, Terpenoids and Glycosides, Steroids, Alkaloid, Phenols, Acids and Aldehydes. Natural Product Library is a useful tool for drug discovery that can be used for high-throughput screening (HTS) and high-content screening (HCS).

Cat. No.	Product Name	Type

HY-D2314

Cyanine 7-amine chloride hydrochloride	Dyes
Cyanine 7-amine (chloride hydrochloride) can be used to label cationic nanoparticles (NPs) or to NP conjugates (NPCs). It can track the residence time and clearance of nanoparticles in the body .

Cat. No.	Product Name	Type

HY-152229

G0-C14	Drug Delivery
G0-C14 is a cationic lipid-like compound alkyl-modified polyamidoamine (PAMAM) dendrimer. G0-C14 involves in the preparation of a series of macrophage-targeted nanoparticles (NPs). NPs can be used for agent and vaccine delivery .

Cat. No.	Product Name	Target	Research Area

HY-P10646

Muscle homing peptide M12	Biochemical Assay Reagents	Neurological Disease
Muscle homing peptide M12 can preferentially bind to surface protein of muscle cells. Muscle homing peptide M12 mediates enhanced cellular uptake of nanoparticles (NPs) in myoblasts in vitro. Muscle homing peptide M12 is covalently conjugated to PLGA-PEG NPs via the N-terminal α-amino groups of peptides using the N-hydroxysuccinimide ester reaction .

HY-P1438

Neuropeptide S(Rat)	Neuropeptide Y Receptor	Neurological Disease
Neuropeptide S (Rat) is an endogenous ligand of a previously orphan G-protein-coupled receptor now named NPS receptor. Neuropeptide S (Rat) can be used for the research of nervous system disease .

HY-P2491

Atrial Natriuretic Peptide (1-28), human, porcine, Biotin-labeled	Fluorescent Dye	Cardiovascular Disease Endocrinology
Atrial Natriuretic Peptide (1-28), human, porcine, Biotin-labeled, one of three mammalian natriuretic peptides (NPs), has endocrine effects on fluid homeostasis and blood pressure. Atrial Natriuretic Peptide has the potential for cardiovascular diseases research .

HY-P10510

R5 peptide	Biochemical Assay Reagents	Others
R5 peptide is one of the repeating peptide sequences that form the protein diatom in Cylindrotheca fusiformis. R5 peptide can be used as a template for the synthesis of Pd (palladium) nanoparticles (NPs). R5 peptide forms complexes with metal ions through the amine groups in its sequence, and the self-assembled structure of the peptide provides a confined spatial environment for the reduction of metal ions and the nucleation of nanoparticles. R5 peptide can be used in the research of biomimetic nanomaterials .

Cat. No.	Product Name		Classification

HY-152229

G0-C14		Cationic Lipids
G0-C14 is a cationic lipid-like compound alkyl-modified polyamidoamine (PAMAM) dendrimer. G0-C14 involves in the preparation of a series of macrophage-targeted nanoparticles (NPs). NPs can be used for agent and vaccine delivery .

HY-RS09502

NPS Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
NPS Human Pre-designed siRNA Set A contains three designed siRNAs for NPS gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

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