Dimethocaine hydrochloride (Synonyms: Larocaine hydrochloride)

Name: Dimethocaine hydrochloride
Brand: MedChemExpress
SKU: HY-121870A
Rating: 4.5 (1 reviews)

Cat. No.: HY-121870A Purity: 99.36%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

Dimethocaine (Larocaine) hydrochloride is distributed and consumed as "new psychoactive substance" (NPS) without any safety testing

For research use only. We do not sell to patients.

Dimethocaine hydrochloride Chemical Structure

CAS No. : 553-63-9

Size	Price	Stock	Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	USD 66	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	USD 66	In-stock	Estimated Time of Arrival: December 31
Solid
100 mg	USD 60	In-stock	Estimated Time of Arrival: December 31
500 mg	USD 120	In-stock	Estimated Time of Arrival: December 31
1 g		Get quote
5 g		Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

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Biological Activity
Purity & Documentation
References
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Description

Dimethocaine (Larocaine) hydrochloride is distributed and consumed as "new psychoactive substance" (NPS) without any safety testing^[1]

Molecular Weight

314.85

Formula

C₁₆H₂₇ClN₂O₂

CAS No.

553-63-9

Appearance

Solid

Color

Off-white to light yellow

SMILES

CC(CN(CC)CC)(C)COC(C1=CC=C(N)C=C1)=O.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility

In Vitro:

DMSO : 250 mg/mL (794.03 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H₂O : 100 mg/mL (317.61 mM; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.1761 mL	15.8806 mL	31.7612 mL
5 mM	0.6352 mL	3.1761 mL	6.3522 mL
10 mM	0.3176 mL	1.5881 mL	3.1761 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.08 mg/mL (6.61 mM); Clear solution

This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.08 mg/mL (6.61 mM); Clear solution

This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 2.08 mg/mL (6.61 mM); Clear solution

This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: 99.36%

Select Batch:

Data Sheet (268 KB) SDS (418 KB)

COA (244 KB) HNMR (268 KB) LCMS (266 KB)

Handling Instructions (2659 KB)

References

[1]. Meyer MR, et al. Dimethocaine, a synthetic cocaine derivative: studies on its in vitro metabolism catalyzed by P450s and NAT2. Toxicol Lett. 2014;225(1):139-146. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O / DMSO	1 mM	3.1761 mL	15.8806 mL	31.7612 mL	79.4029 mL
	5 mM	0.6352 mL	3.1761 mL	6.3522 mL	15.8806 mL
	10 mM	0.3176 mL	1.5881 mL	3.1761 mL	7.9403 mL
	15 mM	0.2117 mL	1.0587 mL	2.1174 mL	5.2935 mL
	20 mM	0.1588 mL	0.7940 mL	1.5881 mL	3.9701 mL
	25 mM	0.1270 mL	0.6352 mL	1.2704 mL	3.1761 mL
	30 mM	0.1059 mL	0.5294 mL	1.0587 mL	2.6468 mL
	40 mM	0.0794 mL	0.3970 mL	0.7940 mL	1.9851 mL
	50 mM	0.0635 mL	0.3176 mL	0.6352 mL	1.5881 mL
	60 mM	0.0529 mL	0.2647 mL	0.5294 mL	1.3234 mL
	80 mM	0.0397 mL	0.1985 mL	0.3970 mL	0.9925 mL
	100 mM	0.0318 mL	0.1588 mL	0.3176 mL	0.7940 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Dimethocaine hydrochloride Related Classifications

Neurological Disease

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Dimethocaine553-63-9LarocaineOthersnew psychoactive substanceNPSsafety testingInhibitorinhibitorinhibit

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Dimethocaine hydrochloride (Synonyms: Larocaine hydrochloride)

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Dimethocaine hydrochloride Related Antibodies

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•Related Small Molecules:

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Complete Stock Solution Preparation Table

Dimethocaine hydrochloride Related Classifications

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