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NR4A1

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By Targets:	Apoptosis (1) FXR (2) Nuclear Hormone Receptor 4A/NR4A (6) Small Interfering RNA (siRNA) (1)
By Research Areas:	Cancer (4) Inflammation/Immunology (2)
Oligonucleotides:	siRNAs (1)

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Cat. No.	Product Name	Target	Research Areas	Chemical Structure

Cytosporone B Maximum Cited Publications 9 Publications Verification Csn-B; Dothiorelone G	Nuclear Hormone Receptor 4A/NR4A	Cancer
Cytosporone B (Csn-B; Dothiorelone G) is a naturally occurring nuclear orphan receptor *Nur77/NR4A1* agonist with an EC₅₀ of 0.278 nM.

DIM-C-pPhCO2Me	Nuclear Hormone Receptor 4A/NR4A	Cancer
DIM-C-pPhCO2Me is a nuclear receptor 4A1 (NR4A1) antagonist . Antineoplastic activity .

DIM-C-pPhOH 4 Publications Verification	Nuclear Hormone Receptor 4A/NR4A Apoptosis	Cancer
DIM-C-pPhOH is a nuclear receptor 4A1 (NR4A1) antagonist. DIM-C-pPhOH inhibits cancer cell growth and mTOR signaling, induce apoptosis and cellular stress. DIM-C-pPhOH reduces cell proliferation with IC50 values of 13.6 μM and 13.0 μM for ACHN cells and 786-O cells, respectively .

Teduglutide 1 Publications Verification ALX-0600	Nuclear Hormone Receptor 4A/NR4A FXR	Inflammation/Immunology
Teduglutide (ALX-0600) is an analog of human glucagon like peptide-2 (GLP-2). Teduglutide can activate the expression of nuclear receptor subfamily 4 group a member 1 *(NR4a1)/nur77* and intestinal FXR signaling in human hepatic stellate cells, thereby improving liver inflammation and fibrosis in mice with sclerosing cholangitis. Teduglutide can alleviate intestinal dysfunction in mice, improve lung injury, alleviate obesity related neuroinflammation and cell apoptosis .

NR4A1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
NR4A1 Human Pre-designed siRNA Set A contains three designed siRNAs for NR4A1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

NR4A1 Human Pre-designed siRNA Set A NR4A1 Human Pre-designed siRNA Set A

Amoitone B	Nuclear Hormone Receptor 4A/NR4A	Cancer
Amoitone B, a derivative of cystosporone B, is an agonist of *NR4A1*. Amoitone B has anticancer activity .

Teduglutide TFA ALX-0600 TFA	Nuclear Hormone Receptor 4A/NR4A FXR	Inflammation/Immunology
Teduglutide TFA is a dipeptidyl peptidase IV resistant glucagon-like peptide 2 (GLP-2) analogue. Teduglutide TFA can activate the expression of nuclear receptor subfamily 4 group a member 1 *(NR4a1)/nur77* and intestinal FXR signaling in human hepatic stellate cells, thereby improving liver inflammation and fibrosis in mice with sclerosing cholangitis. Teduglutide TFA can alleviate intestinal dysfunction in mice, improve lung injury, alleviate obesity related neuroinflammation and cell apoptosis .

Cat. No.	Product Name	Target	Research Area

Teduglutide 1 Publications Verification ALX-0600	Nuclear Hormone Receptor 4A/NR4A FXR	Inflammation/Immunology
Teduglutide (ALX-0600) is an analog of human glucagon like peptide-2 (GLP-2). Teduglutide can activate the expression of nuclear receptor subfamily 4 group a member 1 *(NR4a1)/nur77* and intestinal FXR signaling in human hepatic stellate cells, thereby improving liver inflammation and fibrosis in mice with sclerosing cholangitis. Teduglutide can alleviate intestinal dysfunction in mice, improve lung injury, alleviate obesity related neuroinflammation and cell apoptosis .

Teduglutide TFA ALX-0600 TFA	Nuclear Hormone Receptor 4A/NR4A FXR	Inflammation/Immunology
Teduglutide TFA is a dipeptidyl peptidase IV resistant glucagon-like peptide 2 (GLP-2) analogue. Teduglutide TFA can activate the expression of nuclear receptor subfamily 4 group a member 1 *(NR4a1)/nur77* and intestinal FXR signaling in human hepatic stellate cells, thereby improving liver inflammation and fibrosis in mice with sclerosing cholangitis. Teduglutide TFA can alleviate intestinal dysfunction in mice, improve lung injury, alleviate obesity related neuroinflammation and cell apoptosis .

Cat. No.	Compare	Product Name	Application	Reactivity

	NUR77 Antibody (YA1462) NR4A1; GFRP1; HMR; NAK1; Nuclear receptor subfamily 4 group A member 1; Early response protein NAK1; Nuclear hormone receptor NUR/77; Nur77; Orphan nuclear receptor HMR; Orphan nuclear receptor TR3; ST-59; Testicular receptor 3	WB	Rat
	NUR77 Antibody (YA1462) is a biotin-conjugated non-conjugated IgG antibody, targeting NUR77, with a predicted molecular weight of 64 kDa (observed band size: 64 kDa). NUR77 Antibody (YA1462) can be used for WB experiment in rat background.

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Cat. No.	Product Name		Classification

NR4A1 Human Pre-designed siRNA Set A		siRNAs
NR4A1 Human Pre-designed siRNA Set A contains three designed siRNAs for NR4A1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

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