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Results for "

NTRK1

" in MedChemExpress (MCE) Product Catalog:

By Targets:	ROS Kinase (2) Small Interfering RNA (siRNA) (3) Trk Receptor (2)
By Research Areas:	Cancer (4)
Oligonucleotides:	Pre-designed siRNA Sets (3) siRNAs (3)

Inhibitors & Agonists

Recombinant Proteins

Antibodies

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-131003

Taletrectinib 1 Publications Verification DS-6051b; AB-106; IBI-344	ROS Kinase	Cancer
Taletrectinib (DS-6051b) is a potent, orally active, and next-generation selective *ROS1/NTRK* inhibitor. Taletrectinib potently inhibits recombinant ROS1, NTRK1, NTRK2, and NTRK3 with IC₅₀s of 0.207, 0.622, 2.28, and 0.98 nM, respectively. Taletrectinib also inhibits ROS1 G2032R and other Crizotinib-resistant ROS1 mutants ^[1] .

HY-RS09628

NTRK1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
NTRK1 Human Pre-designed siRNA Set A contains three designed siRNAs for NTRK1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

NTRK1 Human Pre-designed siRNA Set A NTRK1 Human Pre-designed siRNA Set A

HY-RS09629

Ntrk1 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Ntrk1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Ntrk1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Ntrk1 Mouse Pre-designed siRNA Set A Ntrk1 Mouse Pre-designed siRNA Set A

HY-RS09630

Ntrk1 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Ntrk1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Ntrk1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Ntrk1 Rat Pre-designed siRNA Set A Ntrk1 Rat Pre-designed siRNA Set A

HY-156086

TRK-IN-24	Trk Receptor	Cancer
TRK-IN-24 (compound 10g) is a Trk Receptor inhibitor that inhibits TRKA, TRKC, TRKA ^G595R, TRKA ^G667C and TRKA ^F589L IC₅₀s are 5.21, 4.51, 6.77, 1.42 and 6.13 nM respectively. TRK-IN-24 has antitumor efficacy in BaF3-CD74-NTRK1 ^G595R and BaF3-CD74-NTRK1 ^G667C xenograft models. TRK-IN-24 inhibits the proliferation of Ba/F3 cells transfected with single mutants such as SF, GK, and xDFG, with an IC₅₀ of 1.43-47.56 nM ^[1].

HY-144451

TRK-IN-12	Trk Receptor	Cancer
TRK-IN-12 (Compound 9e) is a potent inhibitor of TRK (TRK ^G595R IC₅₀ = 13.1 nM). TRK-IN-12 is a macrocyclic derivative compound. TRK-IN-12 shows significant antiproliferative activity in the Ba/F3-LMNA-NTRK1 cell line (IC₅₀ = 0.080 μM). TRK-IN-12 has shown a better inhibitory effect (IC₅₀ = 0.646 μM) than control agent LOXO-101 in Ba/F3-LMNA-NTRK1-G595R cell line ^[1].

HY-131003A

Taletrectinib free base DS-6051b free base; AB-106 free base; IBI-344 free base	ROS Kinase	Cancer
Taletrectinib (DS-6051b) free base is a potent, orally active, and next-generation selective *ROS1/NTRK* inhibitor. Taletrectinib free base potently inhibits recombinant ROS1, NTRK1, NTRK2, and NTRK3 with IC₅₀s of 0.207, 0.622, 2.28, and 0.98 nM, respectively. Taletrectinib free base also inhibits ROS1 G2032R and other Crizotinib-resistant ROS1 mutants ^[1] .

Species:	Human (4) Rat (2) Mouse (2) Rabbit (1) Canine (2)
Tag:	His (6) Tag Free (1) Avi (1) Flag (1) Fc (4)
Source:	HEK293 (10) Sf9 insect cells (1)

Cat. No.	Compare	Product Name	Species	Source

HY-P7308

	TrkA Protein, Human (HEK293) 1 Publications Verification rHuTrkA; NTRK1; MTC; TRK	Human	HEK293
	TrkA Protein, Human (HEK293) is the high affinity catalytic receptor for the neurotrophin, nerve growth factor (NGF), and mediates the multiple effects of NGF, which include neuronal differentiation and avoidance of programmed cell death.

HY-P73456

	TrkA Protein, Canine (HEK293, His) High affinity nerve growth factor receptor; Trk-A; NTRK1; MTC; TRK	Canine	HEK293
	TrkA Protein (isoform 3) belongs to the nerve growth factor receptor family and can promote angiogenesis and has carcinogenic activity when overexpressed. TrkA Protein (isoform 3) antagonizes the anti-proliferative NGF-NTRK1 signaling that promotes the differentiation of neuronal precursors. TrkA Protein, Canine (HEK293, His) is the recombinant canine-derived TrkA protein, expressed by HEK293 , with N-His labeled tag.

HY-P73457

	TrkA Protein, Human (HEK293, His) High affinity nerve growth factor receptor; Trk-A; NTRK1; MTC; TRK	Human	HEK293
	Pentraxin 3/TSG-14 protein is a multifunctional protein that plays a role in immune response and inflammation. It is involved in the recognition and clearance of pathogens, as well as regulation of inflammatory processes. Dysregulation of Pentraxin 3/TSG-14 protein has been associated with various diseases, including cardiovascular disorders and infections. Targeting Pentraxin 3/TSG-14 protein may hold therapeutic potential in these conditions. TrkA Protein, Human (HEK293, His) is the recombinant human-derived TrkA protein, expressed by HEK293 , with N-His labeled tag. The total length of TrkA Protein, Human (HEK293, His) is 220 a.a., with molecular weight of 35-60 kDa.

HY-P73460

	TrkA Protein, Rat (HEK293, His) High affinity nerve growth factor receptor; Trk-A; NTRK1; MTC; TRK	Rat	HEK293
	The TrkA protein is a receptor tyrosine kinase that is critical in central and peripheral nervous system development, regulating neuronal proliferation, differentiation, and survival. As a high-affinity NGF receptor, TrkA undergoes homodimerization and autophosphorylation upon ligand binding, activating downstream effectors (SHC1, FRS2, SH2B1, SH2B2, PLCG1) cascade. TrkA Protein, Rat (HEK293, His) is the recombinant rat-derived TrkA protein, expressed by HEK293 , with C-His labeled tag. The total length of TrkA Protein, Rat (HEK293, His) is 386 a.a., with molecular weight of ~70-95 kDa.

HY-P73577

	TrkA Protein, Rabbit (HEK293, His) High affinity nerve growth factor receptor; Trk-A; NTRK1; MTC; TRK	Rabbit	HEK293
	TrkA Protein, Rabbit (HEK293, His) is a nerve growth factor (NGF) receptor that belongs to the tyrosine kinase receptor family. TRKA (NTRK1) gene encodes the high affinity receptor for a neurotrophin nerve growth factor (NGF). It is critical for the correct development of many types of neurons including pain-mediating sensory neurons and also controls proliferation, differentiation and survival of many neuronal and non-neuronal cells. TrkA Protein, Rabbit (HEK293, His) is the recombinant Rabbit-derived TrkA protein, expressed by HEK293 , with C-His labeled tag.

HY-P73578

	TrkA Protein, Canine (HEK293, Fc) High affinity nerve growth factor receptor; Trk-A; NTRK1; MTC; TRK	Canine	HEK293
	TrkA Protein (isoform 3) belongs to the nerve growth factor receptor family and can promote angiogenesis and has carcinogenic activity when overexpressed. TrkA Protein (isoform 3) antagonizes the anti-proliferative NGF-NTRK1 signaling that promotes the differentiation of neuronal precursors. TrkA Protein, Canine (HEK293, Fc) is the recombinant canine-derived TrkA protein, expressed by HEK293 , with N-hFc labeled tag.

HY-P76116

	TrkA Protein, Mouse (HEK293, His) High affinity nerve growth factor receptor; Trk-A; NTRK1; MTC; TRK	Mouse	HEK293
	TrkA protein is a key receptor tyrosine kinase that guides the development and maturation of the nervous system and affects neuronal proliferation, differentiation, and survival. TrkA serves as a high-affinity receptor for NGF (its primary ligand) and also responds to NTF3/neurotropin-3. TrkA Protein, Mouse (HEK293, His) is the recombinant mouse-derived TrkA protein, expressed by HEK293 , with C-His, C-8*His labeled tag.

HY-P702762

	NTRK1/TrkA-I Protein, Human (Biotinylated, sf9, Flag, Avi) High affinity nerve growth factor receptor; Neurotrophic tyrosine kinase receptor type 1; NTRK-1; NTRK1; Slow nerve growth factor receptor; p140-TrkA; Trk-A; Trk; Trka; TRK1-transforming tyrosine kinase protein; TRKAOncogene TRK; TRKTRK1; tyrosine kinase receptor A	Human	Sf9 insect cells
	TrkA protein is an important receptor tyrosine kinase that regulates the development of the central and peripheral nervous systems and affects the proliferation, differentiation, and survival of neurons. As a high-affinity receptor for NGF, TrkA is activated upon NGF binding through homodimerization and autophosphorylation. NTRK1/TrkA-I Protein, Human (Biotinylated, sf9, Flag, Avi) is the recombinant human-derived NTRK1/TrkA-I, expressed by Sf9 insect cells , with Avi, Flag labeled tag. ,

HY-P73459

	TrkA Protein, Rat (HEK293, Fc) High affinity nerve growth factor receptor; Trk-A; NTRK1; MTC; TRK	Rat	HEK293
	The TrkA protein is a receptor tyrosine kinase that is critical in central and peripheral nervous system development, regulating neuronal proliferation, differentiation, and survival. As a high-affinity NGF receptor, TrkA undergoes homodimerization and autophosphorylation upon ligand binding, activating downstream effectors (SHC1, FRS2, SH2B1, SH2B2, PLCG1) cascade. TrkA Protein, Rat (HEK293, Fc) is the recombinant rat-derived TrkA protein, expressed by HEK293 , with C-hFc labeled tag.

HY-P76115

	TrkA Protein, Mouse (HEK293, Fc) High affinity nerve growth factor receptor; Trk-A; NTRK1; MTC; TRK	Mouse	HEK293
	TrkA protein is a key receptor tyrosine kinase that guides the development and maturation of the nervous system and affects neuronal proliferation, differentiation, and survival. TrkA serves as a high-affinity receptor for NGF (its primary ligand) and also responds to NTF3/neurotropin-3. TrkA Protein, Mouse (HEK293, Fc) is the recombinant mouse-derived TrkA protein, expressed by HEK293 , with C-hFc labeled tag.

HY-P73458

	TrkA Protein, Human (HEK293, His-Fc) High affinity nerve growth factor receptor; Trk-A; NTRK1; MTC; TRK	Human	HEK293
	TrkA protein is an important receptor tyrosine kinase that regulates the development of the central and peripheral nervous systems and affects the proliferation, differentiation, and survival of neurons. As a high-affinity receptor for NGF, TrkA is activated upon NGF binding through homodimerization and autophosphorylation. TrkA Protein, Human (HEK293, His-Fc) is the recombinant human-derived TrkA protein, expressed by HEK293 , with C-hFc, C-His labeled tag. The total length of TrkA Protein, Human (HEK293, His-Fc) is 382 a.a., with molecular weight of 85-95 kDa.

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HY-P81744

	Trk A Antibody (YA1489) NTRK1; MTC; TRK; TRKA; High affinity nerve growth factor receptor; Neurotrophic tyrosine kinase receptor type 1; TRK1-transforming tyrosine kinase protein; Tropomyosin-related kinase A; Tyrosine kinase receptor; Tyrosine kinase receptor A	WB, IHC-P, ICC/IF, IP, FC	Human, Mouse, Rat
	Trk A Antibody (YA1489) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA1489), targeting Trk A, with a predicted molecular weight of 87 kDa. Trk A Antibody (YA1489) can be used for WB, IHC-P, ICC/IF, IP, FC experiment in human, mouse, rat background.

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Size	* This product has been "discontinued". Optimized version of product available: / In-stock - + Add to Cart Get quote

NTRK1 Human Pre-designed siRNA Set A		siRNAs Pre-designed siRNA Sets
NTRK1 Human Pre-designed siRNA Set A contains three designed siRNAs for NTRK1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

Ntrk1 Mouse Pre-designed siRNA Set A		siRNAs Pre-designed siRNA Sets
Ntrk1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Ntrk1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Ntrk1 Rat Pre-designed siRNA Set A		siRNAs Pre-designed siRNA Sets
Ntrk1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Ntrk1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

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