Search Result
Results for "
Orexin Receptor
" in MedChemExpress (MCE) Product Catalog:
1
Isotope-Labeled Compounds
| Cat. No. |
Product Name |
Target |
Research Areas |
Chemical Structure |
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- HY-136922
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- HY-137093
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- HY-138695
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- HY-19320
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- HY-153458
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- HY-162977
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- HY-146517
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Orexin Receptor (OX Receptor)
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Neurological Disease
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Orexin receptor antagonist 4 is potent and selective orexin 2 receptor (OX2R) antagonist with an IC50 of 4.27 nM. Orexin receptor antagonist 4 is 61-fold selective for the OX2R over the OX1R (IC50 of 295 nM) (WO2018206959A1; example 1) .
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- HY-P10079
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- HY-P10080
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- HY-113555
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- HY-133898
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TAK-925
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Orexin Receptor (OX Receptor)
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Others
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Danavorexton (TAK-925) is an orexin receptor agonist with brain permeability. Danavorexton induces a physiological pattern of OX2R activation in vitro to wake up sleepy mice and improve sleepiness symptoms .
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- HY-163276
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- HY-108683
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Orexin Receptor (OX Receptor)
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Neurological Disease
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ACT-335827 is a selective, orally active, brain-penetrant orexin type 1 receptor antagonist. ACT-33582 acts on OXR1 and OXR2 with IC50 values of 6 nM and 417 nM, respectively. ACT-33582 can be used in studies related to neurological disorders .
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- HY-106224B
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Hypocretin-1 (human, rat, mouse) (acetate)
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Orexin Receptor (OX Receptor)
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Neurological Disease
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Orexin A (Hypocretin-1) (human, rat, mouse) acetate is a hypothalamic neuropeptide with analgesic properties (crosses the blood-brain barrier). Orexin A (human, rat, mouse) acetate binds and activates two types of G protein-coupled receptors, the orexin-1 receptor (OX1R) and the orexin-2 receptor (OX2R). Orexin A (human, rat, mouse) acetate can be used in studies of appetite regulation, neurodegenerative diseases and modulation of injurious messaging .
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- HY-106224
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Hypocretin-1 (human, rat, mouse)
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Orexin Receptor (OX Receptor)
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Neurological Disease
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Orexin A (human, rat, mouse) (Hypocretin-1 (human, rat, mouse)), a 33 amino acid excitatory neuropeptide, orchestrates diverse central and peripheral processes. Orexin A (human, rat, mouse) binds and activates two types of G protein-coupled receptors, the orexin-1 receptor (OX1R) and the orexin-2 receptor (OX2R). Orexin A (human, rat, mouse) has a role in the regulation of feeding behavior. Orexin A (human, rat, mouse) is an effective anti-nociceptive and anti-hyperalgesic agent in mice and rats .
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- HY-106224A
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Hypocretin-1 (human, rat, mouse) (TFA)
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Orexin Receptor (OX Receptor)
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Neurological Disease
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Orexin A (human, rat, mouse) (Hypocretin-1 (human, rat, mouse)) TFA, a 33 amino acid excitatory neuropeptide, orchestrates diverse central and peripheral processes. Orexin A (human, rat, mouse) TFA binds and activates two types of G protein-coupled receptors, the orexin-1 receptor (OX1R) and the orexin-2 receptor (OX2R). Orexin A (human, rat, mouse) TFA has a role in the regulation of feeding behavior. Orexin A (human, rat, mouse) TFA is an effective anti-nociceptive and anti-hyperalgesic agent in mice and rats .
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- HY-P1349
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- HY-P1339B
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Human Orexin B acetate
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Orexin Receptor (OX Receptor)
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Cardiovascular Disease
Neurological Disease
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Orexin B, human acetate is the acetate form of Orexin B, human (HY-P1339). Orexin B, human acetate is the agonist for Orexin Receptor, with Ki of 420 nM and 36 nM for OX1 and OX2. Orexin B, human acetate participates in the regulation of appetite, wakefulness, cardiovascular function and neuroendocrine .
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- HY-P1339
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- HY-101834
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Orexin Receptor (OX Receptor)
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Others
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ACT-462206 is an orally active and potent dual Orexin 1/Orexin 2 receptor antagonist with IC50s of 60 nM (Orexin 1) and 11 nM (Orexin 2), respectively. ACT-462206 exhibits brain penetration properties, and can be used for insomnia, stress/anxiety-related disorders and addiction research .
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- HY-P1339A
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- HY-123737
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- HY-P1349A
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Rat Orexin B TFA; Orexin B (mouse) TFA
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Orexin Receptor (OX Receptor)
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Neurological Disease
Endocrinology
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Orexin B, rat, mouse (Rat orexin B) TFA is an endogenous orexin receptor agonist. Orexin B, rat, mouse TFA binds and activates two closely related orphan G protein-coupled receptors OX1-R and OX2-R. Orexin B, rat, mouse TFA stimulates food intake and energy expenditure and plays a significant role in sleep-wakefulness regulation .
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- HY-P1340
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Orexin Receptor (OX Receptor)
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Neurological Disease
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[Ala11,D-Leu15]-Orexin B(human) is a potent and selective orexin-2 receptor (OX2) agonist. [Ala11,D-Leu15]-Orexin B(human) shows a 400-fold selectivity for the OX2 (EC50=0.13 nM) over OX1 (52 nM) .
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![[Ala11,D-Leu15]-Orexin B(human)](//file.medchemexpress.eu/product_pic/hy-p1340.gif)
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- HY-10805S
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- HY-P1340A
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Orexin Receptor (OX Receptor)
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Neurological Disease
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[Ala11,D-Leu15]-Orexin B(human) TFA is a potent and selective orexin-2 receptor (OX2) agonist. [Ala11,D-Leu15]-Orexin B(human) TFA shows a 400-fold selectivity for the OX2 (EC50=0.13 nM) over OX1 (52 nM) .
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![[Ala11,D-Leu15]-Orexin B(human) TFA](//file.medchemexpress.eu/product_pic/hy-p1340a.gif)
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- HY-147294
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- HY-101534
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- HY-172436
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- HY-172412
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ALKS 2680
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Orexin Receptor (OX Receptor)
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Metabolic Disease
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Alixorexton (ALKS 2680) is the orally active, selective agonist for orexin-2 receptor and can be used for obesity and hypersomnias research. Alixorexton can cross blood-brain barrier .
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- HY-159835
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- HY-154789
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- HY-P1341
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Orexin A (17-33) (human, mouse, rat, bovine)
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Orexin Receptor (OX Receptor)
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Neurological Disease
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OXA(17-33) is a potent and selective orexin-1 receptor (OX1) agonist. OXA(17-33) shows a ∼23-fold selectivity for the OX1 (EC50=8.29 nM) over OX2 (187 nM) .
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- HY-137452A
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- HY-P3867
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- HY-152843
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- HY-12301
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- HY-10805A
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ACT 078573 hydrochloride
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Orexin Receptor (OX Receptor)
Calcium Channel
Caspase
Apoptosis
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Neurological Disease
Endocrinology
Cancer
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Almorexant (ACT 078573) hydrochloride is an orally active, potent and competitive dual orexin receptor antagonist, with Kd values of 1.3 nM (OX1) and 0.17 nM (OX2), respectively. Almorexant hydrochloride reversibly blocks signaling of orexin-A and orexin-B peptides. Almorexant hydrochloride totally blocked the intracellular Ca 2+ signal pathway. Almorexant hydrochloride stimulates caspase-3 activity in AsPC-1 cells and induces apoptosis .
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- HY-10805
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ACT 078573
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Orexin Receptor (OX Receptor)
Calcium Channel
Caspase
Apoptosis
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Neurological Disease
Endocrinology
Cancer
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Almorexant (ACT 078573) is an orally active, potent and competitive dual orexin receptor antagonist, with Kd values of 1.3 nM (OX1) and 0.17 nM (OX2), respectively. Almorexant reversibly blocks signaling of orexin-A and orexin-B peptides. Almorexant totally blocked the intracellular Ca 2+ signal pathway. Almorexant stimulates caspase-3 activity in AsPC-1 cells and induces apoptosis .
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- HY-P1341A
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Orexin A (17-33) (human, mouse, rat, bovine) TFA
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Orexin Receptor (OX Receptor)
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Neurological Disease
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OXA(17-33) TFA is a potent and selective orexin-1 receptor (OX1) agonist. OXA(17-33) TFA shows a ∼23-fold selectivity for the OX1 (EC50=8.29 nM) over OX2 (187 nM) .
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- HY-P99911
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- HY-137452
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- HY-10806
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- HY-100452A
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OX2R antagonist
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Orexin Receptor (OX Receptor)
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Endocrinology
Cancer
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TCS-OX2-29 (hydrochloride) is a potent, high affinities and selective orexin-2 receptor (OX2R) antagonist with an IC50 value of 40 nM and a pKI value of 7.5. TCS-OX2-29 displays ~250-fold selectivity for OX2 over OX1 .
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- HY-100452
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Orexin Receptor (OX Receptor)
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Endocrinology
Cancer
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TCS-OX2-29 is a potent, high affinities and selective orexin-2 receptor (OX2R) antagonist with an IC50 value of 40 nM and a pKI value of 7.5. TCS-OX2-29 displays ~250-fold selectivity for OX2 over OX1 .
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- HY-109012
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JNJ-42847922
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Orexin Receptor (OX Receptor)
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Neurological Disease
Endocrinology
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Seltorexant (JNJ-42847922) is an orally active, high-affinity, and selective orexin-2 receptor (OX2R) antagonist (pKi values of 8.0 and 8.1 for human and rat OX2R). Seltorexant (JNJ-42847922) crosses the blood-brain barrier and quickly occupies OX2R binding sites in the rat brain .
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- HY-10900
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- HY-76612
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- HY-161567
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- HY-134188
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Orexin Receptor (OX Receptor)
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Neurological Disease
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JNJ-54717793, as a brain penetrant, is an orally active, selective and high affinity orexin-1 receptor (OX1R) antagonist (plasma EC50=85 ng/mL). The Ki values of JNJ-54717793 for hOX1R (human OX1R) and hOX2R are 16 nM and 700 nM, respectively. JNJ-54717793 is a potent compound of anxiety disorders .
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- HY-10898
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- HY-137440A
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TAK-994
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Orexin Receptor (OX Receptor)
ERK
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Neurological Disease
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Firazorexton hydrate (TAK-994) is an orally active and brain-penetrant orexin type 2 receptor (OX2R) selective agonist. Firazorexton hydrate can promote wakefulness and has the potential to improve narcolepsy-like symptoms in mice .
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- HY-10896
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- HY-162235
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Orexin Receptor (OX Receptor)
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Cardiovascular Disease
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CVN766 is an orally active inhibitor of orexin 1 receptor antagonist with blood-brain permeability with the IC50 values of 8 nM and >10 μM for OX1R and OX2R, respectively. CVN766 can be used for study schizophrenia .
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- HY-108682
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EMPA
Maximum Cited Publications
8 Publications Verification
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Orexin Receptor (OX Receptor)
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Neurological Disease
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EMPA is a high-affinity, reversible and selective orexin OX2 receptor antagonist. [ 3H]EMPA binds to human and rat OX2-HEK293 membranes with KD values of 1.1 and 1.4 nM respectively .
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- HY-149014
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Orexin Receptor (OX Receptor)
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Neurological Disease
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OX2R-IN-1 (compound 15) is a low cytotoxicity profile OX2R-IN-1 antagonist (a potential OX2R binder) with an IC50 value of 484 μM. OX2R-IN-1 (compound 15) can cross the BBB into the brain with a short half-life .
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- HY-10895
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SB 334867A
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Orexin Receptor (OX Receptor)
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Neurological Disease
Endocrinology
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SB-334867 (SB 334867A) is an excellent,selective and blood–brain barrier permeable orexin-1 (OX1) receptor antagonist, shows selectivity over OX2 (pKb=7.4), 100-fold over 5-HT2B, 5-HT2C with pKi values of 5.4 and 5.3, respectively . SB-334867 reduces ethanol consumption and inhibits the acquisition of morphine-induced sensitization to locomotor activity in vivo .
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- HY-137440
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TAK-994 free base
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Orexin Receptor (OX Receptor)
ERK
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Neurological Disease
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Firazorexton (TAK-994 free base) is an orally active and brain-penetrant orexin type 2 receptor (OX2R) selective agonist. Firazorexton (TAK-994 free base) can promote wakefulness and has the potential to improve narcolepsy-like symptoms in mice .
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- HY-10895A
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SB334867A free base
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Orexin Receptor (OX Receptor)
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Neurological Disease
Endocrinology
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SB-334867 free base (SB334867A free base) is an excellent, selective and blood–brain barrier permeable orexin-1 (OX1) receptor antagonist, shows selectivity over OX2 (pKb=7.4), 100-fold over 5-HT2B, 5-HT2C with pKi values of 5.4 and 5.3, respectively . SB-334867 reduces ethanol consumption and inhibits the acquisition of morphine-induced sensitization to locomotor activity in vivo .
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- HY-136181A
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Orexin Receptor (OX Receptor)
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Neurological Disease
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YNT-185 is a nonpeptide, selective orexin type-2 receptor (OX2R) agonist, with EC50s of 0.028 and 2.75 μM for OX2R and OX1R, respectively. YNT-185 ameliorates narcolepsy-cataplexy symptoms in mouse models .
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- HY-136181
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Orexin Receptor (OX Receptor)
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Neurological Disease
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YNT-185 dihydrochloride is a nonpeptide, selective orexin type-2 receptor (OX2R) agonist, with EC50s of 0.028 and 2.75 μM for OX2R and OX1R, respectively. YNT-185 dihydrochloride ameliorates narcolepsy-cataplexy symptoms in mouse models .
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- HY-114761
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Prostaglandin Receptor
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Cardiovascular Disease
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Prostaglandin F2α dimethyl amine is a Prostaglandin F2α (HY-12956) derivative. Prostaglandin F2α dimethyl amine is an antagonist for Prostaglandin F receptor (FP) . Prostaglandin F2α dimethyl amine blocks the cardiovascular responses induced by orexin and Arachidonic acid (HY-109590) .
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- HY-137440B
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(2R,3R)-TAK-994 free base
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Orexin Receptor (OX Receptor)
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Neurological Disease
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(2R,3R)-Firazorexton ((2R,3R)-TAK-994 free base) is an isomer of Firazorexton (HY-137440). Firazorexton is an orally active, brain-penetrating orexin type 2 receptor (OX2R) agonist that may improve narcolepsy-like symptoms ..
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| Cat. No. |
Product Name |
Target |
Research Area |
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- HY-106224B
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Hypocretin-1 (human, rat, mouse) (acetate)
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Orexin Receptor (OX Receptor)
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Neurological Disease
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Orexin A (Hypocretin-1) (human, rat, mouse) acetate is a hypothalamic neuropeptide with analgesic properties (crosses the blood-brain barrier). Orexin A (human, rat, mouse) acetate binds and activates two types of G protein-coupled receptors, the orexin-1 receptor (OX1R) and the orexin-2 receptor (OX2R). Orexin A (human, rat, mouse) acetate can be used in studies of appetite regulation, neurodegenerative diseases and modulation of injurious messaging .
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- HY-106224
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Hypocretin-1 (human, rat, mouse)
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Orexin Receptor (OX Receptor)
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Neurological Disease
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Orexin A (human, rat, mouse) (Hypocretin-1 (human, rat, mouse)), a 33 amino acid excitatory neuropeptide, orchestrates diverse central and peripheral processes. Orexin A (human, rat, mouse) binds and activates two types of G protein-coupled receptors, the orexin-1 receptor (OX1R) and the orexin-2 receptor (OX2R). Orexin A (human, rat, mouse) has a role in the regulation of feeding behavior. Orexin A (human, rat, mouse) is an effective anti-nociceptive and anti-hyperalgesic agent in mice and rats .
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- HY-106224A
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Hypocretin-1 (human, rat, mouse) (TFA)
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Orexin Receptor (OX Receptor)
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Neurological Disease
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Orexin A (human, rat, mouse) (Hypocretin-1 (human, rat, mouse)) TFA, a 33 amino acid excitatory neuropeptide, orchestrates diverse central and peripheral processes. Orexin A (human, rat, mouse) TFA binds and activates two types of G protein-coupled receptors, the orexin-1 receptor (OX1R) and the orexin-2 receptor (OX2R). Orexin A (human, rat, mouse) TFA has a role in the regulation of feeding behavior. Orexin A (human, rat, mouse) TFA is an effective anti-nociceptive and anti-hyperalgesic agent in mice and rats .
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- HY-P1349
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- HY-P1339B
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Human Orexin B acetate
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Orexin Receptor (OX Receptor)
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Cardiovascular Disease
Neurological Disease
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Orexin B, human acetate is the acetate form of Orexin B, human (HY-P1339). Orexin B, human acetate is the agonist for Orexin Receptor, with Ki of 420 nM and 36 nM for OX1 and OX2. Orexin B, human acetate participates in the regulation of appetite, wakefulness, cardiovascular function and neuroendocrine .
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- HY-P1339A
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- HY-P1349A
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Rat Orexin B TFA; Orexin B (mouse) TFA
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Orexin Receptor (OX Receptor)
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Neurological Disease
Endocrinology
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Orexin B, rat, mouse (Rat orexin B) TFA is an endogenous orexin receptor agonist. Orexin B, rat, mouse TFA binds and activates two closely related orphan G protein-coupled receptors OX1-R and OX2-R. Orexin B, rat, mouse TFA stimulates food intake and energy expenditure and plays a significant role in sleep-wakefulness regulation .
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- HY-P10079
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- HY-P10080
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- HY-P1339
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- HY-P1340
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Orexin Receptor (OX Receptor)
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Neurological Disease
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[Ala11,D-Leu15]-Orexin B(human) is a potent and selective orexin-2 receptor (OX2) agonist. [Ala11,D-Leu15]-Orexin B(human) shows a 400-fold selectivity for the OX2 (EC50=0.13 nM) over OX1 (52 nM) .
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- HY-P1340A
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Orexin Receptor (OX Receptor)
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Neurological Disease
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[Ala11,D-Leu15]-Orexin B(human) TFA is a potent and selective orexin-2 receptor (OX2) agonist. [Ala11,D-Leu15]-Orexin B(human) TFA shows a 400-fold selectivity for the OX2 (EC50=0.13 nM) over OX1 (52 nM) .
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- HY-P1341
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Orexin A (17-33) (human, mouse, rat, bovine)
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Orexin Receptor (OX Receptor)
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Neurological Disease
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OXA(17-33) is a potent and selective orexin-1 receptor (OX1) agonist. OXA(17-33) shows a ∼23-fold selectivity for the OX1 (EC50=8.29 nM) over OX2 (187 nM) .
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- HY-P3867
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- HY-P1341A
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Orexin A (17-33) (human, mouse, rat, bovine) TFA
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Orexin Receptor (OX Receptor)
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Neurological Disease
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OXA(17-33) TFA is a potent and selective orexin-1 receptor (OX1) agonist. OXA(17-33) TFA shows a ∼23-fold selectivity for the OX1 (EC50=8.29 nM) over OX2 (187 nM) .
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- HY-10805S
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Almorexant- 13C,d3 is the 13C- and deuterium labeled Almorexant. Almorexant (ACT 078573) is a potent and competitive dual orexin 1 receptor (OX1)/orexin 2 receptor (OX2) antagonist with Ki values of 1.3 and 0.17 nM, respectively.
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![[Ala11,D-Leu15]-Orexin B(human)](http://file.medchemexpress.eu/product_pic/hy-p1340.gif)
![[Ala11,D-Leu15]-Orexin B(human) TFA](http://file.medchemexpress.eu/product_pic/hy-p1340a.gif)
