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Results for "

PIP2

" in MedChemExpress (MCE) Product Catalog:

12

Inhibitors & Agonists

3

Peptides

1

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Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-150135B
    D-myo-Inositol 1,4,5-trisphosphate tripotassium
    1 Publications Verification

    Inositol 1,4,5-trisphosphate tripotassium; Ins(1,4,5)-P3 tripotassium

    		 Calcium Channel Neurological Disease
    D-myo-Inositol 1,4,5-trisphosphate tripotassium, a second messenger, elicits Ca 2+ mobilization. D-myo-Inositol 1,4,5-trisphosphate tripotassium inhibits the binding of phosphoinositide-specific phospholipase C-delta 1 (PLC-delta 1) to bilayer membranes composed of phosphatidylcholine (PC) and phosphatidylinositol 4,5-bisphosphate (PIP2) .
    D-myo-Inositol 1,4,5-trisphosphate tripotassium
  • HY-P1045
    187-1, N-WASP inhibitor
    1 Publications Verification

    		 Arp2/3 Complex Others
    187-1, N-WASP inhibitor, a 14-aa cyclic peptide, is an allosteric neural Wiskott-Aldrich syndrome protein (N-WASP) inhibitor. 187-1, N-WASP inhibitor potently inhibits actin assembly induced by phosphatidylinositol 4,5-bisphosphate (PIP2) with an IC50 of 2 μM. 187-1, N-WASP inhibitor prevents the activation of Arp2/3 complex by N-WASP by stabilizing the autoinhibited state of the protein [2].
    187-1, N-WASP inhibitor
  • HY-101562
    Inavolisib
    4 Publications Verification

    GDC-0077; RG6114

    		 PI3K Apoptosis Cancer
    Inavolisib (GDC-0077) is a potent, orally active, and selective PI3Kα inhibitor (IC50=0.038 nM). Inavolisib exerts its activity by binding to the ATP binding site of PI3K, thereby inhibiting the phosphorylation of PIP2 to PIP3. Inavolisib is more selective for mutant versus wild-type PI3Kα. Inavolisib can be used for the study of breast cancer .
    Inavolisib
  • HY-130344
    SKF 83959
    1 Publications Verification

    		 Dopamine Receptor Sigma Receptor Neurological Disease
    SKF83959 is a potent and selective dopamine D1-like receptor partial agonist. SKF83959 Ki values for rat D1, D5, D2 and D3 receptors are 1.18, 7.56, 920 and 399 nM, respectively. SKF83959 is a potent allosteric modulator of sigma (σ)-1 receptor. SKF83959 belongs to benzazepine family and has improvements on cognitive dysfunction. SKF83959 can be used for the research of Alzheimer's disease and depression [2] .
    SKF 83959
  • HY-103412
    SKF 83959 hydrobromide
    1 Publications Verification

    		 Dopamine Receptor Sigma Receptor Neurological Disease
    SKF83959 hydrobromide is a potent and selective dopamine D1-like receptor partial agonist. SKF83959 hydrobromide Ki values for rat D1, D5, D2 and D3 receptors are 1.18, 7.56, 920 and 399 nM, respectively. SKF83959 hydrobromide is a potent allosteric modulator of sigma (σ)-1 receptor. SKF83959 hydrobromide belongs to benzazepine family and has improvements on cognitive dysfunction. SKF83959 hydrobromide can be used for the research of Alzheimer's disease and depression [2] .
    SKF 83959 hydrobromide
  • HY-P1045A
    187-1, N-WASP inhibitor TFA

    		Arp2/3 Complex Others
    187-1, N-WASP inhibitor TFA, a 14-aa cyclic peptide, is an allosteric neural Wiskott-Aldrich syndrome protein (N-WASP) inhibitor. 187-1, N-WASP inhibitor TFA potently inhibits actin assembly induced by phosphatidylinositol 4,5-bisphosphate (PIP2) with an IC50 of 2 μM. 187-1, N-WASP inhibitor TFA prevents the activation of Arp2/3 complex by N-WASP by stabilizing the autoinhibited state of the protein [2].
    187-1, N-WASP inhibitor TFA
  • HY-163735
    BA6b9

    		Potassium Channel Cardiovascular Disease
    BA6b9 is an allosteric inhibitor of SK4 channels that targets the CaM–PIP2-binding domain with a IC50 value of 8.6 µM (WT SK4). BA6b9 inhibits SK4 channels by interacting with two specific residues, Arg191 and His192 in the S4–S5 linker. BA6b9 significantly prolongs atrial and atrioventricular effective refractory period (ERP) and reduces atrial fibrillation (AF) induction in rat isolated hearts, which has the potential to be used for the research of arrhythmia .
    BA6b9
  • HY-159617
    Cbz-Pip-2C-Pip-C-Pip

    		PROTAC Linkers Cancer
    Cbz-Pip-2C-Pip-C-Pip is a PROTAC linker. Cbz-Pip-2C-Pip-C-Pip can be used for synthesis PROTAC Cbl-b-IN-1 (HY-159608) .
    Cbz-Pip-2C-Pip-C-Pip
  • HY-159618
    (3S)Lenalidomide-5-Pip-C-Pip-2C-Pip

    		E3 Ligase Ligand-Linker Conjugates Cancer
    (3S)Lenalidomide-5-Pip-C-Pip-2C-Pip is an E3 Ligase Ligand-Linker Conjugate. (3S)Lenalidomide-5-Pip-C-Pip-2C-Pip can be used to synthesize PROTAC Cbl-b-IN-1 (HY-159608) .
    (3S)Lenalidomide-5-Pip-C-Pip-2C-Pip
  • HY-159608
    PROTAC Cbl-b-IN-1

    		PROTACs Cancer
    PROTAC Cbl-b-IN-1 (compound 64) is a PROTAC targeting Cbl-b. PROTAC Cbl-b-IN-1 is composed of PROTAC target protein ligand Cbl-b-IN-21 (HY-159615), PROTAC Linker Cbz-Pip-2C-Pip-C-Pip (HY-159617) and E3 ubiquitin ligase ligand (3S) Lenalidomide-5-Br (HY-W797329), where the E3 ubiquitin ligase ligand + Linker conjugate is (3S) Lenalidomide-5-Pip-C-Pip-2C-Pip (HY-159618) [1] .
    PROTAC Cbl-b-IN-1
  • HY-110150
    UNC3230
    Maximum Cited Publications
    6 Publications Verification

    		 Others Inflammation/Immunology Cancer
    UNC3230 is a potent, selective and ATP-competitive PIP5K1C inhibitor with an IC50 of ~41 nM. UNC3230 also inhibits PIP4K2C and does not inhibit any of the other lipid kinases that regulate phosphoinositide levels. UNC3230 has antinociceptive and anticancer effects .
    UNC3230
  • HY-131445
    RJW100
    1 Publications Verification

    		 MicroRNA Endocrinology Cancer
    RJW100 is a potent liver receptor homolog 1 (LRH-1, NR5A2) and steroidogenic factor-1 (SF-1, NR5A1) agonist with pEC50s of 6.6 and 7.5, respectively . RJW100 also causes strong activation of the miR-200c (miRNA-200c, microRNA-200c) promoter [2].
    RJW100

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