2. GPCR/G Protein Neuronal Signaling
  3. Dopamine Receptor Sigma Receptor
  4. SKF 83959

SKF83959 is a potent and selective dopamine D1-like receptor partial agonist. SKF83959 Ki values for rat D1, D5, D2 and D3 receptors are 1.18, 7.56, 920 and 399 nM, respectively. SKF83959 is a potent allosteric modulator of sigma (σ)-1 receptor. SKF83959 belongs to benzazepine family and has improvements on cognitive dysfunction. SKF83959 can be used for the research of Alzheimer's disease and depression.

For research use only. We do not sell to patients.

SKF 83959 Chemical Structure

SKF 83959 Chemical Structure

CAS No. : 80751-85-5

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Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 275 In-stock
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10 mM * 1 mL in DMSO USD 275 In-stock
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10 mg USD 400 In-stock
25 mg USD 800 In-stock
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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of SKF 83959:

SKF 83959 Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE SKF 83959

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Dopamine Receptor D1 Receptor D2 Receptor D3 Receptor D4 Receptor D5 Receptor

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Sigma 1 Receptor Sigma 2 Receptor

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

SKF83959 is a potent and selective dopamine D1-like receptor partial agonist. SKF83959 Ki values for rat D1, D5, D2 and D3 receptors are 1.18, 7.56, 920 and 399 nM, respectively. SKF83959 is a potent allosteric modulator of sigma (σ)-1 receptor. SKF83959 belongs to benzazepine family and has improvements on cognitive dysfunction. SKF83959 can be used for the research of Alzheimer's disease and depression[1][2][3][4].

IC50 & Target[3][4]

D1 Receptor

1.18 nM (Ki)

Sigma 1 Receptor

 

D5 Receptor

7.56 nM (Ki)

D2 Receptor

920 nM (Ki)

D3 Receptor

399 nM (Ki)

In Vitro

SKF83959 (10~250 μM) stimulates PIP2 hydrolysis in membranes. SKF83959 (0.1~10 μM; PC12 cell) changes the EC50 value of SKF81297 from 0.5 nM in control tissue to 31.6 nM, 251.2 nM and 631.0 nM[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

SKF 83959 Related Antibodies
In Vivo

SKF83959 (0.5 and 1 mg/kg; i.p.; 1 hour) reverses the scopolamine-induced cognitive impairments in the passive avoidance task and Y-Maze test[1].
SKF83959 (1 mg/kg; i.p.; 30 minutes) induced memory enhancing effects are prevented by brain-derived neurotrophic factor system blockade[1].
SKF83959 has anti-amnesic activities and restores the scopolamine-decreased BDNF signaling pathway in the hippocampus in mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male ICR male mice (8 weeks)[1]
Dosage: 0.5 and 1 mg/kg
Administration: I.p.; 1 hour
Result: Reversed the scopolamine-induced cognitive impairments in the passive avoidance task and Y-Maze test.
Animal Model: Male ICR male mice (8 weeks)[1]
Dosage: 1 mg/kg
Administration: I.p.; 30 minutes
Result: The memory enhancing effects were prevented by BDNF system blockade.
Molecular Weight

317.81

Formula

C18H20ClNO2
CAS No.
Appearance

Solid

Color

White to light yellow

SMILES

OC1=C(O)C=C2C(C3=CC=CC(C)=C3)CN(C)CCC2=C1Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (314.65 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.1465 mL 15.7327 mL 31.4653 mL
5 mM 0.6293 mL 3.1465 mL 6.2931 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.1465 mL 15.7327 mL 31.4653 mL 78.6634 mL
5 mM 0.6293 mL 3.1465 mL 6.2931 mL 15.7327 mL
10 mM 0.3147 mL 1.5733 mL 3.1465 mL 7.8663 mL
15 mM 0.2098 mL 1.0488 mL 2.0977 mL 5.2442 mL
20 mM 0.1573 mL 0.7866 mL 1.5733 mL 3.9332 mL
25 mM 0.1259 mL 0.6293 mL 1.2586 mL 3.1465 mL
30 mM 0.1049 mL 0.5244 mL 1.0488 mL 2.6221 mL
40 mM 0.0787 mL 0.3933 mL 0.7866 mL 1.9666 mL
50 mM 0.0629 mL 0.3147 mL 0.6293 mL 1.5733 mL
60 mM 0.0524 mL 0.2622 mL 0.5244 mL 1.3111 mL
80 mM 0.0393 mL 0.1967 mL 0.3933 mL 0.9833 mL
100 mM 0.0315 mL 0.1573 mL 0.3147 mL 0.7866 mL
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SKF 83959 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SKF 8395980751-85-5SKF83959SKF-83959Dopamine ReceptorSigma ReceptorPC12PIP2hydrolysisdopaminebenzazepinecognitivedysfunctionAlzheimerInhibitorinhibitorinhibit

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