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Results for "

PKM2

" in MedChemExpress (MCE) Product Catalog:

By Targets:	AIM2 (2) Akt (1) Aldehyde Dehydrogenase (ALDH) (1) Apoptosis (9) Autophagy (1) Bacterial (4) Chloride Channel (2) COX (1) Cytochrome P450 (1) DNA/RNA Synthesis (2) EGFR (1) Endogenous Metabolite (2) Fluorescent Dye (1) Fungal (5) HIF/HIF Prolyl-Hydroxylase (1) HIV (2) Influenza Virus (2) Insecticide (1) Interleukin Related (1) JAK (1) NF-κB (2) NO Synthase (1) Parasite (2) PDK-1 (2) Pyruvate Kinase (32) Reactive Oxygen Species (1) STAT (1) TNF Receptor (3)
By Research Areas:	Cancer (30) Cardiovascular Disease (2) Infection (5) Inflammation/Immunology (3) Metabolic Disease (5) Neurological Disease (2)

By Targets:

AIM2 (2)

Akt (1)

Aldehyde Dehydrogenase (ALDH) (1)

Apoptosis (9)

Autophagy (1)

Bacterial (4)

Chloride Channel (2)

COX (1)

Cytochrome P450 (1)

DNA/RNA Synthesis (2)

EGFR (1)

Endogenous Metabolite (2)

Fluorescent Dye (1)

Fungal (5)

HIF/HIF Prolyl-Hydroxylase (1)

HIV (2)

Influenza Virus (2)

Insecticide (1)

Interleukin Related (1)

JAK (1)

NF-κB (2)

NO Synthase (1)

Parasite (2)

PDK-1 (2)

Pyruvate Kinase (32)

Reactive Oxygen Species (1)

STAT (1)

TNF Receptor (3)

By Research Areas:

Cancer (30)

Cardiovascular Disease (2)

Infection (5)

Inflammation/Immunology (3)

Metabolic Disease (5)

Neurological Disease (2)

Inhibitors & Agonists

Fluorescent Dye

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-148324

PKM2 activator 5	Pyruvate Kinase	Cancer
PKM2 activator 5 (compound 8) is a *PKM2* activator with an AC₅₀ value of 0.316 µM. PKM2 activator 5 has the potential to alter the aberrant metabolism of cancer cells .

HY-147368

PKM2 activator 2	Pyruvate Kinase	Cancer
PKM2 activator 2 (compound 28) is a pyruvate kinase M2 (PKM2) activitor with an AC₅₀ value of 66 nM. PKM2 activator 2 can restore normal glycolytic metabolism in cells .

HY-157913

PKM2-IN-6	Pyruvate Kinase Apoptosis	Cancer
PKM2-IN-6 (compound 7d) is a potent and orally active *PKM2* inhibitor with an IC₅₀ value of 23 nM. PKM2-IN-6 induces apoptosis and cell cycle arrest at G2 phase. PKM2-IN-6 reduces the level of PKM1 and PKM2 at the mRNA level. PKM2-IN-6 shows anticancer activity and has the potential for the research of triple-negative breast cancer .

HY-139667

PKM2-IN-3	Pyruvate Kinase	Neurological Disease
PKM2-IN-3 is an inhibitor of PKM2 kinase with an IC₅₀ value of 4.1 μM. PKM2-IN-3 exhibits an anti-neuroinflammatory effect by inhibiting PKM2-mediated glycolysis and NLRP3 activation .

HY-155216

PKM2 activator 10	Others	Cancer
PKM2 activator 10 (Compd I) is a *PKM2* activator with anti-tumor activity. PKM2 activator 10 can be utilized in cancer research .

HY-147397

PKM2 activator 3	Pyruvate Kinase	Cancer
PKM2 activator 3 is a potent *PKM2* activator with an AC₅₀ value of 90 nM. PKM2 activator 3 has good Caco-2 permeability, a low efflux ratio and high microsomal stability. PKM2 activator 3 can be used for researching anticancer . ^{(AC₅₀: the concentration which gives 50% activation of enzyme.)}

HY-148313

PKM2 activator 4	Pyruvate Kinase	Cancer
PKM2 activator 4 is a *PKM2* activator with an AC₅₀ value of 1-10 μM. PKM2 activator 4 can be used for the research of cancer .

HY-156375

PKM2 activator 6	Pyruvate Kinase PDK-1	Cancer
PKM2 activator 6 (Compound Z10) is a *PKM2* activator and PDK1 inhibitor (K_D: 121 and 19.6 μM respectively). PKM2 activator 6 induces colorectal cell apoptosis, and inhibits cell proliferation and migration . PKM2 activator 6 inhibits glycolysis. PKM2 activator 6 inhibits proliferation of DLD-1, HCT-8, HT-29, MCF-10A cells (IC₅₀: 10.04, 2.16, 3.57, 66.39 μM) .

HY-161519

PKM2 activator 7	Pyruvate Kinase	Inflammation/Immunology
PKM2 activator 7 (Compd B4) is a *PKM2* activator with the AC₅₀ of 0.144 μM. PKM2 activator 7 suppresses DSS (HY-116282C)-induced colitis by inhibiting T cell growth in mouse colitis model .

HY-132215

PF-06284674 PKM2 activator 1	Pyruvate Kinase	Cancer
PF-06284674 (PKM2 activator 1) (Compound 8) is a *PKM2* activator that can be used in cancer research .

HY-170577

PKM2-IN-8	Pyruvate Kinase Apoptosis	Cancer
PKM2-IN-8 (Compound 9b) is a pyruvate kinase M2 (PKM2) inhibitor (IC₅₀ = 0.31 μM). PKM2-IN-8 has potent antiproliferative activity against U87MG glioma cells. PKM2-IN-8 can induce early apoptosis and reduce lactate levels. PKM2-IN-8 can be used for the research of glioblastoma .

HY-169883

PKM2-IN-7	Pyruvate Kinase Aldehyde Dehydrogenase (ALDH)	Cancer
PKM2-IN-7 (compound 34) can inhibit the interaction between *PKM2* and ALDH1A3 without showing significant toxicity to normal cells. PKM2-IN-7 can be used for research in the field of tumors .

HY-162071

PKM2-IN-5	Pyruvate Kinase	Cancer
PKM2-IN-5 (Compound G1) is an inhibitor for pyruvate kinase M2 (PKM2), with IC₅₀ >70 μM .

HY-103617

PKM2-IN-1 15+ Cited Publications	Pyruvate Kinase	Cancer
PKM2-IN-1 (compound 3k) is a pyruvate kinase M2 (PKM2) inhibitor with an IC₅₀ of 2.95 μM .

HY-149275

PKM2/PDK1-IN-1	Pyruvate Kinase PDK-1 Akt EGFR Apoptosis	Cancer
PKM2/PDK1-IN-1, one of shikonin thioether derivatives, is a dual inhibitor of *PKM2/PDK1*. PKM2/PDK1-IN-1 inhibits the proliferation of NSCLC cells, and induces apoptosis. PKM2/PDK1-IN-1 induces intercellular ROS production, and regulates the apoptotic proteins, to involves in mitochondrial and death receptor pathway .

HY-155849

PKM2-IN-4	Pyruvate Kinase	Cancer
Pkm2-in-4 (compound 5C) is a selective inhibitor of PKM2 (IC₅₀=0.35 μM), which regulates pyruvate-dependent respiration and induces mitochondrial H202 production rate and electron transport system coupling .

HY-121275

Benserazide	Pyruvate Kinase	Cancer
Benserazide is a PKM2 inhibitor. Benserazide directly binds to and blocks PKM2 enzyme activity, leading to inhibition of aerobic glycolysis concurrent up-regulation of OXPHOS. Benserazide can be used for the research of melanoma .

HY-D1456

TEPC466	Pyruvate Kinase	Cancer
TEPC466 is a novel TEPP-46-based aggregation-induced emission (AIE) probe. TEPC466 shows a high degree of selectivity and sensitivity for the detection of PKM2 protein via the AIE effect. EPC466 can be used for the detection of PKM2. TEPC466 is successfully applied in imaging the PKM2 protein in colorectal cancer cells with low toxicity. TEPC466 is a useful tool for cancer diagnosis and research .

HY-D1876

ZY-2	Fluorescent Dye	Cancer
ZY-2 is a specific fluorescent probe for pyruvate kinase M2 (PKM2). ZY-2 can image in *PKM2*-positive cells in a time- and concentration-dependent manner. ZY-2 can be used for the detection of cancer cells .

HY-D1877

ZY-1	Pyruvate Kinase	Others
ZY-1 is a control molecule of ZY-2 (HY-D1876, a PKM2 fluorescent probe). ZY-1 shows a low fluorescence emission in HeLa, a cervical cancer cell abundant in PKM2 expression .

HY-126585

SAICAR 1 Publications Verification	Endogenous Metabolite	Cancer
SAICAR is an intermediate of de novo purine nucleotide biosynthesis, activates pyruvate kinase isoform M2 (PKM2) in an isozyme-selective manner, with an EC₅₀ of 0.3 mM. SAICAR stimulates PKM2 and promotes cancer cell survival in glucose-limited conditions ^[2].

HY-126585S

SAICAR-d1	Endogenous Metabolite	Metabolic Disease
SAICAR-d is the deuterium labeled SAICAR. SAICAR is an intermediate of de novo purine nucleotide biosynthesis, activates pyruvate kinase isoform M2 (PKM2) in an isozyme-selective manner, with an EC50 of 0.3 mM. SAICAR stimulates PKM2 and promotes cancer cell survival in glucose-limited conditions[1][2].

HY-148615

NPD10084	Pyruvate Kinase	Cancer
NPD10084 is a pyruvate kinase *PKM2* inhibitor that inhibits non-glycolytic signaling in cancer cells. NPD10084 disrupts the interaction between PKM2 and β-catenin or STAT3 and inhibits downstream signaling. NPD10084 has antiproliferative activity against colorectal cancer cells in vitro and in vivo .

HY-B1814

Vitamin K5 Synkamin; Synkamin base	Pyruvate Kinase Bacterial Fungal Apoptosis	Infection Cancer
Vitamin K5 (Synkamin) is a photosensitizer and a antimicrobial agent. Vitamin K5 is a specific *PKM2* inhibitor with IC₅₀ values of 28, 191 and 120 μM for PKM2, PKM1 and PKL. Vitamin K5 induces apoptosis of colon 26 cells. Vitamin K5 can be used for the research of infection and cancer, and it also can be used as a preservative for pharmaceuticals, foods, and beverages ^[2] .

HY-N2552

Vitamin K5 hydrochloride	Pyruvate Kinase Bacterial Fungal Apoptosis	Infection Cancer
Vitamin K5 hydrochloride is a photosensitizer and a antimicrobial agent. Vitamin K5 hydrochloride is a specific *PKM2* inhibitor with IC₅₀ values of 28, 191 and 120 μM for PKM2, PKM1 and PKL. Vitamin K5 hydrochloride induces apoptosis of colon 26 cells. Vitamin K5 hydrochloride can be used for the research of infection and cancer, and it also can be used as a preservative for pharmaceuticals, foods, and beverages ^[2] .

HY-19330

DASA-58 10+ Cited Publications	Pyruvate Kinase	Metabolic Disease Cancer
DASA-58 is a potential pyruvate kinase isozyme (PKM2) allosteric activator. DASA-58 can be used for the research of metabolism and kinds of cancer .

HY-18657

TEPP-46 35+ Cited Publications ML-265	Pyruvate Kinase	Cancer
TEPP-46 (ML-265) is a potent and selective pyruvate kinase M2 (PKM2) activator with an AC₅₀ of 92 nM, showing little or no effect on PKM1, PKL and PKR .

HY-119874

Alkannin	Pyruvate Kinase	Inflammation/Immunology Cancer
Alkannin is a potent and specific inhibitor of tumor-specific pyruvate kinase-M2 (PKM2). Alkannin does not inhibit PKM1 and pyruvate kinase-L (PKL). Alkannin acts as a potential anticancer agent .

HY-155785

MTP	Apoptosis Autophagy Reactive Oxygen Species JAK	Cancer
MTP is a *PKM2* inhibitor. MTP induces cancer cell apoptosis by modulating caspase-3 activation. MTP induces autophagy and increases ROS generation. MTP also inhibits *JAK2* signaling. MTP can be used for research of oral squamous cell carcinoma .

HY-N7064

Iminostilbene	Pyruvate Kinase COX HIF/HIF Prolyl-Hydroxylase STAT NO Synthase Interleukin Related TNF Receptor	Cardiovascular Disease Inflammation/Immunology
Iminostilbene is a chemical precursor of carbamazepine. Additionally, Iminostilbene is an orally active inhibitor of *PKM2* (Pyruvate Kinase M2) and *COX2* (Cyclooxygenase-2). Iminostilbene exerts its effects by inhibiting *PKM2* and its interaction with HIF-1α and STAT3, reducing *COX2* and iNOS expression, and decreasing LPS-induced release of IL-1β, IL-6, TNF-α, and MCP-1, thereby suppressing macrophage-mediated inflammatory responses and improving myocardial ischemia/reperfusion (MI/R) injury. Iminostilbene holds promise for research in inflammation regulation, cardiovascular diseases (such as MI/R injury), and macrophage-mediated immune-related diseases ^[2].

HY-155850

CIAC001	Pyruvate Kinase	Neurological Disease
CIAC001 is a Pyruvate Kinase PKM2 inhibitor with anti-neuroinflammatory activity. CIAC001 inhibits LPS-induced proinflammatory nitric oxide (NO) production and protects immunologically active BV-2 cells (IC₅₀=2.5 μM). CIAC001 also has anti-neuroinflammation in mouse models and inhibits chronic morphine-induced addiction .

HY-N0822

Shikonin Maximum Cited Publications 42 Publications Verification C.I. 75535; Isoarnebin 4	Chloride Channel Pyruvate Kinase NF-κB TNF Receptor HIV AIM2	Cancer
Shikonin is a major component of a Chinese herbal medicine named zicao. Shikonin is a potent TMEM16A chloride channel inhibitor with an IC₅₀ of 6.5 μM . Shikonin is a specific pyruvate kinase M2 (PKM2) inhibitor ^[2] and can also inhibit TNF-α and NF-κB pathway . Shikonin decreases exosome secretion through the inhibition of glycolysis . Shikonin inhibits *AIM2* inflammasome activation .

HY-N0822R

Shikonin (Standard)	Chloride Channel Pyruvate Kinase NF-κB TNF Receptor HIV AIM2	Cancer
Shikonin (Standard) is the analytical standard of Shikonin. This product is intended for research and analytical applications. Shikonin is a major component of a Chinese herbal medicine named zicao. Shikonin is a potent TMEM16A chloride channel inhibitor with an IC₅₀ of 6.5 μM . Shikonin is a specific pyruvate kinase M2 (PKM2) inhibitor ^[2] and can also inhibit TNF-α and NF-κB pathway . Shikonin decreases exosome secretion through the inhibition of glycolysis . Shikonin inhibits AIM2 inflammasome activation .

HY-W587878

Thujopsene	Cytochrome P450 Pyruvate Kinase Fungal Apoptosis Insecticide	Infection Cancer
Thujopsene is the inhibitor for cytochrome P450, that inhibits *CYP2B6, CYP3A4, CYP2C19, CYP2C8, CYP2C9* with IC₅₀s of 1.3, 12.6, 13.6, 29.8, and 44.9 μM, respectively. Thujopsene binds to *PKM2, inhibits the metabolism pathway of cancer cell, induces apoptosis* in MKN45, thereby exhibiting antitumor efficacy. Thujopsene exhibits anti-termite and antifungal activities through autoxidation ^[2] .

HY-12689

Mitapivat 1 Publications Verification AG-348	Pyruvate Kinase	Metabolic Disease
Mitapivat (AG-348) is an orally active pyruvate kinase allosteric activator. Mitapivat increases enzymatic activity, protein stability, and ATP levels over a broad range of PKLR genotypes, shows the potential to restore the activity of PK (pyruvate kinase)-deficient glycolytic pathways. Mitapivat can be used in study of PK deficiency ^[2] .

HY-12689A

Mitapivat hemisulfate sesquihydrate AG-348 hemisulfate sesquihydrate	Pyruvate Kinase	Metabolic Disease
Mitapivat hemisulfate sesquihydrate (AG-348) is an orally active pyruvate kinase allosteric activator. Mitapivat increases enzymatic activity, protein stability, and ATP levels over a broad range of PKLR genotypes, shows the potential to restore the activity of PK (pyruvate kinase)-deficient glycolytic pathways. Mitapivat can be used in study of PK deficiency ^[2] .

HY-12689B

Mitapivat hemisulfate AG-348 hemisulfate	Pyruvate Kinase	Metabolic Disease
Mitapivat hemisulfate is an orally active pyruvate kinase allosteric activator. Mitapivat hemisulfate increases enzymatic activity, protein stability, and ATP levels over a broad range of PKLR genotypes, shows the potential to restore the activity of PK (pyruvate kinase)-deficient glycolytic pathways. Mitapivat hemisulfate can be used in study of PK deficiency ^[2] .

HY-N0540

Cynaroside 5+ Cited Publications Luteolin 7-glucoside; Luteolin 7-O-β-D-glucoside	Influenza Virus DNA/RNA Synthesis Apoptosis Parasite Bacterial Fungal	Infection Cardiovascular Disease Cancer
Cynaroside (Luteolin 7-glucoside) is a flavonoid compound that exhibits anti-oxidative capabilities. Cynaroside is also a potent influenza RNA-dependent RNA polymerase inhibitor with an IC₅₀ of 32 nM. Cynaroside also is a promising inhibitor for H₂O₂-induced apoptosis, has cytoprotection against oxidative stress-induced cardiovascular diseases. Cynaroside also has antibacterial, antifungal and anticancer activities, antioxidant and anti-inflammatory activities .

HY-N0540R

Cynaroside (Standard) Luteolin 7-glucoside (Standard); Luteolin 7-O-β-D-glucoside (Standard)	Apoptosis DNA/RNA Synthesis Parasite Bacterial Influenza Virus Fungal	Infection Cancer
Cynaroside (Standard) is the analytical standard of Cynaroside. This product is intended for research and analytical applications. Cynaroside (Luteolin 7-glucoside) is a flavonoid compound that exhibits anti-oxidative capabilities. Cynaroside is also a potent influenza RNA-dependent RNA polymerase inhibitor with an IC₅₀ of 32 nM. Cynaroside also is a promising inhibitor for H₂O₂-induced apoptosis, has cytoprotection against oxidative stress-induced cardiovascular diseases. Cynaroside also has antibacterial, antifungal and anticancer activities, antioxidant and anti-inflammatory activities .

Cat. No.	Product Name	Type

HY-D1456

TEPC466	Fluorescent Dyes/Probes
TEPC466 is a novel TEPP-46-based aggregation-induced emission (AIE) probe. TEPC466 shows a high degree of selectivity and sensitivity for the detection of PKM2 protein via the AIE effect. EPC466 can be used for the detection of PKM2. TEPC466 is successfully applied in imaging the PKM2 protein in colorectal cancer cells with low toxicity. TEPC466 is a useful tool for cancer diagnosis and research .

TEPC466

Fluorescent Dyes/Probes

TEPC466 is a novel TEPP-46-based aggregation-induced emission (AIE) probe. TEPC466 shows a high degree of selectivity and sensitivity for the detection of PKM2 protein via the AIE effect. EPC466 can be used for the detection of PKM2. TEPC466 is successfully applied in imaging the PKM2 protein in colorectal cancer cells with low toxicity. TEPC466 is a useful tool for cancer diagnosis and research .

HY-D1876

ZY-2	Fluorescent Dyes/Probes
ZY-2 is a specific fluorescent probe for pyruvate kinase M2 (PKM2). ZY-2 can image in *PKM2*-positive cells in a time- and concentration-dependent manner. ZY-2 can be used for the detection of cancer cells .

HY-D1877

ZY-1	Fluorescent Dyes/Probes
ZY-1 is a control molecule of ZY-2 (HY-D1876, a PKM2 fluorescent probe). ZY-1 shows a low fluorescence emission in HeLa, a cervical cancer cell abundant in PKM2 expression .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-126585

SAICAR 1 Publications Verification	Structural Classification Human Gut Microbiota Metabolites Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Source classification Disease markers Endocrine diseases Nervous System Disorder Endogenous metabolite Disease Research Fields Cancer	Endogenous Metabolite
SAICAR is an intermediate of de novo purine nucleotide biosynthesis, activates pyruvate kinase isoform M2 (PKM2) in an isozyme-selective manner, with an EC₅₀ of 0.3 mM. SAICAR stimulates PKM2 and promotes cancer cell survival in glucose-limited conditions ^[2].

HY-N0822

Shikonin Maximum Cited Publications 42 Publications Verification C.I. 75535; Isoarnebin 4	Quinones Structural Classification Classification of Application Fields Plants Lithospermum erythrorhizon Sieb. et Zucc. Naphthalene Quinones Boraginaceae Disease Research Fields Cancer	Chloride Channel Pyruvate Kinase NF-κB TNF Receptor HIV AIM2
Shikonin is a major component of a Chinese herbal medicine named zicao. Shikonin is a potent TMEM16A chloride channel inhibitor with an IC₅₀ of 6.5 μM . Shikonin is a specific pyruvate kinase M2 (PKM2) inhibitor ^[2] and can also inhibit TNF-α and NF-κB pathway . Shikonin decreases exosome secretion through the inhibition of glycolysis . Shikonin inhibits *AIM2* inflammasome activation .

HY-N0540

Cynaroside 5+ Cited Publications Luteolin 7-glucoside; Luteolin 7-O-β-D-glucoside	Infection Structural Classification Flavonoids Classification of Application Fields Flavones Centaurea ornata Phenols Polyphenols Umbelliferae Plants Disease Research Fields	Influenza Virus DNA/RNA Synthesis Apoptosis Parasite Bacterial Fungal
Cynaroside (Luteolin 7-glucoside) is a flavonoid compound that exhibits anti-oxidative capabilities. Cynaroside is also a potent influenza RNA-dependent RNA polymerase inhibitor with an IC₅₀ of 32 nM. Cynaroside also is a promising inhibitor for H₂O₂-induced apoptosis, has cytoprotection against oxidative stress-induced cardiovascular diseases. Cynaroside also has antibacterial, antifungal and anticancer activities, antioxidant and anti-inflammatory activities .

HY-119874

Alkannin	Quinones Structural Classification Monophenols Ohwia caudata (Thunberg) H. Ohashi Classification of Application Fields Source classification Phenols Plants Compositae Naphthalene Quinones Inflammation/Immunology Disease Research Fields	Pyruvate Kinase
Alkannin is a potent and specific inhibitor of tumor-specific pyruvate kinase-M2 (PKM2). Alkannin does not inhibit PKM1 and pyruvate kinase-L (PKL). Alkannin acts as a potential anticancer agent .

HY-N0822R

Shikonin (Standard)	Quinones Structural Classification Plants Lithospermum erythrorhizon Sieb. et Zucc. Naphthalene Quinones Boraginaceae	Chloride Channel Pyruvate Kinase NF-κB TNF Receptor HIV AIM2
Shikonin (Standard) is the analytical standard of Shikonin. This product is intended for research and analytical applications. Shikonin is a major component of a Chinese herbal medicine named zicao. Shikonin is a potent TMEM16A chloride channel inhibitor with an IC₅₀ of 6.5 μM . Shikonin is a specific pyruvate kinase M2 (PKM2) inhibitor ^[2] and can also inhibit TNF-α and NF-κB pathway . Shikonin decreases exosome secretion through the inhibition of glycolysis . Shikonin inhibits AIM2 inflammasome activation .

HY-N0540R

Cynaroside (Standard) Luteolin 7-glucoside (Standard); Luteolin 7-O-β-D-glucoside (Standard)	Structural Classification Flavonoids Flavones Centaurea ornata Phenols Polyphenols Umbelliferae Plants	Apoptosis DNA/RNA Synthesis Parasite Bacterial Influenza Virus Fungal
Cynaroside (Standard) is the analytical standard of Cynaroside. This product is intended for research and analytical applications. Cynaroside (Luteolin 7-glucoside) is a flavonoid compound that exhibits anti-oxidative capabilities. Cynaroside is also a potent influenza RNA-dependent RNA polymerase inhibitor with an IC₅₀ of 32 nM. Cynaroside also is a promising inhibitor for H₂O₂-induced apoptosis, has cytoprotection against oxidative stress-induced cardiovascular diseases. Cynaroside also has antibacterial, antifungal and anticancer activities, antioxidant and anti-inflammatory activities .

Species:	Human (3) Mouse (2)
Tag:	His (4) Tag Free (1)
Source:	Sf9 insect cells (2) E. coli (3)

Cat. No.	Compare	Product Name	Species	Source

HY-P74629

	PKM2 Protein, Mouse (sf9, His) Pyruvate Kinase M2; PKM2; CTHBP; OIP-3; THBP1	Mouse	Sf9 insect cells
	PKM2 protein catalyzes the final step of glycolysis, transferring a phosphoryl group from PEP to ADP to generate ATP.In the nucleus, transcriptional activation of PKM2 contributes to cancer progression, promoting cell proliferation and tumorigenesis.PKM2 is also involved in caspase-independent cell death in tumors.PKM2 Protein, Mouse (sf9, His) is the recombinant mouse-derived PKM2 protein, expressed by Sf9 insect cells , with N-His labeled tag.

HY-P7803

	PKM2 Protein, Human (420 a.a, His) rHuPyruvate Kinase M2/PKM2, His; Pyruvate Kinase M2; PKM2; CTHBP; OIP-3; THBP1	Human	E. coli
	PKM2 Protein, Human (420 a.a, His) is a multifunctional protein, is exclusively expressed in embryonic and adult dividing/tumor cells. PKM2 can catabolize glucose and involved in many nonglycolytic pathways.

HY-P72053

	PKM2 Protein, Mouse (sf9, His, solution) PKM; Pk3; PKM2; PykmPyruvate kinase PKM; EC 2.7.1.40; Pyruvate kinase muscle isozyme	Mouse	Sf9 insect cells
	PKM2 protein catalyzes the final step of glycolysis, transferring a phosphoryl group from PEP to ADP to generate ATP.In the nucleus, transcriptional activation of PKM2 contributes to cancer progression, promoting cell proliferation and tumorigenesis.PKM2 is also involved in caspase-independent cell death in tumors.PKM2 Protein, Mouse (Baculovirus, His) is the recombinant mouse-derived PKM2 protein, expressed by Sf9 insect cells , with N-10*His labeled tag.

HY-P70599

	PKM2 Protein, Human (530a.a, His) Pyruvate kinase PKM; CTHBP; OIP-3; THBP1	Human	E. coli
	PKM2 Protein, Human (530a.a, His) is a recombinant PKM2 protein with a His-Flag. PKM2 Protein is one of the rate-limiting enzymes in glycolysis.

HY-P702845

	PKM2 Protein, Human Pyruvate kinase PKM; CTHBP; OIP-3; THBP1	Human	E. coli
	PKM2 Protein, Human is a recombinant PKM2 protein with no tagged. PKM2 Protein is one of the rate-limiting enzymes in glycolysis.

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Cat. No.	Product Name	Chemical Structure

HY-126585S

SAICAR-d1
SAICAR-d is the deuterium labeled SAICAR. SAICAR is an intermediate of de novo purine nucleotide biosynthesis, activates pyruvate kinase isoform M2 (PKM2) in an isozyme-selective manner, with an EC50 of 0.3 mM. SAICAR stimulates PKM2 and promotes cancer cell survival in glucose-limited conditions[1][2].

Cat. No.	Compare	Product Name	Application	Reactivity

HY-P80870

	PKM2 Antibody PKM; OIP3; PK2; PK3; PKM2; Pyruvate kinase isozymes M1/M2; Cytosolic thyroid hormone-binding protein; CTHBP; Opa-interacting protein 3; OIP-3; Pyruvate kinase 2/3; Pyruvate kinase muscle isozyme; Thyroid hormone-binding protein 1; THBP1; Tu	WB, IHC-P, ICC/IF, FC	Human, Mouse, Rat
	PKM2 Antibody is a non-conjugated and Rabbit origined polyclonal antibody about 58 kDa, targeting to PKM2. It can be used for WB,IHC-P,ICC/IF,FC assays with tag free, in the background of Human, Mouse, Rat.

HY-P83644

	*Phospho-PKM2(Tyr105)Antibody* PKM2 (Phospho Tyr105); PKM2 (Phospho Y105); PK 1; PK 2; PK 3; PK Muscle type; PK1; PK2; Pk3; PKL; PKLR; PKM 2; PKM; PYKM; Pyruvate kinase 1; Pyruvate kinase 2/3; Pyruvate kinase 3; Pyruvate kinase isozyme R/L; Pyruvate kinase isozymes M1/M2; Pyruvate kinase liver and blood cell; Pyruvate kinase liver and RBC; Pyruvate kinase liver and RBC type; Pyruvate kinase M2; Pyruvate kinase muscle; Pyruvate kinase muscle isozyme; Pyruvate kinase type L; R type/L type pyruvate kinase; Red cell/liver pyruvate kinase; RPK; TCB; THBP 1; THBP1; Thyroid hormone binding protein cytosolic; CTHBP; Cytosolic thyroid hormone binding protein; MGC3932; OIP 3; Oip3; Tumor M2-PK; p58; OIP-3.	IHC-P, IHC-F, ICC/IF, FC, ELISA	Human, Rat
	Phospho-PKM2(Tyr105)Antibody is a rabbit-derived non-conjugated IgG antibody, targeting Phospho-PKM2(Tyr105)Antibody, with a predicted molecular weight of 58 kDa. Phospho-PKM2(Tyr105)Antibody can be used for IHC-P, IHC-F, ICC/IF, FC, ELISA experiments in human, rat backgrounds.