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Papain-like

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Apoptosis (2) Autophagy (2) Bacterial (1) Deubiquitinase (3) DNA Methyltransferase (2) Endogenous Metabolite (2) Fluorescent Dye (1) HIF/HIF Prolyl-Hydroxylase (1) SARS-CoV (21) Virus Protease (2)
By Research Areas:	Cancer (4) Infection (20) Inflammation/Immunology (3)

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Targets Recommended: Polo-like Kinase (PLK) NOD-like Receptor (NLR) Toll-like Receptor (TLR) KLF ANGPTL PERK ULK METTL3 MASTL ADAMTS IGF-1R LOX-1 Nuclear Hormone Receptor 4A/NR4A FLT3

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-150784

XR8-89	SARS-CoV	Infection
XR8-89 is a potent papain-like protease (PL ^pro) inhibitor with an IC₅₀ value of 0.1 μM. XR8-89 induces conformational changes in SARS-COV-2 papain-like protease, inhibiting SARS-CoV-2 replication. XR8-89 can be used for SARS-CoV-2 research .

HY-150786

PLP_Snyder530	SARS-CoV	Infection
PLP_Snyder530 is a potent papain-like protease (PL ^pro) inhibitor with an IC₅₀ value of 6.4 μM. PLP_Snyder530 induces conformational changes in SARS-COV-2 papain-like protease, inhibiting SARS-CoV-2 replication. PLP_Snyder530 can be used for SARS-CoV-2 research .

HY-150783

SARS-CoV-2-IN-24	SARS-CoV	Infection
SARS-CoV-2-IN-24 (compound 7) is a potent papain-like protease (PL ^pro) inhibitor. SARS-CoV-2-IN-24 induces conformational changes in SARS-COV-2 papain-like protease, inhibiting SARS-CoV-2 replication. SARS-CoV-2-IN-24 can be used for SARS-CoV-2 research .

HY-168584

SARS-CoV-2-IN-102	SARS-CoV	Infection
SARS-CoV-2-IN-102 (example 58) is a *SARS-CoV papain-like* protease (PLpro) inhibitor with an IC₅₀** <100 nM .

HY-150789

SARS-CoV-2-IN-23	SARS-CoV	Infection
SARS-CoV-2-IN-23 (compound GRL-0617) is a SARS-COV-2 papain-like protease (PLpro) inhibitor with an IC₅₀ value of 2.3 μM .

HY-161729

PLpro-IN-3	SARS-CoV	Infection
PLpro-IN-3 (compound 26R) is a potent Papain-like protease (PLpro) inhibitor with a IC₅₀ of 1.0μM. PLpro-IN-3 exhibits antiviral activity against SARS-CoV-2 with a EC₅₀ of 4.3 μM .

HY-162981

PLpro-IN-7	SARS-CoV	Cancer
PLpro-IN-7 (compund 83) is a novel papain-like protease (PLpro) inhibitor with IC₅₀ of 3 nM .

HY-161365

PLpro-IN-2	SARS-CoV	Infection
PLpro-IN-2 (Compound 16) is an inhibitor for SARS-CoV-2 papain-like protease (PLpro), with an IC₅₀ of 0.25 μM .

HY-159655

PLpro-IN-6	SARS-CoV	Infection Inflammation/Immunology
PLpro-IN-6 (compound 6) is a papain-like protease (PLpro) inhibitor, with an IC₅₀ of 0.019 μM for SARS CoV2 PLpro enzyme .

HY-P2296

Abz-FRLKGGAPIKGV-EDDNP TFA	Fluorescent Dye	Others
Abz-FRLKGGAPIKGV-EDDNP TFA is a fluorogenic substrate used to measure the enzymatic activities of protease forms, such as papain-like protease 2 (PLP2) from severe acute respiratory syndrome coronavirus (SARS-CoV). Abz-FRLKGGAPIKGV-EDDNP TFA has the potential for study 2019-nCoV (COVID-19) infection .

HY-157439

SARS-CoV-2-IN-72	SARS-CoV	Infection
SARS-CoV-2-IN-72 (compound 12) is a potent allosteric inhibitor of the SARS-COV-2 papain-like protease domain that can trigger the degradation of NSP3 .

HY-N1910

4'-O-Methylbavachalcone 1 Publications Verification	SARS-CoV	Infection
4'-O-Methylbavachalcone is a chalcone isolated from Psoralea corylifolia, inhibits severe acute respiratory syndrome coronavirus (SARS-CoV) papain-like protease (PLpro) activity, with an IC₅₀ of 10.1 μM .

HY-17542

PLpro inhibitor 5+ Cited Publications	SARS-CoV	Infection
PLpro inhibitor is a potent inhibitor of papain-like protease (PLpro) with an IC₅₀ of 2.6 µM . PLpro inhibitor inhibits SARS-CoV-2 PLpro with an IC₅₀ of 5.0 µM and an EC₅₀ of 21.0 µM .

HY-164868

SARS-CoV-2-IN-106	SARS-CoV	Infection
SARS-CoV-2-IN-106 (compound 19) is a *SARS-CoV-2 papain-like* protease inhibitor with the IC₅₀** values of 0.44 μM and 0.18 μM for PLpro enzymatic and viral replication ,respectively .

HY-157403

Jun12682	SARS-CoV	Infection
Jun12682 is an inhibitor of SARS-CoV-2 papain-like protease. Jun12682 inhibits PL ^pro with a K_i value of 37.7 nM. Jun12682 has EC₅₀ value of 1.1 μM in the FlipGFP PL ^pro assay. Jun12682 has orally activity .

HY-13765

6-Thioguanine 5+ Cited Publications Thioguanine; 2-Amino-6-purinethiol	SARS-CoV Deubiquitinase DNA Methyltransferase Autophagy Apoptosis Endogenous Metabolite	Infection Inflammation/Immunology Cancer
6-Thioguanine (Thioguanine; 2-Amino-6-purinethiol) is an anti-leukemia and immunosuppressant agent, acts as an inhibitor of SARS and MERS coronavirus papain-like proteases (PLpros) and also potently inhibits USP2 activity, with IC₅₀s of 25 μM and 40 μM for Plpros and recombinant human USP2, respectively.

HY-117043

GRL0617 Maximum Cited Publications 10 Publications Verification	Deubiquitinase SARS-CoV	Infection
GRL0617 is a selective and competitive noncovalent inhibitor of *severe acute respiratory syndrome (SARS-CoV) papain-like* protease (PLpro), with an IC₅₀ of 0.6 μM and a Ki value of 0.49 μM. GRL0617 also inhibits SARS-CoV with an EC₅₀** of 14.5 μM. GRL0617 can be used for the research of severe acute respiratory syndrome .

HY-W088075

Acriflavine hydrochloride 5+ Cited Publications Acriflavinium chloride hydrochloride	HIF/HIF Prolyl-Hydroxylase Bacterial SARS-CoV	Infection Cancer
Acriflavine hydrochloride (Acriflavinium chloride hydrochloride) is a fluorescent acridine dye that can be used to label nucleic acid . Acriflavine hydrochloride is an antiseptic. Acriflavine hydrochloride is a potent HIF-1 inhibitor, with antitumor activity. Acriflavine hydrochloride has antimicrobial and antiviral activities . Acriflavine hydrochloride is a potent papain-like protease (PL ^pro) inhibitor, which inhibits SARS-CoV-2

HY-169092

PF-07957472	SARS-CoV Virus Protease	Infection
PF-07957472 (Compound 4) is an orally active SARS-CoV-2 papain-like protease (PLpro) inhibitor. PF-07957472 shows cytopathic effect in SARS-CoV-2 infected NHBE cells (EC₅₀ = 13.9 nM). PF-07957472 shows antiviral effect in a mouse-adapted model of COVID-19 infection model .

HY-168259

PLpro-IN-8	SARS-CoV	Infection
PLpro-IN-8 (compound 1) is a *SARS-CoV papain-like* protease (PLpro) inhibitor with IC₅₀** values of 5.9 μM and 0.46 μM for SARS-CoV-2 PLpro and SARS -CoV-1 PLpro, respectively. PLpro-IN-8 inhibits Wuhan strain WK-521 of SARS-CoV-2 with an EC₅₀ of 2.7 μM .

HY-13765R

6-Thioguanine (Standard)	SARS-CoV Deubiquitinase DNA Methyltransferase Autophagy Apoptosis Endogenous Metabolite	Infection Inflammation/Immunology Cancer
6-Thioguanine (Standard) is the analytical standard of 6-Thioguanine. This product is intended for research and analytical applications. 6-Thioguanine (Thioguanine; 2-Amino-6-purinethiol) is an anti-leukemia and immunosuppressant agent, acts as an inhibitor of SARS and MERS coronavirus papain-like proteases (PLpros) and also potently inhibits USP2 activity, with IC₅₀s of 25 μM and 40 μM for Plpros and recombinant human USP2, respectively.

HY-162484

GZNL-P36	SARS-CoV Virus Protease	Infection
GZNL-P36 is an orally active inhibitor for SARS-CoV-2 papain-like protease (PL ^pro), with an IC₅₀ of 6.45 nM. GZNL-P36 inhibits SARS-CoV and its variants with EC₅₀ range from 58.2 nM to 2.66 μM. GZNL-P36 exhibits a peak plasma concentration C_max of 549 ng/mL, a half-life T_1/2 of 1.45 h and a bioavailability of 74.7% in CD-1 mouse. GZNL-P36 exhibits antiviral activity in SARS-CoV-2 XXB.1 infection in mouse .

Cat. No.	Product Name	Target	Research Area

HY-P2296

Abz-FRLKGGAPIKGV-EDDNP TFA	Fluorescent Dye	Others
Abz-FRLKGGAPIKGV-EDDNP TFA is a fluorogenic substrate used to measure the enzymatic activities of protease forms, such as papain-like protease 2 (PLP2) from severe acute respiratory syndrome coronavirus (SARS-CoV). Abz-FRLKGGAPIKGV-EDDNP TFA has the potential for study 2019-nCoV (COVID-19) infection .

4'-O-Methylbavachalcone 1 Publications Verification	Infection Structural Classification Chalcones Flavonoids Classification of Application Fields Leguminosae Source classification Phenols Polyphenols Psoralea corylifolia L. Plants Disease Research Fields	SARS-CoV
4'-O-Methylbavachalcone is a chalcone isolated from Psoralea corylifolia, inhibits severe acute respiratory syndrome coronavirus (SARS-CoV) papain-like protease (PLpro) activity, with an IC₅₀ of 10.1 μM .

6-Thioguanine 5+ Cited Publications Thioguanine; 2-Amino-6-purinethiol	Infection Structural Classification Natural Products Classification of Application Fields Source classification Endogenous metabolite Inflammation/Immunology Disease Research Fields Cancer	SARS-CoV Deubiquitinase DNA Methyltransferase Autophagy Apoptosis Endogenous Metabolite
6-Thioguanine (Thioguanine; 2-Amino-6-purinethiol) is an anti-leukemia and immunosuppressant agent, acts as an inhibitor of SARS and MERS coronavirus papain-like proteases (PLpros) and also potently inhibits USP2 activity, with IC₅₀s of 25 μM and 40 μM for Plpros and recombinant human USP2, respectively.

6-Thioguanine (Standard)	Structural Classification Natural Products Source classification Endogenous metabolite	SARS-CoV Deubiquitinase DNA Methyltransferase Autophagy Apoptosis Endogenous Metabolite
6-Thioguanine (Standard) is the analytical standard of 6-Thioguanine. This product is intended for research and analytical applications. 6-Thioguanine (Thioguanine; 2-Amino-6-purinethiol) is an anti-leukemia and immunosuppressant agent, acts as an inhibitor of SARS and MERS coronavirus papain-like proteases (PLpros) and also potently inhibits USP2 activity, with IC₅₀s of 25 μM and 40 μM for Plpros and recombinant human USP2, respectively.

Species:	Virus (5)
Tag:	His (4) Tag Free (1) Avi (1)
Source:	E. coli Cell-free (1) E. coli (4)

Cat. No.	Compare	Product Name	Species	Source

HY-P70122

	SARS-CoV-2 PLpro Protein 1 Publications Verification rReplicase polyprotein 1ab/2019-nCoV Papain-like Protease; Papain-like Protease; PLpro; PL-PRO; pp1a; Replicase polyprotein 1a	Virus	E. coli
	The multifunctional SARS-CoV-2 PP1ab protein is essential for viral RNA transcription and replication, utilizing proteases for multi-protein cleavage. It inhibits host translation by binding to the 40S subunit and blocks ribosomal mRNA entry channels, thereby hindering the antiviral response. SARS-CoV-2 PLpro Protein is the recombinant Virus-derived SARS-CoV-2 PLpro protein, expressed by E. coli , with tag free. The total length of SARS-CoV-2 PLpro Protein is 315 a.a., with molecular weight of ~34.0 kDa.

HY-P74581

	*SARS-CoV Plpro/papain-like* protease Protein (His)** SARS-CoV (strain WH20) Plpro / Papain-like protease	Virus	E. coli
	SARS CoV ORF1ab polyprotein (PP1ab) is a 7073 residues long polyprotein which further produces 5 non-structural proteins (NSPs) after processing through virally encoded proteases (NSP12-NSP16).All these 5 proteins are mainly involved in viral replication, assembly, and immune response modulation.SARS-CoV Plpro/papain-like protease Protein (His) is the recombinant Virus-derived SARS-CoV Plpro/papain-like protease protein, expressed by E.coli , with C-His labeled tag.

HY-P76021

	*SARS-CoV-2 Plpro/Papain-like* protease Protein (His)** SARS-CoV-2 (2019-nCoV) Plpro/Papain-like protease-His Protein	Virus	E. coli
	SARS-CoV-2 NSP3 (NSP3) is one of non-structure protein that binds to viral RNA, nucleocapsid protein, as well as other viral proteins, and contributes in polyprotein processing. NSP3 has also an important role in innate immune response antagonism and is responsible for release of NSP1, NSP2, and NSP3 from the N-terminal region of pp1a and pp1ab. SARS-CoV-2 Plpro/Papain-like protease Protein (His) is the recombinant Virus-derived SARS-CoV-2 Plpro/Papain-like protease protein, expressed by E. coli , with N-His labeled tag.

HY-P77831

	*SARS Plpro/papain-like* protease Protein (His-Avi)** Replicase polyprotein 1a; pp1a; nsp1; PL2-PRO; PL-PRO; Papain-like Protease; Plpro	Virus	E. coli
	The multifunctional SARS Plpro/papain-like protease protein utilizes essential proteases for multi-protein cleavage to strategically coordinate viral RNA transcription and replication. It blocks host translation by interacting with the 40S ribosomal subunit, causing endonucleolytic cleavage near the 5'UTR of host mRNAs, thereby targeting them for degradation. SARS Plpro/papain-like protease Protein (His-Avi) is the recombinant Virus-derived SARS Plpro/papain-like protease protein, expressed by E. coli , with N-His, N-Avi labeled tag. The total length of SARS Plpro/papain-like protease Protein (His-Avi) is 314 a.a., with molecular weight of ~38.6 kDa.

HY-P702421

	Replicase 1AB polyprotein Protein, SARS-CoV (Cell-Free, His) Growth factor-like peptide; Leader protein; Non-structural protein 10; Non-structural protein 2; Non-structural protein 3; Non-structural protein 4; Non-structural protein 6; Non-structural protein 7; Non-structural protein 8; Non-structural protein 9; Papain-like proteinase; p65 homolog	Virus	E. coli Cell-free
	Replicase 1AB polyprotein Protein, SARS-CoV (Cell-Free, His) is the recombinant Virus-derived Replicase 1AB polyprotein protein, expressed by E. coli Cell-free , with N-10*His labeled tag. The total length of Replicase 1AB polyprotein Protein, SARS-CoV (Cell-Free, His) is 290 a.a., with molecular weight of 35.8 kDa.

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Papain-like

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