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ProstaglandinD2 (PGD2) is one of the major PGs actively produced in the brain of various mammals . ProstaglandinD2 is one of the most potent endogenous sleep promoting substances . PGD2 plays a protective role by suppressing inflammation .
ProstaglandinD2 methyl ester is a prodrug form of ProstaglandinD2. ProstaglandinD2 methyl ester binds to the human and mouse PGD2 receptors (DP and CRTH2) with Ki values of 160 nM, 175 nM, 460 nM, and 270 nM for mCRTH2, mDP, hCRTH2, and hDP, respectively .
ProstaglandinD2-d9 is the deuterium labeled ProstaglandinD2. ProstaglandinD2 (PGD2) is one of the major PGs actively produced in the brain of various mammals[1]. ProstaglandinD2 is one of the most potent endogenous sleep promoting substances[2]. PGD2 plays a protective role by suppressing inflammation[3].
ProstaglandinD2 (Standard) is the analytical standard of ProstaglandinD2. This product is intended for research and analytical applications. ProstaglandinD2 (PGD2) is one of the major PGs actively produced in the brain of various mammals . ProstaglandinD2 is one of the most potent endogenous sleep promoting substances . PGD2 plays a protective role by suppressing inflammation .
ProstaglandinD2-d4 is the deuterium labeled ProstaglandinD2. ProstaglandinD2 (PGD2) is one of the major PGs actively produced in the brain of various mammals[1]. ProstaglandinD2 is one of the most potent endogenous sleep promoting substances[2]. PGD2 plays a protective role by suppressing inflammation[3].
Δ12(E)-ProstaglandinD2 is a derivative of ProstaglandinD2 (HY-101988). ProstaglandinD2 is one of the major Prostaglandins actively produced in the brain of various mammals .
13,14-Dihydro-15-keto-tetranor prostaglandinD2 (Compound VI) is a prostaglandinD2 metabolite. 13,14-Dihydro-15-keto-tetranor prostaglandinD2 as a biomarker can be used to study prostaglandinD2-related diseases .
15(R)-ProstaglandinD2 is a potential prostatic hormone DP(2) receptor (Prostaglandin Receptor) agonist with anti-inflammatory activity. 15(R)-ProstaglandinD2 increases actin polymerization in human eosinophils and increases cAMP levels in platelets .
15-deoxy-Δ12,14-ProstaglandinD2 (15-Deoxy-Δ12,14-PGD2), a metabolite of PGD2 (HY-101988), is an agonist of prostaglandin receptor 2 (DP2). 15-deoxy-Δ12,14-ProstaglandinD2 binds to DP2 (Ki=50 nM) and induces eosinophil activation (EC50=8 nM). 15-deoxy-Δ12,14-ProstaglandinD2 also stimulates the recruitment of steroid receptor coactivator-1 (SRC-1) to peroxisome proliferator-activated receptor γ (PPARγ), inducing PPARγ-mediated transcription. 15-deoxy-Δ12,14-ProstaglandinD2 (15-Deoxy-Δ12,14-PGD2) is cytotoxic to L1210 murine leukemia cells (IC50=0.3 μg/ml) and inhibits ADP-induced platelet aggregation (IC50=320 ng/mL).
11-keto Fluprostenol is an analog of prostaglandinD2 (PGD2) with structural modifications intended to give it a prolonged half-life and greater potency. Fluprostenol is a well-studied, potent analog of PGF2α and acts primarily through the FP receptor. Oxidation at C-11 of fluprostenol yields 11-keto fluprostenol. 11-keto Fluprostenol exhibits moderate binding to the CRTH2/DP2 receptor compared to PGD2 and essentially no activity at the DP1 receptor.
13, 14-Dihydro-15-keto prostaglandinD2 (DK-PGD2) is a PGD2 metabolite formed by the 15-hydroxyl PGDH pathway. 13, 14-Dihydro-15-keto prostaglandinD2 is a selective agonist for the DP2 receptor. 13, 14-Dihydro-15-keto prostaglandinD2 can inhibit ion flux in canine colonic mucosa preparation .
15(R)-15-Methyl prostaglandinD2 (15(R)-15-methyl PGD2) is a metabolically stable synthetic analog of PGD2. The physiological actions of PGD2 include regulation of sleep, lowering of body temperature, inhibition of platelet aggregation and relaxation of vascular smooth muscle. PGD2 mediates its effects by 2 distinct G-protein-coupled receptors, DP1and CRTH2/DP2. 15(R)-15-Methyl prostaglandinD2 is a potent, selective agonist for the CRTH2/DP2 receptor. The EC50 values for eosinophil CD11b expression, actin polymerization, and chemotaxis are 1.4, 3.8, and 1.7 nM, respectively, each of which is approximately 3-5 fold lower than those for PGD2. In contrast the EC50 for the DP1-mediated increase in platelet cAMP by 15(R)-15-methyl PGD2 is >10 μM.
15(S)-15-methyl ProstaglandinD2 (15(S)-15-methyl PGD2) is a metabolically stable synthetic analog of PGD2. In contrast to PGD2, 15(S)-15-methyl PGD2 induces vasoconstriction and increases systemic blood pressure with much reduced inhibitory activity on ADP-induced platelet aggregation. It also exhibits strong antifertility activity in hamsters (200-fold more potent than PGD2).
13,14-Dihydro-15-keto prostaglandinD2-d4(DK-PGD2-d4) is deuterium labeled 13,14-Dihydro-15-keto prostaglandinD2. 13, 14-Dihydro-15-keto prostaglandinD2 (DK-PGD2) is a PGD2 metabolite formed by the 15-hydroxyl PGDH pathway. 13, 14-Dihydro-15-keto prostaglandinD2 is a selective agonist for the DP2 receptor. 13, 14-Dihydro-15-keto prostaglandinD2 can inhibit ion flux in canine colonic mucosa preparation .
13,14-Dihydro-15-keto prostaglandinD2-d9(DK-PGD2-d9) is deuterium labeled 13,14-Dihydro-15-keto prostaglandinD2. 13, 14-Dihydro-15-keto prostaglandinD2 (DK-PGD2) is a PGD2 metabolite formed by the 15-hydroxyl PGDH pathway. 13, 14-Dihydro-15-keto prostaglandinD2 is a selective agonist for the DP2 receptor. 13, 14-Dihydro-15-keto prostaglandinD2 can inhibit ion flux in canine colonic mucosa preparation .
PGDM (ProstaglandinD Metabolite) is the main urinary metabolite of ProstaglandinD2 and is prone to reversible cyclization. PGDM may serve as a biomarker for the endogenous production of PGD2 or be used to evaluate the severity of acute allergic reactions .
L 888607 Racemate is a selective prostaglandinD2 receptor subtype 1 (DP1) antagonist, with Kis of 132 nM and 17 nM for DP1 and thromboxane A2 receptor (TP), respectively.
Delta-12-Prostaglandin J2 (Δ12-PGJ2) is a cyclopentenone prostaglandin (PG) with anti-proliferative effect on various tumor cell growth. Delta-12-Prostaglandin J2, a naturally occurring dehydration product of prostaglandinD2, is able to induce apoptosis in HeLa cells via caspase activation .
11-Deoxy-11-methylene PGD2 (11d-11m-PGD2) is a chemically stable, isosteric analogue of Prostaglandin 2 in which the 11-keto group is replaced by an exocyclic methylene. 11-Deoxy-11-methylene PGD2 is significantly stimulating the storage of fats suppressed in the presence of Indomethacin .
Nedocromil (Standard) is the analytical standard of Nedocromil. This product is intended for research and analytical applications. Nedocromil suppresses the action or formation of multiple mediators, including histamine, leukotriene C4 (LTC4), and prostaglandinD2 (PGD2).
BW A868C, a hydantoin compound, is a BW245C structural analogue. BW A868C is a selective and potent competitive prostaglandinD2 (PGD2) antagonist. BW A868C has no effect on other prostaglandin receptors (IP, EP1, EP2, TP and FP) .
Fevipiprant (QAW039, NVP-QAW039) is s an orally active, selective, reversible prostaglandinD2 (DP2) receptor antagonist with an Kd value of 1.14 nM. Fevipiprant has the potential for the research of bronchial asthma .
CAY10471 (TM30089) is a potent, selective, and orally active prostaglandinD2 receptor CRTH2 antagonist. CAY10471 attenuates the progression of tubulointerstitial fibrosis and chronic contact hypersensitivity (CHS) in animal model .
Prostaglandin J2 (PGJ2), an endogenous metabolite of ProstaglandinD2 (PGD2; HY-101988), is a potent PGD2 receptor (DP) agonist with Kis of 0.9 nM and 6.6 nM for hDP and hCRTH2, respectively. Prostaglandin J2 stimulates intracellular cyclic AMP production with an EC50 value of 1.2 nM. Prostaglandin J2 induces oxidative stress and neuronal apoptosis. Prostaglandin J2 induces the accumulation/aggregation of ubiquitinated (Ub) proteins. Prostaglandin J2 is highly neurotoxic and potentially contributes to many neurodegenerative conditions, including Alzheimer's (AD) and Parkinson's diseases (PD) .
AM211 is a potent, selective and orally bioavailable prostaglandinD2 (PGD2) receptor type 2 (DP2) antagonist, with IC50s of 4.9 nM, 7.8 nM, 4.9 nM, 10.4 nM for human, mouse, guinea pig, and rat DP2, respectively.
AM211 sodium is a potent, selective and orally bioavailable prostaglandinD2 (PGD2) receptor type 2 (DP2) antagonist, with IC50s of 4.9 nM, 7.8 nM, 4.9 nM, 10.4 nM for human, mouse, guinea pig, and rat DP2, respectively.
Tranilast (MK-341) acts as an anti-atopic agent. Tranilast suppresses production of prostaglandinD2 (PGD2, IC50= 0.1 mM). Tranilast sodium exhibits anti-inflammatory and immunomodulatory effects . Tranilast sodium antagonizes angiotensin II and inhibits its biological effects in vascular smooth muscle cells .
Tranilast sodium (MK-341 sodium) acts as an anti-atopic agent. Tranilast suppresses production of prostaglandinD2 (PGD2, IC50= 0.1 mM). Tranilast sodium exhibits anti-inflammatory and immunomodulatory effects . Tranilast sodium antagonizes angiotensin II and inhibits its biological effects in vascular smooth muscle cells .
L-644698 is a potent and selective human recombinant prostaglandinD2 (PGD2) receptor (hDP) agonist with Ki values of 0.9, 267, 3730, 9280 nM for hDP, hEP2, hEP3, hEP4, respectively. L-644698 induces cyclic AMP production with an EC50 value of 0.5 nM .
CAY10471 Racemate (TM30089 Racemate) is a potent and highly selective prostaglandinD2 receptor CRTH2 antagonist, with a Ki of 0.6 nM for hCRTH2, selective over human thromboxane A2 receptor TP (Ki, >10000 nM) or PGD2 receptor DP (Ki, 1200 nM). CAY10471 Racemate also has effect on mouse and rat orthologs of CRTH2 .
Pizuglanstat hydrate (TAS-205) is a hematopoietic prostaglandinD synthase (HPGDS) inhibitor. TAS-205 selectively inhibits the synthesis of prostaglandinD2 (PGD2) in cell-based enzymatic tests and in vivo models, and effectively reduces the entry of eosinophils into the nasal cavity and late-stage nasal congestion. When used in combination with montelukast (HY-13315A), TAS-205 showed a significant synergistic inhibitory effect; when used in combination with fexofenadine (HY-B0801A), it also had a certain inhibitory effect on early and late nasal congestion.
Tranilast (Standard) is the analytical standard of Tranilast. This product is intended for research and analytical applications. Tranilast (MK-341) acts as an anti-atopic agent. Tranilast suppresses production of prostaglandinD2 (PGD2, IC50= 0.1 mM). Tranilast sodium exhibits anti-inflammatory and immunomodulatory effects . Tranilast sodium antagonizes angiotensin II and inhibits its biological effects in vascular smooth muscle cells .
O-Desmethyl-N-deschlorobenzoyl indomethacin is a metabolite of the non-steroidal anti-inflammatory drug (NSAID) and COX inhibitor indomethacin (HY-14397). It is formed from indomethacin in isolated rabbit hepatocytes. O-Desmethyl-N-deschlorobenzoyl indomethacin (600 μM) decreases the viability of HL-60 leukemia cells when cultured with glucose oxidase. It has also been used in the synthesis of prostaglandinD2 (HY-101988) receptor antagonists.
17-Phenyl-18,19,20-trinor-PGD2 (17-Phenyl-PGD2) is an analogue of prostaglandinD2 (PGD2; HY-101988). 17-Phenyl-18,19,20-trinor-PGD2 is a potent inhibitor of platelet aggregation caused by aenosine diphosphate (ADP), with the IC50 of 8.4 μM (PGD2 IC50 = 18.6 nM). 17-Phenyl-18,19,20-trinor-PGD2 is a weak agonist of cyclic AMP accumulation .
N1-Acetyl-5-methoxykynuramine (AMK) hydrochloride is an active metabolite of the neurohormone melatonin (HY-B0075). N1-Acetyl-5-methoxykynuramine hydrochloride (200 µM) effectively scavenges singlet oxygen (ROS).1 It also inhibits the production of prostaglandin E2 (PGE2) and prostaglandinD2 (PGD2) induced by epinephrine and arachidonic acid in a concentration- and time-dependent manner, and suppresses the increase in COX-2 levels induced by LPS (HY-D1056) in RAW 264.7 macrophages at a concentration of 500 µM. In a mouse model of Parkinson's disease induced by MPTP (HY-15608), N1-Acetyl-5-methoxykynuramine hydrochloride (20 mg/kg) reduces the increase in lipid peroxidation in the cytosol and mitochondria of the substantia nigra and striatum. N1-Acetyl-5-methoxykynuramine hydrochloride can be used in research on metabolic and neurological diseases
Abz-AGLA-Nba is a fluorogenic substrate for the determination of protease activity. Abz-AGLA-Nba is hydrolyzed to release aminoacyl benzimide (Abz-AGLA) and 2-naphthylaminoacyl (Nba). The product Abz-AGLA produced by this hydrolysis reaction is fluorescent under ultraviolet light and can emit a fluorescent signal .
Abz-AGLA-Nba is a fluorogenic substrate for the determination of protease activity. Abz-AGLA-Nba is hydrolyzed to release aminoacyl benzimide (Abz-AGLA) and 2-naphthylaminoacyl (Nba). The product Abz-AGLA produced by this hydrolysis reaction is fluorescent under ultraviolet light and can emit a fluorescent signal .
ProstaglandinD2 (PGD2) is one of the major PGs actively produced in the brain of various mammals . ProstaglandinD2 is one of the most potent endogenous sleep promoting substances . PGD2 plays a protective role by suppressing inflammation .
Delta-12-Prostaglandin J2 (Δ12-PGJ2) is a cyclopentenone prostaglandin (PG) with anti-proliferative effect on various tumor cell growth. Delta-12-Prostaglandin J2, a naturally occurring dehydration product of prostaglandinD2, is able to induce apoptosis in HeLa cells via caspase activation .
Prostaglandin J2 (PGJ2), an endogenous metabolite of ProstaglandinD2 (PGD2; HY-101988), is a potent PGD2 receptor (DP) agonist with Kis of 0.9 nM and 6.6 nM for hDP and hCRTH2, respectively. Prostaglandin J2 stimulates intracellular cyclic AMP production with an EC50 value of 1.2 nM. Prostaglandin J2 induces oxidative stress and neuronal apoptosis. Prostaglandin J2 induces the accumulation/aggregation of ubiquitinated (Ub) proteins. Prostaglandin J2 is highly neurotoxic and potentially contributes to many neurodegenerative conditions, including Alzheimer's (AD) and Parkinson's diseases (PD) .
ProstaglandinD2 (Standard) is the analytical standard of ProstaglandinD2. This product is intended for research and analytical applications. ProstaglandinD2 (PGD2) is one of the major PGs actively produced in the brain of various mammals . ProstaglandinD2 is one of the most potent endogenous sleep promoting substances . PGD2 plays a protective role by suppressing inflammation .
The PTGDS protein catalyzes the conversion of PGH2 to PGD2, a prostaglandin that affects smooth muscle activity and platelet aggregation. It plays a role in central nervous system functions such as sedation, sleep, and allodynia. PTGDS Protein, Human (His, solution) is the recombinant human-derived PTGDS protein, expressed by HEK293 , with C-6*His labeled tag.
The PTGDS protein catalyzes the conversion of PGH2 to PGD2, a prostaglandin that affects smooth muscle activity and platelet aggregation. It plays a role in central nervous system functions such as sedation, sleep, and allodynia. PTGDS Protein, Human (HEK293, C-His) is the recombinant human-derived PTGDS protein, expressed by HEK293 , with C-10*His labeled tag.
ProstaglandinD2-d9 is the deuterium labeled ProstaglandinD2. ProstaglandinD2 (PGD2) is one of the major PGs actively produced in the brain of various mammals[1]. ProstaglandinD2 is one of the most potent endogenous sleep promoting substances[2]. PGD2 plays a protective role by suppressing inflammation[3].
ProstaglandinD2-d4 is the deuterium labeled ProstaglandinD2. ProstaglandinD2 (PGD2) is one of the major PGs actively produced in the brain of various mammals[1]. ProstaglandinD2 is one of the most potent endogenous sleep promoting substances[2]. PGD2 plays a protective role by suppressing inflammation[3].
13,14-Dihydro-15-keto prostaglandinD2-d4(DK-PGD2-d4) is deuterium labeled 13,14-Dihydro-15-keto prostaglandinD2. 13, 14-Dihydro-15-keto prostaglandinD2 (DK-PGD2) is a PGD2 metabolite formed by the 15-hydroxyl PGDH pathway. 13, 14-Dihydro-15-keto prostaglandinD2 is a selective agonist for the DP2 receptor. 13, 14-Dihydro-15-keto prostaglandinD2 can inhibit ion flux in canine colonic mucosa preparation .
13,14-Dihydro-15-keto prostaglandinD2-d9(DK-PGD2-d9) is deuterium labeled 13,14-Dihydro-15-keto prostaglandinD2. 13, 14-Dihydro-15-keto prostaglandinD2 (DK-PGD2) is a PGD2 metabolite formed by the 15-hydroxyl PGDH pathway. 13, 14-Dihydro-15-keto prostaglandinD2 is a selective agonist for the DP2 receptor. 13, 14-Dihydro-15-keto prostaglandinD2 can inhibit ion flux in canine colonic mucosa preparation .
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