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Results for "

Pyroptosis inhibitor

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Pyroptosis (27) AIM2 (1) Aldehyde Dehydrogenase (ALDH) (2) AMPK (1) Apoptosis (6) Autophagy (1) Bcl-2 Family (3) Btk (1) c-Myc (1) Carbonic Anhydrase (2) Caspase (3) Cuproptosis (2) Deubiquitinase (1) DNA/RNA Synthesis (1) Enterovirus (1) ERK (1) FGFR (1) Flavivirus (1) Fluorescent Dye (1) HBV (2) IKK (1) Interleukin Related (3) NF-κB (1) NOD-like Receptor (NLR) (17) Parasite (2) PARP (2) PERK (1) Reactive Oxygen Species (1) STAT (1) TrxR (1)
By Research Areas:	Cancer (8) Cardiovascular Disease (2) Infection (6) Inflammation/Immunology (30) Metabolic Disease (2) Neurological Disease (3)
Click Chemistry:	Azide (1)

Inhibitors & Agonists

Screening Libraries

Fluorescent Dye

Peptides

Natural
Products

Click Chemistry

Targets Recommended: Pyroptosis

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-144226

NLRP3/AIM2-IN-3 5 Publications Verification	NOD-like Receptor (NLR) AIM2 Pyroptosis	Inflammation/Immunology
NLRP3/AIM2-IN-3 (compound 59) is a potent inhibitor with differential species specific effects against NLRP3 and AIM2 inflammasome-dependent *pyroptosis. NLRP3/AIM2-IN-3 shows inhibitory efficacy against pyroptosis* in THP-1 macrophages stimulated with LPS/nigericin, with an IC₅₀ of 0.077 ± 0.008 μM. NLRP3/AIM2-IN-3 disturbs the interaction of NLRP3 or AIM2 with the adaptor protein ASC and inhibited ASC oligomerization .

HY-162150

Azalamellarin N AZL-N	Pyroptosis	Inflammation/Immunology
Azalamellarin N is an inhibitor of *pyroptosis* and has different inhibitory effects on different *pyroptosis* inducers. Azalamellarin N inhibits *pyroptosis* by targeting molecules that act upstream of NLRP3 inflammasome activation, rather than directly targeting components of the NLRP3 inflammasome. Inhibitory potency against different pyroptosis inducers: Nigericin (HY-127019) > R837 (HY-B0180) .

HY-111770

2-Bromohexadecanoic acid 2 Publications Verification 2-Bromopalmitic acid; 2-Bromopalmitate	Pyroptosis	Infection Inflammation/Immunology Cancer
2-Bromohexadecanoic acid (2-Bromopalmitate; 2-BP) is a palmitoylation inhibitor targeting DHHC (Asp-His-His-Cys) protein palmitoyltransferase. 2-Bromohexadecanoic acid inhibits palmitoylation of GSDME-C during *pyroptosis* and inhibits BAK/BAX-Caspase 3-GSDME pathway-mediated pyroptosis .

HY-42068

(-)-Aspartic acid (R)-Aspartic acid; D-(-)-Aspartic acid	Pyroptosis	Neurological Disease
(-)-Aspartic acid is a pyroptosis inhibitor. (-)-Aspartic acid acts as a neurotransmitter and neuromodulator, participates in hormone synthesis and regulation, and plays a role in nervous system development and endocrine system .

HY-124857

7DG 7-Desacetoxy-6,7-dehydrogedunin	PERK	Inflammation/Immunology
7DG (7-Desacetoxy-6,7-dehydrogedunin) is a protein kinase R (PKR) inhibitor. 7DG protects macrophages from lethal toxin-induced pyroptosis .

HY-B0621

Triclabendazole 4 Publications Verification CGA89317	Parasite Caspase Bcl-2 Family PARP Pyroptosis	Infection
Triclabendazole is an orally active parasite inhibitor. Triclabendazole has anti-Leishmania activity and induces gasdermin E (GSDME)-dependent *pyroptosis* by caspase-3 activation. Triclabendazole can be used for the research of fasciola hepatica .

HY-161043

ECDD-S16	Pyroptosis	Inflammation/Immunology
ECDD-S16 is a potent inhibitor of *pyroptosis. ECDD-S16 inhibits* surface and endosomal TLR ligands activated pyroptosis in Raw264.7 cells .

HY-N9921

Antcin A	Pyroptosis NOD-like Receptor (NLR)	Inflammation/Immunology
Antcin A is a potent NLRP3 inhibitor that inhibits the assembly and activation of the NLRP3 inflammasome. Antcin A can inhibit Kupffer cell *pyroptosis* and has liver protective activity. Antcin A can be used to study inflammation, such as non-alcoholic fatty liver disease .

HY-170529

NLRP3-IN-61	NOD-like Receptor (NLR) Pyroptosis	Inflammation/Immunology
NLRP3-IN-61 (Compound 1) is an inhibitor for NLRP3. NLRP3-IN-61 inhibits pyroptosis in THP-1 cell with an IC₅₀ of 12.6 nM, inhibits IL-β release with an IC₅₀ of 25.3 nM .

HY-170530

NLRP3-IN-62	NOD-like Receptor (NLR) Pyroptosis	Inflammation/Immunology
NLRP3-IN-62 (Compound 1) is an inhibitor for NLRP3. NLRP3-IN-62 inhibits *pyroptosis* in THP-1 cell with an IC₅₀ of 0.7 nM, inhibits IL-β release with an IC₅₀ of 108.5 nM .

HY-42068R

(-)-Aspartic acid (Standard)	Pyroptosis	Neurological Disease
(-)-Aspartic acid (Standard) is the analytical standard of (-)-Aspartic acid. This product is intended for research and analytical applications. (-)-Aspartic acid is a pyroptosis inhibitor. (-)-Aspartic acid acts as a neurotransmitter and neuromodulator, participates in hormone synthesis and regulation, and plays a role in nervous system development and endocrine system .

HY-D2376

BH-Vis	Fluorescent Dye	Cancer
BH-Vis is a two-photon fluorescent probe that inhibits cell plasma membrane (CPM). BH-Vis has great potential to accurately identify pyroptosis at the cellular level during AAA development in the mouse abdominal aortic aneurysm AAA model .

HY-149604

NLRP3-IN-21	NOD-like Receptor (NLR)	Inflammation/Immunology
NLRP3-IN-21 (compound L38) is a NLRP3 inflammasome inhibitor with inflammatory properties. NLRP3-IN-21 inhibits NLRP3 inflammasome activation and pyroptosis by suppressing gasdermin D cleavage, ASC oligomerization, and NLRP3 inflammasome assembly .

HY-156034

JT001 NLRP3-IN-19	NOD-like Receptor (NLR)	Inflammation/Immunology
JT001 (NLRP3-IN-19) is a potent, specific and orally active inhibitor of NLRP3. JT001 can inhibit NLRP3 inflammasome assembly, resulting in the inhibition of cytokine release and the prevention of pyroptosis. JT001 can be used for the research of nonalcoholic steatohepatitis and liver fibrosis .

HY-156034A

JT001 sodium NLRP3-IN-19 sodium	NOD-like Receptor (NLR)	Inflammation/Immunology
JT001 (NLRP3-IN-19) sodium is a potent, specific and orally active inhibitor of NLRP3. JT001 sodium can inhibit NLRP3 inflammasome assembly, resulting in the inhibition of cytokine release and the prevention of pyroptosis. JT001 sodium can be used for the research of nonalcoholic steatohepatitis and liver fibrosis .

HY-155053

ZIKV-IN-6	Flavivirus DNA/RNA Synthesis	Inflammation/Immunology
ZIKV-IN-6 (compound 22) is an inhibitor of Zika virus (ZIKV), with low cytotoxicity (CC₅₀＞50 μM). ZIKV-IN-6 binds to ZIKV RdRp directly and inhibits viral RNA synthesis by ZIKV NS5. ZIKV-IN-6 suppresses the excessive inflammatory response and *pyroptosis* .

HY-170364

NLRP3-IN-60	NOD-like Receptor (NLR) Pyroptosis	Inflammation/Immunology
NLRP3-IN-60 (Compound 39) is the orally active inhibitor for NLRP3. NLRP3-IN-60 inhibits *pyroptosis* with an IC₅₀ of 13 nM in THP-1 cell. NLRP3-IN-60 inhibits IL-1β release with an IC₅₀ of 225 nM in human whole blood .

HY-163179

NLRP3-IN-28	NOD-like Receptor (NLR) Pyroptosis	Inflammation/Immunology
NLRP3-IN-28 (compound N77) is a potent inhibitor of NLRP3. NLRP3-IN-28 inhibits Nigericin (HY-127019)-induced *pyroptosis* with an EC₅₀ of 0.07μM. NLRP3-IN-28 alleviates the inflammatory reaction in vivo .

HY-159589

BTK-IN-37	Btk Apoptosis	Cancer
BTK-IN-37 (compound 8d) is a BTK inhibitor that can induce apoptosis in cancer cells. BTK-IN-37 targets BTK with K_i and IC₅₀ of 5.07 nM and 3.6 nM, respectively. BTK-IN-37 can also selectively induce enrichment of genes involved in necroptosis and pyroptosis .

HY-164304

INF 195	Pyroptosis Interleukin Related NOD-like Receptor (NLR)	Cardiovascular Disease Inflammation/Immunology
INF 195 is an NLRP3 inhibitor. INF 195 can inhibit NLRP3 driven macrophage *pyroptosis* and IL-1β release, with an EC₅₀ value of 0.15 μM. INF 195 can reduce the infarct size of isolated mouse hearts at low doses, effectively preventing myocardial ischemia/reperfusion injury .

HY-P3496

Pep19-2.5	Pyroptosis	Inflammation/Immunology
Pep19-2.5 is an synthetic and antitoxin peptide, blocks the intracellular endotoxin signaling cascade. Pep19-2.5 inhibits signaling of lipopeptides (LP) and lipopolysaccharides (LPS) mediated by transmembrane and cytosolic pattern recognition receptors (PRRs). The signaling cascades lead to inflammation and cell *pyroptosis* .

HY-N12482

Callicarboric acid A	NOD-like Receptor (NLR)	Inflammation/Immunology
NLRP3-IN-27 (compound 1) is an inhibitor of NLRP3 with an IC₅₀ value of 0.74 μM. NLRP3 reduces inflammasome-induced pyroptosis in J774A.1 cells. NLRP3-IN-27 can be isolated from Callicarpa arborea Rox .

HY-B0621R

Triclabendazole (Standard)	Parasite Caspase Bcl-2 Family PARP Pyroptosis	Infection
Triclabendazole (Standard) is the analytical standard of Triclabendazole. This product is intended for research and analytical applications. Triclabendazole is an orally active parasite inhibitor. Triclabendazole has anti-Leishmania activity and induces gasdermin E (GSDME)-dependent *pyroptosis* by caspase-3 activation. Triclabendazole can be used for the research of fasciola hepatica .

HY-16990

Ac-YVAD-cmk 10+ Cited Publications Caspase-1 inhibitor II	Caspase	Inflammation/Immunology
Ac-YVAD-cmk (Caspase-1 Inhibitor II) is a selective caspase-1 (IL-1beta converting enzyme, ICE)) inhibitor with neuroprotective and anti-inflammatory effects. Ac-YVAD-cmk effectively suppresses the expression of IL-1β and IL-18. Ac-YVAD-cmk inhibits *pyroptosis* in many diseases .

HY-156374

D359-0396	NOD-like Receptor (NLR) Pyroptosis	Inflammation/Immunology
D359-0396 is an orally active NLRP3 inflammasome inhibitor. D359-0396 inhibits *pyroptosis* and IL-1β release in macrophages. D359-0396 also inhibits the oligomerization of NLRP3, ASC and the cleavage of GSDMD. D359-0396 alleviates EAE, and also improves survival after septic shock in mice .

HY-P3434

Ac-FEID-CMK	Pyroptosis	Inflammation/Immunology
Ac-FEID-CMK is a potent zebrafish-specific GSDMEb-derived peptide inhibitor. Ac-FEID-CMK can attenuate the mortality and kidney injury during septic shock. Ac-FEID-CMK inhibits *pyroptosis* and attenuates septic AKI (acute kidney injury) in vivo. Ac-FEID-CMK can suppress the caspy2-mediated noncanonical inflammasome pathway .

HY-169227

NLRP3-IN-55	Pyroptosis NOD-like Receptor (NLR)	Inflammation/Immunology
NLRP3-IN-55 (Compound 19) is a potent NLRP3 inhibitor (IC₅₀ = 0.34 μM). NLRP3-IN-55 directly targets the NLRP3 protein (K_D = 0.45 μM), blocking the assembly and activation of the NLRP3 inflammasome, leading to anti-inflammatory effects and inhibition of cellular *pyroptosis* .

HY-P3434A

Ac-FEID-CMK TFA	Pyroptosis	Inflammation/Immunology
Ac-FEID-CMK TFA is a potent zebrafish-specific GSDMEb-derived peptide inhibitor. Ac-FEID-CMK TFA can attenuate the mortality and kidney injury during septic shock. Ac-FEID-CMK TFA inhibits *pyroptosis* and attenuates septic AKI (acute kidney injury) in vivo. Ac-FEID-CMK TFA can suppress the caspy2-mediated noncanonical inflammasome pathway .

HY-157082

ZHSI-1	Enterovirus	Infection
ZHSI-1 is an EV71 (Enterovirus 71) inhibitor that inhibits EV71/CVA16 replication and virus-induced pyroptosis associated with viral pathogenesis. ZHSI-1 effectively prevents EV71 infection in neonatal and young mice in animal models. ZHSI-1 can be used to study viral infections such as hand, foot and mouth disease (HFMD) .

HY-N0639

Punicalin	HBV Pyroptosis Carbonic Anhydrase	Infection Inflammation/Immunology
Punicalin is a species that can be isolated from the leaves of Punica granatum. Punicalin is an active molecule against hepatitis b virus (HBV). Punicalin can induce *pyroptosis. Punicalin is a Carbonic anhydrase* inhibitor. Punicalin blocks the binding of S-glycoprotein and ACE2 receptors. Pnuicalin has anti-inflammatory, antioxidant and antiviral activity .

HY-158111

NLRP3-IN-34	NOD-like Receptor (NLR)	Inflammation/Immunology
NLRP3-IN-34 (Compound T10) is an inhibitor for NLRP3 inflammasome. NLRP3-IN-34 inhibits ROS production, NLRP3 inflammasome-dependent IL-1β production (IC₅₀ is 0.48 μM in cells J774A.1), and inhibits *pyroptosis*. NLRP3-IN-34 exhibits anti-inflammatory activity against DSS-induced peritonitis .

HY-168927

Apoptosis inducer 36	Apoptosis Pyroptosis	Cancer
Apoptosis inducer 36 (Compound 42) exhibits anti-leukemic activity through reduction of leukemia stem cells (LSCs) and induction of differentiation. Apoptosis inducer 36 inhibits the proliferation of AML cells, arrests cell cycle at G1 phase, and induces PANoptosis including apoptosis, pyroptosis and necrosis. Prodrug of apoptosis inducer 36 exhibits orally active antitumor efficacy in mouse model .

HY-B0240

Disulfiram 80+ Cited Publications Tetraethylthiuram disulfide; TETD	Aldehyde Dehydrogenase (ALDH) Interleukin Related Pyroptosis Apoptosis Cuproptosis	Metabolic Disease Cancer
Disulfiram (Tetraethylthiuram disulfide) is a specific inhibitor of aldehyde-dehydrogenase (ALDH1), used for the treatment of chronic alcoholism by producing an acute sensitivity to alcohol. Disulfiram inhibits gasdermin D (GSDMD) pore formation in liposomes and inflammasome-mediated pyroptosis and IL-1β secretion in human and mouse cells. Disulfiram, a copper ion carrier, with Cu ²⁺ increases intracellular ROS levels and induces cuproptosis .

HY-164853

Kanglexin	Pyroptosis NOD-like Receptor (NLR) ERK FGFR AMPK	Cardiovascular Disease Neurological Disease Inflammation/Immunology
Kanglexin is an orally active and novel anthraquinone compound. Kanglexin inhibits NLRP3 inflammatory body activation and cell pyroptosis, and has a cardioprotective effect. Kanglexin promotes angiogenesis through FGFR1/ERK signaling pathway and accelerates diabetic wound healing. In addition, Kanglexin has the effect of lipid-lowering and inhibiting the dedifferentiation of vascular smooth muscle cells, and can be used in the study of hyperlipidemia, fatty liver and atherosclerosis .

HY-149478

JT002	NOD-like Receptor (NLR)	Inflammation/Immunology
JT002 is an orally active inhibitor of the NLRP3 inflammasome. JT002 reduces NLRP3-dependent proinflammatory cytokine (such as IL-1β, IL-1α, IL-18) production and *pyroptosis*. JT002 blocks NLRP3 inflammasome complex formation. JT002 reduces airway hyperresponsiveness and airway neutrophilia in mice .

HY-138071

8α-Tigloyloxyhirsutinolide 13-O-acetate 8αTGH	STAT Pyroptosis Apoptosis Reactive Oxygen Species c-Myc Bcl-2 Family TrxR	Cancer
8α-Tigloyloxyhirsutinolide 13-O-acetate (8αTGH) is a potent and orally active STAT3 inhibitor. 8α-Tigloyloxyhirsutinolide 13-O-acetate induces early oxidative stress and *pyroptosis, and late DNA damage, cell cycle arrest, apoptosis* in the TNBC cells. 8α-Tigloyloxyhirsutinolide 13-O-acetate suppresses tumor cell growth in vitro and tumor growth in vivo .

HY-B0240R

Disulfiram (Standard)	Aldehyde Dehydrogenase (ALDH) Interleukin Related Pyroptosis Apoptosis Cuproptosis	Metabolic Disease Cancer
Disulfiram (Standard) is the analytical standard of Disulfiram. This product is intended for research and analytical applications. Disulfiram (Tetraethylthiuram disulfide) is a specific inhibitor of aldehyde-dehydrogenase (ALDH1), used for the treatment of chronic alcoholism by producing an acute sensitivity to alcohol. Disulfiram inhibits gasdermin D (GSDMD) pore formation in liposomes and inflammasome-mediated pyroptosis and IL-1β secretion in human and mouse cells. Disulfiram + Cu ²⁺ increases intracellular ROS levels triggering apoptosis of ovarian cancer stem cells ^[1-6].

HY-N0639R

Punicalin (Standard)	HBV Pyroptosis Carbonic Anhydrase	Infection Inflammation/Immunology
Punicalin (Standard) is the analytical standard of Punicalin. This product is intended for research and analytical applications. Punicalin is a species that can be isolated from the leaves of Punica granatum. Punicalin is an active molecule against hepatitis b virus (HBV). Punicalin can induce pyroptosis. Punicalin is a Carbonic anhydrase inhibitor. Punicalin blocks the binding of S-glycoprotein and ACE2 receptors. Pnuicalin has anti-inflammatory, antioxidant and antiviral activity .

HY-N0272R

Eleutheroside E (Standard)	Others	Inflammation/Immunology
Eleutheroside E (Standard) is the analytical standard of Eleutheroside E. This product is intended for research and analytical applications. Eleutheroside E is an important component of Eleutheroside and has antioxidant, anti-fatigue, anti-inflammatory, antibacterial, immunomodulatory and cardioprotective effects. Eleutheroside E may inhibit the MAPK signaling pathway, thereby inhibiting H/R-induced NF-κB activation and oxidative stress, reducing metabolic reprogramming, and protecting myocardium from ischemia-reperfusion (I/R) injury. Eleutheroside E also counteracts the effects of high altitude hypobaric hypoxia (HAHI) by inhibiting inflammation and pyroptosis .

HY-13453

BAY 11-7082 Maximum Cited Publications 331 Publications Verification BAY 11-7821	IKK Deubiquitinase Autophagy Apoptosis NF-κB	Inflammation/Immunology Cancer
BAY 11-7082 is an IκBα phosphorylation and NF-κB inhibitor. BAY 11-7082 selectively and irreversibly inhibits the TNF-α-induced phosphorylation of IκB-α, and decreases NF-κB and expression of adhesion molecules. BAY 11-7082 inhibits ubiquitin-specific protease USP7 and USP21 (IC₅₀=0.19, 0.96 μM, respectively). BAY 11-7082 inhibits gasdermin D (GSDMD) pore formation in liposomes and inflammasome-mediated pyroptosis and IL-1β secretion in human and mouse cells .

HY-155517

INF200	NOD-like Receptor (NLR) Pyroptosis	Inflammation/Immunology
INF200 (compound 5) is a sulfonylurea-based inhibitor of NLRP3 and NLRP3-mediated *pyroptosis*. INF200 has beneficial cardiometabolic effects in rat model of high-fat diet (HFD)-induced metaflammation，and shows anti-inflammatory activity to (10 μM) decreases IL-1β release in human macrophages. INF200 improves glucose and lipid profiles，and attenuates systemic inflammation and biomarkers of cardiac dysfunction (particularly BNP). INF200 also improves myocardial damage-dependent ischemia/reperfusion injury (IRI) in hemodynamic evaluation .

Cat. No.	Product Name

HY-L133

Cuproptosis Compound Library	253 compounds
Copper is an important co-factor of all biological enzymes, but if the concentration exceeds the threshold of maintaining the homeostasis mechanism, copper will lead to cytotoxicity. This death mechanism has been named "Cuproptosis". The mechanism of cuproptosis distinct from all other known mechanisms of regulated cell death, including apoptosis, pyroptosis, necroptosis, and ferroptosis. Copper combine with the lipoylated components of the tricarboxylic acid cycle (TCA), leading to lipoylated protein aggregation and subsequent loss of iron-sulfur cluster proteins, ultimately resulting in protein toxicity stress and cell death. Studies have shown that the necessary factors for cuproptosis include the presence of glutathione, mitochondrial metabolism of galactose and pyruvate, and glutamine metabolism. Targeted regulation of cuproptosis is a potential choice to treat cancer, rheumatoid arthritis, and other diseases. For example, up-regulation of LIPT1 may inhibit the occurrence and development of tumors by destroying TCA in mitochondria and then inducing cuproptosis. MCE supplies a unique collection of 253 cuproptosis-related compounds, all of which act on the targets or signaling pathways related to cuproptosis and may have in inhibitory or activated effect on cuproptosis. MCE Cuproptosis Library is a useful tool for drug research related to cancer, rheumatoid arthritis, and other diseases.

Cuproptosis Compound Library

253 compounds

Copper is an important co-factor of all biological enzymes, but if the concentration exceeds the threshold of maintaining the homeostasis mechanism, copper will lead to cytotoxicity. This death mechanism has been named "Cuproptosis".

The mechanism of cuproptosis distinct from all other known mechanisms of regulated cell death, including apoptosis, pyroptosis, necroptosis, and ferroptosis.

Copper combine with the lipoylated components of the tricarboxylic acid cycle (TCA), leading to lipoylated protein aggregation and subsequent loss of iron-sulfur cluster proteins, ultimately resulting in protein toxicity stress and cell death. Studies have shown that the necessary factors for cuproptosis include the presence of glutathione, mitochondrial metabolism of galactose and pyruvate, and glutamine metabolism.

Targeted regulation of cuproptosis is a potential choice to treat cancer, rheumatoid arthritis, and other diseases. For example, up-regulation of LIPT1 may inhibit the occurrence and development of tumors by destroying TCA in mitochondria and then inducing cuproptosis.

MCE supplies a unique collection of 253 cuproptosis-related compounds, all of which act on the targets or signaling pathways related to cuproptosis and may have in inhibitory or activated effect on cuproptosis. MCE Cuproptosis Library is a useful tool for drug research related to cancer, rheumatoid arthritis, and other diseases.

Cat. No.	Product Name	Type