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Results for "

QS

" in MedChemExpress (MCE) Product Catalog:

42

Inhibitors & Agonists

3

Peptides

8

Natural
Products

2

Isotope-Labeled Compounds

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-101092
    QS-21
    4 Publications Verification

    Stimulon

    		 NOD-like Receptor (NLR) Inflammation/Immunology Cancer
    QS-21, an immunostimulatory saponin, could be used as a potent vaccine adjuvant. QS-21 stimulates Th2 humoral and Th1 cell-mediated immune responses through action on antigen presenting cells (APCs) and T cells. QS-21 can activate the NLRP3 inflammasome with subsequent release of caspase-1 dependent cytokines, IL-1β and IL-18 .
    QS-21
  • HY-12762
    QS11
    1 Publications Verification

    		 β-catenin Cancer
    QS11 is an inhibitor of ARFGAP1 (ADP-ribosylation factor GTPase-activating protein 1), with an EC50 of 1.5 μM. QS11 modulates Wnt/β-catenin signaling through an effect on protein trafficking. QS11 inhibits migration of ARFGAP overexpressing breast cancer cells .
    QS11
  • HY-124796
    Qstatin

    		Bacterial Infection
    QStatin is a potent and selective inhibitor of SmcR (V. harveyi LuxR homologue) with an EC50 of 208.9 nM, binding tightly to SmcR and changes the flexibility of the protein, thereby altering its transcription regulatory activity. QStatin shows pan-QS (Vibrio quorum sensing) inhibitor activity in diverse Vibrio species and attenuates their virulence in an aquatic host. QStatin may be a sustainable antivibriosis agent useful in aquacultures .
    Qstatin
  • HY-158730
    N-3-Hydroxybutyryl-L-homoserine lactone

    3-OH-C4-HSL; N-3-Hydroxybutanoyl-L-homoserine lactone; N-3-Hydroxybutyryl-L-HSL

    		 Bacterial Infection
    N-3-Hydroxybutyryl-L-homoserine lactone (3-OH-C4-HSL) is an acyl-homoserine lactone, that can be isolated from Vibrionaceae. N-3-Hydroxybutyryl-L-homoserine lactone is a signaling molecule that is involved in bacterial quorum sensing (QS). N-3-Hydroxybutyryl-L-homoserine lactone senses the density of bacterial population, regulates the cellular process, such as bioluminescence, biofilm formation, and exo-enzyme production .
    N-3-Hydroxybutyryl-L-homoserine lactone
  • HY-133683
    N-(3-Oxotetradecanoyl)-DL-homoserine lactone

    3-Oxo-C14-AHL

    		 Bacterial Metabolic Disease
    N-(3-Oxotetradecanoyl)-DL-homoserine lactone, a member of N-Acyl homoserine lactone (AHL) from gram-negative bacteria, is a quorum sensing (QS) signaling molecule .
    N-(3-Oxotetradecanoyl)-DL-homoserine lactone
  • HY-P2454
    CSP1

    		Bacterial Infection
    CSP1 is a potent and selective ComD1 receptor agonist, with an IC50 of 10.3 nM. CSP1 is a major variants of competence-stimulating peptide (CSP), and it can regulate genetic transformation of S. pneumonia by modulating quorum sensing (QS). CSP1 can act as an antibacterial agent .
    CSP1
  • HY-N9517
    QS 7

    QS 7 Api

    		 Biochemical Assay Reagents Inflammation/Immunology Cancer
    QS 7 (QS 7 Api) is a saponin compound that can be extracted from the Quillaja saponaria tree. QS 7 activates immune cells, enhances their antigen presentation ability and cytokine secretion. QS 7 can be used as vaccine adjuvant for immunostimulating, anti-tumor, and anti-infectious activities .
    QS 7
  • HY-169081
    QS-57

    		PROTACs Molecular Glues Others
    QS-57 is a PROTAC targeting BRD4. QS-57 can be used as a 14-3-3 molecular glue. (Red: EN171 (HY-W1005067), black: (2-Aminoethyl) carbamic acid (HY-W398806), Blue: JQ-1 (carboxylic acid) (HY-78695)) .
    QS-57
  • HY-130317
    trans-11-Methyl-2-dodecenic acid

    trans-δ2-11-Methyl-dodecenoic acid

    		 Fungal Infection
    trans-11-Methyl-2-dodecenic acid is a isomer of cis-11-Methyl-2-dodecenoic acid (HY-134215). cis-11-Methyl-2-dodecenoic acid is a quorum sensing (QS) signal that acts as a diffusion signaling factor (DSF) in extracellular microbial and fungal communication systems .
    trans-11-Methyl-2-dodecenic acid
  • HY-159170
    Quorum sensing-IN-7

    		Bacterial Infection
    Quorum sensing-IN-7 (compound HSL 4) is a potent quorum sensing (QS) inhibitor. Quorum sensing-IN-7 interacts with Leu 72 and Gln 95 in the CviR binding pocket. Quorum sensing-IN-7, an antibacterial agent, is highly effective at inhibiting the production of homoserine lactones (HSLs) and biofilm in C. violaceum at 0.25-1 mg/mL .
    Quorum sensing-IN-7
  • HY-131337
    RhlR antagonist 1

    		Bacterial Infection
    RhlR antagonist 1 is a potent RhlR antagonist with an IC50 of 26 μM. RhlR antagonist 1 displays selective RhlR antagonism over LasR and PqsR, strong inhibition of biofilm formation in static and dynamic settings, and reduces production of virulence factors such as rhamnolipid and pyocyanin in P. aeruginosa. RhlR antagonist 1 can be utilized for developing QS-modulating molecules in the control of P. aeruginosa infections . RhlR antagonist 1 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    RhlR antagonist 1
  • HY-W398806
    (2-Aminoethyl)carbamic acid

    		PROTAC Linkers Cancer
    (2-Aminoethyl)carbamic acid is a PROTAC linker that belongs to the PEG class. (2-Aminoethyl)carbamic acid can be used to synthesize QS-57 (HY-169081) .
    (2-Aminoethyl)carbamic acid
  • HY-153552
    NH2-UAMC1110

    		Drug Derivative FAP Cancer
    NH2-UAMC1110 is a UAMC1110 (HY-100684) derivative that can be used in the synthesis of FAPI-QS. FAPI-QS is a chelating agent that can be used to manufacture high tumor selectivity and high dose radiotracers for the diagnosis and treatment of tumors .
    NH2-UAMC1110
  • HY-153552A
    NH2-UAMC1110 TFA

    		FAP Cancer
    NH2-UAMC1110 TFA is a UAMC1110 derivative that can be used in the synthesis of FAPI-QS. UAMC1110 is a fibroblast activation protein (FAP) inhibitor. FAPI-QS is a chelating agent that can be used to synthesize high tumor selectivity and high dose radiotracers for the diagnosis and treatment of tumors .
    NH2-UAMC1110 TFA
  • HY-P2073
    Cyclo(δ-Ala-L-Val)

    		Bacterial Infection
    Cyclo(Δ-Ala-L-Val) is a cyclic dipeptide and a putative quinolone signal (QS) molecule produced by Pseudomonas aeruginosa .
    Cyclo(δ-Ala-L-Val)
  • HY-163838
    Quorum sensing-IN-6

    		Bacterial Infection
    Quorum sensing-IN-6 (compound 27) is a quorum sensing (QS) inhibitor with IC50 values of 8 and 106 nM for E.coli and Pyocyanin, respectively .
    Quorum sensing-IN-6
  • HY-129405
    N-(Ketocaproyl)-DL-homoserine lactone

    		Bacterial Infection
    N-(Ketocaproyl)-DL-homoserine lactone is a natural, very active ligand of LuxR. N-(Ketocaproyl)-DL-homoserine lactone is a quorum sensing (QS) autoinducer .
    N-(Ketocaproyl)-DL-homoserine lactone
  • HY-161086
    Antibiofilm agent-4

    		Bacterial Infection
    Antibiofilm agent-4 (compound 4p) is a LasR inhibitor. Antibiofilm agent-4 shows the best antibiofilm and anti-QS properties .
    Antibiofilm agent-4
  • HY-158124
    LasR antagonist 1

    		Bacterial Infection
    LasR antagonist 1 (Compound 7) is an antagonist for LasR with an IC50 of 0.4 μM, that modulates the quorum sensing (QS) in the opportunistic pathogen Pseudomonas aeruginosa .
    LasR antagonist 1
  • HY-N4117
    Hamamelitannin

    		Bacterial Infection
    Hamamelitannin, a polyphenol extracted from the bark of Hamamelis virginiana, is a quorum-sensing (QS) inhibitor. Hamamelitannin increases antibiotic susceptibility of staphylococcus aureus biofilms by affecting peptidoglycan biosynthesis and eDNA release .
    Hamamelitannin
  • HY-149762
    IMBI

    		Bacterial Infection
    IMBI (compound 32) is an antibacterial agent that inhibits quorum sensing (QS) against drug-resistant pathogens. IMBI inhibits biofilm formation of Salmonella marcescens and restores or increases its susceptibility to antimicrobial drugs .
    IMBI
  • HY-122143
    V-06-018

    		Bacterial Infection
    V-06-018 is a potent LasR antagonist with an IC50 value of 5.2 µM. V-06-018 can be used as chemical probes of quorum sensing (QS) in Pseudomonas aeruginosa .
    V-06-018
  • HY-P10486
    AIP-II

    		Bacterial Infection
    AIP-II is a macrocyclic peptide signaling molecule used for quorum sensing, which can be produced be Staphylococcus aureus. AIP-II binds to AgrC-II receptor, regulates the virulence gene expression in Staphylococcus aureus. AIP-II is an antagonist for AgrC-I receptor .
    AIP-II
  • HY-111278
    Pyocyanin
    1 Publications Verification

    Pyocyanine; Sanazin; Sanasin

    		 Reactive Oxygen Species Bacterial Drug Metabolite Endogenous Metabolite Infection Inflammation/Immunology
    Pyocyanin (Pyocyanine) is a toxic, quorum sensing (QS) controlled metabolite produced by Pseudomonas aeruginosa. Pyocyanin is a REDOX active compound that promotes the production of reactive oxygen species (ROS). Pyocyanin has antibacterial and anti-inflammatory activity .
    Pyocyanin
  • HY-118697
    N-dodecanoyl-L-Homoserine lactone
    1 Publications Verification

    C12-HSL

    		 Bacterial Infection
    N-dodecanoyl-L-Homoserine lactone (C12-HSL) is a quorum sensing (QS) signaling molecule. N-dodecanoyl-L-Homoserine lactone (C12-HSL) aptamers blocks qurom sensing and inhibits biofilm formation in Pseudomonas aeruginosa .
    N-dodecanoyl-L-Homoserine lactone
  • HY-134215
    cis-11-Methyl-2-dodecenoic acid

    		Bacterial Fungal Infection
    cis-11-Methyl-2-dodecenoic acid is a quorum sensing (QS) signal that acts as a diffusion signaling factor (DSF) in extracellular microbial and fungal communication systems. DSF is involved in the regulation of virulence and biofilm formation of a variety of bacterial pathogens .
    cis-11-Methyl-2-dodecenoic acid
  • HY-N7788
    cis-2-Dodecenoic acid

    		Bacterial Infection
    cis-2-Dodecenoic acid, originally discovered in Burkholderia cenocepacia, can interfere with the bacterial quorum sensing system and inhibit bacterial biofilm formation and virulence factor production .
    cis-2-Dodecenoic acid
  • HY-120504
    N-Acetyltyramine
    1 Publications Verification

    		 Bacterial Infection Cancer
    N-Acetyltyramine is a quorum-sensing inhibitor (QSI) compound produced by V. alginolyticus M3-10. N-Acetyltyramine is capable of inhibiting the QS of C. violaceum ATCC 12472. N-acetyltyramine reverses resistance in Doxorubicin-resistant leukemia P388 cells .
    N-Acetyltyramine
  • HY-162957
    LasR-IN-5

    		Bacterial Antibiotic Infection
    LasR-IN-5 (compound 3C) is a LasR antagonist with an IC50 of 1.37 μM, demonstrating a 77% inhibition of biofilm formation in Pseudomonas aeruginosa. LasR-IN-5 also exhibits quorum sensing (QS) inhibition activity and has potential applications in Pseudomonas aeruginosa infection research .
    LasR-IN-5
  • HY-129405R
    N-(Ketocaproyl)-DL-homoserine lactone (Standard)

    		Bacterial Infection
    N-(Ketocaproyl)-DL-homoserine lactone (Standard) is the analytical standard of N-(Ketocaproyl)-DL-homoserine lactone. This product is intended for research and analytical applications. N-(Ketocaproyl)-DL-homoserine lactone is a natural, very active ligand of LuxR. N-(Ketocaproyl)-DL-homoserine lactone is a quorum sensing (QS) autoinducer .
    N-(Ketocaproyl)-DL-homoserine lactone (Standard)
  • HY-N10192
    Aculene D

    		Endogenous Metabolite Bacterial Infection
    Aculene D, a fungal metabolite, shows quorum sensing (QS) inhibitory activity against Chromobacterium violaceum CV026, and could significantly reduce violacein production in N-hexanoyl-l-homoserine lactone (C6-HSL) induced C. violaceum CV026 cultures at sub-inhibitory concentrations .
    Aculene D
  • HY-W007390
    Methyl 2-amino-5-bromobenzoate

    		Bacterial Infection
    Methyl 2-amino-5-bromobenzoate (compound 8/12) can be used for synthesis of 2-benzamidobenzoic acids, which are known FabH inhibitors. The derivates also inhibit PqsD, the pqs quorum sensing (QS) system of Pseudomonas aeruginosa, involving the production of a number of virulence factors and biofilm formation .
    Methyl 2-amino-5-bromobenzoate
  • HY-146304
    YXL-13

    		Bacterial Infection
    YXL-13 is a potent Pseudomonas aeruginosa (PAO1) inhibitor with an IC50 value of 3.686 μM. YXL-13 can inhibit virulence factors and biofilm formation of PAO1. YXL-13 reduces the pathogenicity and agent resistance of PAO1 by inhibition of the quorum sensing (QS) system. YXL-13 can be used for researching anti-bacteria .
    YXL-13
  • HY-124352
    2-Nonyl-3-hydroxy-4-quinolone

    		Bacterial Others
    2-nonyl-3-hydroxy-4-Quinolone (C9-PQS) is a quinolone compound produced by P. aeruginosa and other related bacterias. 2-nonyl-3-hydroxy-4-Quinolone is a quorum sensing (QS) signal molecule that controls the expression of many virulence genes as a function of cell population density .
    2-Nonyl-3-hydroxy-4-quinolone
  • HY-B1118
    Secnidazole

    RP-14539; PM-185184

    		 Parasite Antibiotic Bacterial Infection
    Secnidazole (RP-14539) is an orally active azole antibiotic and a imidazole mitigator of Serratia marcescens virulence. Secnidazole, as an analog of acylhomoserine lactones, effectively inhibits QS resulting in the attenuation of Pseudomonas aeruginosa pathogenesis. Secnidazole has antimicrobial activity against many anaerobic Gram-negative and Gram-positive bacterial species in vitro. Secnidazole can be used for the research of various diseases, such as amoebiasis and giardiasis, and bacterial vaginitis .
    Secnidazole
  • HY-B1118A
    Secnidazole hemihydrate

    RP-14539 hemihydrate; PM-185184 hemihydrate

    		 Antibiotic Bacterial Parasite Infection
    Secnidazole (RP-14539) hemihydrate is an orally active azole antibiotic and a imidazole mitigator of Serratia marcescens virulence. Secnidazole hemihydrate, as an analog of acylhomoserine lactones, effectively inhibits QS resulting in the attenuation of Pseudomonas aeruginosa pathogenesis. Secnidazole hemihydrate has antimicrobial activity against many anaerobic Gram-negative and Gram-positive bacterial species in vitro. Secnidazole hemihydrate can be used for the research of various diseases, such as amoebiasis and giardiasis, and bacterial vaginitis .
    Secnidazole hemihydrate
  • HY-133683R
    N-(3-Oxotetradecanoyl)-DL-homoserine lactone (Standard)

    		Others Metabolic Disease
    N-(3-Oxotetradecanoyl)-DL-homoserine lactone (Standard)
  • HY-145462
    N-cis-Octadec-9Z-enoyl-L-homoserine lactone

    		Bacterial Infection
    N-cis-octadec-9Z-enoyl-L-Homoserine lactone is a potent inhibitor of AhyI. AhyI (expressing acylhomoserine lactone) is responsible for the biosynthesis of autoinducer-1 (AI-1), commonly referred to as a quorum sensing (QS) signaling molecule, which plays an essential role in bacterial communication. N-cis-octadec-9Z-enoyl-L-Homoserine lactone is a competitive inhibitor of AI-1 biosynthesis .
    N-cis-Octadec-9Z-enoyl-L-homoserine lactone
  • HY-124237
    N-Octanoyl-DL-homoserine lactone

    		Bacterial Others
    N-Octanoyl-DL-homoserine lactone is a member of N-acyl homoserine lactones (AHLs) family, also one of the signal molecule of quorum-sensing (QS) signals. N-Octanoyl-DL-homoserine lactone can regulate the production of siderophores and present positive correlation in Aeromonas sobria strain AS7. N-Octanoyl-DL-homoserine lactone can also regulate the secretion of proteases and stimulate the production of total volatile basic nitrogen (TVB-N) .
    N-Octanoyl-DL-homoserine lactone
  • HY-B1118S2
    Secnidazole-d4

    RP-14539-d4; PM-185184-d4

    		 Bacterial Parasite Antibiotic Infection
    Secnidazole-d4 is the deuterium labeled Secnidazole[1]. Secnidazole (RP-14539) is an orally active azole antibiotic and a imidazole mitigator of Serratia marcescens virulence. Secnidazole, as an analog of acylhomoserine lactones, effectively inhibits QS resulting in the attenuation of Pseudomonas aeruginosa pathogenesis. Secnidazole has antimicrobial activity against many anaerobic Gram-negative and Gram-positive bacterial species in vitro. Secnidazole can be used for the research of various diseases, such as amoebiasis and giardiasis, and bacterial vaginitis[1][2][3].
    Secnidazole-d4
  • HY-B1118R
    Secnidazole (Standard)

    		Parasite Antibiotic Bacterial Infection
    Secnidazole (Standard) is the analytical standard of Secnidazole. This product is intended for research and analytical applications. Secnidazole (RP-14539) is an orally active azole antibiotic and a imidazole mitigator of Serratia marcescens virulence. Secnidazole, as an analog of acylhomoserine lactones, effectively inhibits QS resulting in the attenuation of Pseudomonas aeruginosa pathogenesis. Secnidazole has antimicrobial activity against many anaerobic Gram-negative and Gram-positive bacterial species in vitro. Secnidazole can be used for the research of various diseases, such as amoebiasis and giardiasis, and bacterial vaginitis .
    Secnidazole (Standard)
  • HY-124352S
    2-Nonyl-3-hydroxy-4-quinolone-d4

    C9-PQS-d4

    		 Isotope-Labeled Compounds Bacterial Others
    2-Nonyl-3-hydroxy-4-quinolone-d4 (C9-PQS-d4) is deuterium labeled 2-Nonyl-3-hydroxy-4-quinolone. 2-nonyl-3-hydroxy-4-Quinolone (C9-PQS) is a quinolone compound produced by P. aeruginosa and other related bacterias. 2-nonyl-3-hydroxy-4-Quinolone is a quorum sensing (QS) signal molecule that controls the expression of many virulence genes as a function of cell population density .
    2-Nonyl-3-hydroxy-4-quinolone-d4

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