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Quinine

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Bacterial (3) Cytochrome P450 (2) Dengue virus (7) Drug Metabolite (1) Flavivirus (7) Parasite (14) Potassium Channel (10)
By Research Areas:	Cancer (1) Cardiovascular Disease (2) Infection (15) Neurological Disease (1)

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Products

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-D0143

*Quinine* 3 Publications Verification	Flavivirus Dengue virus Parasite Potassium Channel	Infection
Quinine is an alkaloid derived from the bark of the cinchona tree, acts as an anti-malaria agent. Quinine is a potassium channel inhibitor that inhibits WT mouse Slo3 (K_Ca5.1) channel currents evoked by voltage pulses to +100 mV with an IC₅₀ of 169 μM .

HY-B0433A

Quinine hydrochloride dihydrate 3 Publications Verification	Flavivirus Dengue virus Parasite Potassium Channel	Infection
Quinine hydrochloride dihydrate (Qualaquin) is an orally active and can be used in anti-malarial studies. Quinine hydrochloride dihydrate is a potassium channel inhibitor that inhibits WT mouse Slo3 (K_Ca5.1) channel currents evoked by voltage pulses to +100 mV with an IC₅₀ of 169 μM .

HY-W010668

Quinine sulfate hydrate 3 Publications Verification	Flavivirus Dengue virus Parasite Potassium Channel	Others
Quinine sulfate hydrate (2:1:4) is an orally active alkaloid extracted from cinchona bark and can be used in anti-malarial studies. Quinine sulfate hydrate (2:1:4) is a potassium channel inhibitor that inhibits WT mouse Slo3 (K_Ca5.1) channel currents evoked by voltage pulses to +100?mV with an IC₅₀ of 169 μM .

HY-B0433AR

Quinine hydrochloride dihydrate (Standard)	Dengue virus Flavivirus Parasite Potassium Channel	Infection
Quinine (hydrochloride dihydrate) (Standard) is the analytical standard of Quinine (hydrochloride dihydrate). This product is intended for research and analytical applications. Quinine hydrochloride dihydrate (Qualaquin) is an orally active and can be used in anti-malarial studies. Quinine hydrochloride dihydrate is a potassium channel inhibitor that inhibits WT mouse Slo3 (KCa5.1) channel currents evoked by voltage pulses to +100?mV with an IC₅₀ of 169 μM .

HY-D0143A

Quinine dihydrochloride	Flavivirus Dengue virus Parasite Potassium Channel	Infection
Quinine dihydrochloride is an orally active alkaloid extracted from cinchona bark and can be used in anti-malarial studies. Quinine dihydrochloride is a potassium channel inhibitor that inhibits WT mouse Slo3 (K_Ca5.1) channel currents evoked by voltage pulses to +100 mV with an IC₅₀ of 169 μM .

HY-B0433B

Quinine hemisulfate	Flavivirus Dengue virus Parasite Potassium Channel	Infection
Quinine hemisulfate is an orally active alkaloid extracted from cinchona bark and can be used in anti-malarial studies. Quinine hemisulfate is a potassium channel inhibitor that inhibits WT mouse Slo3 (K_Ca5.1) channel currents evoked by voltage pulses to +100 mV with an IC₅₀ of 169 μM .

HY-B1401

Euquinine Quinine ethyl carbonate	Others	Infection
Euquinine is an odorless salt that can be used as a substitute for quinine. Euquinine has anti-Plasmodium falciparum activity. Euquinine can be used for the study of multidrug resistance and bioavailability of Plasmodium falciparum .

HY-D0143R

Quinine (Standard)	Dengue virus Flavivirus Parasite Potassium Channel	Infection
Quinine (Standard) is the analytical standard of Quinine. This product is intended for research and analytical applications. Quinine is an alkaloid derived from the bark of the cinchona tree, acts as an anti-malaria agent. Quinine is a potassium channel inhibitor that inhibits WT mouse Slo3 (K_Ca5.1) channel currents evoked by voltage pulses to +100 mV with an IC₅₀ of 169 μM .

HY-D0143B

Quinine hemisulfate hydrate	Parasite Potassium Channel	Infection
Quinine hemisulfate hydrate, an alkaloid derived from the bark of the cinchona tree, acts as an anti-malaria agent. Quinine hemisulfate hydrate is a potassium channel inhibitor that inhibits WT mouse Slo3 (K_Ca5.1) channel currents evoked by voltage pulses to +100 mV, with an IC₅₀ of 169 μM .

HY-B1751B

Quinine sulfate	Parasite Potassium Channel Cytochrome P450	Infection Cardiovascular Disease Cancer
Quinidine sulfate is an antiarrhythmic agent. Quinidine sulfate is a potent, orally active, selective cytochrome P450db inhibitor. Quinidine sulfate is also a K ⁺ channel blocker with an IC₅₀ of 19.9 μM. Quinidine sulfate can be used for malaria research .

HY-B1751C

Quinine hydrobromide	Parasite Cytochrome P450 Potassium Channel	Infection
Quinidine hydrobromide is an antiarrhythmic agent. Quinidine is a potent, orally active, selective cytochrome P450db inhibitor. Quinidine hydrobromide is also a K ⁺ channel blocker with an IC₅₀ of 19.9 μM. Quinidine hydrobromide can be used for malaria research .

HY-W072459

6'-Hydroxydihydrocinchonidine	Drug Metabolite	Infection
6'-Hydroxydihydrocinchonidine is a metabolite of Quinine (HY-D0143) (antimalarial agent) .

HY-W048510

Epiquinidine	Others	Others
Epiquinidine, a quinine analogue, can be used as the ggTas2r1 agonist. Epiquinidine activates ggTas2r1 at or beyond 10 µM .

HY-W037282

O-Desmethyl quinidine Cupreidine	Others	Neurological Disease
O-Desmethyl quinidine (Cupreidine) is an orally active metabolite of Quinine (HY-D0143). O-Desmethyl quinidine reduces frequency of cramps in rats with spinal cord injury and shows low blood toxicity .

HY-167647

Menoctone	Parasite	Infection
Menoctone is an orally active antimalarial agent that demonstrates suppressive effects against blood-induced rodent malaria. Menoctone enhances the anti-malarias effect of chloroquine or quinine and can be utilized in malarias research .

HY-N7354

Quininic acid	Others	Cardiovascular Disease
Quininic acid, purified from Eucalyptus globulus, cinchona bark, and other plant products, is the most abundant organic acid .

HY-N13110

23-Aldehyde-16-O-angeloybarringtogenol C	Others	Others
23-Aldehyde-16-O-angeloybarringtogenol C (compound 7) is a tea seed saponin, an acid hydrolysis product obtained by oxidative alkaline degradation. Tea seed saponins have potential quinine oxidoreductase inducing activity .

HY-136429

Ethylhydrocupreine Optochin	Bacterial Parasite	Infection
Ethylhydrocupreine (Optochin) is a quinine derivate with antimicrobial activity against *S. pneumoniae. Ethylhydrocupreine also possesses antimalarial activity against Plasmodium falciparum, with an IC₅₀* of 25.75 nM. Ethylhydrocupreine is a Gallus gallus taste 2 receptors (ggTas2r1, ggTas2r2 and ggTas2r7) agonist .

HY-136429A

Ethylhydrocupreine hydrochloride Optochin hydrochloride	Bacterial Parasite	Infection
Ethylhydrocupreine hydrochloride (Optochin hydrochloride) is a quinine derivate with antimicrobial activity against *S. pneumoniae. Ethylhydrocupreine hydrochloride also possesses antimalarial activity against Plasmodium falciparum, with an IC₅₀* of 25.75 nM. Ethylhydrocupreine hydrochloride is a Gallus gallus taste 2 receptors (ggTas2r1, ggTas2r2 and ggTas2r7) agonist .

HY-136429AR

Ethylhydrocupreine hydrochloride (Standard)	Bacterial Parasite	Infection
Ethylhydrocupreine (hydrochloride) (Standard) is the analytical standard of Ethylhydrocupreine (hydrochloride). This product is intended for research and analytical applications. Ethylhydrocupreine hydrochloride (Optochin hydrochloride) is a quinine derivate with antimicrobial activity against S. pneumoniae. Ethylhydrocupreine hydrochloride also possesses antimalarial activity against Plasmodium falciparum, with an IC₅₀ of 25.75 nM. Ethylhydrocupreine hydrochloride is a Gallus gallus taste 2 receptors (ggTas2r1, ggTas2r2 and ggTas2r7) agonist .

Cat. No.	Product Name

HY-L071

Alkaloids Library	547 compounds
Alkaloids are a large and complex group of cyclic compounds that contain N. About 2,000 different alkaloids have been isolated. Important alkaloids include morphine, strychnine, atropine, colchicine, ephedrine, quinine, and nicotine. Alkaloids are useful as diet ingredients, supplements, and pharmaceuticals, in medicine and in other applications in human life. They showed anti-inflammatory, anticancer, analgesics, local anesthetic and pain relief, neuropharmacologic, antimicrobial, antifungal, and many other activities. Alkaloids are also important compounds in organic synthesis for searching new semisynthetic and synthetic compounds with possibly better biological activity than parent compounds. MCE designs a unique collection of 547 alkaloids that all come from natural products. MCE Alkaloids Library is a useful tool for drug discovery that can be used for high throughput screening (HTS) and high content screening (HCS).

Alkaloids Library

547 compounds

Alkaloids are a large and complex group of cyclic compounds that contain N. About 2,000 different alkaloids have been isolated. Important alkaloids include morphine, strychnine, atropine, colchicine, ephedrine, quinine, and nicotine. Alkaloids are useful as diet ingredients, supplements, and pharmaceuticals, in medicine and in other applications in human life. They showed anti-inflammatory, anticancer, analgesics, local anesthetic and pain relief, neuropharmacologic, antimicrobial, antifungal, and many other activities. Alkaloids are also important compounds in organic synthesis for searching new semisynthetic and synthetic compounds with possibly better biological activity than parent compounds.

MCE designs a unique collection of 547 alkaloids that all come from natural products. MCE Alkaloids Library is a useful tool for drug discovery that can be used for high throughput screening (HTS) and high content screening (HCS).

6'-Hydroxydihydrocinchonidine	Biochemical Assay Reagents
6'-Hydroxydihydrocinchonidine is a metabolite of Quinine (HY-D0143) (antimalarial agent) .

*Quinine* 3 Publications Verification	Cinchona succirubra Pav. ex Klotzsch Infection Alkaloids Structural Classification Classification of Application Fields Source classification Rubiaceae Quinoline Alkaloids Plants Disease Research Fields	Flavivirus Dengue virus Parasite Potassium Channel
Quinine is an alkaloid derived from the bark of the cinchona tree, acts as an anti-malaria agent. Quinine is a potassium channel inhibitor that inhibits WT mouse Slo3 (K_Ca5.1) channel currents evoked by voltage pulses to +100 mV with an IC₅₀ of 169 μM .

Quinine hydrochloride dihydrate 3 Publications Verification	Infection Alkaloids Structural Classification Classification of Application Fields Source classification Rubiaceae Cinchona calisaya Wedd. Quinoline Alkaloids Plants Disease Research Fields	Flavivirus Dengue virus Parasite Potassium Channel
Quinine hydrochloride dihydrate (Qualaquin) is an orally active and can be used in anti-malarial studies. Quinine hydrochloride dihydrate is a potassium channel inhibitor that inhibits WT mouse Slo3 (K_Ca5.1) channel currents evoked by voltage pulses to +100 mV with an IC₅₀ of 169 μM .

Quinine sulfate hydrate 3 Publications Verification	Source classification Plants	Flavivirus Dengue virus Parasite Potassium Channel
Quinine sulfate hydrate (2:1:4) is an orally active alkaloid extracted from cinchona bark and can be used in anti-malarial studies. Quinine sulfate hydrate (2:1:4) is a potassium channel inhibitor that inhibits WT mouse Slo3 (K_Ca5.1) channel currents evoked by voltage pulses to +100?mV with an IC₅₀ of 169 μM .

Epiquinidine	Alkaloids Structural Classification other families Classification of Application Fields Source classification Other Diseases Quinoline Alkaloids Plants Disease Research Fields	Others
Epiquinidine, a quinine analogue, can be used as the ggTas2r1 agonist. Epiquinidine activates ggTas2r1 at or beyond 10 µM .

Quininic acid	Cardiovascular Disease Classification of Application Fields Ketones, Aldehydes, Acids Source classification Rubiaceae Cinchona calisaya Wedd. Plants Disease Research Fields	Others
Quininic acid, purified from Eucalyptus globulus, cinchona bark, and other plant products, is the most abundant organic acid .

Quinine hydrochloride dihydrate (Standard)	Alkaloids Structural Classification Source classification Rubiaceae Cinchona calisaya Wedd. Quinoline Alkaloids Plants	Dengue virus Flavivirus Parasite Potassium Channel
Quinine (hydrochloride dihydrate) (Standard) is the analytical standard of Quinine (hydrochloride dihydrate). This product is intended for research and analytical applications. Quinine hydrochloride dihydrate (Qualaquin) is an orally active and can be used in anti-malarial studies. Quinine hydrochloride dihydrate is a potassium channel inhibitor that inhibits WT mouse Slo3 (KCa5.1) channel currents evoked by voltage pulses to +100?mV with an IC₅₀ of 169 μM .

Quinine dihydrochloride	Cinchona succirubra Pav. ex Klotzsch Natural Products Source classification Rubiaceae Plants	Flavivirus Dengue virus Parasite Potassium Channel
Quinine dihydrochloride is an orally active alkaloid extracted from cinchona bark and can be used in anti-malarial studies. Quinine dihydrochloride is a potassium channel inhibitor that inhibits WT mouse Slo3 (K_Ca5.1) channel currents evoked by voltage pulses to +100 mV with an IC₅₀ of 169 μM .

Quinine hemisulfate	Cinchona succirubra Pav. ex Klotzsch Source classification Rubiaceae Quinoline Alkaloids Plants	Flavivirus Dengue virus Parasite Potassium Channel
Quinine hemisulfate is an orally active alkaloid extracted from cinchona bark and can be used in anti-malarial studies. Quinine hemisulfate is a potassium channel inhibitor that inhibits WT mouse Slo3 (K_Ca5.1) channel currents evoked by voltage pulses to +100 mV with an IC₅₀ of 169 μM .

Quinine (Standard)	Cinchona succirubra Pav. ex Klotzsch Alkaloids Structural Classification Source classification Rubiaceae Quinoline Alkaloids Plants	Dengue virus Flavivirus Parasite Potassium Channel
Quinine (Standard) is the analytical standard of Quinine. This product is intended for research and analytical applications. Quinine is an alkaloid derived from the bark of the cinchona tree, acts as an anti-malaria agent. Quinine is a potassium channel inhibitor that inhibits WT mouse Slo3 (K_Ca5.1) channel currents evoked by voltage pulses to +100 mV with an IC₅₀ of 169 μM .

Quinine hemisulfate hydrate	Infection Alkaloids Structural Classification Classification of Application Fields Source classification Rubiaceae Cinchona calisaya Wedd. Quinoline Alkaloids Plants Disease Research Fields	Parasite Potassium Channel
Quinine hemisulfate hydrate, an alkaloid derived from the bark of the cinchona tree, acts as an anti-malaria agent. Quinine hemisulfate hydrate is a potassium channel inhibitor that inhibits WT mouse Slo3 (K_Ca5.1) channel currents evoked by voltage pulses to +100 mV, with an IC₅₀ of 169 μM .

23-Aldehyde-16-O-angeloybarringtogenol C	Triterpenes Structural Classification Terpenoids Source classification Camellia sinensis (L.) O. Ktze. Plants Theaceae	Others
23-Aldehyde-16-O-angeloybarringtogenol C (compound 7) is a tea seed saponin, an acid hydrolysis product obtained by oxidative alkaline degradation. Tea seed saponins have potential quinine oxidoreductase inducing activity .

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