RNase-H

By Targets:	Apolipoprotein (1) DNA/RNA Synthesis (4) HBV (1) HCV (1) HIV (5) HIV Integrase (1) Reverse Transcriptase (1) Small Interfering RNA (siRNA) (4)
By Research Areas:	Cancer (1) Infection (8) Metabolic Disease (1) Neurological Disease (2)
Oligonucleotides:	Pre-designed siRNA Sets (4) Antisense Oligonucleotides (3) siRNAs (4)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-E70098

RNase H2	Others	Cancer
RNase H2 is the predominant source of RNase H activity in mammalian and human cells. RNase H2 protects genome integrity. RNase H2 has been associated with ribonucleotide removal from genomic DNA in yeast and mouse, where it is required for embryonic development .

HY-W028350

NSC727447	HIV DNA/RNA Synthesis	Infection
NSC727447 is an inhibitor of ribonuclease H (Rnase H) of HIV-1 and HIV-2. NSC727447 has little activity against E. coli RNase H, but great selectivity over human Rnase H, with IC₅₀s value of 2.0 μM, 2.5 μM, 100 μM, 10.6 μM, respectively .

HY-132580A

Tofersen sodium BIIB067 sodium; ISIS-SOD1Rx sodium	DNA/RNA Synthesis	Neurological Disease
Tofersen sodium is an antisense oligonucleotide that mediates RNase H-dependent degradation of superoxide dismutase 1 (SOD1) mRNA to reduce the synthesis of SOD1 protein. Tofersen sodium can be used for the research of amyotrophic lateral sclerosis (ALS) .

HY-RS12024

RNASEH1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
RNASEH1 Human Pre-designed siRNA Set A contains three designed siRNAs for RNASEH1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

RNASEH1 Human Pre-designed siRNA Set A RNASEH1 Human Pre-designed siRNA Set A

HY-RS12025

RNASEH2A Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
RNASEH2A Human Pre-designed siRNA Set A contains three designed siRNAs for RNASEH2A gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

RNASEH2A Human Pre-designed siRNA Set A RNASEH2A Human Pre-designed siRNA Set A

HY-RS12026

RNASEH2B Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
RNASEH2B Human Pre-designed siRNA Set A contains three designed siRNAs for RNASEH2B gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

RNASEH2B Human Pre-designed siRNA Set A RNASEH2B Human Pre-designed siRNA Set A

HY-RS12027

RNASEH2C Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
RNASEH2C Human Pre-designed siRNA Set A contains three designed siRNAs for RNASEH2C gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

RNASEH2C Human Pre-designed siRNA Set A RNASEH2C Human Pre-designed siRNA Set A

HY-N12387

Laccaic acid C	Others	Infection
Laccaic acid C is an potent inhibitor of *RNase H* with an IC₅₀ of 8.1 μM. Laccaic acid C also inhibits viral proliferation in cell .

HY-132572

HIV-1 integrase inhibitor 9	HIV	Infection
HIV-1 integrase inhibitor 9 (compound 8a) is a potent HIV-1 RNase H inhibitor with an IC₅₀ of 12.3 μM. HIV-1 integrase inhibitor 9 shows an antiviral activity .

HY-116454

GSK5750	Reverse Transcriptase HIV	Infection
GSK5750 is a specific and potent HIV-1 reverse transcriptase ribonuclease H inhibitor with an IC₅₀ value of 0.33 μM. GSK5750 is bound at the RNase H active site through a metalion chelation mechanism .

HY-132580

Tofersen BIIB067; ISIS-SOD1Rx	DNA/RNA Synthesis	Neurological Disease
Tofersen (BIIB067) is an antisense oligonucleotide that mediates RNase H-dependent degradation of superoxide dismutase 1 (SOD1) mRNA to reduce the synthesis of SOD1 protein. Tofersen can be used for the research of amyotrophic lateral sclerosis (ALS) .

HY-150759

HIV-1 inhibitor-45	HIV	Infection
HIV-1 inhibitor-45 (compound IA-6) is a potent HIV-1 RNase H inhibitor with an IC₅₀ value of 0.067 μM. HIV-1 inhibitor-45 shows an antiviral activity .

HY-N10776

Kaempferol-3-O-(6′′-galloyl)-β-glucopyranoside	HIV	Infection
Kaempferol-3-O-(6′′-galloyl)-β-glucopyranoside is a glucopyranoside. Kaempferol-3-O-(6′′-galloyl)-β-glucopyranoside inhibts HIV-2 RNase H with an IC₅₀ value of 5.19 μM .

HY-W103287

2-Hydroxyisoquinoline-1,3(2H,4H)-dione	HIV Integrase	Infection
Hydroxyisoquinoline-1,3(2H,4H)-dione (compound 6a) is a HIV-1 integrase (IN) and HIV-1 reverse transcriptase (RT) ribonuclease H (RNase H) inhibitor with an IC₅₀ value of 6.32, 5.9 µM, respectively .

HY-W060316

β-Thujaplicinol 3-Hydroxy-5-isopropyltropolone	HBV DNA/RNA Synthesis	Infection
β-Thujaplicinol (3-Hydroxy-5-isopropyltropolone) is an inhibitor of hepatitis B virus (HBV) ribonuclease H. β-Thujaplicinol inhibits RNAseHs of HBV genotypes D and H with IC₅₀ values of 5.9 and 2.3 μM, respectively .

HY-108764

Mipomersen sodium ISIS 301012	Apolipoprotein HCV	Metabolic Disease
Mipomersen sodium (ISIS 301012) is an antisense oligonucleotide inhibitor of apolipoprotein B (apoB). Mipomersen has anti-HCV effect and reduces the infectivity of the HCV. Mipomersen sodium can be used for the research of homozygous familial hypercholesterolemia (HoFH) .

Cat. No.	Product Name

HY-KE7058

*RNase H*
RNase H is an endoribonuclease expressed and purified from Escherichia coli and can specifically hydrolyze RNA in DNA-RNA hybrid strands.

HY-KE8004

Reverse Transcriptase
Reverse Transcriptase is a reverse transcriptase that clones and expresses the deletion mutant RNase H- of M-MuLV through genetic recombination technology.

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N10776

Kaempferol-3-O-(6′′-galloyl)-β-glucopyranoside	Structural Classification Flavonoids Leguminosae Flavonones Source classification Sophora japonica (L.) Schott Plants	HIV
Kaempferol-3-O-(6′′-galloyl)-β-glucopyranoside is a glucopyranoside. Kaempferol-3-O-(6′′-galloyl)-β-glucopyranoside inhibts HIV-2 RNase H with an IC₅₀ value of 5.19 μM .

HY-N12387

Laccaic acid C	Quinones Structural Classification Animals Anthraquinones Source classification	Others
Laccaic acid C is an potent inhibitor of *RNase H* with an IC₅₀ of 8.1 μM. Laccaic acid C also inhibits viral proliferation in cell .

HY-W060316

β-Thujaplicinol 3-Hydroxy-5-isopropyltropolone	Structural Classification Cupressaceae Ketones, Aldehydes, Acids Source classification Plants	HBV DNA/RNA Synthesis
β-Thujaplicinol (3-Hydroxy-5-isopropyltropolone) is an inhibitor of hepatitis B virus (HBV) ribonuclease H. β-Thujaplicinol inhibits RNAseHs of HBV genotypes D and H with IC₅₀ values of 5.9 and 2.3 μM, respectively .

Cat. No.	Compare	Product Name	Species	Source

HY-P702773

	RNASEH1 Protein, Human (His) Ribonuclease H type II; Ribonuclease H1; RNH1; RNase H1	Human	E. coli
	RNASEH1 Protein, Human (His) is the recombinant human-derived RNASEH1, expressed by E. coli , with C-6*His labeled tag. ,

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