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Pathways Recommended:	Stem Cell/Wnt Cell Cycle/DNA Damage

Results for "

Raji cells

" in MedChemExpress (MCE) Product Catalog:

By Targets:	ADC Cytotoxin (2) Akt (1) Apoptosis (2) Autophagy (1) Btk (2) CD47 (1) DNA Methyltransferase (1) Epigenetic Reader Domain (3) Haspin Kinase (1) Interleukin Related (1) JAK (1) LAG-3 (1) MALT1 (1) PI3K (2) PROTACs (2) Topoisomerase (1)
By Research Areas:	Cancer (16) Infection (1) Inflammation/Immunology (2)

Inhibitors & Agonists

Inhibitory Antibodies

Natural
Products

Targets Recommended: Nuclear Factor of activated T Cells (NFAT)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-79256

MMAF-OMe 1 Publications Verification Monomethyl auristatin F methyl ester	ADC Cytotoxin	Cancer
MMAF-Ome, an antitubulin agent, is also an ADC cytotoxin. MMAF-Ome inhibits several tumor cell lines with IC₅₀s of 0.056 nM, 0.166 nM, 0.183 nM, and 0.449 nM for MDAMB435/5T4, MDAMB361DYT2, MDAMB468, and Raji (5T4 ^-) cell lines, respectively.

HY-133131

PROTAC BRD4 Degrader-1	PROTACs Epigenetic Reader Domain	Cancer
PROTAC BRD4 Degrader-1 is a PROTAC connected by ligands for Cereblon and BRD4 with an IC₅₀ of 41.8 nM against BRD4 BD1. PROTAC BRD4 Degrader-1 can effectively degrade BRD4 protein and suppress c-Myc expression .

HY-P99533

Urabrelimab SRF-231; SRF231	CD47 Interleukin Related	Cancer
Urabrelimab (SRF231) is a fully human anti-CD47 monoclonal antibody that blocks the CD47-SIRP interaction .

HY-N7507

Sempervirine	Others	Cancer
Sempervirine is an indole alkaloid isolated from Gelsemium sempervirens with anti-tumor activities. Sempervirine is against sempervirine-sensitive tumor cells with EC₅₀ values of 2.7 μM, 1.77 μM, and 1.96 μM for Raji, MDA-MB-231 and HeLa cells, respectively .

HY-143427

MALT1-IN-9	MALT1	Cancer
MALT1-IN-9 is a potent MALT1 protease inhibitor with a IC₅₀ of <500 nM in Raji MALT1-GloSensor cells. MALT1-IN-9 has anticancer effects (WO2021000855A1; Compound 5) .

HY-136342

Antitumor agent-23	Others	Cancer
Antitumor agent-23 is a potent anti-cancer agent with GI₅₀s of 38, 48, 5, 27, 80, and 28 nM for lymphoma cell line GRANTA-519, KARPAS-422, KARPAS-299, RAMOS, DAUDI, and RAJI, respectively. Antitumoral activity .

HY-104072

BRD4-IN-3	Epigenetic Reader Domain	Infection Inflammation/Immunology
BRD4-IN-3 (compound 141) is a potent BRD4 inhibitor with an IC₅₀ of <0.5 µM. BRD4-IN-3 shows cytoxicity for MYC-Raji with an IC₅₀ value of >1 µM .

HY-108352

HU 331 VCE 004	Topoisomerase	Cancer
HU 331 (HU 331) is a highly specific Topoisomerase II inhibitor with anticancer activity. HU 331 has shown promising inhibitory effects on human cancer cell lines in vitro and human tumor xenografts in nude mice in vivo .

HY-163858

Haspin-IN-4	Haspin Kinase	Cancer
Haspin-IN-4 (Compound 60) is a selective inhibitor of Haspin with an IC₅₀ value of 0.01 nM. Haspin-IN-4 possesses anticancer activity and can be used in cancer research .

HY-W743654

Capsorubin	Others	Cancer
Capsorubin is a carotenoid found in peppers with multiple biological activities. Capsorubin (167 μM) inhibits lipid peroxidation induced by 2,2'-azobis(2,4-dimethylvaleronitrile) (AMVN) in vitro. Capsorubin (1 μM) reduces UVB-induced DNA strand breaks and apoptosis in human dermal fibroblasts. Capsorubin also inhibits Epstein-Barr virus early antigen (EBV-EA) activation induced by phorbol 12-myristate 13-acetate in Raji cells, a marker of tumorigenesis.

HY-P99736

Miptenalimab BI-754111	LAG-3	Cancer
Miptenalimab (BI-754111) is an anti-human LAG-3 antibody (K_D: 88.6 nM for h LAG-3). Miptenalimab blocks the interaction of LAG-3 with its ligand MHC-II .

HY-W743654R

Capsorubin (Standard)	Others	Cancer
Capsorubin (Standard) is the analytical standard of Capsorubin. This product is intended for research and analytical applications. Capsorubin is a carotenoid found in peppers with multiple biological activities. Capsorubin (167 μM) inhibits lipid peroxidation induced by 2,2'-azobis(2,4-dimethylvaleronitrile) (AMVN) in vitro. Capsorubin (1 μM) reduces UVB-induced DNA strand breaks and apoptosis in human dermal fibroblasts. Capsorubin also inhibits Epstein-Barr virus early antigen (EBV-EA) activation induced by phorbol 12-myristate 13-acetate in Raji cells, a marker of tumorigenesis.

HY-151808

JS25	Btk	Cancer
JS25 is a selective and covalent inhibitor of BTK that inactivates BTK with an IC₅₀ value of 5.8 nM by chelating Tyr551. JS25 inhibits cancer cells proliferation, pronounces cell death, and promotes murine xenograft model of Burkitt’s lymphoma. JS25 effectively crosses the blood-brain barrier .

HY-143472

PI3Kδ-IN-11	PI3K Akt Apoptosis	Cancer
PI3Kδ-IN-11 is a highly potent and selective PI3Kδ inhibitor with IC₅₀ value of 27.5 nM. PI3Kδ-IN-11 dose-dependently blocks the activity of PI3K/Akt pathway. PI3Kδ-IN-11 can be used for researching B or T cell-related malignancies .

HY-19826

Isofistularin-3	DNA Methyltransferase ADC Cytotoxin Autophagy Apoptosis	Cancer
Isofistularin-3 is a direct, DNA-competitive DNMT1 inhibitor, with an IC₅₀ of 13.5 μM. Isofistularin-3, as a DNA demethylating agent, induces cell cycle arrest and sensitization to TRAIL in cancer cells. Isofistularin-3 can be used as an ADC cytotoxin .

HY-147754

JAK3/BTK-IN-6	Btk JAK	Inflammation/Immunology
JAK3/BTK-IN-6 (compound 14h) is a potent BTK and JAK3 dual inhibitor, with IC₅₀ values of 0.6 and 0.4 nM, respectively. JAK3/BTK-IN-6 shows good metabolic stability in human liver microsome. JAK3/BTK-IN-6 can be used for hematological and immune diseases research .

HY-112608

CHMFL-PI3KD-317	PI3K	Cancer
CHMFL-PI3KD-317 is a highly potent, selective and orally active PI3Kδ inhibitor, with an IC₅₀ of 6 nM, and exhibits over 10-1500 fold selectivity over other class I, II and III PIKK family isoforms, such as PI3Kα (IC₅₀, 62.6 nM), PI3Kβ (IC₅₀, 284 nM), PI3Kγ (IC₅₀, 202.7 nM), PIK3C2A (IC₅₀, >10000 nM), PIK3C2B (IC₅₀, 882.3 nM), VPS34 (IC₅₀, 1801.7 nM), PI4KIIIA (IC₅₀, 574.1 nM) and PI4KIIIB (IC₅₀, 300.2 nM). CHMFL-PI3KD-317 inhibits PI3Kδ-mediated Akt T308 phosphorylation in Raji cells, with an EC₅₀ of 4.3 nM. CHMFL-PI3KD-317 has antiproliferative effects on cancer cells .

HY-133136

PROTAC BRD4 Degrader-2	PROTACs Epigenetic Reader Domain	Cancer
PROTAC BRD4 Degrader-2 is a PROTAC connected by ligands for Cereblon and BRD4 with an IC₅₀ of 14.2 nM against BRD4 BD1 .

Cat. No.	Product Name	Target	Research Area

HY-P99533

Urabrelimab SRF-231; SRF231	CD47 Interleukin Related	Cancer
Urabrelimab (SRF231) is a fully human anti-CD47 monoclonal antibody that blocks the CD47-SIRP interaction .

HY-P99736

Miptenalimab BI-754111	LAG-3	Cancer
Miptenalimab (BI-754111) is an anti-human LAG-3 antibody (K_D: 88.6 nM for h LAG-3). Miptenalimab blocks the interaction of LAG-3 with its ligand MHC-II .

Sempervirine	Alkaloids Classification of Application Fields Source classification Loganiaceae Plants Gelsemium eleganis (Gardn. et Champ.) Benth. Disease Research Fields Indole Alkaloids Cancer	Others
Sempervirine is an indole alkaloid isolated from Gelsemium sempervirens with anti-tumor activities. Sempervirine is against sempervirine-sensitive tumor cells with EC₅₀ values of 2.7 μM, 1.77 μM, and 1.96 μM for Raji, MDA-MB-231 and HeLa cells, respectively .

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Raji cells

Inhibitors & Agonists

Inhibitory Antibodies

NaturalProducts

Natural
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