2. PI3K/Akt/mTOR Apoptosis
  3. PI3K Akt Apoptosis
  4. PI3Kδ-IN-11

PI3Kδ-IN-11 is a highly potent and selective PI3Kδ inhibitor with IC50 value of 27.5 nM. PI3Kδ-IN-11 dose-dependently blocks the activity of PI3K/Akt pathway. PI3Kδ-IN-11 can be used for researching B or T cell-related malignancies.

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PI3Kδ-IN-11 Chemical Structure

PI3Kδ-IN-11 Chemical Structure

CAS No. : 2413257-51-7

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PI3Kδ-IN-11 Related Antibodies

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Description

PI3Kδ-IN-11 is a highly potent and selective PI3Kδ inhibitor with IC50 value of 27.5 nM. PI3Kδ-IN-11 dose-dependently blocks the activity of PI3K/Akt pathway. PI3Kδ-IN-11 can be used for researching B or T cell-related malignancies[1].

IC50 & Target

PI3Kδ

27.5 nM (IC50)

Cellular Effect
Cell Line Type Value Description References
Raji IC50
8.5 μM
Compound: 15c
Antiproliferative activity against human Raji cells assessed as inhibition of cell growth after 48 hrs by MTT assay
Antiproliferative activity against human Raji cells assessed as inhibition of cell growth after 48 hrs by MTT assay
[PMID: 32987316]
Ramos IC50
5.4 μM
Compound: 15c
Antiproliferative activity against human Ramos cells assessed as inhibition of cell growth after 48 hrs by MTT assay
Antiproliferative activity against human Ramos cells assessed as inhibition of cell growth after 48 hrs by MTT assay
[PMID: 32987316]
In Vitro

PI3Kδ-IN-11 (compound 15c) (0-10 μM; 48 hours) inhibits Raji and Ramos with IC50s of 8.5 μM and 5.4 μM, respectively[1].
PI3Kδ-IN-11 (0.2-15 μM; 0-48 hours) dampens the proliferation of Raji cells in a dose- and time-dependent manner[1].
PI3Kδ-IN-11 (5 μM; 24 hours) triggers 10.78% apoptosis of cells[1].
PI3Kδ-IN-11 (1-1000 nM; 24 hours) dose-dependently reduces the phosphorylation of Akt (S473)[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

PI3Kδ-IN-11 Related Antibodies

Cell Viability Assay

Cell Line: Raji and Ramos[1]
Concentration: 0-10 μM
Incubation Time: 48 hours
Result: Inhibited Raji and Ramos with IC50s of 8.5 μM and 5.4 μM, respectively.

Cell Proliferation Assay

Cell Line: Raji[1]
Concentration: 0.2, 1, 4, 8, 10 and 15 μM
Incubation Time: 0, 12, 24, 36, 48 hours
Result: Dampened the proliferation of Raji cells in a dose- and time-dependent manner.

Apoptosis Analysis

Cell Line: Raji[1]
Concentration: 5 μM
Incubation Time: 24 hours
Result: Triggered 10.78% apoptosis of cells.

Western Blot Analysis

Cell Line: Raji[1]
Concentration: 1, 10, 100, 500 and 1000 nM
Incubation Time: 24 hours
Result: Dose-dependently reduced the phosphorylation of Akt (S473), illustrating that the activity of PI3K/Akt pathway was efficiently blocked.
Molecular Weight

431.49

Formula

C27H21N5O
CAS No.
SMILES

C=CC(NC1=CC(NC2=C3C=C(C4=CC5=CC=CC=C5N=C4)C=CC3=NC=N2)=CC=C1C)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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PI3Kδ-IN-11 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PI3Kδ-IN-112413257-51-7PI3KAktApoptosisPhosphoinositide 3-kinasePKBProtein kinase BQuinazoline derivativesMalignanciesPI3K/Akt pathwaySelectivityRaji cellsRamos cellsInhibitorinhibitorinhibit

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