Search Result

Results for "

Reverse transcription

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Reverse Transcriptase (3) AP-1 (1) Autophagy (1) Bacterial (1) Biochemical Assay Reagents (2) c-Myc (1) DNA Methyltransferase (1) DNA/RNA Synthesis (2) Endogenous Metabolite (1) Epigenetic Reader Domain (1) ERK (2) HDAC (1) HIV (9) iGluR (1) MEK (1) Phosphatase (1) PKA (1)
By Research Areas:	Cancer (3) Infection (10) Inflammation/Immunology (2) Metabolic Disease (1) Neurological Disease (2)
Click Chemistry:	Azide (1)
Oligonucleotides:	Nucleotides and their Analogs (1)

Inhibitors & Agonists

Biochemical Assay Reagents

MCE Kits

Click Chemistry

Oligonucleotides

Targets Recommended: Reverse Transcriptase OLIG2 ATF6 RUNX

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-14267

Lersivirine UK-453061	HIV Reverse Transcriptase	Infection
Lersivirine (UK-453061) is potent and selective non-nucleoside reverse transcription inhibitor (NNRTI; IC₅₀=119 nM) with excellent efficacy against NNRTI-resistant viruses. Lersivirine exhibits potent antiretroviral activity against wild-type HIV virus and clinically relevant NNRTI-resistant strains .

HY-103038

ML327 4 Publications Verification	c-Myc Autophagy	Cancer
ML327 is a blocker of MYC which can also de-repress E-cadherin transcription and reverse Epithelial-to-Mesenchymal Transition (EMT).

HY-W008661

Deoxyguanosine triphosphate (trisodium) solution (100mM) dGTP (trisodium) solution (100mM); 2'-Deoxyguanosine-5'-triphosphate (trisodium) solution (100mM)	DNA/RNA Synthesis	Others
Deoxyguanosine triphosphate (dGTP) trisodium solution (100mM) is a nucleotide precursor in cells for DNA synthesis. Deoxyguanosine triphosphate trisodium salt is used in reverse transcription-polymerase chain reaction (RT-PCR) for DNA amplification .

HY-142066

4′-Demethylnobiletin	PKA ERK iGluR	Neurological Disease
4′-Demethylnobiletin is a bioactive metabolite that activates the PKA/ERK/CREB signaling pathway, enhances CRE-mediated transcription in hippocampal neurons, and reverses memory impairment associated with NMDA receptor antagonism by stimulating ERK signaling .

HY-138657

NCGC00378430 1 Publications Verification	Phosphatase	Cancer
NCGC00378430 is a potent SIX1/EYA2 interaction inhibitor. NCGC00378430 partially reverses transcriptional and metabolic profiles mediated by SIX1 overexpression and reverses SIX1-induced TGF-β signaling and epithelial-mesenchymal transition (EMT). NCGC00378430 inhibits SIX1-mediated breast cancer metastasis in a mouse model .

HY-146352

HIV-1 inhibitor-28	HIV	Infection Inflammation/Immunology
HIV-1 inhibitor-28 (compound 14j2) is a highly potent and selective HIV-1 inhibitor with an EC₅₀ of 58 nM for WT HIV-1 strain and an IC₅₀ of 3.37 μM for HIV-1 WT reverse transcription (RT). HIV-1 inhibitor-28 exhibits relatively low cytotoxicity in MT-4 cells (CC₅₀ = 38.6 μM). HIV-1 inhibitor-28 can be used for researching AIDS .

HY-E70403

Warm-Start M-MLV Reverse Transcriptase	Biochemical Assay Reagents	Others
Warm-Start M-MLV Reverse Transcriptase is a reverse transcriptase active below 37°C and can completely release reverse transcription activity at 55°C without affecting cDNA synthesis .

HY-139158

Ainuovirine	HIV	Infection
Ainuovirine is a second-generation non-nucleoside reverse transcriptase inhibitor (NNRTI). Ainuovirine inhibits HIV replication by non-competitively binding to HIV reverse transcriptase and blocking the reverse transcription process of viral RNA. Ainuovirine can be used for human immunodeficiency virus (HIV) type 1 infection .

HY-19111

R-82150 TIBO-R 82150	HIV Reverse Transcriptase	Infection
R-82150 (TIBO-R 82150) is an *HIV-1 reverse* transcriptase** inhibitor that blocks the reverse transcription of viral RNA by binding to the non-substrate binding site of reverse transcriptase, thereby inhibiting viral replication. R-82150 does not inhibit the replication of HIV-2, other RNA viruses, and DNA viruses .

HY-162461

HIV-1 inhibitor-66	Reverse Transcriptase HIV	Infection
HIV-1 inhibitor-66 is an orally active non-nucleoside **reverse transcription inhibitor (NNRTI). HIV-1 inhibitor-66 shows inhibitory activity against wild-type HIV-1 reverse transcriptase with an IC₅₀** of 40 nM .

HY-W013098

2'-Deoxyadenosine 5'-triphosphate disodium 5'-Dexoadenosine triphosphate disodium	Biochemical Assay Reagents
2'-Deoxyadenosine 5'-triphosphate disodium (5'-Dexoadenosine triphosphate disodium) is a nucleotide with important biological activities and can serve as a substrate for a variety of polymerases, including DNA polymerases and reverse transcriptases. 2'-Deoxyadenosine 5'-triphosphate disodium plays a key role in DNA synthesis and reverse transcription. 2'-Deoxyadenosine 5'-triphosphate disodium is also widely used in in vitro reactions in molecular biology research.

HY-114268

BRD-K98645985 2 Publications Verification	HIV	Infection
BRD-K98645985 is a *BAF (mammalian SWI/SNF) transcriptional* repression inhibitor with an EC₅₀ of ~2.37 µM. BRD-K98645985 binds ARID1A-specific BAF** complexes, prevents nucleosomal positioning, and potently reverses HIV-1 latency, without T cell activation or toxicity .

HY-119490

UMB-136	Epigenetic Reader Domain HIV	Infection
UMB-136 is a bromodomain inhibitor. UMB-136 is a promising latency-reversing agent (LRA) for HIV-1 eradication. UMB-136 reactivates HIV-1 in multiple cell models. UMB-136 enhances HIV-1 transcription and increases viral production through the release of P-TEFb .

HY-402361

TERT activator-1	MEK ERK AP-1	Neurological Disease Inflammation/Immunology
TERT activator-1 is a small molecule activator of telomerase reverse transcriptase (TERT). TERT activator-1 promotes TERT transcription through the MEK/ERK/AP-1 signaling cascade. TERT activator-1 promotes adult neurogenesis and enhances neuromuscular function. TERT activator-1 reduces cellular senescence and systemic inflammation in aged mice, and can be used in the study of aging .

HY-43515

ESI1	Endogenous Metabolite	Metabolic Disease
ESI1 is a small molecule epigenetic silencing inhibitor. ESI1 can trigger the formation of nuclear condensates of key lipid metabolism regulators SREBP1/2, concentrating transcriptional co-activators to drive lipid/cholesterol biosynthesis. ESI1 can promote myelin regeneration in demyelinated animal models and facilitate de novo myelination on regenerating CNS axons, reversing age-related declines in cognitive abilities .

HY-171317

SMARt751	Bacterial	Infection
SMARt751 targets the transcriptional regulatory factor VirS, inhibits its DNA binding ability, upregulates the mymA operon expression, thereby activating Ethionamide (HY-B0276), enhancing the antimicrobial activity of Ethionamide. SMARt751 enhances the antibacterial activity of Ethionamide against M. tuberculosis, reverses the Ethionamide resistance. SMARt751 improves the antibacterial effect of Ethionamide and reduces its effective dose in mouse models. SMARt751 can cross blood brain barrier .

HY-168088

DNMT1/HDAC-IN-1	HDAC DNA Methyltransferase	Cancer
DNMT1/HDAC-IN-1 (compound (R)-23a) is a DNMT1/HDAC dual inhibitor (HDAC1:IC₅₀=0.05 μM), HDAC1 is a major HDAC isoform that interacts with DNMT1 in multiple protein complexes for transcriptional silencing of TSGs. DNMT1/HDAC-IN-1 can reshape the tumor immune microenvironment and induce tumor regression, and effectively reverse cancer-specific epigenetic abnormalities .

HY-120072

PF-3450074 3 Publications Verification PF-74	HIV	Infection
PF-3450074 (PF-74) is a specifical inhibitor of?HIV-1 capsid protein (CA) and displays a broad-spectrum inhibition of HIV isolates with submicromolar potency (EC₅₀=8-640 nM). PF-3450074 (PF-74) acts at an early stage of HIV-1 infection, inhibits viral replication by directly competing with the binding of CPSF6 and NUP153, and blocks the uncoating, assembly, and the reverse transcription steps of the viral life cycle . CPSF6: nuclear host factors cleavage and polyadenylation specific factor 6; NUP153: nucleoporin 153.

HY-126781

Fozivudine tidoxil BM-211290	HIV DNA/RNA Synthesis	Infection
Fozivudine tidoxil (BM-211290) is an orally active thioether lipid-zidovudine (ZDV) conjugate with anti-HIV activity. Fozivudine tidoxil, a member of the NRTI family of agent, is incorporated into the newly synthesized strand of DNA during intracellular viral replication and irreversibly binds viral RT which disrupts viral reverse-transcription . Fozivudine tidoxil is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

Cat. No.	Product Name	Type

HY-W008661

Deoxyguanosine triphosphate (trisodium) solution (100mM) dGTP (trisodium) solution (100mM); 2'-Deoxyguanosine-5'-triphosphate (trisodium) solution (100mM)	Gene Sequencing and Synthesis
Deoxyguanosine triphosphate (dGTP) trisodium solution (100mM) is a nucleotide precursor in cells for DNA synthesis. Deoxyguanosine triphosphate trisodium salt is used in reverse transcription-polymerase chain reaction (RT-PCR) for DNA amplification .

HY-W013098

2'-Deoxyadenosine 5'-triphosphate disodium 5'-Dexoadenosine triphosphate disodium	Enzyme Substrates
2'-Deoxyadenosine 5'-triphosphate disodium (5'-Dexoadenosine triphosphate disodium) is a nucleotide with important biological activities and can serve as a substrate for a variety of polymerases, including DNA polymerases and reverse transcriptases. 2'-Deoxyadenosine 5'-triphosphate disodium plays a key role in DNA synthesis and reverse transcription. 2'-Deoxyadenosine 5'-triphosphate disodium is also widely used in in vitro reactions in molecular biology research.

2'-Deoxyadenosine 5'-triphosphate disodium

5'-Dexoadenosine triphosphate disodium

Enzyme Substrates

2'-Deoxyadenosine 5'-triphosphate disodium (5'-Dexoadenosine triphosphate disodium) is a nucleotide with important biological activities and can serve as a substrate for a variety of polymerases, including DNA polymerases and reverse transcriptases. 2'-Deoxyadenosine 5'-triphosphate disodium plays a key role in DNA synthesis and reverse transcription. 2'-Deoxyadenosine 5'-triphosphate disodium is also widely used in in vitro reactions in molecular biology research.

Cat. No.	Product Name

HY-K0510A

RT Master Mix for qPCR II Maximum Cited Publications 95 Publications Verification
MCE RT Master Mix for qPCR II is a convenient, ready-to-use formulation for reverse transcription. With advanced reverse transcriptase, this kit can synthesize cDNA more rapidly, more specifically.

HY-K0511A

RT Master Mix for qPCR II (gDNA digester plus) 25+ Cited Publications
MCE RT Master Mix for qPCR II is a convenient, ready-to-use formulation for reverse transcription and can eliminate genomic DNA (gDNA) contaminations in RNA samples. With updated reverse transcriptase, this kit can synthesize cDNA more rapidly, more specifically.

HY-K0511

RT Master Mix for qPCR (gDNA digester plus) 25+ Cited Publications
MCE RT Master Mix for qPCR (gDNA digester plus) is a convenient, ready-to-use formulation for reverse transcription and can eliminate genomic DNA (gDNA) contaminations in RNA samples. The cDNA product can be directly applied as a template in a standard PCR and real time quantitative PCR (qPCR).

HY-K0512

microRNA RT Master Mix for qPCR Ⅲ (poly A)
MCE microRNA RT Master Mix for qPCR Ⅲ (poly A) uses poly(A)-tailing method to perform reverse transcription from miRNA first-strand to cDNA.

HY-K0513

RT Master Mix for qPCR III
MCE MCE Reverse Transcription Kit III is suitable for the conventional synthesis of cDNA from RNA and the stem-loop method for the synthesis of cDNA from microRNA (miRNA).

Cat. No.	Product Name		Classification

HY-126781

Fozivudine tidoxil BM-211290		Azide
Fozivudine tidoxil (BM-211290) is an orally active thioether lipid-zidovudine (ZDV) conjugate with anti-HIV activity. Fozivudine tidoxil, a member of the NRTI family of agent, is incorporated into the newly synthesized strand of DNA during intracellular viral replication and irreversibly binds viral RT which disrupts viral reverse-transcription . Fozivudine tidoxil is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

Cat. No.	Product Name		Classification

HY-W008661

Deoxyguanosine triphosphate (trisodium) solution (100mM) dGTP (trisodium) solution (100mM); 2'-Deoxyguanosine-5'-triphosphate (trisodium) solution (100mM)		Nucleotides and their Analogs
Deoxyguanosine triphosphate (dGTP) trisodium solution (100mM) is a nucleotide precursor in cells for DNA synthesis. Deoxyguanosine triphosphate trisodium salt is used in reverse transcription-polymerase chain reaction (RT-PCR) for DNA amplification .

Inquiry Online

Your information is safe with us. * Required Fields.

MCE Japan Authorized Agent ナミキ商事株式会社コスモ・バイオ株式会社
Salutation			Country or Region *
Applicant Name *			Organization Name *
Department *
Email Address *			Product Name *
Cat. No.			Requested quantity *
Phone Number *
Remarks

Inquiry Online

Inquiry Information

Product Name:
Cat. No.:
Quantity:
MCE Japan Authorized Agent:

Name
Email *

	Sorry, but the email address you supplied was invalid.