2. Anti-infection
  3. Bacterial
  4. SMARt751

SMARt751 targets the transcriptional regulatory factor VirS, inhibits its DNA binding ability, upregulates the mymA operon expression, thereby activating Ethionamide (HY-B0276), enhancing the antimicrobial activity of Ethionamide. SMARt751 enhances the antibacterial activity of Ethionamide against M. tuberculosis, reverses the Ethionamide resistance. SMARt751 improves the antibacterial effect of Ethionamide and reduces its effective dose in mouse models. SMARt751 can cross blood brain barrier.

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SMARt751 Chemical Structure

SMARt751 Chemical Structure

CAS No. : 1616370-52-5

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Description

SMARt751 targets the transcriptional regulatory factor VirS, inhibits its DNA binding ability, upregulates the mymA operon expression, thereby activating Ethionamide (HY-B0276), enhancing the antimicrobial activity of Ethionamide. SMARt751 enhances the antibacterial activity of Ethionamide against M. tuberculosis, reverses the Ethionamide resistance. SMARt751 improves the antibacterial effect of Ethionamide and reduces its effective dose in mouse models. SMARt751 can cross blood brain barrier[1].

Molecular Weight

303.30

Formula

C15H17F4NO
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(CCC(F)(F)F)N1CCC(CC1)C2=CC=C(C=C2)F
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (329.71 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.2971 mL 16.4853 mL 32.9707 mL
5 mM 0.6594 mL 3.2971 mL 6.5941 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.2971 mL 16.4853 mL 32.9707 mL 82.4266 mL
5 mM 0.6594 mL 3.2971 mL 6.5941 mL 16.4853 mL
10 mM 0.3297 mL 1.6485 mL 3.2971 mL 8.2427 mL
15 mM 0.2198 mL 1.0990 mL 2.1980 mL 5.4951 mL
20 mM 0.1649 mL 0.8243 mL 1.6485 mL 4.1213 mL
25 mM 0.1319 mL 0.6594 mL 1.3188 mL 3.2971 mL
30 mM 0.1099 mL 0.5495 mL 1.0990 mL 2.7476 mL
40 mM 0.0824 mL 0.4121 mL 0.8243 mL 2.0607 mL
50 mM 0.0659 mL 0.3297 mL 0.6594 mL 1.6485 mL
60 mM 0.0550 mL 0.2748 mL 0.5495 mL 1.3738 mL
80 mM 0.0412 mL 0.2061 mL 0.4121 mL 1.0303 mL
100 mM 0.0330 mL 0.1649 mL 0.3297 mL 0.8243 mL
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SMARt751 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SMARt7511616370-52-5SMARt 751SMARt-751BacterialBBB penetrableMycobacterium tuberculosisC57BL/6 mouseanti-tuberculosisInhibitorinhibitorinhibit

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