Ribosomal S6 Kinase (RSK)

By Targets:	Ribosomal S6 Kinase (RSK) (7) Endogenous Metabolite (2) Keap1-Nrf2 (2) YB-1 (1)
By Research Areas:	Cancer (6) Cardiovascular Disease (1)

Targets Recommended: Ribosomal S6 Kinase (RSK)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-52101C

FMK-MEA	Ribosomal S6 Kinase (RSK)	Cancer
FMK-MEA is a potent and selective p90 Ribosomal S6 Kinase (RSK) inhibitor.

HY-16104

BIX 02565 5+ Cited Publications	Ribosomal S6 Kinase (RSK)	Cardiovascular Disease
BIX 02565 is a potent ribosomal S6 kinase 2 (RSK2) inhibitor with IC₅₀ of 1.1 nM.

HY-15237

SL 0101-1 4 Publications Verification SL0101	Ribosomal S6 Kinase (RSK)	Cancer
SL 0101-1 (SL0101), a kaempferol glycoside, isolated from the tropical plant F. refracta, is a cell-permeable, selective, reversible, ATP-competitive p90 Ribosomal S6 Kinase (RSK) inhibitor, with an IC₅₀ of 89 nM . SL 0101-1 (SL0101) is a selective *RSK1/2* inhibitor, with a K_i of 1 μM .

HY-19713

LJI308 4 Publications Verification	Ribosomal S6 Kinase (RSK) YB-1	Cancer
LJI308 is a potent pan-ribosomal S6 kinase (RSK) inhibitor, with IC₅₀s of 6 nM, 4 nM, and 13 nM for RSK1, RSK2, and RSK3, respectively. LJI308 inhibits the phosphorylation of RSK (T359/S363) and YB-1 (S102) after irradiation, treatment with EGF, and in cells expressing a KRAS mutation .

HY-N0643

Carnosol Maximum Cited Publications 12 Publications Verification	Ribosomal S6 Kinase (RSK) Keap1-Nrf2 Endogenous Metabolite	Cancer
Carnosol is a potent Ribosomal S6 Kinase *(RSK2)* inhibitor that could be useful for treating gastric cancer, with an IC₅₀ of ~5.5 μM . Carnosol, a Nrf2 activator, increases the nuclear levels of Nrf2 and can promote the expression of heme oxygenase 1 (HMOX1) .

HY-P3814

S6 Kinase Substrate Peptide 32	Ribosomal S6 Kinase (RSK)	Cancer
S6 Kinase Substrate Peptide 32 is a substrate of Ribosomal S6 Kinase (RSK). S6 Kinase Substrate Peptide 32 can be used to measure the activity of RSKs which phosphorylate ribosomal protein S6 .

HY-N0643R

Carnosol (Standard)	Ribosomal S6 Kinase (RSK) Keap1-Nrf2 Endogenous Metabolite	Cancer
Carnosol (Standard) is the analytical standard of Carnosol. This product is intended for research and analytical applications. Carnosol is a potent Ribosomal S6 Kinase (RSK2) inhibitor that could be useful for treating gastric cancer, with an IC₅₀ of ~5.5 μM . Carnosol, a Nrf2 activator, increases the nuclear levels of Nrf2 and can promote the expression of heme oxygenase 1 (HMOX1) .

Cat. No.	Product Name	Target	Research Area

HY-P3814

S6 Kinase Substrate Peptide 32	Ribosomal S6 Kinase (RSK)	Cancer
S6 Kinase Substrate Peptide 32 is a substrate of Ribosomal S6 Kinase (RSK). S6 Kinase Substrate Peptide 32 can be used to measure the activity of RSKs which phosphorylate ribosomal protein S6 .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-15237

SL 0101-1 4 Publications Verification SL0101	Structural Classification Flavonols Flavonoids other families Classification of Application Fields Pityrogramma triangularis Plants Disease Research Fields Cancer	Ribosomal S6 Kinase (RSK)
SL 0101-1 (SL0101), a kaempferol glycoside, isolated from the tropical plant F. refracta, is a cell-permeable, selective, reversible, ATP-competitive p90 Ribosomal S6 Kinase (RSK) inhibitor, with an IC₅₀ of 89 nM . SL 0101-1 (SL0101) is a selective *RSK1/2* inhibitor, with a K_i of 1 μM .

HY-N0643

Carnosol 10+ Cited Publications	Structural Classification Classification of Application Fields Paramacrolobium coeruleum (Taub.) J.Léonard Food Preservation Research Source classification Plants Agricultural Research Terpenoids Labiatae Phenols Polyphenols Diterpenoids Disease Research Fields Cancer	Ribosomal S6 Kinase (RSK) Keap1-Nrf2 Endogenous Metabolite
Carnosol is a potent Ribosomal S6 Kinase *(RSK2)* inhibitor that could be useful for treating gastric cancer, with an IC₅₀ of ~5.5 μM . Carnosol, a Nrf2 activator, increases the nuclear levels of Nrf2 and can promote the expression of heme oxygenase 1 (HMOX1) .

HY-N0643R

Carnosol (Standard)	Structural Classification Paramacrolobium coeruleum (Taub.) J.Léonard Terpenoids Labiatae Source classification Phenols Polyphenols Diterpenoids Plants	Ribosomal S6 Kinase (RSK) Keap1-Nrf2 Endogenous Metabolite
Carnosol (Standard) is the analytical standard of Carnosol. This product is intended for research and analytical applications. Carnosol is a potent Ribosomal S6 Kinase (RSK2) inhibitor that could be useful for treating gastric cancer, with an IC₅₀ of ~5.5 μM . Carnosol, a Nrf2 activator, increases the nuclear levels of Nrf2 and can promote the expression of heme oxygenase 1 (HMOX1) .

Species:	Human (8)
Tag:	His (3) Tag Free (2) GST (4)
Source:	Sf9 insect cells (6) E. coli (2)

Cat. No.	Compare	Product Name	Species	Source

HY-P701773

	RSK2 Protein, Human RPS6KA3; Ribosomal protein S6 Kinase alpha-3; S6K-alpha-3; 90 kDa Ribosomal protein S6 Kinase 3; p90-RSK 3; p90RSK3; Insulin-stimulated protein Kinase 1; ISPK-1; MAP Kinase-activated protein Kinase 1b; MAPK-activated protein Kinase 1b; MAPKAP Kinase 1b; MAPKAPK-1b; Ribosomal S6 Kinase 2; RSK-2; pp90RSK2	Human	E. coli
	RSK2 is a kinase downstream of ERK signaling and plays a critical role in mediating mitosis and stress responses. It activates transcription factors (CREB1, ETV1, NR4A1), affecting proliferation, survival and differentiation. RSK2 Protein, Human is the recombinant human-derived RSK2 protein, expressed by E. coli , with tag free. The total length of RSK2 Protein, Human is 341 a.a., .

HY-P702651

	RPS6KA6 Protein, Human (sf9, GST) RPS6KA6; Ribosomal protein S6 Kinase, 90kDa, polypeptide 6; Ribosomal protein S6 Kinase, 90kD, polypeptide 6; Ribosomal protein S6 Kinase alpha-6; RSK4; RSK-4; p90RSK6; p90-RSK 6; S6K-alpha 6; S6K-alpha-6; Ribosomal S6 Kinase 4; 90 kDa Ribosomal protein S6 Kinase 6; PP90RSK4	Human	Sf9 insect cells
	RSK4 (ribosomal S6 kinase 4) is a serine/threonine protein kinase that is constitutively active and does not require the presence of growth factors to function. It is involved in cell signaling pathways related to cell growth arrest, especially those mediated by p53/TP53 proteins. RPS6KA6 Protein, Human (sf9, GST) is the recombinant human-derived RPS6KA6, expressed by Sf9 insect cells , with GST labeled tag. ,

HY-P701771

	RSK1 Protein, Human (Sf9) RPS6KA1; Ribosomal protein S6 Kinase alpha-1; S6K-alpha-1; 90 kDa Ribosomal protein S6 Kinase 1; p90-RSK 1; p90RSK1; p90S6K; MAP Kinase-activated protein Kinase 1a; MAPK-activated protein Kinase 1a; MAPKAP Kinase 1a; MAPKAPK-1a; Ribosomal S6 Kinase 1; RSK-1	Human	Sf9 insect cells
	RSK1 is a kinase downstream of ERK signaling and is critical for mitosis and stress-induced responses. It activates transcription factors (CREB1, ETV1, NR4A1), affecting proliferation, survival and differentiation. RSK1 Protein, Human (Sf9) is the recombinant human-derived RSK1 protein, expressed by Sf9 insect cells , with tag free. The total length of RSK1 Protein, Human (Sf9) is 321 a.a., .

HY-P702650

	RPS6KA4 Protein, Human (sf9, His, GST) RPS6KA4; Ribosomal protein S6 Kinase, 90kDa, polypeptide 4; Ribosomal protein S6 Kinase, 90kD, polypeptide 4; Ribosomal protein S6 Kinase alpha-4; MSK2; RSK B; RSKB; S6K-alpha-4; Ribosomal protein Kinase B; Ribosomal protein S6 Kinase alpha 4; 90 kDa Ribosomal protein S6 Kinase 4; mitogen- and stress-activated protein Kinase 2; nuclear mitogen- and stress-activated protein Kinase 2; RSK-B	Human	Sf9 insect cells
	RPS6KA4 Protein, Human (sf9, His, GST) is the recombinant human-derived RPS6KA4, expressed by Sf9 insect cells , with N-His, N-GST labeled tag. ,

HY-P701772

	RSK1 Protein, Human (Sf9, His) RPS6KA1; Ribosomal protein S6 Kinase alpha-1; S6K-alpha-1; 90 kDa Ribosomal protein S6 Kinase 1; p90-RSK 1; p90RSK1; p90S6K; MAP Kinase-activated protein Kinase 1a; MAPK-activated protein Kinase 1a; MAPKAP Kinase 1a; MAPKAPK-1a; Ribosomal S6 Kinase 1; RSK-1	Human	Sf9 insect cells
	RSK1 is a kinase downstream of ERK signaling and is critical for mitosis and stress-induced responses. It activates transcription factors (CREB1, ETV1, NR4A1), affecting proliferation, survival and differentiation. RSK1 Protein, Human (Sf9, His) is the recombinant human-derived RSK1 protein, expressed by Sf9 insect cells , with N-8*His labeled tag. The total length of RSK1 Protein, Human (Sf9, His) is 321 a.a., .

HY-P701774

	RSK2 Protein, Human (His) RPS6KA3; Ribosomal protein S6 Kinase alpha-3; S6K-alpha-3; 90 kDa Ribosomal protein S6 Kinase 3; p90-RSK 3; p90RSK3; Insulin-stimulated protein Kinase 1; ISPK-1; MAP Kinase-activated protein Kinase 1b; MAPK-activated protein Kinase 1b; MAPKAP Kinase 1b; MAPKAPK-1b; Ribosomal S6 Kinase 2; RSK-2; pp90RSK2	Human	E. coli
	RSK2 is a kinase downstream of ERK signaling and plays a critical role in mediating mitosis and stress responses. It activates transcription factors (CREB1, ETV1, NR4A1), affecting proliferation, survival and differentiation. RSK2 Protein, Human (His) is the recombinant human-derived RSK2 protein, expressed by E. coli , with N-6*His labeled tag. The total length of RSK2 Protein, Human (His) is 341 a.a., .

HY-P701819

	MSK1 Protein, Human (Sf9, GST) RPS6KA5; Ribosomal protein S6 Kinase alpha-5; S6K-alpha-5; 90 kDa Ribosomal protein S6 Kinase 5; Nuclear mitogen- and stress-activated protein Kinase 1; RSK-like protein Kinase; RSKL	Human	Sf9 insect cells
	MSK1 is a serine/threonine protein kinase that centralizes multiple cellular processes by phosphorylating key transcription factors. In response to stimuli such as UV-C irradiation, EGF, and anisomycin, MSK1 activates CREB1 and ATF1, affecting gene expression through histone phosphorylation. MSK1 Protein, Human (Sf9, GST) is the recombinant human-derived MSK1 protein, expressed by Sf9 insect cells , with N-GST labeled tag. The total length of MSK1 Protein, Human (Sf9, GST) is 801 a.a., .

HY-P76011

	RSK3 Protein, Human (sf9, GST) Ribosomal protein S6 Kinase alpha-2; S6K-alpha-2; p90-RSK 2; RSK-3; RPS6KA2; MAPKAPK1C	Human	Sf9 insect cells
	RSK3, a kinase downstream of ERK signaling, crucially mediates mitogenic and stress-induced transcription factor activation. It regulates translation, impacting proliferation, survival, and differentiation. In epithelial ovarian cancer cells, RSK3 may act as a tumor suppressor, highlighting its diverse roles in cellular homeostasis and potential implications in cancer biology. RSK3 Protein, Human (sf9, GST) is the recombinant human-derived RSK3 protein, expressed by Sf9 insect cells , with N-GST labeled tag.

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Cat. No.	Compare	Product Name	Application	Reactivity

HY-P80887

	RSK3 Antibody RPS6KA2; MAPKAPK1C; RSK3; Ribosomal protein S6 Kinase alpha-2; S6K-alpha-2; 90 kDa Ribosomal protein S6 Kinase 2; p90-RSK 2; p90RSK2; MAP Kinase-activated protein Kinase 1c; MAPK-activated protein Kinase 1c; MAPKAP Kinase 1c; MAPKAPK-1c; Ri	WB, IHC-F, IHC-P, ICC/IF, IP	Human, Hamster
	RSK3 Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 83 kDa, targeting to RSK3. It can be used for WB,IHC-F,IHC-P,ICC/IF,IP assays with tag free, in the background of Human, Hamster.

HY-P80835

	Phospho-MSK1 (Ser360) Antibody RPS6KA5; MSK1; Ribosomal protein S6 Kinase alpha-5; S6K-alpha-5; 90 kDa Ribosomal protein S6 Kinase 5; Nuclear mitogen- and stress-activated protein Kinase 1; RSK-like protein Kinase; RSKL	WB, ICC/IF, IP	Human, Mouse, Rat, Hamster
	Phospho-MSK1 (Ser360) Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 90 kDa, targeting to Phospho-MSK1 (Ser360). It can be used for WB,ICC/IF,IP assays with tag free, in the background of Human, Mouse, Rat, Hamster.

HY-P80848

	Phospho-RSK1 p90 (Ser380) Antibody RPS6KA1; MAPKAPK1A; RSK1; Ribosomal protein S6 Kinase alpha-1; S6K-alpha-1; 90 kDa Ribosomal protein S6 Kinase 1; p90-RSK 1; p90RSK1; p90S6K; MAP Kinase-activated protein Kinase 1a; MAPK-activated protein Kinase 1a; MAPKAP Kinase 1a; MAPKAP	WB, ICC/IF, IP	Human, Rat, Mouse
	Phospho-RSK1 p90 (Ser380) Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 83 kDa, targeting to Phospho-RSK1 p90 (Ser380). It can be used for WB, ICC/IF, IP assays with tag free, in the background of Human, Mouse and Rat.

HY-P80849

	Phospho-RSK1 p90 (Thr359/Ser363) Antibody RPS6KA1; MAPKAPK1A; RSK1; Ribosomal protein S6 Kinase alpha-1; S6K-alpha-1; 90 kDa Ribosomal protein S6 Kinase 1; p90-RSK 1; p90RSK1; p90S6K; MAP Kinase-activated protein Kinase 1a; MAPK-activated protein Kinase 1a; MAPKAP Kinase 1a; MAPKAP	WB, IP	Human, Mouse, Rat
	Phospho-RSK1 p90 (Thr359/Ser363) Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 83 kDa, targeting to Phospho-RSK1 p90 (Thr359/Ser363). It can be used for WB,IP assays with tag free, in the background of Human, Mouse, Rat.

HY-P80851

	Phospho-RSK4 (Ser232) Antibody RPS6KA6; RSK4; Ribosomal protein S6 Kinase alpha-6; S6K-alpha-6; 90 kDa Ribosomal protein S6 Kinase 6; p90-RSK 6; p90RSK6; Ribosomal S6 Kinase 4; RSK-4; pp90RSK4	WB, ICC/IF	Human
	Phospho-RSK4 (Ser232) Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 84 kDa, targeting to Phospho-RSK4 (Ser232). It can be used for WB,ICC/IF assays with tag free, in the background of Human.

HY-P80850

	Phospho-RSK2 (Ser227) Antibody RPS6KA3; ISPK1; MAPKAPK1B; RSK2; Ribosomal protein S6 Kinase alpha-3; S6K-alpha-3; 90 kDa Ribosomal protein S6 Kinase 3; p90-RSK 3; p90RSK3; Insulin-stimulated protein Kinase 1; ISPK-1; MAP Kinase-activated protein Kinase 1b; MAPK-activated	WB, IP	Human, Mouse, Rat
	Phospho-RSK2 (Ser227) Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 84 kDa, targeting to Phospho-RSK2 (Ser227). It can be used for WB,IP assays with tag free, in the background of Human, Mouse, Rat.

HY-P80836

	Phospho-MSK1 (Ser376) Antibody RPS6KA5; MSK1; Ribosomal protein S6 Kinase alpha-5; S6K-alpha-5; 90 kDa Ribosomal protein S6 Kinase 5; Nuclear mitogen- and stress-activated protein Kinase 1; RSK-like protein Kinase; RSKL	WB, IHC-P, IP	Human, Rat
	Phospho-MSK1 (Ser376) Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 90 kDa, targeting to Phospho-MSK1 (Ser376). It can be used for WB,IHC-P,IP assays with tag free, in the background of Human, Rat.

HY-P80886

	RSK1 p90 Antibody (YA676) RPS6KA1; MAPKAPK1A; RSK1; Ribosomal protein S6 Kinase alpha-1; S6K-alpha-1; 90 kDa Ribosomal protein S6 Kinase 1; p90-RSK 1; p90RSK1; p90S6K; MAP Kinase-activated protein Kinase 1a; MAPK-activated protein Kinase 1a; MAPKAP Kinase 1a; MAPKAP	WB, IP	Human, Mouse, Monkey
	RSK1 p90 Antibody (YA676) is a non-conjugated and Mouse origined monoclonal antibody about 83 kDa, targeting to RSK1 p90 (6B9). It can be used for WB,IP assays with tag free, in the background of Human, Mouse, Monkey.

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