SL 0101-1 (Synonyms: SL0101)

Name: SL 0101-1
Brand: MedChemExpress
SKU: HY-15237
Rating: 5.0 (4 reviews)

Cat. No.: HY-15237 Purity: ≥98.0%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

SL 0101-1 (SL0101), a kaempferol glycoside, isolated from the tropical plant F. refracta, is a cell-permeable, selective, reversible, ATP-competitive p90 Ribosomal S6 Kinase (RSK) inhibitor, with an IC₅₀ of 89 nM. SL 0101-1 (SL0101) is a selective RSK1/2 inhibitor, with a K_i of 1 μM.

For research use only. We do not sell to patients.

SL 0101-1 Chemical Structure

CAS No. : 77307-50-7

Size	Price	Stock	Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	USD 450	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	USD 450	In-stock	Estimated Time of Arrival: December 31
Solid
1 mg	USD 165	In-stock	Estimated Time of Arrival: December 31
5 mg	USD 396	In-stock	Estimated Time of Arrival: December 31
10 mg		Get quote
50 mg		Get quote

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Customer Review

Based on 4 publication(s) in Google Scholar

4 Publications Citing Use of MCE SL 0101-1

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View All Isoforms

p70S6K RSK1 RSK2 RSK3 RSK4

Biological Activity
Purity & Documentation
References
Customer Review

Description

SL 0101-1 (SL0101), a kaempferol glycoside, isolated from the tropical plant F. refracta, is a cell-permeable, selective, reversible, ATP-competitive p90 Ribosomal S6 Kinase (RSK) inhibitor, with an IC₅₀ of 89 nM^[1]. SL 0101-1 (SL0101) is a selective RSK1/2 inhibitor, with a K_i of 1 μM^[2].

IC₅₀ & Target

RSK1

Cellular Effect

Cell Line	Type	Value	Description	References
HCC70	IC₅₀	15 μM Compound: 52; SL0101	Anticancer activity against human HCC70 cells assessed as cell growth inhibition incubated up to 72 hrs by Cell-Titre Glo assay Anticancer activity against human HCC70 cells assessed as cell growth inhibition incubated up to 72 hrs by Cell-Titre Glo assay	[PMID: 33650861]
MCF7	IC₅₀	45.6 μM Compound: 1, SL0101	Antiproliferative activity against human MCF7 cells after 48 hrs by CellTiter-GloTM assay Antiproliferative activity against human MCF7 cells after 48 hrs by CellTiter-GloTM assay	[PMID: 22464132]
MDA-MB-231	IC₅₀	3 μM Compound: 52; SL0101	Anticancer activity against human MDA-MB-231 cells assessed as cell growth inhibition incubated up to 72 hrs by Cell-Titre Glo assay Anticancer activity against human MDA-MB-231 cells assessed as cell growth inhibition incubated up to 72 hrs by Cell-Titre Glo assay	[PMID: 33650861]
Sf9	IC₅₀	0.583 μM Compound: 1, SL0101	Inhibition of His-tagged RSK2 expressed in Sf9 cells using ERalpha-Ser167 RLASTND as substrate after 120 mins by chemiluminescence assay Inhibition of His-tagged RSK2 expressed in Sf9 cells using ERalpha-Ser167 RLASTND as substrate after 120 mins by chemiluminescence assay	[PMID: 22464132]
Sf9	IC₅₀	0.99 μM Compound: 1, SL0101	Inhibition of recombinant RSK2 (unknown origin) expressed in baculovirus infected Sf9 cells assessed as decrease in substrate phosphorylation using GST-fusion protein containing ERalpha-Ser167 sequence-RLASTND as substrate by chemiluminescence analysis Inhibition of recombinant RSK2 (unknown origin) expressed in baculovirus infected Sf9 cells assessed as decrease in substrate phosphorylation using GST-fusion protein containing ERalpha-Ser167 sequence-RLASTND as substrate by chemiluminescence analysis	[PMID: 23519677]
Sf9	IC₅₀	89 nM Compound: SL0101	Inhibition of his-tagged active RSK2 (unknown origin) expressed in Sf9 cells after 10 to 45 mins by ELISA Inhibition of his-tagged active RSK2 (unknown origin) expressed in Sf9 cells after 10 to 45 mins by ELISA	[PMID: 25147152]

In Vitro

SL 0101-1 (SL0101) shows proliferation inhibition in human breast cancer cell line MCF-7 and produces a cell cycle block in G₁ phase^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

516.45

Formula

C₂₅H₂₄O₁₂

CAS No.

77307-50-7

Appearance

Solid

Color

White to yellow

SMILES

OC1=CC(O)=C(C(C(O[C@@H]2O[C@@H](C)[C@H](OC(C)=O)[C@@H](OC(C)=O)[C@H]2O)=C(C3=CC=C(O)C=C3)O4)=O)C4=C1

Structure Classification

Initial Source

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 10 mg/mL (19.36 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.9363 mL	9.6815 mL	19.3630 mL
5 mM	0.3873 mL	1.9363 mL	3.8726 mL
10 mM	0.1936 mL	0.9681 mL	1.9363 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: ≥98.0%

Select Batch:

Data Sheet (280 KB) SDS (393 KB)

COA (259 KB)

Handling Instructions (2659 KB)

References

[1]. Smith JA, et al. Identification of the first specific inhibitor of p90 ribosomal S6 kinase (RSK) reveals an unexpected role for RSK in cancer cell proliferation. Cancer Res. 2005 Feb 1;65(3):1027-34. [Content Brief]

[2]. Yu Li, et al. The Affinity of RSK for Cylitol Analogues of SL0101 Is Critically Dependent on the B-ring C-4'-hydroxy. Chem Commun (Camb). 2020 Mar 10;56(20):3058-3060. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.9363 mL	9.6815 mL	19.3630 mL	48.4074 mL
	5 mM	0.3873 mL	1.9363 mL	3.8726 mL	9.6815 mL
	10 mM	0.1936 mL	0.9681 mL	1.9363 mL	4.8407 mL
	15 mM	0.1291 mL	0.6454 mL	1.2909 mL	3.2272 mL

SL 0101-1 Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SL 0101-177307-50-7SL0101SL 0101SL-0101Ribosomal S6 Kinase (RSK)S6KInhibitorinhibitorinhibit

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SL 0101-1 (Synonyms: SL0101)

Customer Review

SL 0101-1 Related Antibodies

4 Publications Citing Use of MCE SL 0101-1

Featured Recommendations

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

View All Ribosomal S6 Kinase (RSK) Isoform Specific Products:

Biological Activity

Purity & Documentation

References

Customer Review

SL 0101-1 Related Antibodies

Molarity Calculator

Dilution Calculator

Complete Stock Solution Preparation Table

SL 0101-1 Related Classifications

Keywords:

Your Recently Viewed Products:

Customer Review

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