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SSRI Inhibitor

" in MedChemExpress (MCE) Product Catalog:

40

Inhibitors & Agonists

1

Natural
Products

12

Isotope-Labeled Compounds

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-B1287
    Citalopram hydrobromide
    5+ Cited Publications

    (±)-Citalopram hydrobromide; Lu 10-171

    		 Serotonin Transporter Autophagy Neurological Disease Cancer
    Citalopram hydrobromide is a selective serotonin reuptake inhibitor (SSRI). Citalopram hydrobromide inhibits 5-HT uptake into synaptosomes with an IC50 of 1.8 nM. Citalopram hydrobromideinhibits the 5-HT uptake in rabbit blood platelets with an IC50 of 14 nM. Antidepressant effect .
    Citalopram hydrobromide
  • HY-B0304AS
    Dapoxetine-d7 hydrochloride

    LY-210448-d7 hydrochloride

    		 Serotonin Transporter Neurological Disease
    Dapoxetine-d7 (hydrochloride) is the deuterium labeled Dapoxetine hydrochloride. Dapoxetine hydrochloride is a short-acting selective serotonin reuptake inhibitor (SSRI)[1].
    Dapoxetine-d7 hydrochloride
  • HY-121203S
    Citalopram-d4 hydrobromide

    		Isotope-Labeled Compounds Serotonin Transporter Neurological Disease
    Citalopram-d4 (hydrobromide) is the deuterium labeled Citalopram hydrobromide. Citalopram hydrobromide is a selective serotonin reuptake inhibitor (SSRI)[1].
    Citalopram-d4 hydrobromide
  • HY-B0102B
    (S)-Fluoxetine hydrochloride

    		Serotonin Transporter Neurological Disease
    (S)-Fluoxetine hydrochloride, an antidepressant, is serotonin reuptake inhibitor (SSRI) .
    (S)-Fluoxetine hydrochloride
  • HY-110029
    Paroxetine maleate

    BRL29060 maleate

    		 Serotonin Transporter Neurological Disease
    Paroxetine maleate is a potent and selective inhibitor of SSRI. Paroxetine maleate is used in generalized anxiety disorder, post traumatic stress disorder, premenstrual dysphoric disorder and chronic headache research .
    Paroxetine maleate
  • HY-B0773
    Paroxetine mesylate

    BRL29060 mesylate

    		 Serotonin Transporter Adrenergic Receptor Neurological Disease
    Paroxetine mesylate, a phenylpiperidine derivative, is a potent and selective serotonin reuptake inhibitor (SSRI). Paroxetine mesylate is a very weak inhibitor of norepinephrine (NE) uptake but it is still more potent at this site than the other SSRIs .
    Paroxetine mesylate
  • HY-122272S2
    Paroxetine-d6-1

    BRL29060-d6-1

    		 Isotope-Labeled Compounds Adrenergic Receptor Serotonin Transporter Neurological Disease
    Paroxetine-d6-1 is a deuterated labeled Paroxetine . Paroxetine, a phenylpiperidine derivative, is a potent and selective serotonin reuptake inhibitor (SSRI). Paroxetine is a very weak inhibitor of norepinephrine (NE) uptake but it is still more potent at this site than the other SSRIs .
    Paroxetine-d6-1
  • HY-B0102D
    Fluoxetine oxalate

    LY-110140 oxalate

    		 Serotonin Transporter Autophagy Neurological Disease
    Fluoxetine oxalate is a selective serotonin reuptake inhibitor (SSRI) class used for antidepressant research.
    Fluoxetine oxalate
  • HY-106397A
    Delucemine hydrochloride

    NPS-1506 hydrochloride

    		 Serotonin Transporter iGluR Neurological Disease
    Delucemine hydrochloride is a selective serotonin reuptake inhibitor (SSRI) and NMDAR antagonist. Delucemine hydrochloride can be used as an antidepressant .
    Delucemine hydrochloride
  • HY-106397
    Delucemine

    NPS-1506

    		 Serotonin Transporter iGluR Neurological Disease
    Delucemine is a selective serotonin reuptake inhibitor (SSRI) and NMDAR antagonist. Delucemine can be used as an antidepressant .
    Delucemine
  • HY-B0102
    Fluoxetine
    Maximum Cited Publications
    25 Publications Verification

    LY-110140 free base

    		 Serotonin Transporter Autophagy Neurological Disease
    Fluoxetine (LY-110140 free base) is a selective serotonin reuptake inhibitor (SSRI) class used for antidepressant research.
    Fluoxetine
  • HY-B0176A
    Sertraline hydrochloride
    5+ Cited Publications

    		 Serotonin Transporter Neurological Disease Cancer
    Sertraline hydrochloride is an antidepressant of the selective serotonin reuptake inhibitor (SSRI) class. Sertraline hydrochloride is researched for a number of diseases, such as major depressive disorder and obsessive .
    Sertraline hydrochloride
  • HY-B0304A
    Dapoxetine hydrochloride
    1 Publications Verification

    LY-210448 hydrochloride

    		 Serotonin Transporter Neurological Disease
    Dapoxetine (LY-210448) hydrochloride is an orally active and selective serotonin reuptake inhibitor (SSRI). Dapoxetine hydrochloride can be used for the research of premature ejaculation (PE) .
    Dapoxetine hydrochloride
  • HY-B0304
    Dapoxetine

    (S)-(+)-Dapoxetine; LY-210448

    		 Serotonin Transporter Neurological Disease
    Dapoxetine (LY-210448) is an orally active and selective serotonin reuptake inhibitor (SSRI). Dapoxetine can be used for the research of premature ejaculation (PE) .
    Dapoxetine
  • HY-B0304AS1
    Dapoxetine-d6 hydrochloride

    LY-210448-d6 hydrochloride

    		 Isotope-Labeled Compounds Serotonin Transporter Neurological Disease
    Dapoxetine-d6 (LY-210448-d6) hydrochloride is the deuterium labeled Dapoxetine hydrochloride. Dapoxetine hydrochloride is a short-acting selective serotonin reuptake inhibitor (SSRI)
    Dapoxetine-d6 hydrochloride
  • HY-14261S
    Vilazodone-d8

    		5-HT Receptor Serotonin Transporter Neurological Disease
    Vilazodone-d8 is the a deuterium labeled vilazodone, which is a combined serotonin specific reuptake inhibitor (SSRI) and 5-HT1A receptor partial agonist.
    Vilazodone-d8
  • HY-121203
    Citalopram
    5+ Cited Publications

    		 Serotonin Transporter Neurological Disease Cancer
    Citalopram is a racemate mixture of the active S(+)-enantiomer (Escitalopram; HY-14258) and R(-)-enantiomer. Citalopram is an orally active selective serotonin reuptake inhibitor (SSRI). Citalopram is an antidepressant and enhances serotoninergic neurotransmission .
    Citalopram
  • HY-133732
    Alaproclate hydrochloride

    GEA 654 hydrochloride; A03 hydrochloride

    		 Serotonin Transporter 5-HT Receptor iGluR Neurological Disease
    Alaproclate (GEA 654) hydrochloride is a selective and orally active serotonin re-uptake inhibitor (SSRI). Alaproclate hydrochloride also acts as a potent, reversible and noncompetitive antagonist of the NMDA receptor coupled ion flow .
    Alaproclate hydrochloride
  • HY-B0176AS1
    (±)-cis-Sertraline-d3 hydrochloride

    		Serotonin Transporter Neurological Disease
    (±)-cis-Sertraline-d3 (hydrochloride) is the deuterium labeled Sertraline hydrochloride. Sertraline hydrochloride is an antidepressant of the selective serotonin reuptake inhibitor (SSRI) class. Sertraline hydrochloride is researched for a number of diseases, such as major depressive disorder and obsessive[1][2].
    (±)-cis-Sertraline-d3 hydrochloride
  • HY-B0176AS
    rel-Sertraline-d3 hydrochloride

    		Serotonin Transporter Neurological Disease
    rel-Sertraline-d3 (hydrochloride) is the deuterium labeled Sertraline hydrochloride. Sertraline hydrochloride is an antidepressant of the selective serotonin reuptake inhibitor (SSRI) class. Sertraline hydrochloride is researched for a number of diseases, such as major depressive disorder and obsessive[1][2].
    rel-Sertraline-d3 hydrochloride
  • HY-B0176AR
    Sertraline hydrochloride (Standard)

    		Serotonin Transporter Neurological Disease Cancer
    Sertraline (hydrochloride) (Standard) is the analytical standard of Sertraline (hydrochloride). This product is intended for research and analytical applications. Sertraline hydrochloride is an antidepressant of the selective serotonin reuptake inhibitor (SSRI) class. Sertraline hydrochloride is researched for a number of diseases, such as major depressive disorder and obsessive .
    Sertraline hydrochloride (Standard)
  • HY-B0102C
    (R)-Fluoxetine hydrochloride

    		Serotonin Transporter Neurological Disease
    (R)-Fluoxetine hydrochloride, an antidepressant, is serotonin reuptake inhibitor (SSRI). (R)-Fluoxetine hydrochloride has modest affinity at the 5-HT2A and 5-HT2C receptors .
    (R)-Fluoxetine hydrochloride
  • HY-B0304S
    Dapoxetine-d6

    		Serotonin Transporter Neurological Disease
    Dapoxetine-d6 is the deuterium labeled Dapoxetine[1]. Dapoxetine (LY-210448) is an orally active and selective serotonin reuptake inhibitor (SSRI). Dapoxetine can be used for the research of premature ejaculation (PE)[2].
    Dapoxetine-d6
  • HY-B0304AR
    Dapoxetine hydrochloride (Standard)

    		Serotonin Transporter Neurological Disease
    Dapoxetine (hydrochloride) (Standard) is the analytical standard of Dapoxetine (hydrochloride). This product is intended for research and analytical applications. Dapoxetine (LY-210448) hydrochloride is an orally active and selective serotonin reuptake inhibitor (SSRI). Dapoxetine hydrochloride can be used for the research of premature ejaculation (PE) .
    Dapoxetine hydrochloride (Standard)
  • HY-B0304R
    Dapoxetine (Standard)

    		Serotonin Transporter Neurological Disease
    Dapoxetine (Standard) is the analytical standard of Dapoxetine. This product is intended for research and analytical applications. Dapoxetine (LY-210448) is an orally active and selective serotonin reuptake inhibitor (SSRI). Dapoxetine can be used for the research of premature ejaculation (PE) .
    Dapoxetine (Standard)
  • HY-121203S4
    Citalopram-d3 hydrochloride

    		Serotonin Transporter Isotope-Labeled Compounds Neurological Disease Cancer
    Citalopram-d3 hydrochloride is deuterated labeled Citalopram (HY-121203). Citalopram is a racemate mixture of the active S(+)-enantiomer (Escitalopram; HY-14258) and R(-)-enantiomer. Citalopram is an orally active selective serotonin reuptake inhibitor (SSRI). Citalopram is an antidepressant and enhances serotoninergic neurotransmission .
    Citalopram-d3 hydrochloride
  • HY-121203R
    Citalopram (Standard)

    		Serotonin Transporter Neurological Disease Cancer
    Citalopram (Standard) is the analytical standard of Citalopram. This product is intended for research and analytical applications. Citalopram is a racemate mixture of the active S(+)-enantiomer (Escitalopram; HY-14258) and R(-)-enantiomer. Citalopram is an orally active selective serotonin reuptake inhibitor (SSRI). Citalopram is an antidepressant and enhances serotoninergic neurotransmission .
    Citalopram (Standard)
  • HY-14262
    Vilazodone
    4 Publications Verification

    EMD 68843; SB659746A

    		 5-HT Receptor Serotonin Transporter Neurological Disease
    Vilazodone (EMD 68843; SB 659746A) is a potent, selective and orally active serotonin reuptake inhibitor (SSRI) and partial 5-HT1A receptor agonist. Vilazodone exhibits antidepressant efficacy in vivo can be used for the research of major depressive disorder (MDD) and affective disorders .
    Vilazodone
  • HY-B1287R
    Citalopram hydrobromide (Standard)

    (±)-Citalopram hydrobromide(Standard); Lu 10-171 (Standard)

    		 Serotonin Transporter Autophagy Neurological Disease Cancer
    Citalopram (hydrobromide) (Standard) is the analytical standard of Citalopram (hydrobromide). This product is intended for research and analytical applications. Citalopram hydrobromide is a selective serotonin reuptake inhibitor (SSRI). Citalopram hydrobromide inhibits 5-HT uptake into synaptosomes with an IC50 of 1.8 nM. Citalopram hydrobromideinhibits the 5-HT uptake in rabbit blood platelets with an IC50 of 14 nM. Antidepressant effect .
    Citalopram hydrobromide (Standard)
  • HY-14258
    Escitalopram
    3 Publications Verification

    (S)-Citalopram; (S)-(+)-Citalopram

    		 Serotonin Transporter Neurological Disease
    Escitalopram ((S)-Citalopram), the S-enantiomer of racemic Citalopram, is a selective serotonin reuptake inhibitor (SSRI) with a Ki of 0.89 nM. Escitalopram has ∼30 fold higher binding affinity than its R(-)-enantiomer and shows selectivity over both dopamine transporter (DAT) and norepinephrine transporter (NET). Escitalopram is an antidepressant for the research of major depression .
    Escitalopram
  • HY-14258A
    Escitalopram oxalate
    3 Publications Verification

    (S)-Citalopram oxalate; (S)-(+)-Citalopram oxalate

    		 Serotonin Transporter Neurological Disease Cancer
    Escitalopram ((S)-Citalopram) oxalate, the S-enantiomer of racemic Citalopram, is a selective serotonin reuptake inhibitor (SSRI) with a Ki of 0.89 nM. Escitalopram oxalate has ∼30 fold higher binding affinity than its R(-)-enantiomer and shows selectivity over both dopamine transporter (DAT) and norepinephrine transporter (NET). Escitalopram oxalate is an antidepressant for the research of major depression .
    Escitalopram oxalate
  • HY-124779A
    (S)-Alaproclate hydrochloride

    (S)-GEA 654 hydrochloride; (S)-A03 hydrochloride

    		 Serotonin Transporter Neurological Disease
    (S)-Alaproclate ((S)-A03) hydrochloride is a potent selective serotonin reuptake inhibitor (SSRI), which is used as an antidepressant agent. (S)-Alaproclate (hydrochloride) also produces a potent block of N-methyl-d-aspartate (NMDA) receptor currents in hippocampal neurons (IC50=1.1 μM) with a potent blocker of K + currents .
    (S)-Alaproclate hydrochloride
  • HY-122272
    Paroxetine
    5+ Cited Publications

    BRL29060

    		 Serotonin Transporter Adrenergic Receptor P2X Receptor Apoptosis Neurological Disease Cancer
    Paroxetine is an oral inhibitor that falls under the category of selective serotonin reuptake inhibitors (SSRIs). Paroxetine is also a very weak norepinephrine (NE) reuptake inhibitor, capable of inducing cell apoptosis and having anti-tumor activity. Paroxetine has antidepressant, anti-anxiety, and pain-relieving effects, and it can help improve conditions like obsessive-compulsive disorder, panic disorder, post-traumatic stress disorder, premenstrual anxiety, and chronic headaches .
    Paroxetine
  • HY-14262S1
    Vilazodone-d8 hydrochloride

    EMD 68843-d8; SB659746A-d8

    		 5-HT Receptor Serotonin Transporter Isotope-Labeled Compounds Neurological Disease
    Vilazodone-d8 hydrochloride is deuterated labeled Vilazodone (HY-14262). Vilazodone (EMD 68843; SB 659746A) is a potent, selective and orally active serotonin reuptake inhibitor (SSRI) and partial 5-HT1A receptor agonist. Vilazodone exhibits antidepressant efficacy in vivo can be used for the research of major depressive disorder (MDD) and affective disorders .
    Vilazodone-d8 hydrochloride
  • HY-14262R
    Vilazodone (Standard)

    		5-HT Receptor Serotonin Transporter Neurological Disease
    Vilazodone (Standard) is the analytical standard of Vilazodone. This product is intended for research and analytical applications. Vilazodone (EMD 68843; SB 659746A) is a potent, selective and orally active serotonin reuptake inhibitor (SSRI) and partial 5-HT1A receptor agonist. Vilazodone exhibits antidepressant efficacy in vivo can be used for the research of major depressive disorder (MDD) and affective disorders .
    Vilazodone (Standard)
  • HY-124357
    Seproxetine hydrochloride

    S-Norfluoxetine hydrochloride; LY 215229 hydrochloride

    		 Others Neurological Disease
    Seproxetine (S-Norfluoxetine) hydrochloride is a selective serotonin reuptake inhibitor (SSRI) that enhances serotonin levels in the brain by specifically inhibiting the serotonin uptake carrier. Seproxetine hydrochloride exhibits strong charge transfer interactions with π-electron acceptors, forming stable complexes that enhance its binding affinity to multiple receptors, including serotonin and dopamine receptors. Seproxetine hydrochloride demonstrates improved biological activity when interacting with charge transfer complexes, leading to increased stability and efficacy in therapeutic applications.
    Seproxetine hydrochloride
  • HY-14258AS
    Escitalopram-d6 oxalate

    		Serotonin Transporter Neurological Disease
    Escitalopram-d6 (oxalate) is the deuterium labeled Escitalopram oxalate. Escitalopram ((S)-Citalopram) oxalate, the S-enantiomer of racemic Citalopram, is a selective serotonin reuptake inhibitor (SSRI) with a Ki of 0.89 nM. Escitalopram oxalate has ∼30 fold higher binding affinity than its R(-)-enantiomer and shows selectivity over both dopamine transporter (DAT) and norepinephrine transporter (NET). Escitalopram oxalate is an antidepressant for the research of major depression[1][2].
    Escitalopram-d6 oxalate
  • HY-14258AS1
    Escitalopram-d4 oxalate

    (S)-Citalopram-d4 oxalate; (S)-(+)-Citalopram-d4 oxalate

    		 Isotope-Labeled Compounds Serotonin Transporter Neurological Disease
    Escitalopram-d4 (oxalate) is deuterium labeled Escitalopram (oxalate). Escitalopram ((S)-Citalopram) oxalate, the S-enantiomer of racemic Citalopram, is a selective serotonin reuptake inhibitor (SSRI) with a Ki of 0.89 nM. Escitalopram oxalate has ∼30 fold higher binding affinity than its R(-)-enantiomer and shows selectivity over both dopamine transporter (DAT) and norepinephrine transporter (NET). Escitalopram oxalate is an antidepressant for the research of major depression[1][2].
    Escitalopram-d4 oxalate
  • HY-14258AR
    Escitalopram oxalate (Standard)

    (S)-Citalopram oxalate (Standard); (S)-(+)-Citalopram oxalate (Standard)

    		 Serotonin Transporter Neurological Disease Cancer
    Escitalopram (oxalate) (Standard) is the analytical standard of Escitalopram (oxalate). This product is intended for research and analytical applications. Escitalopram ((S)-Citalopram) oxalate, the S-enantiomer of racemic Citalopram, is a selective serotonin reuptake inhibitor (SSRI) with a Ki of 0.89 nM. Escitalopram oxalate has ∼30 fold higher binding affinity than its R(-)-enantiomer and shows selectivity over both dopamine transporter (DAT) and norepinephrine transporter (NET). Escitalopram oxalate is an antidepressant for the research of major depression .
    Escitalopram oxalate (Standard)
  • HY-121562
    SB 714786

    		Others Neurological Disease
    SB 714786 is a potent and selective 5-hydroxytryptamine 1D (5-HT1D) receptor antagonist. It was developed from the previously reported series of dual 5-HT1 selective 5-hydroxytryptamine reuptake inhibitors (5HT1-SSRIs). SB 714786 is the first reported highly potent and selective 5-HT1D receptor antagonist, providing an extremely useful pharmacological tool for further understanding the role of 5-HT1 receptor subtypes. It has no or very low intrinsic activity against all three receptors. SB 714786 has pKi values of 6.5, 6.7, 9.1 and 6.5 for 5-HT1A, 5-HT1B, 5-HT1D and SerT receptors, respectively, showing high selectivity for 5-HT1D receptors. These properties make SB 714786 a potential tool compound for studying the function of 5-HT1D receptors and the treatment of related diseases.
    SB 714786

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