2. Neuronal Signaling GPCR/G Protein Membrane Transporter/Ion Channel Apoptosis
  3. Serotonin Transporter Adrenergic Receptor P2X Receptor Apoptosis
  4. Paroxetine

Paroxetine  (Synonyms: BRL29060)

Cat. No.: HY-122272 Purity: 99.92%
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Paroxetine is an oral inhibitor that falls under the category of selective serotonin reuptake inhibitors (SSRIs). Paroxetine is also a very weak norepinephrine (NE) reuptake inhibitor, capable of inducing cell apoptosis and having anti-tumor activity. Paroxetine has antidepressant, anti-anxiety, and pain-relieving effects, and it can help improve conditions like obsessive-compulsive disorder, panic disorder, post-traumatic stress disorder, premenstrual anxiety, and chronic headaches.

For research use only. We do not sell to patients.

Paroxetine Chemical Structure

Paroxetine Chemical Structure

CAS No. : 61869-08-7

Size Price Stock Quantity
Liquid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 77 In-stock
Solution
10 mM * 1 mL in DMSO USD 77 In-stock
Liquid
100 mg USD 70 In-stock
500 mg USD 198 In-stock
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Based on 8 publication(s) in Google Scholar

Other Forms of Paroxetine:

Paroxetine Related Antibodies

Top Publications Citing Use of Products

    Paroxetine purchased from MedChemExpress. Usage Cited in: Brain Res. 2019 Oct 1;1720:146296.  [Abstract]

    Protein levels of IFNα and IRF2(B) are detected in HA1800 Cells at 6 h, 12 h and 24 h after paroxetine (10μM) treatment by RT-qPCR and western blot respectively.

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    Description

    Paroxetine is an oral inhibitor that falls under the category of selective serotonin reuptake inhibitors (SSRIs). Paroxetine is also a very weak norepinephrine (NE) reuptake inhibitor, capable of inducing cell apoptosis and having anti-tumor activity. Paroxetine has antidepressant, anti-anxiety, and pain-relieving effects, and it can help improve conditions like obsessive-compulsive disorder, panic disorder, post-traumatic stress disorder, premenstrual anxiety, and chronic headaches[1][2][3][4].

    In Vitro

    Paroxetine (10-30 μM, 72 h) reduces the viability of MCF-7 cells in a time- and dose-dependent manner[1].
    Paroxetine (10-30 μM, 1-12 h) induces mitochondrial-mediated apoptosis in MCF-7, increasing ROS generation[1].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Paroxetine Related Antibodies

    Western Blot Analysis[1]

    Cell Line: MCF-7
    Concentration: 0, 10, 30 μM
    Incubation Time: 12 h
    Result: Reduced the expression levels of anti-apoptotic proteins Bcl-2 and Bcl-xL, increased the expression level of pro-apoptotic protein Bax, and caused the cleavage of caspase-8 and caspase-9.

    Cell Viability Assay[1]

    Cell Line: MCF-7, MCF-10A
    Concentration: 10, 30 μM
    Incubation Time: 72 h
    Result: Decreased cell viability.

    Apoptosis Analysis[1]

    Cell Line: MCF-7
    Concentration: 30 μM; 10, 30 μM
    Incubation Time: 12 h; 1, 3, 6, 12 h
    Result: Led to the translocation of cytochrome C, the expression of cytochrome C in the mitochondria was reduced, and the expression of cytochrome C in the cytoplasm was accumulated. The concentration of reduced glutathione was significantly reduced, and the level of ROS was increased.
    In Vivo

    Paroxetine (10 mg/kg, intraperitoneally, once a day for 14 days) reduces neurogenic pain in rats both before and after sciatic nerve injury[2].
    Paroxetine (0.3-10 mg/kg, orally, single dose) has anti-anxiety and antidepressant effects in rats, increasing social interaction time[3].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: Male Wistar rat[2]
    Dosage: 10 mg/kg; daily; 14 days
    Administration: Intraperitoneal injection (i.p.)
    Result: Reduced mechanical and thermal hyperalgesia, and also showed effective relief of existing hyperalgesia and thermal hyperalgesia when administration began 7 days after injury.
    Animal Model: Male Sprague-Dawley rats[3]
    Dosage: 0.3, 1, 3, 10 mg/kg; single dose
    Administration: Oral
    Result: Reduced the synthesis rate of serotonin and increased the social time of rats, but had no effect on motor activity. The motor activity of animals taking the drug for a long time was slightly lower than that of animals taking the drug for a short time.
    Clinical Trial
    Molecular Weight

    329.37

    Formula

    C19H20FNO3
    CAS No.
    Appearance

    Liquid (Density: 1.213±0.06 g/cm3)

    Color

    Colorless to light yellow

    SMILES

    FC1=CC=C(C=C1)[C@H]2[C@@H](CNCC2)COC3=CC=C4OCOC4=C3
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage

    4°C, protect from light

    *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

    Solvent & Solubility
    In Vitro: 

    DMSO : 50 mg/mL (151.80 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 3.0361 mL 15.1805 mL 30.3610 mL
    5 mM 0.6072 mL 3.0361 mL 6.0722 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    Concentration (start)

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    In Vivo:

    Select the appropriate dissolution method based on your experimental animal and administration route.

    For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
    To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
    The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

    • Protocol 1

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

      Solubility: ≥ 2.5 mg/mL (7.59 mM); Clear solution

      This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

      Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

      Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
    • Protocol 2

      Add each solvent one by one:  10% DMSO    90% Corn Oil

      Solubility: ≥ 2.5 mg/mL (7.59 mM); Clear solution

      This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

      Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

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    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
    Please enter your animal formula composition:
    %
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    +
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    Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
    The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
    Calculation results:
    Working solution concentration: mg/mL
    Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).

    *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

    The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
    Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
     If the continuous dosing period exceeds half a month, please choose this protocol carefully.
    Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
    Purity & Documentation

    Purity: 99.92%

    SDS (393 KB)

    COA (251 KB) HNMR (411 KB) LCMS (88 KB)

    Handling Instructions (2659 KB)
    References

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    DMSO 1 mM 3.0361 mL 15.1805 mL 30.3610 mL 75.9025 mL
    5 mM 0.6072 mL 3.0361 mL 6.0722 mL 15.1805 mL
    10 mM 0.3036 mL 1.5180 mL 3.0361 mL 7.5902 mL
    15 mM 0.2024 mL 1.0120 mL 2.0241 mL 5.0602 mL
    20 mM 0.1518 mL 0.7590 mL 1.5180 mL 3.7951 mL
    25 mM 0.1214 mL 0.6072 mL 1.2144 mL 3.0361 mL
    30 mM 0.1012 mL 0.5060 mL 1.0120 mL 2.5301 mL
    40 mM 0.0759 mL 0.3795 mL 0.7590 mL 1.8976 mL
    50 mM 0.0607 mL 0.3036 mL 0.6072 mL 1.5180 mL
    60 mM 0.0506 mL 0.2530 mL 0.5060 mL 1.2650 mL
    80 mM 0.0380 mL 0.1898 mL 0.3795 mL 0.9488 mL
    100 mM 0.0304 mL 0.1518 mL 0.3036 mL 0.7590 mL
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    Paroxetine Related Classifications

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Paroxetine61869-08-7BRL29060BRL 29060BRL-29060Serotonin TransporterAdrenergic ReceptorP2X ReceptorApoptosis5-HTTSERTSLC6A4Beta ReceptorP2XRsAnti-tumoranalgesicserotonin reuptakenorepinephrineInhibitorinhibitorinhibit

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